dolastatin-15 and largazole

dolastatin-15 has been researched along with largazole* in 1 studies

Other Studies

1 other study(ies) available for dolastatin-15 and largazole

Article	Year
Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem : a European journal of chemical biology, 2009, Jul-06, Volume: 10, Issue:10 Combinatorial biosynthesis meets combinatorial pharmacology, cyanobacterial style: A new antimitotic natural product with features of both dolastatins 10 and 15 was isolated from the same Floridian Symploca sp. sample that produced the histone deacetylase inhibitor largazole. Both agents in combination are more effective in inhibiting cancer cell proliferation than either agent alone. Topics: Antimicrobial Cationic Peptides; Antimitotic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cyanobacteria; Depsipeptides; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Peptides; Thiazoles	2009

Article

Year

Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole.

Chembiochem : a European journal of chemical biology, 2009, Jul-06, Volume: 10, Issue:10

Combinatorial biosynthesis meets combinatorial pharmacology, cyanobacterial style: A new antimitotic natural product with features of both dolastatins 10 and 15 was isolated from the same Floridian Symploca sp. sample that produced the histone deacetylase inhibitor largazole. Both agents in combination are more effective in inhibiting cancer cell proliferation than either agent alone.

Topics: Antimicrobial Cationic Peptides; Antimitotic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cyanobacteria; Depsipeptides; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Peptides; Thiazoles

2009