disopyramide and pilsicainide

disopyramide has been researched along with pilsicainide in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19904 (15.38)18.7374
1990's10 (38.46)18.2507
2000's8 (30.77)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Sen, S; Sinha, N1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Arita, M; Kiyosue, T; Sato, T; Wu, B1
Handa, S; Ogawa, S; Okada, Y; Sadanaga, T1
Ikeda, N; Kamiya, K1
Akaike, N; Inomata, N; Ishihara, T1
Aisaka, K; Hattori, Y; Hidaka, T; Ishihara, T; Satoh, F1
Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K1
Hatta, M; Hattori, Y; Hirose, N; Hirotsu, I; Ishihara, T; Kihara, T; Satoh, F1
Aisaka, K; Hamasaki, S; Hidaka, T; Inomata, N; Ishihara, T; Morita, M1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T; Yamahara, Y1
Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y1
Akaike, N; Inomata, N; Ishihara, T; Ohno, T1
Fujiki, A; Inoue, H; Tani, M; Yoshida, S1
Baba, S; Funakoshi, M; Ishide, N; Iwabuchi, K; Katoh, H; Keitoku, M; Miura, M; Satoh, S; Shinozaki, T; Shirato, K; Suzuki, S; Takeuchi, M; Watanabe, J1
Izumi, T; Kitano, Y; Moriguchi, M; Niwano, S1
Hayashi, Y; Hidaka, T; Inomata, N; Inoue, T; Komoriya, K1
Aye, NN; Hashimoto, K; Miyamoto, S; Teramatsu, T; Zhu, B1
Abe, H; Hiraki, T; Ikeda, H; Imaizumi, T; Kumagai, K; Nakashima, H; Nakashima, Y; Oginosawa, Y; Saku, K1
Imai, H; Matoba, Y; Nakagawa, M; Shiraishi, H; Shirayama, T; Yoshida, S1
Ando, A; Hirai, M; Inden, Y; Isobe, S; Murohara, T; Nonokawa, M; Okada, M; Suzuki, A; Takada, Y; Tomita, Y1
Fujimura, A; Sakamoto, K; Shiga, T; Tsuruoka, S; Wakaumi, M1
Aizawa, Y; Chinushi, M; Hirono, T; Komura, S; Sugiura, H1
Imai, T; Kajimoto, K; Kasanuki, H; Minami, Y1

Reviews

1 review(s) available for disopyramide and pilsicainide

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Trials

4 trial(s) available for disopyramide and pilsicainide

ArticleYear
Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6

    Topics: Anti-Arrhythmia Agents; Aprindine; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Sodium Channels

1995
Electrophysiologic mechanisms of adverse effects of class I antiarrhythmic drugs (cibenzoline, pilsicainide, disopyramide, procainamide) in induction of atrioventricular re-entrant tachycardia.
    Cardiovascular drugs and therapy, 1996, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electrophysiology; Female; Heart Conduction System; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Procainamide; Tachycardia, Atrioventricular Nodal Reentry; Wolff-Parkinson-White Syndrome

1996
Single oral administration of pilsicainide versus infusion of disopyramide for termination of paroxysmal atrial fibrillation: a multicenter trial.
    Pacing and clinical electrophysiology : PACE, 2000, Volume: 23, Issue:11 Pt 2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Circadian Rhythm; Disopyramide; Female; Heart Rate; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome

2000
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
    Annals of nuclear medicine, 2004, Volume: 18, Issue:3

    Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Radionuclide Imaging; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left

2004

Other Studies

21 other study(ies) available for disopyramide and pilsicainide

ArticleYear
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
    Cardiovascular research, 1992, Volume: 26, Issue:11

    Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines

1992
[Clinical significance of the use-dependent sodium channel block and reverse use-dependent potassium channel block of class I and class III antiarrhythmic agents and their values to predict drug efficacy].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Electrophysiology; Exercise Test; Humans; Lidocaine; Mexiletine; Middle Aged; Potassium Channels; Sodium Channels

1992
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
    Japanese circulation journal, 1992, Volume: 56 Suppl 5

    Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function

1992
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Parasympatholytics; Potassium Channels; Quinidine; Receptors, Cholinergic

1991
Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles.
    Journal of cardiovascular pharmacology, 1988, Volume: 11, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Complexes, Premature; Disopyramide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Male; Mexiletine; Papillary Muscles; Piperidines; Sodium

1988
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Disopyramide; Dogs; Electroencephalography; Female; Hypothermia; Lidocaine; Male; Mexiletine; Mice; Motor Activity; Muscle Relaxation; Pain; Rabbits; Rats; Rats, Inbred Strains; Seizures; Tremor; Vomiting

1988
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Capillary Permeability; Chemical Phenomena; Chemistry; Digestive System; Disopyramide; Endocrine Glands; Female; Gastric Mucosa; Gastrointestinal Motility; Guinea Pigs; Ileum; Lidocaine; Male; Mexiletine; Mice; Peripheral Nerves; Pregnancy; Pupil; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder; Urogenital System; Uterus; Vas Deferens

1988
N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165): a new potent and long-acting antiarrhythmic agent.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:8

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Membrane; Coronary Circulation; Coronary Vessels; Disopyramide; Dogs; Epinephrine; Female; Guinea Pigs; Halothane; In Vitro Techniques; Lidocaine; Male; Myocardial Contraction; Ouabain; Papillary Muscles

1985
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
    American heart journal, 1993, Volume: 126, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels

1993
Effects of pilsicainide on the atrial fibrillation threshold in guinea pig atria. A comparative study with disopyramide, lidocaine and flecainide.
    Japanese heart journal, 1993, Volume: 34, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male

1993
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Conductivity; Flecainide; Guinea Pigs; Lidocaine; Male; Myocardium; Potassium; Potassium Channels; Propafenone

1993
The rise time of the monophasic action potential--a new index of local use-dependent conductivity by sodium channel blockers in human myocardium.
    Japanese circulation journal, 1997, Volume: 61, Issue:12

    Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Disopyramide; Female; Heart; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Sodium Channel Blockers; Sodium Channels

1997
Transient appearance of antegrade conduction via an AV accessory pathway caused by atrial fibrillation in a patient with intermittent Wolff-Parkinson-White syndrome.
    Heart (British Cardiac Society), 2000, Volume: 83, Issue:5

    Topics: Administration, Oral; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Procainamide; Wolff-Parkinson-White Syndrome

2000
[Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 115, Issue:5

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Hemodynamics; Infusions, Intravenous; Lidocaine; Ligation

2000
QT-prolonging class I drug, disopyramide, does not aggravate but suppresses adrenaline-induced arrhythmias. Comparison with cibenzoline and pilsicainide.
    European journal of pharmacology, 2000, Jul-21, Volume: 400, Issue:2-3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disopyramide; Dogs; Drug Interactions; Electrocardiography; Epinephrine; Female; Heart Rate; Imidazoles; Lidocaine; Male

2000
Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2002, Volume: 4, Issue:4

    Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Disopyramide; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Treatment Outcome

2002
Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:1

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Disopyramide; Female; Humans; Lidocaine; Milk, Human; Propafenone

2005
Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation.
    Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:11

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cholinergic Antagonists; Disopyramide; Dogs; Electrocardiography; Heart Atria; Heart Conduction System; Heart Rate; Lidocaine; Treatment Outcome

2005
Comparison of acute reduction in left ventricular outflow tract pressure gradient in obstructive hypertrophic cardiomyopathy by disopyramide versus pilsicainide versus cibenzoline.
    The American journal of cardiology, 2010, Nov-01, Volume: 106, Issue:9

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Echocardiography, Doppler; Female; Humans; Imidazoles; Lidocaine; Linear Models; Male; Middle Aged; Propranolol; Prospective Studies; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Pressure; Verapamil

2010