Page last updated: 2024-09-04

docetaxel anhydrous and epothilone b

docetaxel anhydrous has been researched along with epothilone b in 14 studies

Compound Research Comparison

Studies (docetaxel anhydrous)	Trials (docetaxel anhydrous)	Recent Studies (post-2010) (docetaxel anhydrous)	Studies (epothilone b)	Trials (epothilone b)	Recent Studies (post-2010) (epothilone b)
12,110	3,216	6,920	305	27	129

Protein Interaction Comparison

Protein	Taxonomy	epothilone b (IC50)
Tubulin beta-4A chain	Homo sapiens (human)	0.0035
Tubulin beta chain	Homo sapiens (human)	0.0035
Tubulin alpha-3C chain	Homo sapiens (human)	0.0035
Tubulin alpha-1B chain	Homo sapiens (human)	0.0035
Tubulin alpha-4A chain	Homo sapiens (human)	0.0035
Tubulin beta-4B chain	Homo sapiens (human)	0.0035
Tubulin beta-3 chain	Homo sapiens (human)	0.0035
Tubulin beta-2A chain	Homo sapiens (human)	0.0035
Tubulin beta-8 chain	Homo sapiens (human)	0.0035
Tubulin alpha-3E chain	Homo sapiens (human)	0.0035
Tubulin alpha-1A chain	Homo sapiens (human)	0.0035
Tubulin alpha-1C chain	Homo sapiens (human)	0.0035
Tubulin beta-6 chain	Homo sapiens (human)	0.0035
Tubulin beta-2B chain	Homo sapiens (human)	0.0035
Tubulin beta-1 chain	Homo sapiens (human)	0.0035

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (71.43)	29.6817
2010's	3 (21.43)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Talele, TT	1
Altmann, KH; Andreu, JM; Calvo, E; Díaz, JF; Field, JJ; Gallego, JE; Jordi, M; Ménchon, G; Miller, JH; Pera, B; Prota, AE; Rodríguez-Salarichs, J; Sáez-Calvo, G; Zuwerra, D	1
Bollbuck, B; Downing, KH; Fojo, T; Giannakakou, P; Gussio, R; Nicolaou, KC; Nogales, E; Poy, G; Sackett, D; Zaharevitz, D	1
Kasparian, J; Meurer-Grob, P; Wade, RH	1
Atadja, P; Bali, P; Bhalla, K; Donapaty, S; Fuino, L; Guo, F; Wang, HG; Wittmann, S; Yamaguchi, H	1
D'Orazio, A; Klem, J; Tyagi, P	1
Hayakawa, Y	1
Escuin, D; Giannakakou, P; Kline, ER	1
Annable, T; Greenberger, LM; Hari, M; Loganzo, F; Morilla, DB; Musto, S; Nettles, JH; Snyder, JP; Tan, X	1
Andreu, JM; Barasoain, I; Buey, RM; Calvo, E; Cerezo, G; Day, BW; Díaz, JF; Edler, MC; Hamel, E; López, JA; Matesanz, R; Pineda, O; Sorensen, EJ; Vanderwal, CD	1
Dawson, NA	1
Chan, AT; Choi, E; Johri, A; Mok, TS; Wong, C; Yau, D; Yeo, W	1
Beardsley, E; Chi, KN; Eigl, BJ; Hotte, SJ; Ko, YJ; Saad, F; Sridhar, SS; Venner, P; Weber, D; Winquist, E	1
Aguera, KN; Davis, GE; Griffin, CT; Kemp, SS; Koller, GM; Lin, PK; Salvador, J; Xie, J	1

Reviews

2 review(s) available for docetaxel anhydrous and epothilone b

Article	Year
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry. Journal of medicinal chemistry, 2018, 03-22, Volume: 61, Issue:6 Topics: Animals; Biological Products; Chemistry, Pharmaceutical; Humans	2018
Epothilones in prostate cancer: review of clinical experience. Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18 Suppl 5 Topics: Animals; Antineoplastic Agents; Docetaxel; Epothilones; Humans; In Vitro Techniques; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Taxoids; Tubulin Modulators	2007

Trials

1 trial(s) available for docetaxel anhydrous and epothilone b

Article	Year
A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a. Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:1 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Canada; Castration; Disease-Free Survival; Docetaxel; Epothilones; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Salvage Therapy; Taxoids	2012

Article

Year

A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a.

Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:1

Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Canada; Castration; Disease-Free Survival; Docetaxel; Epothilones; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Salvage Therapy; Taxoids

2012

Other Studies

11 other study(ies) available for docetaxel anhydrous and epothilone b

Article	Year
Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. Journal of natural products, 2018, 03-23, Volume: 81, Issue:3 Topics: Animals; Binding Sites; Biological Products; Bridged-Ring Compounds; Cattle; Colchicine; Humans; Ligands; Macrolides; Microtubules; Nucleotides; Taxoids; Tubulin	2018
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-14, Volume: 97, Issue:6 Topics: Alkaloids; Antineoplastic Agents; Bridged-Ring Compounds; Diterpenes; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Mutation; Paclitaxel; Protein Conformation; Structure-Activity Relationship; Taxoids; Thiazoles; Tubulin; Tumor Cells, Cultured	2000
Microtubule structure at improved resolution. Biochemistry, 2001, Jul-10, Volume: 40, Issue:27 Topics: Actin Cytoskeleton; Alkaloids; Amino Acid Sequence; Animals; Dimerization; Diterpenes; Docetaxel; Epothilones; Epoxy Compounds; Excipients; Guanosine Triphosphate; Microtubules; Molecular Sequence Data; Paclitaxel; Protein Conformation; Surface Properties; Swine; Taxoids; Thiazoles; Tubulin	2001
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Molecular cancer therapeutics, 2003, Volume: 2, Issue:10 Topics: Annexin A5; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deoxycytidine; Detergents; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epothilones; Flow Cytometry; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab	2003
Highlights from the 39th Annual meeting of the American Society of Clinical Oncology Chicago, Illinois. Clinical prostate cancer, 2003, Volume: 2, Issue:2 Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Docetaxel; Epothilones; Goserelin; Humans; Male; Medical Oncology; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Taxoids	2003
[Structure-activity relationship analysis]. Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:4 Topics: Antineoplastic Agents; Benzamides; Camptothecin; Docetaxel; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Imatinib Mesylate; Irinotecan; Macrolides; Oligopeptides; Paclitaxel; Piperazines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Taxoids; Topotecan; Vinblastine	2004
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer research, 2005, Oct-01, Volume: 65, Issue:19 Topics: 2-Methoxyestradiol; Alkaloids; Alkanes; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Colchicine; Docetaxel; Down-Regulation; Epothilones; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactones; Microtubules; Pyrones; Taxoids; Vincristine	2005
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Molecular cancer therapeutics, 2006, Volume: 5, Issue:2 Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Glutamic Acid; Humans; Mice; Mice, Nude; Microtubules; Paclitaxel; Point Mutation; Protein Conformation; Taxoids; Tubulin; Verapamil	2006
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature chemical biology, 2007, Volume: 3, Issue:2 Topics: Alkanes; Amino Acid Sequence; Asparagine; Binding Sites; Binding, Competitive; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Docetaxel; Epothilones; Humans; Inhibitory Concentration 50; Lactones; Mass Spectrometry; Microtubules; Models, Chemical; Models, Molecular; Molecular Sequence Data; Paclitaxel; Polycyclic Compounds; Protein Binding; Pyrones; Taxoids; Threonine; Tubulin; Tubulin Modulators	2007
Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study. Oncology, 2006, Volume: 71, Issue:3-4 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Epothilones; Humans; Liver Neoplasms; Paclitaxel; Taxoids	2006
Selective and Marked Blockade of Endothelial Sprouting Behavior Using Paclitaxel and Related Pharmacologic Agents. The American journal of pathology, 2021, Volume: 191, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Blood Vessels; Cells, Cultured; Docetaxel; Endothelial Cells; Endothelium, Vascular; Epothilones; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Morphogenesis; Neovascularization, Pathologic; Neovascularization, Physiologic; Paclitaxel	2021