dm-235 and sapunifiram

dm-235 has been researched along with sapunifiram* in 2 studies

Other Studies

2 other study(ies) available for dm-235 and sapunifiram

Article	Year
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. Bioorganic & medicinal chemistry letters, 2012, Mar-01, Volume: 22, Issue:5 A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds. Topics: Adjuvants, Anesthesia; Amnesia; Animals; Avoidance Learning; Cognition; Drug Design; Mice; Nootropic Agents; Piperazines; Scopolamine; Structure-Activity Relationship; Sulfonamides	2012
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. Bioorganic & medicinal chemistry, 2009, Nov-01, Volume: 17, Issue:21 A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds. Topics: Animals; Cognition; Disease Models, Animal; Drug Design; Mice; Nootropic Agents; Piperazines; Sulfonamides	2009

Article

Year

Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.

Bioorganic & medicinal chemistry letters, 2012, Mar-01, Volume: 22, Issue:5

A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.

Topics: Adjuvants, Anesthesia; Amnesia; Animals; Avoidance Learning; Cognition; Drug Design; Mice; Nootropic Agents; Piperazines; Scopolamine; Structure-Activity Relationship; Sulfonamides

2012

Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.

Bioorganic & medicinal chemistry, 2009, Nov-01, Volume: 17, Issue:21

A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds.

Topics: Animals; Cognition; Disease Models, Animal; Drug Design; Mice; Nootropic Agents; Piperazines; Sulfonamides

2009