Compounds > dofequidar
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dofequidar and verapamil

dofequidar has been researched along with verapamil in 5 studies

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

Compound Research Comparison

Studies
(dofequidar)		Trials
(dofequidar)		Recent Studies (post-2010)
(dofequidar)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
402517,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomydofequidar (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tsuruo, T2
Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D1
Hanibuchi, M; Parajuli, P; Shrivastava, P; Sone, S; Tsuruo, T; Yano, S1
Augustine, AM; Baranowska-Kortylewicz, J; Kortylewicz, ZP; McGarry, J; Nearman, J1

Reviews

2 review(s) available for dofequidar and verapamil

ArticleYear
[Development of drugs to overcome drug resistance--basic approaches].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:3

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Drug Resistance, Multiple; Humans; Leukemia P388; Leukemia, Myeloid; Mice; Mice, Nude; Quinolines; Tumor Cells, Cultured; Verapamil

1995
[MDR reversing drugs for clinical development].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:7

    Topics: Animals; Antineoplastic Agents; Cyclosporins; Doxorubicin; Drug Resistance; Drug Synergism; Humans; Leukemia P388; Mice; Quinolines; Verapamil

1994

Other Studies

3 other study(ies) available for dofequidar and verapamil

ArticleYear
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
    Anti-cancer drugs, 1997, Volume: 8, Issue:2

    Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine

1997
Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer cells and its synergistic interaction with cyclosporin A or verapamil.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:6

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Quinolines; Tumor Cells, Cultured; Verapamil

1998
Radioiodinated agents for imaging multidrug resistant tumors.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2009, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hydrophobic and Hydrophilic Interactions; Iodine Radioisotopes; Mice; Mice, Nude; Molecular Structure; Neoplasms; Quinolines; Radionuclide Imaging; Radiopharmaceuticals; Temperature; Time Factors; Tissue Distribution; Verapamil

2009