docetaxel and paclitaxel

docetaxel has been researched along with paclitaxel in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (25.00)18.2507
2000's21 (52.50)29.6817
2010's9 (22.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guénard, D; Guéritte-Voegelein, F; Lavelle, F; Le Goff, MT; Mangatal, L; Potier, P1
Ali, SM; Aubé, J; Georg, GI; Hoemann, MZ; Jayasinghe, LR; McCall, R; Mitscher, LA1
Ali, SM; Datta, A; Georg, GI; Jayasinghe, LR; Vander Velde, DG; Zygmunt, J1
Boge, TC; Georg, GI; Himes, RH; Vander Velde, DG1
Bernacki, RJ; Bissery, MC; Bounaud, PY; Kuduk, SD; Michaud, E; Ojima, I; Pera, P; Slater, JC; Veith, JM; Vrignaud, P1
Ali, SM; Aubé, J; Georg, GI; Hoemann, MZ; Jayasinghe, LR; Mitscher, LA1
Bernacki, RJ; Gimi, RH; Kuduk, SD; Ojima, I; Park, YH; Pera, P; Slater, JC; Sun, CM; Takeuchi, CS; Veith, JM1
Bernacki, RJ; Kuduk, SD; Ojima, I; Pera, P; Veith, JM1
Chidester, CG; DeKoning, TF; Dobrowolski, PJ; Gebhard, I; Johnson, RA; Kelly, RC; Lopes, NM; Mattern, SJ; McGovren, JP; Nidy, EG; Pitts, TW; Qualls, SJ; Weed, SD; Wicnienski, NA1
Bernacki, RJ; Borella, CP; Geng, X; Lin, S; Miller, ML; Ojima, I; Pera, P; Wang, T1
Fang, QC; Fang, WS; Liu, HY; Liu, Y; Wang, L; Xu, SF1
Chiba, J; Iimura, S; Ishiyama, T; Soga, T; Terasawa, H; Uoto, K; Yoshino, T1
Bartle, LM; Borella, CP; Chari, RV; Geng, X; Goldmacher, VS; Leece, BA; Ojima, I; Qu, C; Wilhelm, SD; Wu, X; Xie, H1
Chiba, J; Ishiyama, T; Iwahana, M; Jimbo, T; Soga, T; Takeda, Y; Tanaka, N; Terasawa, H; Uoto, K; Yoshino, T1
Chari, RV; Goldmacher, VS; Leece, BA; Miller, ML; Ojima, I; Roller, EE; Wu, X1
Baloglu, E; Cavanagh, EE; Chari, RV; Goldmacher, VS; Leece, BA; Miller, ML; Roller, EE1
Dubois, J; Guénard, D; Guéritte, F; Querolle, O; Roussi, F; Thoret, S1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL1
Bernacki, RJ; Chen, J; Kuznetsova, L; Ojima, I; Pepe, A; Pera, P; Sun, L; Veith, JM; Wu, X1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andreu, JM; Barasoain, I; Buey, RM; Calvo, E; Cerezo, G; Day, BW; Díaz, JF; Edler, MC; Hamel, E; López, JA; Matesanz, R; Pineda, O; Sorensen, EJ; Vanderwal, CD1
Afragola, J; Ayral-Kaloustian, S; Beyer, C; Gibbons, J; Hernandez, R; Lucas, J; Nguyen, T; Zhang, N1
Ballatore, C; Deiches, RF; Huryn, D; Hyde, E; Lee, VM; Smith, AB; Trojanowski, JQ1
Hansch, C; Verma, RP1
Lombardo, F; Obach, RS; Waters, NJ1
Bar-Sagi, D; Bernacki, RJ; Borella, CP; Chen, J; Gallager, D; Geng, X; Guerriero, JL; Horwitz, SB; Kuznetsova, L; Lin, S; Mallen-St Clair, J; Miller, ML; Ojima, I; Pera, P; Qu, C; Sun, L; Veith, JM; Wang, T; Xia, S; Zanardi, I; Zhao, X1
Allegro, D; Aubert, G; Barthélémy-Requin, M; Béclin, C; Cresteil, T; De Angelis, F; Di, C; Gatti, E; Kraus, JL; Laras, Y; Moret, V; Pasquini, L; Petrucci, E; Peyrot, V; Pierre, P; Ping, DQ; Rolland, A; Testa, U1
Ke, B; Qin, Y; Qu, Y; Zhao, F1
Barasoain, I; Díaz, JF; Fang, WS; Li, X; Matesanz, R1
Das, M; Ojima, I1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP1
Barasoain, I; Carda, M; Díaz, JF; Falomir, E; García-Pla, J; Marco, JA; Murga, J; Notararigo, S; Trigili, C1
Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR1
Chang, J; Hao, XD; Hao, YP; Lu, HF; Sun, X; Yu, JM1
Hoye, TR; Kalscheuer, S; Macosko, CW; Michel, AR; Panyam, J; Wohl, AR1
Bailey-Downs, LC; Bastian, A; Disch, BC; Dybdal-Hargreaves, NF; Gangjee, A; Hamel, E; Ihnat, M; Mooberry, SL; Raghavan, S; Rohena, CC; Thorpe, JE; Zhang, X1
Bai, R; Bailey-Downs, LC; Bastian, A; Disch, BC; Gangjee, A; Hamel, E; Ihnat, MA; Pavana, RK; Thorpe, JE1
Barasoain, I; Canales, A; Díaz, JF; Fang, WS; Jímenez-Barbero, J; Matesanz, R; Nogales, A; Ojima, I; Pera, B; Rodríguez-Salarichs, J; Trigili, C; Zanardi, I1

Reviews

1 review(s) available for docetaxel and paclitaxel

ArticleYear
Recent advances in the chemistry and biology of new generation taxoids.
    Journal of natural products, 2009, Mar-27, Volume: 72, Issue:3

    Topics: Molecular Structure; Taxoids

2009

Other Studies

39 other study(ies) available for docetaxel and paclitaxel

ArticleYear
Relationships between the structure of taxol analogues and their antimitotic activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Alkaloids; Animals; Antineoplastic Agents; Brain; Cell Division; Chemical Phenomena; Chemistry; Leukemia P388; Mice; Microtubules; Molecular Conformation; Molecular Structure; Paclitaxel; Stereoisomerism; Structure-Activity Relationship; Swine; Tubulin

1991
Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel.
    Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19

    Topics: Antineoplastic Agents, Phytogenic; Docetaxel; Humans; Melanoma, Experimental; Microtubules; Molecular Structure; Paclitaxel; Solubility; Taxoids; Tumor Cells, Cultured

1995
Structure-activity studies of antitumor taxanes: synthesis of novel C-13 side chain homologated taxol and taxotere analogs.
    Journal of medicinal chemistry, 1994, Sep-02, Volume: 37, Issue:18

    Topics: Docetaxel; In Vitro Techniques; Molecular Conformation; Paclitaxel; Structure-Activity Relationship; Taxoids; Tubulin

1994
The effect of the aromatic rings of taxol on biological activity and solution conformation: synthesis and evaluation of saturated taxol and taxotere analogues.
    Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20

    Topics: Antineoplastic Agents; Cell Survival; Chloroform; Dimethyl Sulfoxide; Docetaxel; Melanoma, Experimental; Microtubules; Molecular Conformation; Molecular Structure; Paclitaxel; Solutions; Structure-Activity Relationship; Taxoids

1994
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Docetaxel; Drug Resistance, Neoplasm; Female; Humans; Melanoma, Experimental; Mice; Mice, Nude; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Taxoids; Tumor Cells, Cultured

1996
Butitaxel analogues: synthesis and structure-activity relationships.
    Journal of medicinal chemistry, 1997, Jan-17, Volume: 40, Issue:2

    Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Melanoma, Experimental; Mice; Microtubules; Paclitaxel; Solubility; Structure-Activity Relationship; Taxoids

1997
Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
    Journal of medicinal chemistry, 1997, Jan-31, Volume: 40, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Docetaxel; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Taxoids; Tumor Cells, Cultured

1997
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
    Journal of medicinal chemistry, 1997, Jan-31, Volume: 40, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Docetaxel; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Esters; Female; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Taxoids; Tumor Cells, Cultured

1997
12,13-isotaxanes: synthesis of new potent analogs and X-ray crystallographic confirmation of structure.
    Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18

    Topics: Alkaloids; Animals; Antineoplastic Agents; Bridged-Ring Compounds; Crystallography, X-Ray; Female; Humans; Melanoma, Experimental; Mice; Mice, Inbred Strains; Molecular Conformation; Molecular Structure; Ovarian Neoplasms; Paclitaxel; Taxoids; Tumor Cells, Cultured

1997
Synthesis and structure-activity relationships of new second-generation taxoids.
    Bioorganic & medicinal chemistry letters, 1999, Dec-20, Volume: 9, Issue:24

    Topics: Alkaloids; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Paclitaxel; Structure-Activity Relationship; Tumor Cells, Cultured

1999
Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues.
    Bioorganic & medicinal chemistry letters, 2002, Jun-03, Volume: 12, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Docetaxel; Drug Resistance, Neoplasm; Inhibitory Concentration 50; Paclitaxel; Structure-Activity Relationship; Taxoids; Tumor Cells, Cultured

2002
New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 2.
    Bioorganic & medicinal chemistry letters, 2002, Oct-21, Volume: 12, Issue:20

    Topics: Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Indicators and Reagents; Magnetic Resonance Spectroscopy; Paclitaxel; Solubility; Stereoisomerism; Structure-Activity Relationship; Taxoids; Tumor Cells, Cultured

2002
Tumor-specific novel taxoid-monoclonal antibody conjugates.
    Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; ErbB Receptors; Humans; Immunoconjugates; Mice; Mice, SCID; Paclitaxel; Prodrugs; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2002
New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3.
    Bioorganic & medicinal chemistry letters, 2003, Jan-20, Volume: 13, Issue:2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Melanoma, Experimental; Mice; Molecular Conformation; Neoplasm Transplantation; Paclitaxel; Solubility; Tumor Cells, Cultured

2003
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
    Bioorganic & medicinal chemistry letters, 2004, Aug-02, Volume: 14, Issue:15

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Paclitaxel; Structure-Activity Relationship; Taxoids

2004
Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors.
    Bioorganic & medicinal chemistry letters, 2004, Dec-06, Volume: 14, Issue:23

    Topics: Antineoplastic Agents; Drug Delivery Systems; Drug Evaluation, Preclinical; Humans; Taxoids; Tumor Cells, Cultured

2004
Synthesis of C2-C3'N-linked macrocyclic taxoids. Novel docetaxel analogues with high tubulin activity.
    Journal of medicinal chemistry, 2004, Nov-18, Volume: 47, Issue:24

    Topics: Antineoplastic Agents; Binding Sites; Docetaxel; Drug Screening Assays, Antitumor; Humans; KB Cells; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Taxoids; Tubulin

2004
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
    Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18

    Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride

2005
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
    Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fatty Acids, Unsaturated; Humans; Molecular Conformation; Structure-Activity Relationship; Taxoids

2006
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
    Nature chemical biology, 2007, Volume: 3, Issue:2

    Topics: Alkanes; Amino Acid Sequence; Asparagine; Binding Sites; Binding, Competitive; Carbamates; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Docetaxel; Epothilones; Humans; Inhibitory Concentration 50; Lactones; Mass Spectrometry; Microtubules; Models, Chemical; Models, Molecular; Molecular Sequence Data; Paclitaxel; Polycyclic Compounds; Protein Binding; Pyrones; Taxoids; Threonine; Tubulin; Tubulin Modulators

2007
Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.
    Journal of medicinal chemistry, 2007, Jan-25, Volume: 50, Issue:2

    Topics: Administration, Oral; Animals; Cell Proliferation; Female; Humans; Injections, Intravenous; Mice; Mice, Nude; Pyrimidines; Stereoisomerism; Structure-Activity Relationship; Triazoles; Tubulin Modulators; Xenograft Model Antitumor Assays

2007
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies.
    Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Blood-Brain Barrier; Brain; Carbamates; Chemistry, Pharmaceutical; Drug Design; Humans; Mice; Models, Chemical; Neurodegenerative Diseases; Paclitaxel; Permeability; Tauopathies; Time Factors

2007
A QSAR study for the cytotoxic activities of taxoids against macrophage (MPhi)-like cells.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:1

    Topics: Animals; Cells, Cultured; Humans; Macrophages; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; Taxoids

2009
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Design, synthesis, and biological evaluation of new-generation taxoids.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Animals; Antineoplastic Agents; Biopolymers; Cell Line, Tumor; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Point Mutation; Structure-Activity Relationship; Taxoids; Transplantation, Heterologous; Tubulin

2008
Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspases; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Hydroxyquinolines; Male; Structure-Activity Relationship; TNF-Related Apoptosis-Inducing Ligand

2009
Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel.
    Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Docetaxel; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; Paclitaxel; Sulfonic Acids; Taxoids

2008
Synthesis and biological activities of high affinity taxane-based fluorescent probes.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Anisotropy; Bridged-Ring Compounds; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Fluorescein; Fluorescent Dyes; Ligands; Microtubules; Models, Chemical; Plant Extracts; Taxoids; Temperature; Thermodynamics; Tubulin

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water

2010
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:5

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Structure; Pyrones; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured

2011
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
    Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays

2013
Design, synthesis and cytotoxicity of novel 3'-N-alkoxycarbonyl docetaxel analogs.
    Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Docetaxel; Drug Design; Humans; Paclitaxel; Stereoisomerism; Structure-Activity Relationship; Taxoids

2013
Silicate esters of paclitaxel and docetaxel: synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potential.
    Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Coloring Agents; Docetaxel; Drug Delivery Systems; Drug Design; Humans; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Indicators and Reagents; Kinetics; Models, Molecular; Molecular Conformation; Nanoparticles; Paclitaxel; Prodrugs; Silicates; Taxoids; Tetrazolium Salts; Thiazoles

2014
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
    Bioorganic & medicinal chemistry, 2014, Jul-15, Volume: 22, Issue:14

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrimidines; Receptor Protein-Tyrosine Kinases; Solubility; Structure-Activity Relationship; Water

2014
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.
    ACS medicinal chemistry letters, 2014, May-08, Volume: 5, Issue:5

    Topics:

2014
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
    Bioorganic & medicinal chemistry, 2014, Sep-15, Volume: 22, Issue:18

    Topics: Animals; Antineoplastic Agents; Binding Sites; Bridged-Ring Compounds; Cattle; Cell Cycle; Cell Line, Tumor; Cytoskeleton; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; HeLa Cells; Humans; Microtubules; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Structure-Activity Relationship; Taxoids; Thermodynamics; Tubulin

2014