disulfiram has been researched along with ditiocarb in 214 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 114 (53.27) | 18.7374 |
| 1990's | 58 (27.10) | 18.2507 |
| 2000's | 14 (6.54) | 29.6817 |
| 2010's | 14 (6.54) | 24.3611 |
| 2020's | 14 (6.54) | 2.80 |
| Authors | Studies |
|---|---|
| De Guzman, RN; McDonnell, NB; Rice, WG; Summers, MF; Turpin, JA | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Li, L; Li, Z; Pandeya, A; Wei, Y | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Kitson, TM | 3 |
| Greene, FE; Zemaitis, MA | 3 |
| Ho, BT; Schoolar, JC; Schurr, A | 1 |
| Jackson, J; Levinson, W; Mikelens, P; Oppermann, H | 1 |
| Carić-Lazar, M; Rott, R; Scholtissek, C | 1 |
| Baru, AM; Kraeva, VS | 1 |
| Homma, M; Ishii, Y; Yoshikawa, A | 1 |
| Sauter, AM; von Wartburg, JP; Wiegrebe, W | 1 |
| Cohen, G; MacNamee, D | 1 |
| de Saint Blanquat, G; Derache, R; Lindenbaum, A; Vidaillac, G | 1 |
| Lang, M; Marselos, M; Törrönen, R | 2 |
| Da Prada, M; Pletscher, A; Schlichter, D | 1 |
| Sauter, AM; Wartburg, JP | 1 |
| Rainey, JM | 1 |
| Freundt, KJ; Netz, H | 1 |
| Marselos, M; Törrönen, R | 1 |
| Fried, R | 2 |
| Cobby, J; Mayersohn, M; Selliah, S | 2 |
| Artman, L; Dodd, DE; Faiman, MD; Hanzlik, RE; Nolan, RJ | 1 |
| Hooper, AB; Maxwell, PC; Terry, KR | 1 |
| Borchert, P; Fladmoe, AV; Lam, LK; Wattenberg, LW | 1 |
| Fiala, ES | 1 |
| Gordis, E; Peterson, K | 1 |
| Wattenberg, LW | 1 |
| Mendoza, SA; Miller, JH | 1 |
| Dodd, DE; Faiman, MD; Hanzlik, R; Minor, SS | 1 |
| Becker, CE; Rogers, WK; Wilson, KM | 1 |
| Kaaber, K; Menné, T | 1 |
| Bernstein, SP; Deneke, SM; Fanburg, BL | 1 |
| Miyazawa, T; Moriya, M; Ohta, T; Shirasu, Y; Sugiyama, F; Watanabe, K; Watanabe, Y | 1 |
| Faiman, MD; Hart, BW | 2 |
| Khan, S; Lauriault, VV; O'Brien, PJ | 1 |
| Gavish, M; Katz, Y; Weizman, A; Weizman, R | 1 |
| Azenha, A; Baptista, A; Barros, MA | 1 |
| Frank, N; Hadjiolov, D; Moog, C; Spirov, K | 1 |
| Guru, SC; Nagendra, SN; Shetty, KT; Subhash, MN | 1 |
| Angelo, HR; Christensen, JK; Johansson, B; Møller, IW; Rønsted, P | 1 |
| Faiman, MD; Yourick, JJ | 2 |
| Lauriault, VV; O'Brien, PJ | 1 |
| Ishikawa, M; Sasaki, K; Takayanagi, Y | 1 |
| Brady, JF; Gapac, JM; Li, Y; Ning, SM; Wang, MH; Xiao, F; Yang, CS | 1 |
| Boisier, I; Chandía, R; Cid, E; Feuerhake, O | 1 |
| Brazier, JL; Coquet, B; Desage, M; Rousseau-Tsangaris, M; Scappaticci, B; Soubeyrand, J | 1 |
| Johansson, B | 2 |
| Cohen, JD; Robins, HI | 1 |
| Hilsted, L | 1 |
| Danielsson, BR; Dencker, L; Khayat, A | 1 |
| Barretto, PB; Benson, AM; Stanley, JS | 1 |
| Nilsson, GE; Tottmar, O | 1 |
| Arnold, E; Johansson, B; Petersen, EN | 1 |
| Atkins, LM; Gale, GR; Smith, AB | 1 |
| Bravo, C; Chávez, E; Zazueta, C | 1 |
| Ciraulo, DA | 1 |
| Howard, RG; Lukrec, A; Phillips, M | 1 |
| Kitson, TM; Loomes, KM | 1 |
| Johansson, B; Stankiewicz, Z | 2 |
| Cooper, S; DeLanney, LE; Di Monte, D; Irwin, I; Kupsch, A; Langston, JW | 1 |
| Andersen, O; Sørensen, JA | 1 |
| Grates, HE; Valeriote, F | 1 |
| Masuda, Y; Nakamura, Y | 1 |
| Helander, A; Johansson, B | 1 |
| Petersen, EN | 1 |
| Beber, JH; Carper, WR; Dorey, RC | 1 |
| Brinkman, UA; de Jong, GJ; Frei, RW; Irth, H | 1 |
| Benson, AM; Ford, DB | 1 |
| Dogterom, P; Mulder, GJ; Nagelkerke, JF; van Steveninck, J | 1 |
| Masuda, Y; Shibata, K; Yasoshima, M | 1 |
| Helander, A; Tottmar, O | 1 |
| Masuda, Y | 1 |
| MacKerell, AD; Pietruszko, R; Vallari, RC | 1 |
| Agarwal, RP; Brodeur, RJ; Garagusi, VF; Mossman, KL; Phillips, M | 1 |
| Lind, B; Oskarsson, A | 1 |
| Barretto, PB; Benson, AM | 1 |
| Hennighausen, G; Kröning, G; Lange, P | 1 |
| Kohn, FR; Sladek, NE | 1 |
| Büch, HP; Eckes, L | 1 |
| Alexander, NM; Kelner, MJ | 1 |
| Enomoto, K; Inahara, S; Maeda, K; Nishigaki, R; Umemura, K; Utsugi, K | 1 |
| Bodenner, DL; Borch, RF; Dedon, PC; Katz, JC; Keng, PC | 1 |
| Bertram, B; Pool, BL; Tacchi, AM; Wiessler, M | 2 |
| Atchison, WD; Lopachin, RM; Peterson, RE; Williams, KD | 1 |
| Grankvist, K; Hansson, HA; Norlund, L; Norlund, R | 1 |
| Eipper, BA; Mains, RE; Park, LP | 1 |
| Agarwal, RP; Hensley, P; McPherson, RA; Phillips, M | 1 |
| Bobkova, NV; Gromova, EA; Khesin, II; Plakkhinas, LA; Tokareva, AE | 1 |
| Kohn, FR; Landkamer, GJ; Manthey, CL; Ramsay, NK; Sladek, NE | 1 |
| Feledyk, K; Stach, R; Trabka, J | 1 |
| Faiman, MD; Jensen, JC; Lacoursiere, RB | 1 |
| Jasim, S; Tjälve, H | 1 |
| Danielsson, BR | 1 |
| Pavlova, SD; Popov, TA | 1 |
| Oskarsson, A | 1 |
| Evets, MA; Korablev, MV; Kurbat, NM | 1 |
| Fisher, AB; Forman, HJ; York, JL | 1 |
| Faiman, MD; Jensen, JC | 1 |
| Grafström, R; Greene, FE | 1 |
| Chalas, J; Cluet, JL; Etienne, JP; Godin, J; Labayle, D; Leluc, R; Lindenbaum, A | 1 |
| Grafström, R; Holmberg, B | 1 |
| Fukunaga, M; Inoue, K; Yamasawa, K | 1 |
| Christensen, JD | 1 |
| Kajewska, B; Podobiński, M | 1 |
| Ershler, WB; Gamelli, RL; Hacker, MP; Newman, RA | 1 |
| Kiereś, H; Podobiński, M | 1 |
| Baselt, RC; Hanson, VW | 1 |
| Faiman, MD; Hurwitz, A; Jensen, JC | 1 |
| Birnboim, HC | 1 |
| Carlson, GP; Fossa, AA; White, JF | 1 |
| Masłowska, J; Szmich, J | 1 |
| Agarwal, RP; McPherson, RA; Phillips, M | 1 |
| Glisson, BS; Hande, KR; Ross, WE; Wozniak, AJ | 1 |
| Fechter, LD; Millington, WR; Storm, JE | 1 |
| Hanzlik, RP; Traiger, GJ; Vyas, KP | 1 |
| Danielsson, BR; Dencker, L; Oskarsson, A | 1 |
| Caroldi, S; de Paris, P | 1 |
| Gawkrodger, DJ; Healy, J; Howe, AM | 1 |
| Altarac, M; Mueller, GP | 1 |
| Deamer, NJ; Genter, MB | 1 |
| Faiman, MD; Madan, A | 2 |
| Mamatha, RK; Nagendra, SN | 1 |
| Abedinzadeh, Z; Houee-Levin, C; Mankhetkorn, S | 1 |
| Andersen, O; Nielsen, GD | 1 |
| Masukawa, T; Nakanishi, K | 2 |
| Cuéllar, A; Kuroda, MA | 1 |
| Faiman, MD; Madan, A; Nagendra, SN | 1 |
| Faiman, MD; Madan, A; Parkinson, A | 3 |
| Dean, BS; Krenzelok, EP; Kurta, DL | 1 |
| Goh, L; Kitson, KE; Kitson, TM | 1 |
| Guzelian, PS; Hong, JY; Huang, W; Li, D; Pan, J; Schuetz, EG; Yang, CS | 1 |
| Benjamin, D; Bhadra, S; Elkhayat, I; Harris, CM; Lal, H; Prather, PL | 1 |
| Collu, M; Devoto, P; Ruiu, S; Saba, PL; Vaccari, A | 1 |
| Commandeur, JN; Ploemen, JP; van Bladeren, PJ; van Iersel, ML; Vermeulen, NP; Wormhoudt, LW | 1 |
| Fauq, AH; Lam-Holt, J; Lipsky, JJ; Mays, DC; Nelson, AN | 1 |
| Johnson, KL; Lipsky, JJ; Mays, DC; Naylor, S; Veverka, KA | 1 |
| Funakoshi, T; Kojima, S; Ono, H; Shimada, H | 1 |
| Davis, K; Faiman, MD; Nagendra, SN; Newby, X; Schloss, JV; Wu, JY | 1 |
| Aquilina, JW; Berti, JJ; Lipsky, JJ; Mays, DC | 1 |
| Lam, JP; Lipsky, JJ; Mays, DC | 1 |
| Johnson, KL; Lam-Holt, J; Lipsky, JJ; Mays, DC; Naylor, S; Tomlinson, AJ | 1 |
| Fauq, AH; Lam, JP; Lipsky, JJ; Mays, DC; Ortiz-Bermudez, P; Tong, IH | 1 |
| Antonelli, T; Ferraro, L; Mocci, I; Ruiu, S; Saba, P; Tanganelli, S; Vaccari, A | 1 |
| Arnelle, DR; Day, BJ; Stamler, JS | 1 |
| Bartsch, H; Frank, N; Lin, JK; Liu, GY | 1 |
| Ackers, JP; Bouma, MJ; Fairlamb, AH; Snowdon, D | 1 |
| Cai, H; Ito, Y; Koizumi, Y; Nakao, M; Terao, M | 1 |
| Holmdahl, R; Kalden, JR; Mikulowska, A; Voll, RE | 1 |
| Bradberry, SM; Vale, JA | 1 |
| Benson, LM; Lipsky, JJ; Martin, YN; Mays, DC; Naylor, S; Pike, MG | 1 |
| Cai, H; Hori, R; Ito, Y; Nabekura, T; Terao, M | 1 |
| Lipsky, JJ; Naylor, S; Shen, ML | 2 |
| Horie, T; Kobayashi, S; Masubuchi, Y; Narimatsu, S; Yamamoto, K | 1 |
| Hazai, E; Monostory, K; Vereczkey, L | 1 |
| Ahr, HJ; Kayser, M; Mihail, F; Schmuck, G; Stahl, B | 1 |
| DE JONGH, DK; KOK, K | 1 |
| CASIER, H; MERLEVEDE, E | 1 |
| STROMME, JH | 2 |
| STROEMME, JH | 1 |
| STRUME, JH | 1 |
| Aragon, CM; Escarabajal, MD | 1 |
| BERG, K; LINDERHOLM, H | 1 |
| Milatovic, DM; Tonkin, EG; Valentine, HL; Valentine, WM | 1 |
| Ito, Y; Kamei, A; Nagai, N; Takeda, M; Takeuchi, N | 1 |
| Ito, Y; Jiang, TY; Liu, Y; Nagai, N; Nie, SF; Wang, SL; Wu, CF | 1 |
| Namazi, MR | 1 |
| Inomata, M; Ito, Y; Nagai, N | 1 |
| Chipinda, I; Hettick, JM; Siegel, PD; Simoyi, RH | 1 |
| Hollenberg, PF; Lin, HL; Pratt-Hyatt, M | 1 |
| Demare, P; López-Ortiz, M; Muñoz-Clares, RA; Regla, I; Zaldívar-Machorro, VJ | 1 |
| Anil, S; Cameron, AR; Harthill, J; Rena, G; Sutherland, E | 1 |
| Fujiwara, N; Hasegawa, T; Horita, Y; Inagaki, E; Kremer, L; Kuroishi, R; Lee, Y; Makino, T; Mizukami, H; Ogawa, K; Onozaki, K; Sato, Y; Takii, T; Yagi, T; Yamamoto, R | 1 |
| Czeczot, H; Grosicka-Maciąg, E; Grzela, T; Kurpios-Piec, D; Rahden-Staroń, I; Szumiło, M | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
| Chang, J; Han, J; Hua, Y; Liu, L; Shi, W; Yue, X | 1 |
| Higgins, C; Nixon, R | 1 |
| Bartko, J; Boehm, T; Borth, N; Gludovacz, E; Jilma, B; Petroczi, K | 1 |
| Armesilla, AL; Butcher, K; Kannappan, V; Kilari, RS; McConville, C; Morris, MR; Wang, W | 1 |
| Frazier, KR; Long, TE; Moore, JA | 1 |
| Brock, P; Cabral, S; Freyer, DR; Knight, K; Reaman, G; Robinson, PD; Sung, L | 1 |
| Huang, H; Lin, B; Lin, JM; Lu, X; Wang, Y; Xu, N | 1 |
| Ding, J; Hu, S; Liu, P; Meng, Y; Peng, Y; Zhou, W | 1 |
| Farr, L; Ghosh, S; Leaton, LA; Moonah, S; Padalia, J; Shirley, DA; Singh, A; Sullivan, D | 1 |
| Augsburger, F; Blondel, M; Friocourt, G; Herault, Y; Panagaki, T; Randi, EB; Szabo, C; Zuhra, K | 1 |
| Cheng, Z; Liu, H; Liu, R; Shi, H; Suo, Y; Zhang, Z | 1 |
| Ai, H; Liu, L; Pan, M; Wang, C; Xie, Y; Yu, Y; Zeng, X; Zhao, M; Zheng, Q | 1 |
| Chang, C; Chen, Y; Dong, C; Song, F; Yu, L; Zhang, H | 1 |
| Geng, Y; Shen, Y; Sun, R; Zhang, Y; Zhou, Z | 1 |
| Akatov, V; Baburina, Y; Holmuhamedov, E; Krestinina, O; Lomovskaya, Y; Mikheeva, I; Mishukov, A; Odinokova, I; Pavlik, L; Shatalin, Y; Solovieva, M | 1 |
| Guo, Y; Li, Y; Shen, JW; Shen, Q; Sun, J; Sun, Y; Wei, Q; Xu, L | 1 |
| Farr, L; Moonah, S; Sharma, I | 1 |
| Chen, HY; Kang, BK; Li, S; Li, XL; Song, J; Xu, JJ; Yu, Q; Zhou, J | 1 |
| Chen, C; Li, C; Li, S; Liang, J; Liu, S; Liu, T; Song, Z; Tang, C; Xu, N; Zhou, S; Zhu, L | 1 |
9 review(s) available for disulfiram and ditiocarb
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Gasdermin D (GSDMD) as a new target for the treatment of infection.
Topics: | 2019 |
Inhibitors of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Benzopyrenes; Benzyl Compounds; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogens; Disulfiram; Ditiocarb; Humans; Microsomes, Liver; Mixed Function Oxygenases; Selenium; Thiocyanates | 1978 |
[Molecular basis of the antialcoholic mechanism of action of teturam (review)].
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Biotransformation; Catecholamines; Cats; Disulfiram; Ditiocarb; Dogs; Dopamine beta-Hydroxylase; Ethanol; Humans; In Vitro Techniques; Mice; Rabbits; Rats; Serotonin; Tyrosine 3-Monooxygenase; Xanthine Oxidase | 1981 |
Biochemical actions of anti-alcoholic agents.
Topics: Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Behavior; Carbon Disulfide; Cyanamide; Diethylamines; Disulfiram; Ditiocarb; Drug Implants; Glutamine; Humans; Metronidazole | 1980 |
The prevention of nickel contact dermatitis. A review of the use of binding agents and barrier creams.
Topics: Chelating Agents; Dermatitis, Contact; Disulfiram; Ditiocarb; Edetic Acid; Humans; Ligands; Nickel; Ointments; Resins, Plant; Structure-Activity Relationship | 1995 |
Therapeutic review: do diethyldithiocarbamate and disulfiram have a role in acute nickel carbonyl poisoning?
Topics: Animals; Antidotes; Chelating Agents; Disulfiram; Ditiocarb; Humans; Mice; Organometallic Compounds; Rats | 1999 |
Interventions for cisplatin-induced hearing loss in children and adolescents with cancer.
Topics: Acetylcysteine; Adolescent; Amifostine; Anti-Inflammatory Agents; Antineoplastic Agents; Chelating Agents; Child; Cisplatin; Cytoprotection; Dexamethasone; Disulfiram; Ditiocarb; Humans; Neoplasms; Ototoxicity; Thiosulfates | 2019 |
Disulfiram: A Food and Drug Administration-approved multifunctional role in synergistically drug delivery systems for tumor treatment.
Topics: Antineoplastic Agents; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Drug Delivery Systems; Humans; Neoplasms; United States; United States Food and Drug Administration | 2022 |
205 other study(ies) available for disulfiram and ditiocarb
| Article | Year |
|---|---|
Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Amino Acid Sequence; Anti-HIV Agents; Capsid; Capsid Proteins; Cells, Cultured; Cystamine; Disulfiram; Ditiocarb; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Thiamine; Viral Proteins; Zinc Fingers | 1997 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.
Topics: Aldehyde Oxidoreductases; Animals; Disulfiram; Ditiocarb; Drug Synergism; Glutathione; Hydrogen-Ion Concentration; Liver; Mercaptoethanol; Mitochondria, Liver; Sheep | 1975 |
Impairment of hepatic microsomal drug metabolism in the rat during daily disulfiram administration.
Topics: Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Depression, Chemical; Disulfiram; Ditiocarb; Ethylmorphine-N-Demethylase; Male; Microsomes, Liver; NADP; Pharmaceutical Preparations; Rats | 1976 |
The effects of disulfiram on rat liver mitochondrial monoamine oxidase.
Topics: Animals; Disulfiram; Ditiocarb; Ethanol; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Rats; Time Factors | 1978 |
Effect of antabuse (disulfiram) on Rous sarcoma virus and on eukaryotic cells.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Copper; Disulfiram; Ditiocarb; DNA; DNA, Viral; Humans; Protein Biosynthesis; Reverse Transcriptase Inhibitors; RNA | 1978 |
Effect of tetraethyl thiuram disulfide (disulfiram) on the multiplication of enveloped viruses.
Topics: Adsorption; Animals; Culture Techniques; Disulfiram; Ditiocarb; Erythrocytes; Ethanol; Herpesviridae; Herpesvirus 1, Suid; Influenza A virus; Newcastle disease virus; Pseudorabies; Semliki forest virus; Vesicular stomatitis Indiana virus; Virus Replication | 1975 |
[Changes in the noradrenaline level and synthesis of nuclear RNA in the brain of rats with disturbances of the emotions and conditioned-defense behavior].
Topics: Affective Symptoms; Animals; Behavior, Animal; Brain; Conditioning, Classical; Disulfiram; Ditiocarb; Humans; Iproniazid; Male; Norepinephrine; Rats; Reserpine; RNA | 1975 |
Effect of dopamine-beta-hydroxylase inhibitors on thermoregulation in reserpine-treated rats.
Topics: Adrenal Medulla; Animals; Body Temperature Regulation; Brain; Catecholamines; Dihydroxyphenylalanine; Disulfiram; Ditiocarb; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Male; Picolinic Acids; Pimozide; Rats; Reserpine; Thiocarbamates | 1976 |
Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamate.
Topics: Animals; Carboxylic Ester Hydrolases; Cholinesterases; Disulfiram; Ditiocarb; Drug Interactions; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Microsomes, Liver; Procaine; Rats; Thiocarbamates; Time Factors | 1976 |
Determination of disulfiram and its metabolites in human blood.
Topics: Carbon Disulfide; Disulfides; Disulfiram; Ditiocarb; Humans; Spectrophotometry, Ultraviolet | 1976 |
On the absence of "endogenous" acetaldehyde in rat and mouse blood.
Topics: Acetaldehyde; Animals; Chromatography, Gas; Disulfiram; Ditiocarb; Ethanol; Mice; Plasma; Rats | 1976 |
[Digestive absorption, fixation and excretion of oral disulfiram in the rat].
Topics: Administration, Oral; Animals; Disulfiram; Ditiocarb; Feces; Intestinal Absorption; Male; Rats; Time Factors | 1976 |
Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. I. Mixed-function oxygenase.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Disulfiram; Ditiocarb; Liver; Male; Membranes; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Phospholipids; Rats; Thiocarbamates | 1976 |
Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. II. D-Glucuronic acid pathway.
Topics: Alcohol Oxidoreductases; Animals; Carbohydrate Dehydrogenases; Disulfiram; Ditiocarb; Female; Glucosephosphate Dehydrogenase; Glucuronates; Glucuronidase; Glucuronosyltransferase; Liver; Phenobarbital; Pyrophosphatases; Rats; Sugar Acids; Thiocarbamates; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate Glucuronic Acid | 1976 |
Interference of inhibitors of dopamine-beta-hydroxylase with uptake of monoamines by chromaffin granular membranes.
Topics: Adenosine Triphosphatases; Adrenal Medulla; Amines; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Cattle; Chromaffin System; Disulfiram; Ditiocarb; Dopamine; Dopamine beta-Hydroxylase; Fusaric Acid; In Vitro Techniques; Membranes | 1975 |
Some carbamates, thiocarbamates and carbazides.
Topics: Animals; Azides; Carbamates; Carbaryl; Disulfiram; Ditiocarb; Herbicides; Humans; Insecticides; Maneb; Neoplasms, Experimental; Pesticides; Semicarbazides; Thiocarbamates; Thiram; Zineb; Ziram | 1976 |
Quantitative analysis of disulfiram and its metabolites in human blood by gas-liquid chromatography.
Topics: Carbon Disulfide; Chromatography, Gas; Chromatography, Liquid; Disulfides; Disulfiram; Ditiocarb; Hot Temperature; Humans; Methods | 1977 |
Disulfiram toxicity and carbon disulfide poisoning.
Topics: Animals; Carbon Disulfide; Cardiovascular Diseases; Diethylamines; Disulfiram; Ditiocarb; Dyskinesia, Drug-Induced; Environmental Exposure; Gastrointestinal Diseases; Humans; Occupational Diseases; Psychoses, Substance-Induced; Rabbits; Rats; Risk | 1977 |
Behavior of blood acetaldehyde in alcohol-treated rats following administration of thiurams.
Topics: Acetaldehyde; Animals; Disulfiram; Ditiocarb; Ethanol; Female; Rats; Structure-Activity Relationship; Thiocarbamates; Thiram | 1977 |
Comparison of D-glucuronolactone and aldehyde dehydrogenase activities in the rat liver.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Disulfiram; Ditiocarb; Glucuronates; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1977 |
Enzymatic oxidation of diethyldithiocarbamate by xanthine oxidase and its colorimetric assay.
Topics: Colorimetry; Disulfiram; Ditiocarb; Methods; Nitroblue Tetrazolium; Oxidation-Reduction; Thiocarbamates; Xanthine Oxidase | 1976 |
The rapid reduction of disulfiram in blood and plasma.
Topics: Animals; Biotransformation; Chromatography, Gas; Disulfiram; Ditiocarb; Dogs; Drug Stability; Humans; In Vitro Techniques; Kinetics; Oxidation-Reduction; Plasma; Time Factors | 1977 |
A rapid and simple radioactive method for the determination of disulfiram and its metabolites from a single sample of biological fluid or tissue.
Topics: Animals; Blood Proteins; Disulfiram; Ditiocarb; Dogs; Glucuronates; Male; Methods; Mice; Mice, Inbred ICR; Protein Binding; Sulfates; Sulfur Radioisotopes; Time Factors | 1977 |
Hydroxylamine oxidoreductase of Nitrosomonas. Oxidation of diethyldithiocarbamate concomitant with stimulation of nitrite synthesis.
Topics: Cyanides; Cytochrome c Group; Disulfiram; Ditiocarb; Electron Transport; Hydrazines; Hydrogen Peroxide; Hydroxylamines; Methylphenazonium Methosulfate; Nitrates; Nitrites; Nitrosomonas; Oxidoreductases; Oxygen | 1977 |
Inhibits of of colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disulfides; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; Maneb; Mice; Thiocarbamates | 1977 |
Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Carbon Dioxide; Carbon Disulfide; Carcinogens; Dimethylhydrazines; Disulfiram; Ditiocarb; Male; Methylhydrazines; Pesticides; Rats; Rats, Inbred F344 | 1977 |
Methyl diethyldithiocarbamate, a metabolite of disulfiram in man.
Topics: Adult; Alcoholism; Chromatography, Gas; Disulfiram; Ditiocarb; Humans; Male; Mass Spectrometry; Middle Aged; Thiocarbamates | 1977 |
Disulfiram therapy in alcoholism: patient compliance studied with a urine-detection procedure.
Topics: Adult; Alcoholism; Ambulatory Care; Chromatography, Thin Layer; Diethylamines; Disulfiram; Ditiocarb; Female; Humans; Male; Patient Compliance | 1977 |
Lack of protection against oxygen toxicity by in vivo protective agents in the isolated toad bladder.
Topics: Amitrole; Animals; Ascorbic Acid; Biological Transport, Active; Bufo marinus; Catalase; Cysteine; Disulfiram; Ditiocarb; Glutathione; In Vitro Techniques; Oxygen; Sodium; Succinates; Urinary Bladder | 1978 |
Radioactive and nonradioactive methods for the in vivo determination of disulfiram, diethyldithiocarbamate, and diethyldithiocarbamate-methyl ester.
Topics: Blood Chemical Analysis; Brain Chemistry; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Disulfiram; Ditiocarb; Humans; Kidney; Liver; Lung; Methods; Sulfur Radioisotopes; Thiocarbamates | 1978 |
Methods for detecting disulfiram in biologic fluids: application in studies of compliance and effect of divalent cations on bioavailability.
Topics: Antacids; Biological Availability; Breath Tests; Carbon Disulfide; Cations; Disulfiram; Ditiocarb; Drug Therapy, Combination; Ferrous Compounds; Glucuronates; Humans; Methods; Patient Compliance | 1978 |
Disulfiram and cigarettes.
Topics: Acetaldehyde; Disulfiram; Ditiocarb; Drug Interactions; Humans; Lung Neoplasms; Smoking | 1978 |
Treatment of pompholyx due to nickel allergy with chelating agents.
Topics: Aged; Disulfiram; Ditiocarb; Eczema, Dyshidrotic; Female; Humans; Nickel; Thiocarbamates | 1978 |
Enhancement by disulfiram (Antabuse) of toxic effects of 95 to 97% O2 on the rat lung.
Topics: Animals; Antioxidants; Disulfiram; Ditiocarb; Drug Synergism; Glutathione; Lung; Oxygen; Rats; Superoxide Dismutase | 1979 |
In vivo and in vitro effects of thiuram disulfides and dithiocarbamates on hepatic microsomal drug metabolism in the rat.
Topics: Animals; Carbon Disulfide; Dimethyldithiocarbamate; Disulfiram; Ditiocarb; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Rats; Thiocarbamates; Thiram | 1979 |
Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.
Topics: Aminoacetonitrile; Animals; Azo Compounds; Azoxymethane; Carbon Disulfide; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Ditiocarb; Drug Evaluation, Preclinical; Male; Maneb; Methylhydrazines; Mice; Mutagens; Neoplasms, Experimental; Pyrazoles | 1979 |
In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram.
Topics: Aldehyde Dehydrogenase; Animals; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Mitochondria, Liver; Rats | 1992 |
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.
Topics: Animals; Carbon Disulfide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Disulfiram; Ditiocarb; Liver Diseases; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains | 1992 |
Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Disulfiram; Ditiocarb; Flunitrazepam; Isoquinolines; Kidney; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Allergic contact dermatitis on an amputation stump.
Topics: Adult; Amputation Stumps; Artificial Limbs; Dermatitis, Contact; Disulfiram; Ditiocarb; Humans; Male; Rubber; Zinc | 1992 |
Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Diethylnitrosamine; Disulfiram; Ditiocarb; Liver Neoplasms, Experimental; Lymphocytes; Male; Mice; Proline; Rats; Rats, Inbred Strains; Sarcosine; Spleen; Thiocarbamates | 1992 |
Role of glutathione reductase system in disulfiram conversion to diethyldithiocarbamate.
Topics: Disulfiram; Ditiocarb; Glutathione Reductase; Humans; Oxidation-Reduction; Yeasts | 1991 |
Dose-effect relationship of disulfiram in human volunteers. II: A study of the relation between the disulfiram-alcohol reaction and plasma concentrations of acetaldehyde, diethyldithiocarbamic acid methyl ester, and erythrocyte aldehyde dehydrogenase acti
Topics: Acetaldehyde; Adult; Aldehyde Dehydrogenase; Catecholamines; Disulfiram; Ditiocarb; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Erythrocytes; Ethanol; Female; Hemodynamics; Humans; Male; Middle Aged | 1991 |
Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.
Topics: Aldehyde Dehydrogenase; Animals; Carbamates; Disulfides; Disulfiram; Ditiocarb; Kinetics; Liver; Sheep; Thiocarbamates | 1991 |
Disulfiram metabolism as a requirement for the inhibition of rat liver mitochondrial low Km aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; Imidazoles; Kinetics; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1991 |
Disulfiram may mediate erythrocyte hemolysis induced by diethyldithiocarbamate and 1,4-naphthoquinone-2-sulfonate.
Topics: Animals; Cross-Linking Reagents; Disulfiram; Ditiocarb; Erythrocyte Membrane; Glutathione; Hemolysis; Humans; In Vitro Techniques; Male; Membrane Proteins; Naphthoquinones; Oxygen Consumption; Rats; Rats, Inbred Strains; Superoxide Dismutase | 1991 |
Drug interaction effects on antitumour drugs (VIII): prevention of ifosfamide-induced urotoxicity by disulfiram and its effect on antitumour activity and acute toxicity of alkylating agents in mice.
Topics: Animals; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Ifosfamide; Leukopenia; Male; Mice; Neoplasms, Experimental; Urinary Bladder | 1991 |
Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Disulfiram; Ditiocarb; Liver; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Oxygenases; Rats; Rats, Inbred Strains | 1991 |
Plasma concentrations of disulfiram after injection of suspended micropellets into alcoholic subjects.
Topics: Adult; Alcoholism; Animals; Delayed-Action Preparations; Disulfiram; Ditiocarb; Female; Humans; Male; Rats; Rats, Inbred Strains | 1991 |
Determination of sodium diethyldithiocarbamate (Imuthiol) and its S-methyl metabolite by gas chromatography-mass spectrometry. Use of deuteromethyl iodide derivatization.
Topics: Deuterium; Disulfiram; Ditiocarb; Gas Chromatography-Mass Spectrometry; Humans | 1990 |
Plasma protein binding of disulfiram and its metabolite diethylthiocarbamic acid methyl ester.
Topics: Aldehyde Dehydrogenase; Binding Sites; Blood Proteins; Disulfiram; Ditiocarb; Electrophoresis, Agar Gel; Humans; Serum Albumin | 1990 |
Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines.
Topics: Animals; Cell Survival; Disulfiram; Ditiocarb; Drug Screening Assays, Antitumor; Humans; Rodentia; Species Specificity; Tumor Cells, Cultured | 1990 |
Alpha-amidation of gastrin is impaired by diethyldithiocarbamate.
Topics: Amides; Animals; Chromatography, Gel; Copper; Disulfiram; Ditiocarb; Gastric Mucosa; Gastrins; Male; Protein Processing, Post-Translational; Pyloric Antrum; Radioimmunoassay; Rats; Rats, Inbred Strains; Stomach | 1990 |
Foetal and maternal distribution of inhaled mercury vapour in pregnant mice: influence of selenite and dithiocarbamates.
Topics: Administration, Inhalation; Animals; Disulfiram; Ditiocarb; Female; Fetus; Maternal-Fetal Exchange; Mercury; Mice; Mice, Inbred C57BL; Pregnancy; Premedication; Selenious Acid; Selenium; Thiocarbamates; Thiram | 1990 |
Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice.
Topics: Animals; Antineoplastic Agents; Cytosol; Dicumarol; Disulfides; Disulfiram; Ditiocarb; Enzyme Induction; Female; Glutathione Transferase; Isothiocyanates; Mice; Microsomes; Quinone Reductases; Thiocyanates; Thiones | 1986 |
Effects of biogenic aldehydes and aldehyde dehydrogenase inhibitors on rat brain tryptophan hydroxylase activity in vitro.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Brain Stem; Cyclopropanes; Disulfiram; Ditiocarb; Glutamine; Hydroxyindoleacetic Acid; Indoles; Male; Rats; Rats, Inbred Strains; Tyrosine 3-Monooxygenase | 1987 |
Comparative aspects of disulfiram and its metabolites in the disulfiram-ethanol reaction in the rat.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Blood Pressure; Disulfiram; Ditiocarb; Ethanol; Female; Rats; Rats, Inbred Strains | 1989 |
Diethylthiocarbamic acid methyl ester. A potent inhibitor of aldehyde dehydrogenase found in rats treated with disulfiram or diethyldithiocarbamic acid methyl ester.
Topics: Aldehyde Dehydrogenase; Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Ethanol; Heart Rate; Humans; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Thiocarbamates | 1989 |
Comparative effects of disulfiram and diethyldithiocarbamate on cadmium distribution in mice.
Topics: Animals; Cadmium; Cadmium Radioisotopes; Disulfiram; Ditiocarb; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tissue Distribution | 1989 |
Extensive Ca2+ release from energized mitochondria induced by disulfiram.
Topics: Adenosine Diphosphate; Animals; Calcium; Cytoplasm; Disulfiram; Ditiocarb; In Vitro Techniques; Kidney; Mitochondria; Mitochondrial Swelling; NADP; Oxidation-Reduction; Rats | 1989 |
Can disulfiram (Antabuse) be safely co-administered with the monoamine oxidase inhibitor (MAOI) antidepressants? Despite the ability of the major metabolite of disulfiram (diethyldithiocarbamate) to inhibit the enzyme dopamine beta-hydroxylase and a repor
Topics: Animals; Disulfiram; Ditiocarb; Drug Synergism; Monoamine Oxidase Inhibitors; Psychomotor Disorders; Rats; Risk Factors; Seizures; Tranylcypromine | 1989 |
Inhibition of serum lactate dehydrogenase activity by disulfiram and diethyldithiocarbamate.
Topics: Disulfiram; Ditiocarb; Humans; L-Lactate Dehydrogenase | 1989 |
Studies of the action of symmetrical and mixed disulphide thiol-modifying reagents on the esterase activity of cytoplasmic aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Binding Sites; Catalysis; Disulfides; Disulfiram; Ditiocarb; Esterases; Liver; Pyridines; Sheep; Sulfhydryl Compounds; Thiocarbamates | 1989 |
Inhibition of erythrocyte aldehyde dehydrogenase activity and elimination kinetics of diethyldithiocarbamic acid methyl ester and its monothio analogue after administration of single and repeated doses of disulfiram to man.
Topics: Adult; Alcoholism; Aldehyde Dehydrogenase; Disulfiram; Ditiocarb; Erythrocytes; Ethanol; Female; Humans; Male; Middle Aged; Oxidation-Reduction | 1989 |
Diethyldithiocarbamate and disulfiram inhibit MPP+ and dopamine uptake by striatal synaptosomes.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disulfiram; Ditiocarb; Dopamine; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurotoxins; Sulfhydryl Compounds; Synaptosomes | 1989 |
Effects of diethyldithiocarbamate and tetraethylthiuram disulfide on zinc metabolism in mice.
Topics: Animals; Body Burden; Disulfiram; Ditiocarb; Male; Mice; Mice, Inbred CBA; Tissue Distribution; Zinc; Zinc Radioisotopes | 1989 |
Potentiation of nitrogen mustard cytotoxicity by disulfiram, diethyldithiocarbamic acid, and diethylamine in mice.
Topics: Animals; Diethylamines; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Drug Synergism; Leukemia, Experimental; Mechlorethamine; Mice | 1989 |
Oxidation of diethyldithiocarbamate to disulfiram by liver microsomal cytochrome P-450-containing monooxygenase system.
Topics: Animals; Carbon Tetrachloride Poisoning; Catalase; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Inhibition of human erythrocyte and leukocyte aldehyde dehydrogenase activities by diethylthiocarbamic acid methyl ester. An in vivo metabolite of disulfiram.
Topics: Aldehyde Dehydrogenase; Disulfiram; Ditiocarb; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Leukocytes; Structure-Activity Relationship; Thiocarbamates | 1989 |
Pharmacological effects of diethylthiocarbamic acid methyl ester, the active metabolite of disulfiram?
Topics: Animals; Blood Pressure; Body Temperature; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Ethanol; Hemodynamics; Injections, Intraperitoneal; Male; Mice; Rats; Rats, Inbred Strains; Thiocarbamates | 1989 |
Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity.
Topics: Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Disulfiram; Dithiothreitol; Ditiocarb; Horses; Kinetics; Liver; Serum Albumin; Time Factors | 1987 |
Determination of disulfiram and two of its metabolites in urine by reversed-phase liquid chromatography and spectrophotometric detection after post-column complexation.
Topics: Biotransformation; Chromatography, Liquid; Copper; Disulfiram; Ditiocarb; Humans; Indicators and Reagents; Spectrophotometry, Ultraviolet | 1988 |
Differential responses of mouse UDP-glucuronosyltransferases and beta-glucuronidase to disulfiram and related compounds.
Topics: Animals; Biphenyl Compounds; Diet; Disulfides; Disulfiram; Ditiocarb; Female; Glucuronates; Glucuronidase; Glucuronosyltransferase; Hymecromone; Lung; Mice; Microsomes; Microsomes, Liver; Nitrophenols; Thiones | 1988 |
Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon te
Topics: 1-Propanol; Animals; Bromisovalum; Carbon Tetrachloride; Cell Survival; Disulfiram; Ditiocarb; Female; Lipid Peroxides; Liver; Maleates; Peroxides; Propanols; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide; Vitamin E | 1988 |
Effects of carbon disulfide, diethyldithiocarbamate, and disulfiram on drug metabolism in the perfused rat liver.
Topics: Animals; Carbon Disulfide; Disulfiram; Ditiocarb; Enzyme Induction; Glucuronates; Liver; Male; Perfusion; Pharmaceutical Preparations; Rats; Rats, Inbred Strains; Sulfates | 1988 |
Effects of disulfiram, cyanamide and 1-aminocyclopropanol on the aldehyde dehydrogenase activity in human erythrocytes and leukocytes.
Topics: Aldehyde Dehydrogenase; Cyanamide; Cyanides; Cyclopropanes; Disulfiram; Ditiocarb; Erythrocytes; Glutamine; Humans; Leukocytes | 1988 |
Oxidation of diethyldithiocarbamate to disulfiram by liver microsomes in the presence of NADPH and subsequent loss of microsomal enzyme activity in vitro.
Topics: Animals; Cell Fractionation; Disulfiram; Ditiocarb; Glucose-6-Phosphatase; Glutathione; Male; Microsomes, Liver; Models, Biological; NADP; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Inbred Strains | 1988 |
Human mitochondrial aldehyde dehydrogenase inhibition by diethyldithiocarbamic acid methanethiol mixed disulfide: a derivative of disulfiram.
Topics: Aldehyde Dehydrogenase; Disulfiram; Ditiocarb; Humans; Isoenzymes; Kinetics; Mitochondria, Liver; Structure-Activity Relationship; Thiocarbamates | 1985 |
Stability of an injectable disulfiram formulation sterilized by gamma irradiation.
Topics: Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Drug Stability; Gamma Rays; Injections, Subcutaneous; Spectrophotometry, Ultraviolet; Sterilization; Suspensions | 1985 |
Increased lead levels in brain after long-term treatment with lead and dithiocarbamate or thiuram derivatives in rats.
Topics: Animals; Brain; Dimethyldithiocarbamate; Disulfiram; Ditiocarb; Lead; Male; Rats; Rats, Inbred Strains; Thiocarbamates; Thiram; Tissue Distribution | 1985 |
Bis-(diethyldithiocarbamato) copper complex: a new metabolite of disulfiram?
Topics: Copper; Disulfiram; Ditiocarb; Erythrocytes; Glutathione; Humans; Mass Spectrometry; Thiocarbamates | 1985 |
Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs.
Topics: Animals; Body Weight; Crystallization; Disulfides; Disulfiram; Ditiocarb; Female; Glutathione Transferase; Isoenzymes; Isothiocyanates; Liver; Mice; Mice, Inbred Strains; Organ Size; Thiocarbamates; Thiocyanates; Thiones | 1985 |
[Inhibiton of the mitotic activity of thymocytes in mice in vitro by diethyldithiocarbamate].
Topics: Animals; Disulfiram; Ditiocarb; Glutathione; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitosis; T-Lymphocytes; Thiocarbamates | 1985 |
Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines.
Topics: Acrolein; Aldehyde Dehydrogenase; Animals; Bone Marrow Cells; Cisplatin; Colony-Forming Units Assay; Cyanamide; Cyclophosphamide; Disulfiram; Ditiocarb; Drug Synergism; Granulocytes; Hematopoietic Stem Cells; Male; Melphalan; Mice; Mice, Inbred BALB C; Nitrogen Mustard Compounds; Organophosphorus Compounds; Phosphinic Acids; Phosphoramide Mustards | 1985 |
Influence of disulfiram, diethyldithiocarbamate and carbon disulfide on the metabolic formation of trifluoroacetic acid from halothane in the rat.
Topics: Anesthesia, Inhalation; Animals; Carbon Disulfide; Disulfiram; Ditiocarb; Fluoroacetates; Halothane; Kidney; Liver; Male; Rats; Rats, Inbred Strains; Thiocarbamates; Trifluoroacetic Acid | 1985 |
Inhibition of erythrocyte superoxide dismutase by diethyldithiocarbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production.
Topics: Copper; Disulfiram; Dithionitrobenzoic Acid; Ditiocarb; Erythrocytes; Glutathione; Humans; Hydrogen Peroxide; Lipid Peroxides; Methemoglobin; Oxidation-Reduction; Oxyhemoglobins; Superoxide Dismutase; Thiocarbamates | 1986 |
Effects of diethyldithiocarbamate, a metabolite of disulfiram, on the pharmacokinetics of alcohol and acetaldehyde in the rat.
Topics: Acetaldehyde; Animals; Chromatography, Gas; Disulfiram; Ditiocarb; Ethanol; Kinetics; Male; Rats; Rats, Inbred Strains; Thiocarbamates | 1985 |
Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate.
Topics: Animals; Blood Cell Count; Blood Urea Nitrogen; Bone Marrow; Cisplatin; Disulfiram; Ditiocarb; Dogs; Intestines; Kidney; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Rats; Rats, Inbred F344; Thiocarbamates | 1986 |
Use of diethyldithiocarbamate as a probe to detect stable intermediates during the decomposition of several mutagenic and nonmutagenic N-nitroso compounds.
Topics: Animals; Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Drug Interactions; Liver; Male; Mutagenicity Tests; Mutagens; Nitroso Compounds; Rats; Rats, Inbred Strains; Salmonella typhimurium; Thiocarbamates | 1986 |
Antagonism of dithiobiuret toxicity in rats.
Topics: 2,2'-Dipyridyl; Animals; Cysteamine; Disulfiram; Ditiocarb; Edetic Acid; Male; Neuromuscular Diseases; Penicillamine; Pyridines; Rats; Thiourea; Tissue Distribution | 1986 |
Diethyldithiocarbamate, but not disulfiram, inhibits alloxan-induced dye accumulation of isolated mouse islet beta-cells.
Topics: Alloxan; Animals; Cell Membrane Permeability; Disulfiram; Ditiocarb; Evans Blue; Ferrous Compounds; Free Radicals; Glutathione; In Vitro Techniques; Islets of Langerhans; Mice; Oxygen Consumption; Superoxide Dismutase; Thiocarbamates | 1986 |
Rapid and sensitive on-line precolumn purification and high-performance liquid chromatographic assay for disulfiram and its metabolites.
Topics: Alcoholism; Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Humans; Male; Protein Binding; Thiocarbamates | 1986 |
Inhibition of peptide amidation by disulfiram and diethyldithiocarbamate.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Copper; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Male; Melanocyte-Stimulating Hormones; Mice; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases Acting on CH-NH Group Donors; Pituitary Gland; Pituitary Neoplasms; Rats; Thiocarbamates | 1986 |
Serum albumin and the metabolism of disulfiram.
Topics: Disulfides; Disulfiram; Ditiocarb; Hydrogen-Ion Concentration; Kinetics; Serum Albumin; Spectrophotometry, Ultraviolet | 1986 |
[Increased efficacy of teturam combined with L-DOPA in experimental alcoholism in the rat].
Topics: Alcohol Deterrents; Alcoholism; Animals; Brain; Catecholamines; Disulfiram; Ditiocarb; Drug Synergism; Drug Therapy, Combination; Levodopa; Male; Rats; Rats, Inbred Strains | 1986 |
Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.
Topics: Aldehyde Dehydrogenase; Animals; Colony-Forming Units Assay; Cyanamide; Cyclophosphamide; Disulfiram; Ditiocarb; Drug Resistance; Enzyme Inhibitors; Hematopoietic Stem Cells; Humans; Leukemia L1210; Mice; NAD; Organophosphorus Compounds; Phosphinic Acids; Phosphoramide Mustards | 1987 |
The influence of sodium diethyldithiocarbamate on behavior and EEG in cats and rabbits.
Topics: Animals; Behavior, Animal; Brain; Catecholamines; Cats; Disulfiram; Ditiocarb; Dopamine beta-Hydroxylase; Drug Administration Routes; Electroencephalography; Female; Male; Rabbits | 1971 |
Elimination kinetics of disulfiram in alcoholics after single and repeated doses.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Breath Tests; Carbon Disulfide; Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Humans; Kinetics; Male; Middle Aged | 1984 |
Effect of thiuram sulphides on the uptake and distribution of nickel in pregnant and non-pregnant mice.
Topics: Administration, Oral; Animals; Autoradiography; Disulfiram; Ditiocarb; Female; Fetus; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Nickel; Pregnancy; Radioisotopes; Thiocarbamates; Thiram; Tissue Distribution | 1984 |
Placental transfer and fetal distribution of cadmium and mercury after treatment with dithiocarbamates.
Topics: Animals; Autoradiography; Cadmium; Disulfiram; Ditiocarb; Female; Fetus; Maternal-Fetal Exchange; Mercury; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; Thiocarbamates; Thiram; Tissue Distribution | 1984 |
[Use of disulfiram and aminopyrine for evaluating the effect of carbon disulfide].
Topics: Air Pollutants, Occupational; Aminopyrine; Carbon Disulfide; Disulfiram; Ditiocarb; Humans; Thiourea | 1984 |
Dithiocarbamate-induced redistribution and increased brain uptake of lead in rats.
Topics: Animals; Brain; Dimethyldithiocarbamate; Disulfiram; Ditiocarb; Kinetics; Lead; Male; Rats; Thiocarbamates; Thiram; Tissue Distribution | 1984 |
Mechanism for the potentiation of oxygen toxicity by disulfiram.
Topics: Animals; Cytosol; Disulfiram; Ditiocarb; Drug Synergism; Hyperbaric Oxygenation; In Vitro Techniques; Lung; Oxygen; Rats; Superoxide Dismutase; Time Factors | 1980 |
Determination of disulfiram and metabolites from biological fluids by high-performance liquid chromatography.
Topics: Alcoholism; Animals; Carbon Disulfide; Chromatography, High Pressure Liquid; Diethylamines; Disulfiram; Ditiocarb; Humans; Male; Mice; Thiocarbamates | 1980 |
Differential effects of disulfiram and diethyldithiocarbamate on small intestinal and liver microsomal benzo[a]pyrene metabolism.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; In Vitro Techniques; Intestine, Small; Male; Microsomes; Microsomes, Liver; Rats; Thiocarbamates | 1980 |
[Modifications of disulfiram and its metabolites in blood in alcoholic hepatopathy (author's transl)].
Topics: Adult; Aged; Carbon Disulfide; Disulfiram; Ditiocarb; Female; Humans; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Middle Aged | 1981 |
The effect of long term treatment with disulfiram on content of cytochrome P-450 and on benzo(a)pyrene monooxygenase activity in microsomes isolated from the rat small intestinal mucosa.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Intestinal Mucosa; Intestine, Small; Male; Microsomes; Rats; Rats, Inbred Strains | 1980 |
Effect of disulfiram and its reduced metabolite, diethyl-dithiocarbamate on aldehyde dehydrogenase of human erythrocytes.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Disulfiram; Ditiocarb; Erythrocytes; Horseradish Peroxidase; Humans; Thiocarbamates | 1982 |
Disulfiram treatment of three patients with nickel dermatitis.
Topics: Aged; Dermatitis, Contact; Disulfiram; Ditiocarb; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Nickel | 1982 |
[Diagnostic value of antabuse and CBJ-131 test in workers chronically exposed to carbon disulfide].
Topics: Carbon Disulfide; Disulfiram; Ditiocarb; Humans; Occupational Diseases; Rose Bengal; Time Factors | 1981 |
Effect of disulfiram (tetraethylthiuram disulfide) amd diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in mice.
Topics: Animals; Cyclophosphamide; Disulfiram; Ditiocarb; Drug Administration Schedule; Kinetics; Leukemia L1210; Male; Mice; Thiocarbamates; Urinary Bladder | 1982 |
[Urinary excretion of diethyldithiocarbamate (DDC) after antabuse administration to workers chronically exposed to carbon disulfide].
Topics: Adult; Air Pollutants; Air Pollutants, Occupational; Carbon Disulfide; Disulfiram; Ditiocarb; Humans; Male; Middle Aged; Thiocarbamates; Time Factors | 1982 |
Efficacy of orally-administered chelating agents for nickel carbonyl toxicity in rats.
Topics: Animals; Chelating Agents; Disulfiram; Ditiocarb; Female; Nickel; Organometallic Compounds; Penicillamine; Rats; Tissue Distribution | 1982 |
Elimination characteristics of disulfiram over time in five alcoholic volunteers: a preliminary study.
Topics: Adult; Alcoholism; Breath Tests; Carbon Disulfide; Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Humans; Male; Time Factors | 1982 |
Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate.
Topics: Ascorbic Acid; Disulfiram; Ditiocarb; DNA; Glucose; Humans; In Vitro Techniques; Leukocyte Count; Leukocytes; Oxidation-Reduction; Phorbols; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 1982 |
In vitro formation of methyldiethyldithiocarbamate after the reaction of nitrosoacetoxymethylmethylamine or methylnitrosourea with disulfiram.
Topics: Animals; Biotransformation; Chemical Phenomena; Chemistry; Cytosol; Dimethylnitrosamine; Disulfiram; Ditiocarb; Drug Interactions; Liver; Male; Methylnitrosourea; Microsomes, Liver; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Thiocarbamates | 1982 |
Antiarrhythmic effects of disulfiram on epinephrine-induced cardiac arrhythmias in rabbits exposed to trichloroethylene.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbon Disulfide; Disulfiram; Ditiocarb; Epinephrine; Male; Oils; Rabbits; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1982 |
[Comparison of the dithiocarbamate and dicupral methods for the determination of trace amounts of copper (II) in raw materials and cosmetic products].
Topics: Copper; Cosmetics; Disulfiram; Ditiocarb; Drug Contamination; Pharmaceutic Aids; Spectrophotometry; Thiocarbamates | 1983 |
Rapid degradation of disulfiram by serum albumin.
Topics: Disulfiram; Ditiocarb; Humans; In Vitro Techniques; Protein Binding; Serum Albumin | 1983 |
Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Benzoates; Benzoic Acid; Cell Survival; Disulfiram; Ditiocarb; DNA; Etoposide; Leukemia L1210; Mice; NADP; Podophyllotoxin; Thiocarbamates | 1984 |
Diethyldithiocarbamate depresses the acoustic startle response in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Carbon Disulfide; Central Nervous System; Disulfiram; Ditiocarb; Dopamine; Dose-Response Relationship, Drug; Male; Norepinephrine; Rats; Reflex, Startle; Thiocarbamates | 1984 |
Effect of thiocarbonyl compounds on alpha-naphthylisothiocyanate-induced hepatotoxicity and the urinary excretion of [35S]alpha-naphthylisothiocyanate in the rat.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Disulfiram; Ditiocarb; Ethionamide; Male; Rats; Rats, Inbred Strains; Sulfates; Thiocarbamates; Thiocyanates | 1984 |
Placental transfer and fetal distribution of lead in mice after treatment with dithiocarbamates.
Topics: Animals; Disulfiram; Ditiocarb; Female; Fetus; Lead; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; Thiocarbamates; Thiram; Tissue Distribution | 1984 |
In vitro effect of dithiocarbamate pesticides and of CaNa2EDTA on human serum dopamine-beta-hydroxylase.
Topics: Alcohol Deterrents; Biomarkers; Chelating Agents; Disulfiram; Ditiocarb; Dopamine beta-Hydroxylase; Edetic Acid; Female; Humans; Male; Pesticides | 1995 |
Peptide alpha-amidation: differential regulation by disulfiram and its metabolite, diethyldithiocarbamate.
Topics: Animals; Disulfiram; Ditiocarb; Heart Atria; Male; Mixed Function Oxygenases; Multienzyme Complexes; Organ Specificity; Pituitary Gland; Rats; Rats, Sprague-Dawley | 1995 |
Olfactory toxicity of diethyldithiocarbamate (DDTC) and disulfiram and the protective effect of DDTC against the olfactory toxicity of dichlobenil.
Topics: Analysis of Variance; Animals; Benzamides; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Herbicides; Hydroxylation; Liver; Male; Mice; Mice, Inbred C57BL; Neurotoxins; Nitriles; Nitrophenols; Olfactory Mucosa; Oxidoreductases, N-Demethylating; Rats; Species Specificity | 1995 |
Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.
Topics: Aldehyde Dehydrogenase; Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ethanol; Male; Rats; Rats, Sprague-Dawley; Sulfoxides | 1995 |
Effect of disulfiram administration on glutamate uptake by synaptosomes in the rat brain.
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Disulfiram; Ditiocarb; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 1994 |
Antioxidant action of sodium diethyldithiocarbamate: reaction with hydrogen peroxide and superoxide radical.
Topics: Disulfiram; Ditiocarb; Hydrogen Peroxide; Kinetics; Spectrum Analysis; Superoxides | 1994 |
Effect of tetraethylthiuramdisulphide and diethyl-dithiocarbamate on nickel toxicokinetics in mice.
Topics: Administration, Oral; Animals; Biological Transport, Active; Brain; Disulfiram; Ditiocarb; Injections, Intraperitoneal; Kidney; Liver; Lung; Male; Mice; Mice, Inbred CBA; Nickel; Tissue Distribution | 1994 |
Diethyldithiocarbamate methyl ester sulfoxide, an inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase and putative metabolite of disulfiram.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Blood Pressure; Disulfiram; Ditiocarb; Ethanol; In Vitro Techniques; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1994 |
Protection against alloxan-induced diabetes by diethyldithiocarbamate and disulfiram in mice.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disulfiram; Ditiocarb; Drug Interactions; Male; Mice; Mice, Inbred Strains; Pancreas; Superoxide Dismutase; Time Factors | 1994 |
In vivo pharmacodynamic studies of the disulfiram metabolite S-methyl N,N-diethylthiolcarbamate sulfoxide: inhibition of liver aldehyde dehydrogenase.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Cattle; Culture Techniques; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Liver; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1994 |
Deleterious effects of disulfiram on the respiratory electron transport system of liver mitochondria.
Topics: Cytochrome b Group; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Electron Transport; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; In Vitro Techniques; Malates; Mitochondria, Liver; Oxygen Consumption; Succinates; Succinic Acid | 1993 |
Protection by disulfiram and diethyldithiocarbamate against hypoxia-induced lethality in mice.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Copper; Disulfiram; Ditiocarb; Hypoxia; Injections, Intraperitoneal; Mice; Organometallic Compounds; Superoxide Dismutase; Survival Rate; Temperature | 1993 |
S-methyl N,N-diethylthiolcarbamate sulfone, an in vitro and in vivo inhibitor of rat liver mitochondrial low Km aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Disulfiram; Ditiocarb; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Thiocarbamates | 1994 |
Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate.
Topics: Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Sulfoxides; Thiocarbamates | 1993 |
Acute nickel carbonyl poisoning.
Topics: Acute Disease; Combined Modality Therapy; Disulfiram; Ditiocarb; Drug Therapy, Combination; Humans; Male; Middle Aged; Nickel; Occupational Exposure; Organometallic Compounds | 1993 |
Effect of some compounds related to disulfiram on mitochondrial aldehyde dehydrogenase in vitro and in vivo.
Topics: Aldehyde Dehydrogenase; Animals; Carbamates; Disulfides; Disulfiram; Ditiocarb; Female; In Vitro Techniques; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Sheep | 1993 |
Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes.
Topics: Allyl Compounds; Animals; Base Sequence; Cells, Cultured; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Gene Expression Regulation; Growth Hormone; Liver; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones | 1993 |
Anxiogenic effect of disulfiram evaluated in an animal model.
Topics: Acetaldehyde; Animals; Appetitive Behavior; Arousal; Conditioning, Operant; Discrimination Learning; Disease Models, Animal; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Ethanol; Fear; Injections, Intraperitoneal; Male; Pargyline; Pentylenetetrazole; Rats | 1993 |
Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Humans; Male; Microsomes, Liver; Rabbits; Rats; Thiocarbamates | 1995 |
Disulfiram and diethyldithiocarbamate intoxication affects the storage and release of striatal dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Alcohol Deterrents; alpha-Methyltyrosine; Animals; Antidotes; Binding, Competitive; Cattle; Cell Membrane Permeability; Corpus Striatum; Cytoplasm; Disulfiram; Ditiocarb; Dopamine; Enzyme Inhibitors; Injections, Intraperitoneal; Male; Methyltyrosines; Organelles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Reserpine; Synaptic Vesicles; Tyramine | 1996 |
In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.
Topics: Animals; Disulfiram; Dithiothreitol; Ditiocarb; Glutathione; Glutathione Transferase; Humans; Isoenzymes; Rats; Spectrophotometry, Ultraviolet; Time Factors | 1996 |
S-methyl-N,N-diethylthiocarbamate sulfoxide and S-methyl-N,N-diethylthiocarbamate sulfone, two candidates for the active metabolite of disulfiram.
Topics: Alcohol Deterrents; Aldehyde Dehydrogenase; Animals; Biotransformation; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Liver; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1996 |
Inhibition of aldehyde dehydrogenase by disulfiram and its metabolite methyl diethylthiocarbamoyl-sulfoxide.
Topics: Aldehyde Dehydrogenase; Disulfiram; Dithiothreitol; Ditiocarb; Enzyme Inhibitors; Sulfoxides | 1997 |
Comparative effects of disulfiram and diethyldithiocarbamate against testicular toxicity in rats caused by acute exposure to cadmium.
Topics: Animals; Cadmium; Chelating Agents; Disulfiram; Ditiocarb; Lipid Peroxidation; Male; Organ Size; Rats; Rats, Wistar; Testis; Thiobarbituric Acid Reactive Substances; Tissue Distribution | 1997 |
Carbamoylation of brain glutamate receptors by a disulfiram metabolite.
Topics: Animals; Anticonvulsants; Brain; Disulfiram; Ditiocarb; Excitatory Amino Acid Antagonists; Hyperbaric Oxygenation; Male; Mice; Neuroprotective Agents; Receptors, Glutamate; Synaptic Membranes | 1997 |
Effect of a disulfiram metabolite on retinaldehyde metabolism.
Topics: Aldehyde Dehydrogenase; Disulfiram; Ditiocarb; Enzyme Inhibitors; Humans; Male; Retinaldehyde | 1997 |
Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram.
Topics: Aldehyde Dehydrogenase; Animals; Catalysis; Cytosol; Disulfiram; Ditiocarb; Humans; Isoenzymes; Mitochondria, Liver; Rats; Recombinant Proteins; Sulfones | 1997 |
Inhibition of human mitochondrial aldehyde dehydrogenase by the disulfiram metabolite S-methyl-N,N-diethylthiocarbamoyl sulfoxide: structural characterization of the enzyme adduct by HPLC-tandem mass spectrometry.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Disulfiram; Ditiocarb; Enzyme Inhibitors; Humans; Mass Spectrometry; Mitochondria; Molecular Sequence Data; Sulfoxides | 1997 |
Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram.
Topics: Alcohol Deterrents; Aldehyde Dehydrogenase; Disulfiram; Ditiocarb; Enzyme Inhibitors; Humans; Kinetics; Mitochondria; Recombinant Proteins | 1998 |
Differential mechanisms in the effects of disulfiram and diethyldithiocarbamate intoxication on striatal release and vesicular transport of glutamate.
Topics: Alcohol Deterrents; Animals; Antidotes; Biological Transport; Disulfiram; Ditiocarb; Glutamic Acid; Male; Methylamines; Rats; Rats, Sprague-Dawley; Visual Cortex | 1998 |
Diethyl dithiocarbamate-induced decomposition of S-nitrosothiols.
Topics: Disulfides; Disulfiram; Ditiocarb; Glutathione; Kinetics; Nitroso Compounds; S-Nitrosoglutathione; Superoxides | 1997 |
Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins.
Topics: Alcohol Deterrents; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Disulfiram; Ditiocarb; G1 Phase; Humans; Microtubule-Associated Proteins; NF-kappa B; Oxidation-Reduction; Proline; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Thiocarbamates; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 1998 |
Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation.
Topics: Alcohol Deterrents; Aldehyde Dehydrogenase; Biotransformation; Culture Techniques; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Enzyme Inhibitors; Humans; Microsomes, Liver; Oxidation-Reduction | 1998 |
Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus.
Topics: Aerobiosis; Anaerobiosis; Animals; Antiprotozoal Agents; Antitrichomonal Agents; Disulfiram; Ditiocarb; Drug Resistance; Metronidazole; Trichomonas vaginalis; Tritrichomonas foetus | 1998 |
Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats.
Topics: Administration, Intranasal; Animals; Cataract; Disulfiram; Ditiocarb; Drug Carriers; Female; Liposomes; Male; Oxidants; Rats; Rats, Wistar; Selenium; Sodium Selenite; Tissue Distribution | 1999 |
Amelioration of type II collagen induced arthritis in rats by treatment with sodium diethyldithiocarbamate.
Topics: Animals; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Disulfiram; Ditiocarb; Drug Administration Routes; Female; Infusion Pumps, Implantable; NF-kappa B; Prodrugs; Rats; Severity of Illness Index; Tarsus, Animal; Time Factors | 1999 |
Roles of FMO and CYP450 in the metabolism in human liver microsomes of S-methyl-N,N-diethyldithiocarbamate, a disulfiram metabolite.
Topics: Adult; Aged; Alcohol Deterrents; Cytochrome P-450 Enzyme System; Disulfiram; Ditiocarb; Humans; Microsomes, Liver; Middle Aged; NADPH-Ferrihemoprotein Reductase; Oxygenases | 1999 |
Preparation and in vivo ocular absorption studies of disulfiram solid dispersion.
Topics: Absorption; Animals; Cataract; Dimerization; Disulfiram; Ditiocarb; Drug Carriers; Drug Compounding; Drug Delivery Systems; Enzyme Inhibitors; Eye; Male; Povidone; Rabbits | 2000 |
Overview--in vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Animals; Catalytic Domain; Chromatography, High Pressure Liquid; Cysteine; Disulfiram; Ditiocarb; Enzyme Inhibitors; Humans; In Vitro Techniques; Mass Spectrometry; Mitochondria, Liver; Molecular Sequence Data; Protein Structure, Quaternary; Rats; Recombinant Proteins | 2001 |
In vivo inhibition of aldehyde dehydrogenase by disulfiram.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Disulfiram; Ditiocarb; Enzyme Inhibitors; Mitochondria, Liver; Pepsin A; Rats; Spectrometry, Mass, Electrospray Ionization | 2001 |
Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethacrynic Acid; In Vitro Techniques; Lipid Peroxidation; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2001 |
Reduction of toxic metabolite formation of acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Benzoquinones; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Enzyme Inhibitors; Fomepizole; Humans; Imines; Microsomes, Liver; Pyrazoles | 2002 |
Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat.
Topics: Animals; Carbon Disulfide; Cell Survival; Cells, Cultured; Cerebral Cortex; Chlorides; Cytoskeleton; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fungicides, Industrial; Glucose; Muscle, Skeletal; Neurons; Rats; Thiourea; Zinc Compounds; Zineb | 2002 |
Studies on the effect of tetraethylthiuramdisulphide (disulphiram) and of diethyldithiocarbamate (DDC) on the oxygen uptake of rat brain cortex slices; with some methodological remarks.
Topics: Animals; Cerebral Cortex; Disulfiram; Ditiocarb; Oxygen; Rats; Thiocarbamates | 1955 |
[Content of carbon disulfide in the air expired by normal persons and by persons under the influence of ethyl alcohol during treatment by Antabuse (disulfiram) and sodium diethyldithiocarbamate].
Topics: Alcoholism; Carbon; Carbon Disulfide; Chelating Agents; Disulfiram; Ditiocarb; Ethanol; Exhalation; Humans; Sulfides | 1961 |
Effects of diethyldithiocarbamate and disulfiram on glucose metabolism and glutathione content of human erythrocytes.
Topics: Carbamates; Disulfiram; Ditiocarb; Erythrocytes; Esters; Glucose; Glutathione; Humans | 1963 |
Inhibition of hexokinase by disulfiram and diethyldithiocarbamate.
Topics: Carbamates; Disulfiram; Ditiocarb; Esters; Hexokinase; Humans | 1963 |
INTERACTIONS OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE WITH SERUM PROTEINS STUDIED BY MEANS OF GEL-FILTRATION TECHNIQUE.
Topics: Blood Proteins; Carbamates; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Gel; Dextrans; Disulfiram; Ditiocarb; Edetic Acid; Esters; Research; Sulfhydryl Compounds | 1965 |
METABOLISM OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE IN RATS WITH DEMONSTRATION OF AN IN VIVO ETHANOL-INDUCED INHIBITION OF THE GLUCURONIC ACID CONJUGATION OF THE THIOL.
Topics: Blood; Carbamates; Carbon Disulfide; Chemical Phenomena; Chemistry; Chromatography; Dextrans; Disulfiram; Ditiocarb; Esters; Ethanol; Glucuronates; Glucuronic Acid; Metabolism; NAD; Pharmacology; Rats; Research; Sulfhydryl Compounds; Sulfides; Sulfur Isotopes | 1965 |
DDTC, a metabolite of disulfiram, reduces the stimulating effect on ethanol's locomotor activity in mice.
Topics: Alcohol Deterrents; Animals; Central Nervous System Depressants; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Motor Activity | 2003 |
A method for the determination of tetraethylthiuram disulphide (Antabus, Abstinyl) and diethyldithiocarbamate in blood and urine; some studies on the metabolism of tetraethylthiuram disulphide.
Topics: Disulfiram; Ditiocarb; Humans | 1951 |
N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve.
Topics: Alcohol Deterrents; Animals; Chelating Agents; Chromatography, High Pressure Liquid; Copper; Diet; Disulfiram; Ditiocarb; Gas Chromatography-Mass Spectrometry; Histocytochemistry; Isoprostanes; Lipid Peroxidation; Liver; Liver Function Tests; Male; Muscle, Skeletal; Myelin Sheath; Neuromuscular Junction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Silver Staining; Spectrophotometry, Atomic; Tissue Distribution; Weight Gain | 2004 |
Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Cataract; Cornea; Disulfiram; Ditiocarb; Excipients; Hypromellose Derivatives; Image Processing, Computer-Assisted; Indicators and Reagents; Methylcellulose; Ophthalmic Solutions; Rabbits; Rats; Rats, Inbred Strains; Solubility | 2007 |
In vitro cell culture model for anti-cataract drug penetration studies.
Topics: Aldehyde Dehydrogenase; Animals; Cataract; Cell Line; Cell Membrane Permeability; Collagen Type IV; Coloring Agents; Cornea; Disulfiram; Ditiocarb; Electric Conductivity; Epithelial Cells; Epithelium, Corneal; Humans; In Vitro Techniques; Lens, Crystalline; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Trypan Blue | 2007 |
Potantial utility of disulfiram against leishmaniasis.
Topics: Adjuvants, Immunologic; Animals; ATP Binding Cassette Transporter, Subfamily B; Chelating Agents; Disulfiram; Ditiocarb; Drug Resistance; Glutathione; Humans; Leishmania donovani; Leishmania major; Leishmania tropica; Leishmaniasis; Nitric Oxide; Oxidative Stress | 2008 |
Contribution of aldehyde dehydrogenase 3A1 to disulfiram penetration through monolayers consisting of cultured human corneal epithelial cells.
Topics: Aldehyde Dehydrogenase; Antibodies, Blocking; Cells, Cultured; Cornea; Disulfiram; Ditiocarb; Epithelial Cells; Humans; Reverse Transcriptase Polymerase Chain Reaction; RNA; Skin Absorption | 2008 |
Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms.
Topics: Allergens; Animals; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Dermatitis, Allergic Contact; Disulfiram; Ditiocarb; Female; Haptens; Mice; Mice, Inbred BALB C; Oxidation-Reduction | 2008 |
Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Disulfiram; Ditiocarb; Humans; Kinetics; Mutation; Tandem Mass Spectrometry | 2010 |
The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial grow
Topics: Anti-Bacterial Agents; Betaine-Aldehyde Dehydrogenase; Cells, Cultured; Disulfiram; Ditiocarb; Enzyme Activation; Humans; Models, Molecular; Protein Conformation; Pseudomonas aeruginosa; Pseudomonas Infections; Sulfoxides | 2011 |
Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.
Topics: Blotting, Western; Cell Line; Disulfiram; Ditiocarb; Forkhead Box Protein O1; Forkhead Transcription Factors; Gluconeogenesis; Glucose-6-Phosphatase; Humans; Insulin; Monoterpenes; Phosphoenolpyruvate Carboxykinase (ATP); Receptor, IGF Type 1; Signal Transduction; Tropolone; Zinc | 2010 |
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
Topics: Animals; Antitubercular Agents; Disulfiram; Ditiocarb; Enzyme Inhibitors; Extensively Drug-Resistant Tuberculosis; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2012 |
The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis.
Topics: Animals; Annexin A5; Antioxidants; Apoptosis; Catalase; Cell Line; Cell Proliferation; Cell Survival; Colorimetry; Coloring Agents; Cricetinae; Disulfiram; Ditiocarb; DNA Fragmentation; Fibroblasts; Glutathione; Glutathione Peroxidase; Glutathione Reductase; In Situ Nick-End Labeling; Lipid Peroxidation; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Trypan Blue | 2012 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |
A binuclear complex constituted by diethyldithiocarbamate and copper(I) functions as a proteasome activity inhibitor in pancreatic cancer cultures and xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Copper; Disease Models, Animal; Disulfiram; Ditiocarb; Female; Humans; In Situ Nick-End Labeling; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Xenograft Model Antitumor Assays | 2013 |
Facial allergic contact dermatitis without hand involvement caused by disposable latex gloves.
Topics: Benzothiazoles; Biochemistry; Dermatitis, Allergic Contact; Dermatitis, Occupational; Disulfiram; Ditiocarb; Facial Dermatoses; Female; Gloves, Surgical; Humans; Middle Aged; Patch Tests; Zinc Compounds | 2016 |
Recombinant human diamine oxidase activity is not inhibited by ethanol, acetaldehyde, disulfiram, diethyldithiocarbamate or cyanamide.
Topics: Acetaldehyde; Amine Oxidase (Copper-Containing); Animals; Cells, Cultured; Cricetulus; Cyanamide; Disulfiram; Ditiocarb; Enzyme Inhibitors; Ethanol; Humans; Recombinant Proteins | 2016 |
Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line.
Topics: A549 Cells; Antineoplastic Agents; Copper; Disulfiram; Ditiocarb; Humans; Neoplastic Stem Cells; Reactive Oxygen Species; Structure-Activity Relationship; Sulfhydryl Compounds | 2018 |
Antibacterial activity of disulfiram and its metabolites.
Topics: Anti-Bacterial Agents; Disulfiram; Ditiocarb; Gram-Negative Bacteria; Gram-Positive Bacteria | 2019 |
Evaluation of the accumulation of disulfiram and its copper complex in A549 cells using mass spectrometry.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Copper; Disulfiram; Ditiocarb; Humans; Lung Neoplasms; Mass Spectrometry; Organometallic Compounds | 2020 |
Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as a Drug Self-Delivery System for Highly Robust and Specific Cancer Therapy.
Topics: Animals; Cell Line; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Drug Delivery Systems; Female; HEK293 Cells; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Pharmaceutical Preparations; Polymers | 2020 |
COP9 signalosome is an essential and druggable parasite target that regulates protein degradation.
Topics: Animals; COP9 Signalosome Complex; Disulfiram; Ditiocarb; Entamoeba histolytica; Mice; Proteolysis; Protozoan Proteins | 2020 |
Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II).
Topics: Acetaldehyde Dehydrogenase Inhibitors; Animals; Cell Survival; Chelating Agents; Copper; Cystathionine beta-Synthase; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; HCT116 Cells; Humans; Liver; Mice; Mice, Inbred BALB C; Organometallic Compounds | 2020 |
Copper(II)-disulfiram loaded melanin-dots for cancer theranostics.
Topics: Animals; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Female; Hyperthermia, Induced; Melanins; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; NIH 3T3 Cells; Photoacoustic Techniques; Phototherapy; Theranostic Nanomedicine | 2021 |
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.
Topics: Adenosine Triphosphate; Binding Sites; Cloning, Molecular; Coenzymes; Cryoelectron Microscopy; Disulfiram; Ditiocarb; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Models, Molecular; Nuclear Proteins; Organometallic Compounds; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Unfolding; Recombinant Proteins; Substrate Specificity; Ubiquitin; Valosin Containing Protein; Zinc Fingers | 2021 |
Co-delivery of nanoparticle and molecular drug by hollow mesoporous organosilica for tumor-activated and photothermal-augmented chemotherapy of breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Drug Therapy; Female; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Nanoparticles; Particle Size; Phototherapy; Photothermal Therapy; Tumor Microenvironment | 2021 |
Copper (α)/
Topics: Cell Line, Tumor; Cisplatin; Copper; Disulfiram; Ditiocarb; Humans; Nanogels | 2022 |
Disulfiram oxy-derivatives induce entosis or paraptosis-like death in breast cancer MCF-7 cells depending on the duration of treatment.
Topics: Antineoplastic Agents; Breast Neoplasms; Disulfiram; Ditiocarb; Duration of Therapy; Entosis; Female; Humans; MCF-7 Cells | 2022 |
Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite.
Topics: Alcoholism; Animals; Cysts; Disulfiram; Ditiocarb; Entamoeba histolytica; Parasites | 2022 |
Photothermally Triggered Copper Payload Release for Cuproptosis-Promoted Cancer Synergistic Therapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Humans; Neoplasms | 2023 |
DDTC-Cu(I) based metal-organic framework (MOF) for targeted melanoma therapy by inducing SLC7A11/GPX4-mediated ferroptosis.
Topics: Alcoholism; Amino Acid Transport System y+; Animals; Cell Line, Tumor; Copper; Disulfiram; Ditiocarb; Ferroptosis; Humans; Melanoma; Metal-Organic Frameworks; Substance Withdrawal Syndrome | 2023 |