donepezil has been researched along with ascorbic acid in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (78.95) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Alipour, M; Emami, S; Foroumadi, A; Hasanpour, Z; Homayouni Moghadam, F; Khoobi, M; Moradi, A; Nadri, H; Shafiee, A | 1 |
| Amjad, MW; Bukhari, SN; Jantan, I; Mahajan, DT; Masand, VH; Naeem-ul-Hassan, M; Sher, M | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Agrawal, N; Machhi, J; Murumkar, P; Parikh, Z; Pillai, P; Sharma, MK; Shidore, M; Shingala, K; Tripathi, A; Yadav, MR | 1 |
| Kaur, M; Silakari, O; Singh, M; Singh, N | 1 |
| Darekar, MN; Gurjar, AS; Ooi, L; Yeong, KY | 1 |
| Ganeshpurkar, A; Gupta, SK; Gutti, G; Krishnamurthy, S; Kumar, D; Modi, G; Singh, SK | 1 |
| Abbas Bukhari, SN; Abdolahi, Z; Abdollahi, M; Ameri, A; Ayazgok, B; Baeeri, M; Emami, S; Forootanfar, H; Foroumadi, A; Ganjali, MR; Jafari, M; Jalili-Baleh, L; Khoobi, M; Küçükkılınç, TT; Nadri, H; Rahimifard, M | 1 |
| Rai, SN; Shankar, S; Sharma, P; Shrivastava, SK; Singh, SP; Srivastava, P; Srivastava, RK; Tripathi, PN | 1 |
| Seth, A; Sharma, P; Shrivastava, SK; Srivastava, P; Tripathi, PN | 1 |
| Han, J; Ji, L; Li, Z; Ma, J; Wang, M; Wu, M | 1 |
| Miao, Y; Sun, J; Wang, X; Yang, J; Yun, Y | 1 |
| Jiang, X; Liu, XH; Shi, J; Tang, W; Wang, S; Wu, C; Xu, Y; Zha, L; Zhang, J; Zhang, Z; Zuo, J | 1 |
| Andrisano, V; Arce, EM; Barenys, M; Bartolini, M; Bolognesi, ML; Brea, J; De Simone, A; Decker, M; Ginex, T; Gómez-Catalán, J; Griñán-Ferré, C; Loza, MI; Luque, FJ; Martínez, N; Mattellone, A; Muñoz-Torrero, D; Naldi, M; Pallàs, M; Pérez, B; Pont, C; Sabate, R; Scheiner, M; Soriano-Fernández, Y | 1 |
| Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Patil, S; Tawari, S; Umathe, S | 1 |
| Mundhada, D; Nadeem, S; Patil, S; Tawari, S | 1 |
| Arif, M; Ikram, M; Rauf, K; Rehman, NU; Sewell, RD; Tokhi, A | 1 |
1 review(s) available for donepezil and ascorbic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
18 other study(ies) available for donepezil and ascorbic acid
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cell Death; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Horses; Hydrogen Peroxide; Models, Molecular; Molecular Structure; PC12 Cells; Rats; Structure-Activity Relationship; Umbelliferones | 2014 |
Synthesis of α, β-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid β-induced cytotoxicity.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Green Chemistry Technology; Inhibitory Concentration 50; Ketones; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Quantitative Structure-Activity Relationship; Rats | 2014 |
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2016 |
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromans; Dose-Response Relationship, Drug; Drug Design; Female; Glycation End Products, Advanced; Humans; Male; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2017 |
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophorus; Female; Horses; Imidazoles; Male; Maze Learning; Memory Disorders; Mice; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship | 2018 |
Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Diketopiperazines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 2; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship | 2018 |
Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Hydrogen Peroxide; Ligands; Molecular Docking Simulation; Molecular Structure; PC12 Cells; Protein Aggregates; Rats; Reactive Oxygen Species; Structure-Activity Relationship; Thioctic Acid | 2018 |
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
Topics: Antioxidants; Benzoxazoles; Cholinesterase Inhibitors; Drug Design; Humans; Learning; Memory; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2019 |
Design and development of novel N-(pyrimidin-2-yl)-1,3,4-oxadiazole hybrids to treat cognitive dysfunctions.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Design; Humans; Mice; Models, Molecular; Molecular Structure; Oxadiazoles; Pyrimidines; Structure-Activity Relationship | 2019 |
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protective Agents; Protein Multimerization; Rats; Structure-Activity Relationship; Sulfonamides | 2019 |
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumarins; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship | 2020 |
Novel cannabidiol-carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cannabidiol; Carbamates; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Maze Learning; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Neuroprotective Agents; Structure-Activity Relationship | 2021 |
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Topics: Alzheimer Disease; Aminoquinolines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Brain; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Recombinant Proteins; Structure-Activity Relationship; tau Proteins | 2021 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Berberine; Blood Glucose; Body Weight; Brain; Cholinesterase Inhibitors; Cholinesterases; Diabetes Mellitus, Experimental; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Glutathione; Hypoglycemic Agents; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Metformin; Piperidines; Rats; Rats, Wistar | 2011 |
Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats.
Topics: Animals; Ascorbic Acid; Behavior, Animal; Berberine; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Ethanol; Glutathione; Hippocampus; Indans; Lipid Peroxidation; Male; Memory Disorders; Oxidative Stress; Piperidines; Rats | 2015 |
6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment.
Topics: Animals; Ascorbic Acid; Cognitive Dysfunction; Donepezil; Dopamine; Ethanol; Flavones; Hippocampus; Maze Learning; Mice; Norepinephrine | 2022 |