dizocilpine-maleate and 5-6-7-8-tetrahydrofolic-acid

dizocilpine-maleate has been researched along with 5-6-7-8-tetrahydrofolic-acid* in 1 studies

Other Studies

1 other study(ies) available for dizocilpine-maleate and 5-6-7-8-tetrahydrofolic-acid

Article	Year
Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro. Brain research, 1992, Oct-23, Volume: 594, Issue:1 3-Acetylpyridine (3AP) is a potent neurotoxin when administered to laboratory animals. However, its neurotoxic effects have not been investigated extensively in vitro. Cultured cerebellar granule cells are killed by concentrations of 3AP of 0.1-1 mM (ED50 = 220 microM) but not by its 2-acetyl and 4-acetyl analogues. The toxicity of 3AP is enhanced by preexposure to subtoxic concentrations of N-methyl-D-aspartate (NMDA) and is unaffected by the NMDA receptor antagonists MK-801 or APV, as well as by deprenyl, mazindol, or tetrahydrofolic acid. However, 3AP toxicity is completely blocked by preincubating cerebellar granule cells with low concentrations of niacinamide. These data lead us to suggest that 3AP toxicity is due to the substitution of 3AP for niacinamide in the formation of niacinamide adenine dinucleotides (NAD(P)). Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Mazindol; N-Methylaspartate; Neurons; Niacinamide; Pyridines; Rats; Rats, Sprague-Dawley; Selegiline; Tetrahydrofolates	1992

Article

Year

Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro.

Brain research, 1992, Oct-23, Volume: 594, Issue:1

3-Acetylpyridine (3AP) is a potent neurotoxin when administered to laboratory animals. However, its neurotoxic effects have not been investigated extensively in vitro. Cultured cerebellar granule cells are killed by concentrations of 3AP of 0.1-1 mM (ED50 = 220 microM) but not by its 2-acetyl and 4-acetyl analogues. The toxicity of 3AP is enhanced by preexposure to subtoxic concentrations of N-methyl-D-aspartate (NMDA) and is unaffected by the NMDA receptor antagonists MK-801 or APV, as well as by deprenyl, mazindol, or tetrahydrofolic acid. However, 3AP toxicity is completely blocked by preincubating cerebellar granule cells with low concentrations of niacinamide. These data lead us to suggest that 3AP toxicity is due to the substitution of 3AP for niacinamide in the formation of niacinamide adenine dinucleotides (NAD(P)).

Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Mazindol; N-Methylaspartate; Neurons; Niacinamide; Pyridines; Rats; Rats, Sprague-Dawley; Selegiline; Tetrahydrofolates

1992