dizocilpine-maleate and geranylgeranylacetone

dizocilpine-maleate has been researched along with geranylgeranylacetone* in 2 studies

Other Studies

2 other study(ies) available for dizocilpine-maleate and geranylgeranylacetone

Article	Year
Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia. Brain research, 2004, Sep-10, Volume: 1020, Issue:1-2 The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against the delayed neuronal death (DND) of hippocampal neurons an otherwise lethal ischemic insult. Pretreatment with single oral GGA (800 mg/kg, 2 days before ischemia) significantly attenuated DND in gerbil hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-d-aspartate glutamate receptor antagonist, which indicates that the protection was indeed glutamate receptor activation mediated. Topics: Administration, Oral; Animals; Cell Death; Diterpenes; Dizocilpine Maleate; Drug Administration Schedule; Drug Antagonism; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Time Factors	2004
A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus. Brain research, 2004, Sep-24, Volume: 1021, Issue:2 The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against kainic acid (KA)-induced neurotoxicity. Pretreatment with a single oral GGA dose (800 mg/kg, 2 days before KA) significantly attenuated KA-induced seizures and cell death in rat hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-D-aspartate glutamate receptor antagonist, which indicates that the protection was indeed mediated by glutamate receptor activation. Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cell Death; Convulsants; Diterpenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures	2004

Article

Year

Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia.

Brain research, 2004, Sep-10, Volume: 1020, Issue:1-2

The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against the delayed neuronal death (DND) of hippocampal neurons an otherwise lethal ischemic insult. Pretreatment with single oral GGA (800 mg/kg, 2 days before ischemia) significantly attenuated DND in gerbil hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-d-aspartate glutamate receptor antagonist, which indicates that the protection was indeed glutamate receptor activation mediated.

Topics: Administration, Oral; Animals; Cell Death; Diterpenes; Dizocilpine Maleate; Drug Administration Schedule; Drug Antagonism; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Time Factors

2004

A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.

Brain research, 2004, Sep-24, Volume: 1021, Issue:2

The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against kainic acid (KA)-induced neurotoxicity. Pretreatment with a single oral GGA dose (800 mg/kg, 2 days before KA) significantly attenuated KA-induced seizures and cell death in rat hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-D-aspartate glutamate receptor antagonist, which indicates that the protection was indeed mediated by glutamate receptor activation.

Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cell Death; Convulsants; Diterpenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures

2004