disulfiram has been researched along with acetylcysteine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 13 (46.43) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Rotstein, JB; Slaga, TJ | 1 |
| Breimer, DD; Hoogeterp, JJ; van Bladeren, PJ; van der Gen, A | 1 |
| Slaga, TJ; Warren, BS | 1 |
| Bertram, B; Lee, BH; Park, J; Ryu, JC; Wiessler, M | 1 |
| Prestera, T; Talalay, P; Wade, KL; Zhang, Y | 1 |
| Baillie, TA; Hu, P; Jin, L | 1 |
| Botteron, C; Dobbelaere, DA; Fernandez, PC; Heussler, VT; Machado, J; Palmer, GH | 1 |
| Hirszel, P; Pollack, M; Rollwagen, FM; Wu, ZQ; Zhao, A; Zhou, X | 1 |
| Jackson, W; Kumar, KS; Seed, TM; Singh, VK | 1 |
| Barkan, D; Deharo, E; Ginsburg, H; Golenser, J; Krugliak, M | 1 |
| Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V | 1 |
| Jungová, P; Kanicky, V; Navrátilová, J; Preisler, J; Smarda, J; Vanhara, P | 1 |
| Chen, YT; Hung, DZ; Liao, JW | 1 |
| Czeczot, H; Grosicka-Maciąg, E; Grzela, T; Kurpios-Piec, D; Rahden-Staroń, I; Skrzycki, M; Szumiło, M | 1 |
| Adamo, L; Amato, G; Anastasi, G; Buccheri, S; Cavalli, M; Chiarenza, A; Conticello, C; De Maria, R; Di Raimondo, F; Giuffrida, R; Giustolisi, R; Gulisano, M; Lombardo, L; Martinetti, D; Parrinello, N | 1 |
| Caflisch, C; Herdener, M; Oppliger, R; Stohler, R | 1 |
| Caspers, MJ; Faiman, MD; Heemskerk, AA; Kaul, S; Lunte, CE; McCance-Katz, EF; Prisinzano, TE; Williams, TD; Winefield, RD | 1 |
| Calderon-Aparicio, A; Rieber, M; Strasberg-Rieber, M | 1 |
| Ali, SA; Batra, SK; Chakraborty, S; Das, B; Dash, P; Jain, S; Mohanty, AK; Panda, SK; Senapati, S; Suklabaidya, S; Swaminathan, S | 1 |
| Chueh, SH; Hu, MK; Huang, KF; Hung, YC; Lin, KC; Liu, PS; Lo, LC; Ma, KH | 1 |
| Brock, P; Cabral, S; Freyer, DR; Knight, K; Reaman, G; Robinson, PD; Sung, L | 1 |
4 review(s) available for disulfiram and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Mechanisms of inhibition of tumor progression.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Benzoates; Benzoic Acid; Butylated Hydroxyanisole; Carcinogens; Carcinoma; Cell Division; Disulfiram; Glutathione; Glutathione Disulfide; Mice; Papilloma; Skin Neoplasms; Vitamin E | 1993 |
[Treating cocaine addiction].
Topics: Acetylcysteine; Alcohol Deterrents; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Cross-Sectional Studies; Diagnosis, Dual (Psychiatry); Disulfiram; Free Radical Scavengers; Humans; Mental Disorders; Methylphenidate; Modafinil; Muscle Relaxants, Central; Psychotherapy; Switzerland | 2012 |
Interventions for cisplatin-induced hearing loss in children and adolescents with cancer.
Topics: Acetylcysteine; Adolescent; Amifostine; Anti-Inflammatory Agents; Antineoplastic Agents; Chelating Agents; Child; Cisplatin; Cytoprotection; Dexamethasone; Disulfiram; Ditiocarb; Humans; Neoplasms; Ototoxicity; Thiosulfates | 2019 |
24 other study(ies) available for disulfiram and acetylcysteine
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Effect of exogenous glutathione on tumor progression in the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Animals; Antioxidants; Carcinoma; Disulfiram; Free Radicals; Glutathione; Mice; Oxidation-Reduction; Papilloma; Precancerous Conditions; Skin Neoplasms | 1988 |
The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat.
Topics: Acetylcysteine; Animals; Disulfiram; Ethylene Dibromide; Hydrocarbons, Brominated; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1981 |
Fate and distribution of [14C]S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine, an antimutagenic mixed disulfide from disulfiram, in rats.
Topics: Acetylcysteine; Animals; Antimutagenic Agents; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Disulfiram; Intestinal Absorption; Male; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1995 |
Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol.
Topics: Acetylcysteine; Carbon Disulfide; Chromatography, High Pressure Liquid; Disulfiram; Environmental Monitoring; Hydrogen-Ion Concentration; Isothiocyanates; Metals; Sensitivity and Specificity; Sulfhydryl Compounds; Thiocarbamates; Thiones; Thiourea; Thiram | 1996 |
Studies on the metabolic activation of disulfiram in rat. Evidence for electrophilic S-oxygenated metabolites as inhibitors of aldehyde dehydrogenase and precursors of urinary N-acetylcysteine conjugates.
Topics: Acetylcysteine; Alcohol Deterrents; Aldehyde Dehydrogenase; Animals; Biotransformation; Chromatography, Liquid; Disulfiram; Male; Mass Spectrometry; Oxygen; Rats; Rats, Sprague-Dawley | 1997 |
The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine.
Topics: Acetylcysteine; Activating Transcription Factor 2; Apoptosis; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line, Transformed; Cyclic AMP Response Element-Binding Protein; Disulfiram; DNA; DNA Primers; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyrrolidines; T-Lymphocytes; Thiocarbamates; Transcription Factors; Transcription, Genetic | 1999 |
Disulfiram inhibits TNF-alpha-induced cell death.
Topics: Acetylcysteine; Alcohol Deterrents; Amino Acid Chloromethyl Ketones; Animals; Caspase 3; Caspase Inhibitors; Cell Death; Cell Division; Cell Line; Cysteine Proteinase Inhibitors; Disulfiram; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Galactosamine; In Situ Nick-End Labeling; Liver; Male; Membrane Potentials; Mice; Mice, Inbred C3H; Mitochondria; Reactive Oxygen Species; Recombinant Proteins; Swine; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols.
Topics: Acetylcysteine; Amifostine; Animals; Cell Line; Cysteine; Disulfiram; Dithiothreitol; Lipopolysaccharides; Macrophages; Mercaptoethylamines; Mice; Nitric Oxide; Radiation-Protective Agents; Sulfhydryl Compounds | 2003 |
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Drug Synergism; Glutathione; Indomethacin; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum | 2003 |
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors | 2007 |
Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells.
Topics: Acetylcysteine; Cell Count; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Copper; Culture Media, Conditioned; Disulfiram; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Intracellular Space; Ions; Leukemia, Myeloid | 2009 |
Protective effects of fomepizole on 2-chloroethanol toxicity.
Topics: Acetaldehyde; Acetylcysteine; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Antidotes; Antioxidants; Disulfiram; Drug Synergism; Enzyme Inhibitors; Ethylene Chlorohydrin; Fomepizole; Glutathione; Kidney; Lethal Dose 50; Liver; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Solvents | 2010 |
Protective effect of N-acetyl-L-cysteine against disulfiram-induced oxidative stress and apoptosis in V79 cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Line; Cricetinae; Cricetulus; Disulfiram; Dose-Response Relationship, Drug; Fibroblasts; Lipid Peroxidation; Oxidative Stress | 2010 |
Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Copper; Disulfiram; Enzyme Inhibitors; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Membrane Potentials; Mitochondrial Membranes; Multiple Myeloma; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species | 2012 |
N-acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration.
Topics: Acetylcysteine; Animals; Disulfiram; Female; Humans; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Prodrugs; Rats; Rats, Sprague-Dawley; Thiocarbamates | 2015 |
Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.
Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chelating Agents; Copper; Disulfiram; Free Radical Scavengers; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Melanoma; Molybdenum; Mutation, Missense; Proto-Oncogene Proteins B-raf; Reactive Oxygen Species; Receptor, ErbB-2; Superoxide Dismutase | 2015 |
Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disulfiram; Fibrosis; Guinea Pigs; Humans; Pancreas; Pancreatic Neoplasms; Pancreatic Stellate Cells; Pyridones; Rats; Xenograft Model Antitumor Assays | 2016 |
A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel.
Topics: Acetylcysteine; Apoptosis; Arachidonate 12-Lipoxygenase; Caspase 3; Cell Proliferation; Copper; Cytoprotection; Dermis; Disulfiram; Enzyme Activation; Fibroblasts; Gene Silencing; Humans; Ion Channel Gating; Ionophores; Mitochondria; NF-E2-Related Factor 2; Protective Agents; Quinolines; Reactive Oxygen Species; TRPV Cation Channels; Ultraviolet Rays | 2018 |