dolastatin-12 and lyngbyastatin-3

dolastatin-12 has been researched along with lyngbyastatin-3* in 1 studies

Other Studies

1 other study(ies) available for dolastatin-12 and lyngbyastatin-3

Article	Year
Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin Journal of natural products, 2003, Volume: 66, Issue:10 The structure of lyngbyastatin 3 (1), including the configurations of the two unusual amino acid residues, viz., the 3-amino-2-methylhexanoic acid (Amha) and 4-amino-2,2-dimethyl-3-oxopentanoic acid units (Ibu), has been established by chemical degradation. Analysis of the cyanobacterial samples of lyngbyastatin 3 (1), lyngbyastatin 1 (2), and dolastatin 12 (3) demonstrated that they are mixtures of Ibu epimers [R (major) and S (minor)], whereas the structurally related majusculamide C (4) is a single diastereomer having an S-Ibu unit. Topics: Amino Acids; Chromatography, High Pressure Liquid; Cyanobacteria; Depsipeptides; Gas Chromatography-Mass Spectrometry; Guam; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Peptides, Cyclic; Stereoisomerism	2003

Article

Year

Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin

Journal of natural products, 2003, Volume: 66, Issue:10

The structure of lyngbyastatin 3 (1), including the configurations of the two unusual amino acid residues, viz., the 3-amino-2-methylhexanoic acid (Amha) and 4-amino-2,2-dimethyl-3-oxopentanoic acid units (Ibu), has been established by chemical degradation. Analysis of the cyanobacterial samples of lyngbyastatin 3 (1), lyngbyastatin 1 (2), and dolastatin 12 (3) demonstrated that they are mixtures of Ibu epimers [R (major) and S (minor)], whereas the structurally related majusculamide C (4) is a single diastereomer having an S-Ibu unit.

Topics: Amino Acids; Chromatography, High Pressure Liquid; Cyanobacteria; Depsipeptides; Gas Chromatography-Mass Spectrometry; Guam; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Peptides, Cyclic; Stereoisomerism

2003