dizocilpine-maleate has been researched along with trimethyltin-chloride* in 1 studies
1 other study(ies) available for dizocilpine-maleate and trimethyltin-chloride
| Article | Year |
|---|---|
Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis.
The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra). On the other hand, glutamate receptor antagonist (MK801) did not affect the TMT-induced CORT level increase. These results indicate that this transient activation of the hypothalamo-pituitary-adrenocortical axis in TMT-treated rats may be in part attributable to the neuroendocrine effects of IL-1 produced by microglia. Topics: Administration, Oral; Animals; Corticosterone; Dizocilpine Maleate; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin 1 Receptor Antagonist Protein; Male; Necrosis; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Sialoglycoproteins; Trimethyltin Compounds | 1998 |