Page last updated: 2024-09-04

docetaxel anhydrous and gdc 0449

docetaxel anhydrous has been researched along with gdc 0449 in 3 studies

Compound Research Comparison

Studies (docetaxel anhydrous)	Trials (docetaxel anhydrous)	Recent Studies (post-2010) (docetaxel anhydrous)	Studies (gdc 0449)	Trials (gdc 0449)	Recent Studies (post-2010) (gdc 0449)
12,110	3,216	6,920	666	68	611

Protein Interaction Comparison

Protein	Taxonomy	gdc 0449 (IC50)
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	0.02
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.02
Smoothened homolog	Mus musculus (house mouse)	0.07
Sonic hedgehog protein	Homo sapiens (human)	0.8825
Sonic hedgehog protein	Mus musculus (house mouse)	0.0077
Smoothened homolog	Homo sapiens (human)	0.0222
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.4

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Batra, SK; Datta, K; Johansson, SL; Lin, MF; Mimeault, M; Muniyan, S; Rachagani, S; Seshacharyulu, P	1
Bezares, S; Caballero, R; Cazet, AS; Chan, CL; Collot, R; Cooper, C; Cox, TR; Deng, N; Elsworth, BL; Harvey, K; Herrmann, D; Hui, MN; Johan, MZ; Lim, E; Martín, M; McFarland, A; Nair, R; O'Toole, S; Roden, D; Rojo, F; Ruiz-Borrego, M; Samuel, MS; Skhinas, JN; Swarbrick, A; Timpson, P; Trigo, JM; Watkins, DN; Wu, SZ; Yang, J	1

Trials

1 trial(s) available for docetaxel anhydrous and gdc 0449

Article	Year
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer. Nature communications, 2018, 07-24, Volume: 9, Issue:1 Topics: Adult; Aged; Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Female; Humans; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Pyridines; Treatment Outcome; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2018

Article

Year

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer.

Nature communications, 2018, 07-24, Volume: 9, Issue:1

Topics: Adult; Aged; Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Female; Humans; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Pyridines; Treatment Outcome; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2018

Other Studies

2 other study(ies) available for docetaxel anhydrous and gdc 0449

Article	Year
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013
Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer. Oncotarget, 2015, Feb-28, Volume: 6, Issue:6 Topics: Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Docetaxel; Drug Synergism; Hedgehog Proteins; Humans; Male; Mice; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pyridines; Random Allocation; Signal Transduction; Taxoids; Xenograft Model Antitumor Assays	2015

Article

Year

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer.

Oncotarget, 2015, Feb-28, Volume: 6, Issue:6

Topics: Anilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Docetaxel; Drug Synergism; Hedgehog Proteins; Humans; Male; Mice; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pyridines; Random Allocation; Signal Transduction; Taxoids; Xenograft Model Antitumor Assays

2015