dizocilpine-maleate and idebenone

dizocilpine-maleate has been researched along with idebenone* in 1 studies

Other Studies

1 other study(ies) available for dizocilpine-maleate and idebenone

Article	Year
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons. Neuroscience letters, 1994, Sep-12, Volume: 178, Issue:2 The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors. Topics: Animals; Benzoquinones; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Time Factors; Ubiquinone	1994

Article

Year

Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons.

Neuroscience letters, 1994, Sep-12, Volume: 178, Issue:2

The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors.

Topics: Animals; Benzoquinones; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Time Factors; Ubiquinone

1994