Compounds > donepezil

donepezil and indomethacin

donepezil has been researched along with indomethacin in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	14 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Boni, MS; Castro, NG; Coelho, MM; da Silva, FM; da Silva, ML; Dardenne, LE; de Melo, IS; de Paula, CT; Dias, KS; Dos Santos, T; Giusti, FC; Giusti-Paiva, A; Guedes, IA; Guimarães, MJ; Morroni, F; Neves, GA; Pruccoli, L; Souza, IN; Tarozzi, A; Veloso, CC; Viegas, C	1
Camps, I; Castelli, MR; Castro, NG; D'Alincourt da Fonseca Peçanha, D; da Silva, FMR; Dardenne, LE; de Freitas Silva, M; de Oliveira Carneiro Junior, W; Dias Viegas, FP; Divino da Rocha, M; Ferreira, FF; Ferreira-Silva, GÁ; Giusti-Paiva, A; Gontijo, VS; Guedes, IA; Ionta, M; Leomil Coelho, LF; Machado, RP; Mancini, KC; Marques de Oliveira, PC; Morais, ÉP; Neves, GA; Orlandi, L; Pereira, RM; Pinheiro de Oliveira, AC; Pruccoli, L; Quaglio Bellozi, PM; Riquiel, MM; Simões de Lima, LM; Tarozzi, A; Vaz, SM; Veloso, MP; Viegas, C; Vilela, FC	1
Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A	1
Ishii, K; Kubota, Y; Nakahara, T; Sakamoto, K; Shimizu, N	1

Reviews

1 review(s) available for donepezil and indomethacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

13 other study(ies) available for donepezil and indomethacin

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Acrylates; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Male; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Neurons; Neuroprotective Agents; Piperidines; Structure-Activity Relationship	2017
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. European journal of medicinal chemistry, 2018, Mar-10, Volume: 147 Topics: Acetylcholinesterase; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Discovery; Hep G2 Cells; Humans; Hydrazones; Indans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Structure-Activity Relationship	2018
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. European journal of medicinal chemistry, 2019, Apr-01, Volume: 167 Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles	2019
Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder. Pharmacology, 2010, Volume: 86, Issue:5-6 Topics: Animals; Atropine; Cholinesterase Inhibitors; Donepezil; Indans; Indomethacin; Male; Muscle Contraction; Neostigmine; Piperidines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Urinary Bladder	2010