dolichols and geraniol

dolichols has been researched along with geraniol* in 4 studies

Other Studies

4 other study(ies) available for dolichols and geraniol

ArticleYear
Uptake of dolichol by Vero cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, Volume: 70, Issue:6

    Characterization and kinetics of dolichol uptake by a Vero cell line are reported. Vero cells incorporate dolichol in a time- and dose-dependent manner. Optimal uptake is found at 37 degrees C and at a pH of 7.4. In contrast to cholesterol, an inhibitory effect on the dolichol incorporation is found for farnesol, geraniol, and retinol. Long chain polyprenols were slightly stimulatory. The translocation seems not to be highly energy dependent. The lack of substantial inhibition by chloroquine does not plead for a receptor-mediated endocytosis. Incorporated dolichol was distributed over both membranes and supernatant fractions, paralleling the distribution of the lysosomal marker beta-N-acetylhexosaminidase. The incorporated dolichol is subject to a fast efflux process, which is potentiated by the presence of lipid acceptors in the extracellular medium.

    Topics: Acyclic Monoterpenes; Animals; Biological Transport; Chlorocebus aethiops; Cholesterol; Dolichols; Farnesol; Hydrogen-Ion Concentration; Kinetics; Lipoproteins; Liposomes; Subcellular Fractions; Temperature; Terpenes; Time Factors; Vero Cells; Vitamin A

1992
Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibition of choline incorporation in cellular lipid fraction. The growth inhibitory effect was prevented to a large extent by incubation with phosphatidylcholine or diacylglycerol.

    Topics: Acyclic Monoterpenes; Cell Division; Cell Line; Diglycerides; Dolichols; Dose-Response Relationship, Drug; Farnesol; Humans; Isomerism; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Phosphatidylcholines; Squalene; Terpenes

1992
2H NMR investigation of the organization and dynamics of polyisoprenols in membranes.
    The Journal of biological chemistry, 1985, Dec-15, Volume: 260, Issue:29

    The polyisoprenols (PIs) dolichol and undecaprenol function as chemical carriers of glycosyl residues in the membrane-directed synthesis of glycoconjugates in prokaryotic and eukaryotic cells. The molecular details of how these lipid cofactors function is unknown. Presented here are results of deuterium NMR investigations of site specifically 2H-labeled PIs incorporated into model membranes. To complement previous omega-terminal PI labeling schemes, a simple synthesis of head group 2H-labeled PIs is presented in which a PI alcohol is esterified with deuterated acetyl chloride. The 2H-labeled PIs, when incorporated into multilamellar membranes composed of phosphatidylcholine, gave rise to 2H NMR powder patterns interpretable in terms of quadrupole splittings (delta vQ) and spin-lattice relaxation times (T1s). Pure isomers of head group 2H-labeled geraniol (C10) and solanesol (C45) gave rise to single splittings while farnesol (C15) gave rise to two sets of splittings due to cis-trans isomerization at the polar terminal double bond. Membranes containing C45 solanesol exhibited a large isotropic component, indicative of limited partitioning of this poly trans PI into the membrane. T1 measurements revealed high rates of motion for PIs relative to cholesterol in similar membrane hosts and revealed correlation times close to the fatty acyl methyl termini in phosphatidylcholine. The smaller PIs showed higher rates of motion but the T1s of head and tail labels were similar. These data indicate that both ends of the esterified PI molecules see similar environments, probably in the bilayer interior, and suggest that the esterified PIs studied here do not appear to adopt a conventional head group-at-interface orientation of lipids within the bilayer.

    Topics: Acyclic Monoterpenes; Diterpenes; Dolichols; Farnesol; Isomerism; Lipid Bilayers; Magnetic Resonance Spectroscopy; Mathematics; Membranes; Temperature; Terpenes

1985
Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds.
    Pharmacological research communications, 1982, Volume: 14, Issue:10

    Topics: Acyclic Monoterpenes; Animals; Cytosol; Dolichols; In Vitro Techniques; Liver; Mevalonic Acid; Microsomes, Liver; Monoterpenes; Phytol; Rats; Squalene; Sterols; Terpenes; Ubiquinone; Vitamin E

1982