dizocilpine-maleate and 1-(1-3-benzodioxol-5-ylcarbonyl)piperidine

dizocilpine-maleate has been researched along with 1-(1-3-benzodioxol-5-ylcarbonyl)piperidine* in 1 studies

Other Studies

1 other study(ies) available for dizocilpine-maleate and 1-(1-3-benzodioxol-5-ylcarbonyl)piperidine

ArticleYear
Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion.
    European journal of pharmacology, 1997, Aug-06, Volume: 332, Issue:2

    Two allosteric alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor positive modulators, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine (1-BCP) and 1-(quinoxalin-6-ylcarbonyl)piperidine (CX516), and the antipsychotic drug, haloperidol, were tested for their ability to inhibit hyperactivity induced by amphetamine and dizocilpine in mice. Haloperidol (0.03-1.0 mg/kg) and 1-BCP (20.0-120.0 mg/kg) attenuated hyperactivity induced by both amphetamine and dizocilpine, with higher potency against amphetamine. CX516 (30.0-170.0 mg/kg), however, failed to attenuate amphetamine- and dizocilpine-induced hyperactivity up to a dose which decreased spontaneous locomotor activity. These results indicate that AMPA receptor positive modulators may not be uniform with regard to their effects on dopamine-mediated behaviors and their antipsychotic potential.

    Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Dioxoles; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Locomotion; Male; Mice; Piperidines; Receptors, AMPA

1997