disulfiram and isoniazid

disulfiram has been researched along with isoniazid in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199017 (47.22)18.7374
1990's0 (0.00)18.2507
2000's7 (19.44)29.6817
2010's12 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dansette, PM; Fontana, E; Poli, SM1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Byrne, ST; Chong, C; Denkin, SM; Gu, P; Liu, JO; Sullivan, D; Zhang, Y; Zhou, J1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Kutt, H2
Sobue, I1
Mumenthaler, M1
Glogner, P1
Kutt, H; Penry, JK1
Lucas, BG1
Stoliarov, GV1
Cavanagh, JB1
Kutt, H; Verebely, K1
Rothstein, E1
Braham, J1
Gottwald, W1
Grey, L; Whittington, HG1
Cowan, FF; Koppanyi, T; Maengwyn-Davies, GD1
Abernethy, DR; Greenblatt, DJ; Ochs, HR; Shader, RI1
Johansen, T; Jørgensen, L1
Breese, P; Burman, WJ; Cohn, D; Reves, R; Terra, M1
Emery, ME; Kharasch, ED; Spracklin, DK; Thummel, KE1
Geromichalos, GD; Harkitis, P; Karamanakos, PN; Konstandi, M; Marselos, M; Pappas, P; Trafalis, DT1
Braunbeck, T; Strecker, R; Weigt, S1
Boumba, V; Karamanakos, PN; Marselos, M; Pappas, P; Vougiouklakis, T1

Reviews

6 review(s) available for disulfiram and isoniazid

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Exogenous toxic neuropathy (author's transl)].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1976, Aug-10, Volume: 65, Issue:8

    Topics: Acrylamides; Adolescent; Adult; Aged; Aldrin; Carbon Disulfide; Chloramphenicol; Clioquinol; DDT; Disulfiram; Endrin; Ethambutol; Female; Humans; Isoniazid; Male; Middle Aged; Nervous System Diseases; Phenytoin; Sulfonamides; Thalidomide; Thiamphenicol; Trichloroethylene; Vincristine

1976
Biochemical and genetic factors regulating dilantin metabolism in man.
    Annals of the New York Academy of Sciences, 1971, Jul-06, Volume: 179

    Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzyme Induction; Female; Genetics, Medical; Humans; Intestinal Absorption; Isoniazid; Kinetics; Liver Diseases; Male; Metabolism; Microsomes, Liver; Nystagmus, Pathologic; Pedigree; Pharmacogenetics; Phenobarbital; Phenytoin; Rats; Thiazines

1971
Usefulness of blood levels of antiepileptic drugs.
    Archives of neurology, 1974, Volume: 31, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, Gas; Dextropropoxyphene; Diazepam; Dicumarol; Disulfiram; Drug Interactions; Epilepsy; Ethosuximide; Humans; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenylbutazone; Phenytoin; Primidone; Prochlorperazine; Sulfamethizole; Sulfaphenazole; Thiazines

1974
Peripheral neuropathy caused by chemical agents.
    CRC critical reviews in toxicology, 1973, Volume: 2, Issue:3

    Topics: Acrylamides; Animals; Arsenic; Axons; Carbon Disulfide; Disulfiram; Humans; In Vitro Techniques; Isoniazid; Lead Poisoning; Mercury Poisoning; Myelin Sheath; Neurons; Nitrofurans; Organophosphorus Compounds; Peripheral Nervous System Diseases; Porphyrias; Pyridoxine; Thalidomide; Thallium; Thiamine; Thiocarbamates; Vinca Alkaloids

1973

Other Studies

30 other study(ies) available for disulfiram and isoniazid

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Animals; Antitubercular Agents; Ditiocarb; Female; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Pyrrolidines; Rifampin; Thiocarbamates

2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Interactions of antiepileptic drugs.
    Epilepsia, 1975, Volume: 16, Issue:2

    Topics: Anti-Infective Agents; Anticonvulsants; Benzodiazepines; Biotransformation; Blood Proteins; Carbamazepine; Dextropropoxyphene; Dicumarol; Disulfiram; Drug Interactions; Ethosuximide; Humans; Intestinal Absorption; Isoniazid; Methylphenidate; Phenethylamines; Phenobarbital; Phenothiazines; Phenytoin; Primidone; Protein Binding; Thiazines

1975
[Exotoxin-induced polyneuropathies].
    Wiener medizinische Wochenschrift (1946), 1975, Apr-25, Volume: 125, Issue:17

    Topics: Acrylamides; Carbon Tetrachloride Poisoning; DDT; Disulfiram; Ethanol; Humans; Hydralazine; Isoniazid; Lead Poisoning; Meprobamate; Mercury Poisoning; Methaqualone; Oxyquinoline; Polyneuropathies; Sulfur Dioxide; Thalidomide; Thallium

1975
[Unfavorable and problematic drug combinations. IV].
    Der Internist, 1970, Volume: 11, Issue:11

    Topics: Amphetamine; Ataxia; Bone Marrow; Cerebral Hemorrhage; Depression, Chemical; Dicumarol; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Ephedrine; Humans; Hypertension; Hypotension; Isoniazid; Mercaptopurine; Methamphetamine; Microsomes, Liver; Monoamine Oxidase Inhibitors; Norepinephrine; Phenethylamines; Phenytoin; Reserpine; Stimulation, Chemical; Thiazines; Thiopental; Tyramine

1970
"Dilantin" overdosage.
    The Medical journal of Australia, 1968, Oct-12, Volume: 2, Issue:15

    Topics: Aminosalicylic Acids; Anticonvulsants; Calcium; Dicumarol; Disulfiram; Drug Synergism; Drug Tolerance; Humans; Isoniazid; Lactose; Phenylbutazone; Phenytoin; Sulfaphenazole; Sulfates; Thiazines

1968
[On the course of drug psychoses].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Atropine; Barbiturates; Chlorpromazine; Disulfiram; Drug Hypersensitivity; Female; Humans; Isoniazid; Male; Prednisolone; Psychoses, Substance-Induced; Quinacrine; Time Factors

1968
Metabolism of diphenylhydantoin by rat liver microsomes. I. characteristics of the reaction.
    Biochemical pharmacology, 1970, Volume: 19, Issue:3

    Topics: Adenosine Triphosphate; Animals; Azides; Biotransformation; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Diethylstilbestrol; Dimenhydrinate; Disulfiram; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isoniazid; Kinetics; Male; Methylene Blue; Microsomes, Liver; NAD; NADP; Oxygen; Phenobarbital; Phenytoin; Proadifen; Prochlorperazine; Rats; Sodium; Temperature

1970
Rifampin with disulfiram.
    JAMA, 1972, Feb-28, Volume: 219, Issue:9

    Topics: Disulfiram; Drug Combinations; Humans; Isoniazid; Liver; Male; Middle Aged; Rifampin

1972
Adjuvants to L-dopa for Parkinsonism.
    British medical journal, 1970, May-30, Volume: 2, Issue:5708

    Topics: Animals; Cats; Dihydroxyphenylalanine; Disulfiram; Drug Synergism; Humans; Isoniazid; Parkinson Disease

1970
[Adverse effects of drugs in tuberculous patients. Allergic reactions due to isoniazid and hydantoins or disulfiram].
    Medizinische Monatsschrift, 1970, Volume: 24, Issue:3

    Topics: Alcoholism; Disulfiram; Drug Hypersensitivity; Drug Synergism; Epilepsy; Humans; Hydantoins; Isoniazid; Tuberculosis

1970
Possible interaction between disulfiram and isoniazid.
    The American journal of psychiatry, 1969, Volume: 125, Issue:12

    Topics: Adult; Alcoholism; Brain; Brain Chemistry; Disulfiram; Dopamine; Drug Synergism; Humans; Isoniazid; Male; Middle Aged; Tuberculosis

1969
Tachyphylaxis. VI. Amphetamine in the isolated rabbit aortic strip.
    Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 160, Issue:2

    Topics: Amphetamine; Animals; Aorta; Disulfiram; In Vitro Techniques; Iproniazid; Isoniazid; Muscle Contraction; Muscle, Smooth; Nialamide; Rabbits; Spleen; Tachyphylaxis; Tranylcypromine

1966
Benzodiazepine drug-drug interactions commonly occurring in clinical practice.
    Current medical research and opinion, 1984, Volume: 8 Suppl 4

    Topics: Anti-Anxiety Agents; Benzodiazepines; Cimetidine; Contraceptives, Oral; Disulfiram; Drug Interactions; Enzyme Induction; Ethanol; Humans; Isoniazid; Kinetics; Liver; Mixed Function Oxygenases; Propranolol

1984
Affinity of drugs for cytochrome P-450 determined by inhibition of p-nitrophenetole O-deethylation by rat liver microsomes.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:1

    Topics: Animals; Biotransformation; Carbon Monoxide; Chloramphenicol; Cytochrome P-450 Enzyme System; Disulfiram; Drug Interactions; Isoniazid; Kinetics; Male; Microsomes, Liver; Nitrobenzenes; Nitrophenols; Oxidation-Reduction; Phenytoin; Proadifen; Rats; Rats, Inbred Strains

1983
Lack of toxicity from concomitant directly observed disulfiram and isoniazid-containing therapy for active tuberculosis.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2002, Volume: 6, Issue:9

    Topics: Alcohol Deterrents; Alcoholism; Antitubercular Agents; Directly Observed Therapy; Disulfiram; Drug Therapy, Combination; Humans; Isoniazid; Retrospective Studies; Treatment Outcome; Tuberculosis

2002
Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.
    Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Bromides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Halothane; Isoniazid; Liver; Male; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid

2003
Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity.
    Archives of toxicology, 2009, Volume: 83, Issue:6

    Topics: Adult; Animals; Antimutagenic Agents; Binding Sites; Blotting, Western; Cytochrome P-450 CYP2E1 Inhibitors; Disulfiram; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Isoniazid; Male; Models, Molecular; Mutagens; Nitrosamines; Protein Binding; Quinacrine; Rats; Rats, Wistar; Sister Chromatid Exchange

2009
Cartilage and bone malformations in the head of zebrafish (Danio rerio) embryos following exposure to disulfiram and acetic acid hydrazide.
    Toxicology and applied pharmacology, 2013, Apr-15, Volume: 268, Issue:2

    Topics: Abnormalities, Drug-Induced; Acetates; Animals; Bone and Bones; Cartilage; Disulfiram; Head; Isoniazid; Lethal Dose 50; Notochord; Zebrafish

2013
The Alcohol Intolerance Produced by Isoniazid Is Not Due to a Disulfiram-Like Reaction Despite Aldehyde Dehydrogenase Inhibition.
    Pharmacology, 2016, Volume: 98, Issue:5-6

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Disulfiram; Enzyme Inhibitors; Ethanol; Isoniazid; Liver; Male; Rats; Rats, Wistar

2016