donepezil and physostigmine

donepezil has been researched along with physostigmine in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (18.46)	18.2507
2000's	32 (49.23)	29.6817
2010's	16 (24.62)	24.3611
2020's	5 (7.69)	2.80

Authors

Authors	Studies
Cardozo, MG; Hopfinger, AJ; Iimura, Y; Sugimoto, H; Yamanishi, Y	1
Bigg, DC; Briley, M; Calmel, F; Carilla, E; Vidaluc, JL	1
Chapin, D; Chen, YL; Hubbard, S; Ives, JL; Jones, SB; Jung, S; Liston, DR; Mahar, M; Nagel, AA; Vincent, LA	1
Biggers, CK; Blake, JF; Butler, TW; Chapin, DS; Chen, YL; Ives, JL; Jones, SB; Liston, DR; Nagel, AA; Villalobos, A	1
Chen, Y; Collantes, ER; Tong, W; Welsh, WJ	1
Brufani, M; Cellai, L; Perola, E	1
Brossi, A; Greig, NH; Holloway, HW; Whittaker, NF; Yu, QS; Zhu, X	1
Andrisano, V; Banzi, R; Bartolini, M; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V	1
Alley, GM; Brossi, A; Deschamps, JR; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, D; Yu, QS; Zhan, M	1
Andrisano, V; Bartolini, M; Bidon-Chanal, A; de Austria, C; del Monte-Millán, M; Dorronsoro, I; García-Palomero, E; Luque, FJ; Martínez, A; Medina, M; Muñoz-Ruiz, P; Orozco, M; Rubio, L; Usán, P; Valenzuela, R	1
Brossi, A; Greig, NH; Holloway, HW; Kulkarni, SS; Lahiri, DK; Luo, W; Parrish, DA; Shafferman, A; Tweedie, D; Yu, QS	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Darekar, MN; Gurjar, AS; Ooi, L; Yeong, KY	1
Ji, J; Peng, Y; Rakesh, KP; Wang, S; Xu, M; Zhu, L	1
Curtis, MA; Lin, SX; Sperry, J	1
Li, J; Liu, D; Liu, W; Shi, T; Wang, D; Wang, Y; Wang, Z; Yin, G; Zhang, H	1
Andricopulo, AD; Cenci, AR; de Oliveira, AS; Ferreira, LLG; Machado, V; Nunes, RJ; Sandjo, LP; Sens, L; Teixeira, KF; Tizziani, T; Yunes, RA	1
Fujii, T; Fujimoto, K; Kawashima, K; Sato, A; Suzuki, T; Yoshizawa, M	1
Dawson, GR; Iversen, SD	1
Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M	1
Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H	1
Lichtman, SW; Seliger, G; Taverni, JP	1
Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL	1
Kaur, J; Zhang, MQ	1
Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H	1
Braida, D; Ottonello, F; Sala, M; Virag, W	1
Foster, NL; Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Minoshima, S	1
Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y	1
Robert, P	1
Blount, PJ; McDeavitt, JT; Nguyen, CD	1
Tang, XC; Zhao, Q	1
Butler, R; Prabhakaran, P; Warner, J	1
Chapin, D; Hubbard, ST; Jones, SB; Liston, DR; Nason, D; Nielsen, JA; Ramirez, A; Shalaby, IA; Villalobos, A; White, WF	1
Nagura, H	1
Borroni, B; Cattabeni, F; Colciaghi, F; Di Luca, M; Gardoni, F; Marcello, E; Padovani, A; Zimmermann, M	1
Caricati-Neto, A; D'angelo, LC; Garcia, AG; Hyppolito Jurkiewicz, N; Jurkiewicz, A; Reuter, H	1
Arya, P; Butler, R; Warner, J	2
Bertchume, A; Csernansky, CA; Csernansky, JG; Dong, H; Martin, MV; Vallera, D	1
Bertchume, A; Colvin, J; Csernansky, JG; Dong, H; Martin, M; Shah, R	1
Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Minoshima, S; Snyder, SE	1
Butler, R; Warner, J; Wuntakal, B	1
de Boissezon, X; de Boysson, C; Démonet, JF; Peran, P	1
Cerbai, F; Enz, A; Giovannini, MG; Melani, C; Pepeu, G	1
Kircher, T; Leucht, S; Thienel, R; Voss, B	1
Bajda, M; Malawska, B; Musiał, A	1
Hashimoto, K; Ishima, T; Iyo, M; Nishimura, T	1
Ehret, A; Feuerstein, TJ; Förster, S; Jackisch, R; Kammerer, M; Rothmaier, AK; Zentner, J	1
Fujita, Y; Hashimoto, K; Horio, M; Ishima, T; Iyo, M; Kohno, M; Kunitachi, S; Shirayama, Y; Tanibuchi, Y	1
Kamei, C; Masuoka, T	1
Hisatsune, T; Itou, Y; Kuribayashi, H; Nochi, R; Saito, Y	1
Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J	1
Haji, A; Kimura, S; Ohi, Y	1
Bendix, I; Bührer, C; Endesfelder, S; Felderhoff-Mueser, U; Kalb, A; Sifringer, M; Spies, CD; von Haefen, C	1
Darreh-Shori, T; Hosseini, SM; Nordberg, A	1
Boettger, S; Jellestad, L; Jenewein, J; Stocker, L	1
Mellios, G	1
David, B; Gohlke, H; Pietruszka, J; Schäfer, P; Schneider, P	1
Fitzgerald, PJ; Ghimire, A; Hale, PJ; Watson, BO	1

Reviews

14 review(s) available for donepezil and physostigmine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Triazoles	2019
Pyridine alkaloids with activity in the central nervous system. Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24 Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic	2020
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors. Current medicinal chemistry, 2000, Volume: 7, Issue:3 Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine	2000
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine. Current medical research and opinion, 2002, Volume: 18, Issue:3 Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome	2002
Clinical use of cholinomimetic agents: a review. The Journal of head trauma rehabilitation, 2002, Volume: 17, Issue:4 Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as Topic; Cytidine Diphosphate Choline; Donepezil; Female; Follow-Up Studies; Humans; Indans; Injections, Intravenous; Injury Severity Score; Male; Middle Aged; Parasympathomimetics; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome	2002
Dementia. Clinical evidence, 2003, Issue:9 Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E	2003
[Drugs for the treatment of Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl Topics: Acetylcholine; Alzheimer Disease; Antidepressive Agents; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Indans; Injections, Intramuscular; Physostigmine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tacrine	2004
Dementia. Clinical evidence, 2004, Issue:11 Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E	2004
Dementia. Clinical evidence, 2004, Issue:12 Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine	2004
Dementia. Clinical evidence, 2005, Issue:14 Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine	2005
Pharmacotherapy of aphasia: myth or reality? Brain and language, 2007, Volume: 102, Issue:1 Topics: Amphetamine; Aphasia; Bromocriptine; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Fluoxetine; GABA Agonists; Humans; Indans; Neuroprotective Agents; Paroxetine; Physostigmine; Piperidines; Piracetam; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Stroke; Zolpidem	2007
[Therapy of cognitive deficits in schizophrenia with acetylcholinesterase inhibitors. A systematic overview]. Der Nervenarzt, 2008, Volume: 79, Issue:1 Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Physostigmine; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Schizophrenia; Schizophrenic Psychology; Treatment Outcome	2008
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. Current medicinal chemistry, 2007, Volume: 14, Issue:25 Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine	2007

Trials

1 trial(s) available for donepezil and physostigmine

Article	Year
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors. Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors	2014

Article

Year

Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.

Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:2

Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors

2014

Other Studies

50 other study(ies) available for donepezil and physostigmine

Article	Year
QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Cholinesterase Inhibitors; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship	1992
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation. Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15 Topics: Animals; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Molecular Conformation; Rats; Structure-Activity Relationship; Thiourea	1995
Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors. Journal of medicinal chemistry, 1995, Mar-31, Volume: 38, Issue:7 Topics: Animals; Benzothiazoles; Butyrylcholinesterase; Cholinesterase Inhibitors; Corpus Striatum; Drug Design; Male; Mice; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles	1995
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase. Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17 Topics: Acetylcholine; Acetylcholinesterase; Animals; Avoidance Learning; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Computer Graphics; Isoxazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Morpholines; Piperidines; Prosencephalon; Structure-Activity Relationship	1994
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry, 1996, Jan-19, Volume: 39, Issue:2 Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Models, Molecular; Piperidines	1996
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase. Bioorganic & medicinal chemistry letters, 1998, Mar-17, Volume: 8, Issue:6 Topics: Acetamides; Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Erythrocytes; Humans; Protein Conformation; Solubility; Structure-Activity Relationship; Torpedo	1998
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17 Topics: Acetylcholinesterase; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cyclic N-Oxides; Humans; Isomerism; Oxazines; Structure-Activity Relationship	2002
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties. Journal of medicinal chemistry, 2004, Dec-16, Volume: 47, Issue:26 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Piperidines; Polyamines; Structure-Activity Relationship	2004
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4 Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Benzofurans; Butyrylcholinesterase; Carbamates; Cell Line; Cell Survival; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; Neurons; Oxepins; Structure-Activity Relationship	2005
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cell Line, Tumor; Cholinesterase Inhibitors; Dimerization; Drug Design; Erythrocytes; Fluorometry; Humans; Models, Molecular; Nootropic Agents; Protein Binding; Structure-Activity Relationship; Tacrine	2005
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Acetophenones; Acetylcholinesterase; Animals; Benzofurans; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Crystallography, X-Ray; Furans; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Oxepins; Stereoisomerism; Structure-Activity Relationship; Torpedo	2006
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology. Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17 Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease. Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophorus; Female; Horses; Imidazoles; Male; Maze Learning; Memory Disorders; Mice; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship	2018
Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2022, Feb-05, Volume: 229 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Drug Design; Humans; Male; Maze Learning; Molecular Docking Simulation; Neuroprotective Agents; Protein Aggregates; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tryptamines	2022
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies. RSC medicinal chemistry, 2022, Dec-14, Volume: 13, Issue:12 Topics:	2022
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:5 Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Male; Movement; Physostigmine; Piperidines; Radioimmunoassay; Rats; Rats, Wistar; Tacrine	1994
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behavioural brain research, 1993, Nov-30, Volume: 57, Issue:2 Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes	1993
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3 Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine	1996
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:3 Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed	1997
Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation. Brain injury, 1998, Volume: 12, Issue:1 Topics: Adult; Alzheimer Disease; Brain Injuries; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Donepezil; Female; Head Injuries, Closed; Humans; Indans; Male; Memory; Memory Disorders; Mental Recall; Middle Aged; Physical Therapy Modalities; Physostigmine; Piperidines; Temporal Lobe	1998
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999, Volume: 38, Issue:1 Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured	1999
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain. Brain research, 2000, Feb-28, Volume: 857, Issue:1-2 Topics: Acetylcholine; Age Factors; Animals; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Extracellular Space; Glucose; Indans; Macaca mulatta; Male; Microdialysis; Neurons; Physostigmine; Piperidines; Tacrine; Tomography, Emission-Computed; Wakefulness	2000
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit. Pharmacological research, 2000, Volume: 41, Issue:6 Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine	2000
Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Annals of neurology, 2000, Volume: 48, Issue:3 Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Physostigmine; Piperidines; Tomography, Emission-Computed	2000
Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Inhibitory Concentration 50; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rivastigmine; Tacrine; Time Factors	2000
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology, 2002, Nov-29, Volume: 455, Issue:2-3 Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine	2002
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. European journal of pharmacology, 2004, Feb-13, Volume: 486, Issue:1 Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine	2004
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. Journal of neurochemistry, 2004, Volume: 90, Issue:6 Topics: Acetylcholinesterase; ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Atropine; Blotting, Western; Brefeldin A; Bungarotoxins; Carbachol; Cell Differentiation; Cell Fractionation; Cell Line, Tumor; Cholinergic Agonists; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Indans; Membrane Proteins; Metalloendopeptidases; Microscopy, Confocal; Muscarinic Antagonists; Neuroblastoma; Physostigmine; Piperidines; Protein Synthesis Inhibitors; Protein Transport; Tretinoin	2004
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens. European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3 Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens	2004
Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology, 2005, Volume: 181, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Psychological; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Fear; Genetics, Behavioral; Heterozygote; Humans; Indans; Learning; Memory; Memory Disorders; Mice; Mice, Transgenic; Physostigmine; Piperidines; Plaque, Amyloid; Spatial Behavior	2005
Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:12 Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognition; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Galantamine; Indans; Learning; Male; Maze Learning; Mice; Mice, Inbred C57BL; Physostigmine; Piperidines; Receptors, Nicotinic	2005
In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Annals of neurology, 2006, Volume: 59, Issue:1 Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Butyrylcholinesterase; Carbon Radioisotopes; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Physostigmine; Piperidines; Positron-Emission Tomography; Reproducibility of Results; Synapses	2006
N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. European journal of pharmacology, 2007, Oct-31, Volume: 572, Issue:2-3 Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Mass Spectrometry; Microdialysis; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine	2007
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors. Progress in neuro-psychopharmacology & biological psychiatry, 2008, Oct-01, Volume: 32, Issue:7 Topics: Analysis of Variance; Animals; Anisoles; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Indans; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Physostigmine; Piperidines; Propylamines; Rats; Receptors, sigma; Sigma-1 Receptor	2008
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex. Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:3 Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult	2009
Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors. Brain research, 2009, Jul-07, Volume: 1279 Topics: Analysis of Variance; Animals; Anisoles; Brain; Cell Membrane; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Hippocampus; Immunohistochemistry; Indans; Male; Mice; Mice, Inbred ICR; Phencyclidine; Physostigmine; Piperidines; Propylamines; Receptors, sigma; Recognition, Psychology; Sigma-1 Receptor; Tritium	2009
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits. Psychopharmacology, 2009, Volume: 206, Issue:2 Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm	2009
Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus. Hippocampus, 2011, Volume: 21, Issue:4 Topics: Acetylcholine; Aging; Animals; Cell Proliferation; Cholinesterase Inhibitors; Dentate Gyrus; Donepezil; Humans; Indans; Mice; Mice, Transgenic; Microscopy, Confocal; Muscarinic Agonists; Neural Stem Cells; Neurogenesis; Neurons; Nootropic Agents; Physostigmine; Piperidines; Receptors, Muscarinic	2011
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs. Journal of Alzheimer's disease : JAD, 2011, Volume: 26, Issue:1 Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine	2011
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. European journal of pharmacology, 2013, Mar-05, Volume: 703, Issue:1-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Donepezil; Indans; Male; Morphine; Pain; Physostigmine; Piperidines; Rats; Rats, Wistar; Respiratory Insufficiency; Serotonin 5-HT1 Receptor Agonists	2013
Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain. Developmental neuroscience, 2013, Volume: 35, Issue:2-3 Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Female; Hyperoxia; Immunohistochemistry; Indans; Male; Nerve Degeneration; Oxidative Stress; Oxygen; Physostigmine; Piperidines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction	2013
Challenges in the management of delirium: a case of augmentation with donepezil following inadequate response and adverse effects with risperidone. Psychiatria Danubina, 2015, Volume: 27, Issue:1 Topics: Anticholinergic Syndrome; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Burns; Cholinesterase Inhibitors; Delirium; Diagnosis, Differential; Donepezil; Drug Administration Routes; Drug Synergism; Humans; Indans; Male; Middle Aged; Muscle Rigidity; Physostigmine; Piperidines; Risperidone; Treatment Outcome	2015
Donepezil: It is time to replace physostigmine in Anesthesiology. Medical hypotheses, 2016, Volume: 94 Topics: Aging; Anesthesia, General; Anesthesiology; Anesthetics; Brain; Cholinergic Neurons; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Infusions, Intravenous; Learning; Memory; Physostigmine; Piperidines; Postoperative Period; Quality of Life; Time Factors	2016
Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and Journal of enzyme inhibition and medicinal chemistry, 2021, Volume: 36, Issue:1 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Electrophorus; Molecular Docking Simulation; Molecular Structure; Physostigmine; Structure-Activity Relationship	2021
Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test. Behavioural brain research, 2021, 07-09, Volume: 409 Topics: Animals; Antidepressive Agents; Association Learning; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Repositioning; Galantamine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Physostigmine; Rivastigmine; Swimming	2021