dolichol-monophosphate and 9-(tetrahydro-2-furyl)-adenine

dolichol-monophosphate has been researched along with 9-(tetrahydro-2-furyl)-adenine* in 1 studies

Other Studies

1 other study(ies) available for dolichol-monophosphate and 9-(tetrahydro-2-furyl)-adenine

Article	Year
CPP32 activation during dolichyl phosphate-induced apoptosis in U937 leukemia cells. FEBS letters, 1997, Jul-21, Volume: 412, Issue:1 Treatment of U937 cells with dolichyl phosphate led to an increase in the activity of the ICE family protease CPP32, accompanied with cleavage of pre-CPP32 to generate p17. Peptide inhibitors YVAD-cmk and Z-Asp-CH2-DCB (specific to ICE) and DEVD-CHO (specific to CPP32) blocked the dolichyl phosphate-induced apoptosis. The dolichyl phosphate-induced increase of CPP32 activity was inhibited by adenylate cyclase inhibitors, SQ 22536 and 2',5'-dideoxyadenosine. Dolichyl phosphate caused a transient increase of intracellular cAMP concentration. The results suggest that modulation of cAMP synthesis due to the stimulation of adenylate cyclase by dolichyl phosphate plays a critical role in CPP32 activation and apoptosis. Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Apoptosis; Caspase 3; Caspases; Cyclic AMP; Cysteine Endopeptidases; Dideoxyadenosine; DNA Fragmentation; Dolichol Phosphates; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Kinetics; Leukemia, Monocytic, Acute; Tumor Cells, Cultured	1997

Article

Year

CPP32 activation during dolichyl phosphate-induced apoptosis in U937 leukemia cells.

FEBS letters, 1997, Jul-21, Volume: 412, Issue:1

Treatment of U937 cells with dolichyl phosphate led to an increase in the activity of the ICE family protease CPP32, accompanied with cleavage of pre-CPP32 to generate p17. Peptide inhibitors YVAD-cmk and Z-Asp-CH2-DCB (specific to ICE) and DEVD-CHO (specific to CPP32) blocked the dolichyl phosphate-induced apoptosis. The dolichyl phosphate-induced increase of CPP32 activity was inhibited by adenylate cyclase inhibitors, SQ 22536 and 2',5'-dideoxyadenosine. Dolichyl phosphate caused a transient increase of intracellular cAMP concentration. The results suggest that modulation of cAMP synthesis due to the stimulation of adenylate cyclase by dolichyl phosphate plays a critical role in CPP32 activation and apoptosis.

Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Apoptosis; Caspase 3; Caspases; Cyclic AMP; Cysteine Endopeptidases; Dideoxyadenosine; DNA Fragmentation; Dolichol Phosphates; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Kinetics; Leukemia, Monocytic, Acute; Tumor Cells, Cultured

1997