disopyramide has been researched along with mexiletine in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 80 (57.97) | 18.7374 |
| 1990's | 43 (31.16) | 18.2507 |
| 2000's | 11 (7.97) | 29.6817 |
| 2010's | 4 (2.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harakawa, H; Ishii, A; Kubo, K; Kumazawa, T; Nito, M; Obase, H; Oiji, Y; Tomioka, S; Yamada, Y | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Sen, S; Sinha, N | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Theisen, K | 1 |
| Carson, IW; Lyons, SM; Shanks, RG | 1 |
| Troup, PJ; Zipes, DP | 1 |
| Koch-Weser, J | 1 |
| Goldman, AP; Myburgh, DP | 1 |
| Curry, PV; Holt, DW; Tynan, M; Walsh, AC | 1 |
| Anderson, JL; Harrison, DC; Meffin, PJ; Winkle, RA | 1 |
| Kidner, PH | 1 |
| Fujino, T; Hara, M; Ishida, S; Ito, M; Maeda, T; Nakagawa, M; Saikawa, T; Shimoyama, N; Takahashi, N; Yonemochi, H | 1 |
| Arita, M; Kiyosue, T; Sato, T; Wu, B | 1 |
| Furukawa, T; Hiraoka, M; Marumo, F; Nitta, J; Sawanobori, T; Sunami, A | 1 |
| Handa, S; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Ikeda, N; Kamiya, K | 1 |
| Delbressine, L; Harris, N; Kane, KA; Muir, AW; Winslow, E | 1 |
| Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y | 1 |
| Kwieciński, H; Ostrzycki, A; Ryniewicz, B | 1 |
| Fomina, IG; Iankin, VV | 1 |
| Hashimoto, K; He, ZS; Komori, S; Tamura, K | 2 |
| Aihara, N; Kamakura, S; Kurita, T; Matsuhisa, M; Ohe, T; Shimizu, W; Shimomura, K; Takaki, H | 1 |
| Korkushko, OV; Shatilo, VB | 1 |
| Abdalla, A; Mazur, NA; Nazarenko, VA | 1 |
| Hiraoka, M; Motomiya, T; Sakurada, H | 1 |
| Fujimoto, Y; Fukuki, M; Hirokane, Y; Kotake, H; Mashiba, H | 1 |
| Goto, Y; Takahashi, K; Tanabe, T; Yoshioka, K | 1 |
| Gullberg, B; Hansen, O; Johansson, BW | 1 |
| Campbell, JK; Marshall, RJ; Winslow, E | 1 |
| Hashimoto, H; Nakashima, M; Satoh, N | 1 |
| Fukami, M; Hashimoto, T; Itoh, Y; Koike, H; Kumakura, S; Miyake, S; Mizuno, H; Shiga, H; Shimoji, Y; Yorikane, R | 1 |
| Kawamura, T; Kodama, I; Toyama, J | 1 |
| Tanabe, T | 1 |
| Suzuki, M | 2 |
| Hayashi, H; Kawamura, T; Kodama, I; Saito, H; Toyama, J; Yamada, K | 1 |
| Fukuzaki, H; Takarada, A; Yokota, Y | 1 |
| Akaike, N; Yatani, A | 1 |
| Roden, DM | 1 |
| Podrid, PJ | 2 |
| Honerjäger, P; Loibl, E; Schönsteiner, G; Steidl, I; Ulm, K | 1 |
| Aisaka, K; Hattori, Y; Hidaka, T; Ishihara, T; Satoh, F | 1 |
| Abdalla, A; Iavorskaia, NV; Mazur, NA; Sumarokov, AB | 1 |
| Kawakubo, K; Murakawa, Y; Nozaki, A; Sugimoto, T; Toda, I | 1 |
| Mamaev, VI; Orlov, VN; Shpektor, AV; Susliak, NN | 1 |
| Elharrar, V; Nakaya, Y; Surawicz, B; Varro, A | 1 |
| James, MA; Jones, JV; Papouchado, P | 1 |
| Furuya, H; Goto, Y; Ide, M; Tagawa, R; Tanabe, T; Yoshikawa, H | 1 |
| Eckersberger, F; Losert, U; Moritz, A; Probst, P; Schreiner, W; Wolner, E | 1 |
| Borodkin, VV; Dudaev, VA; Liusov, VA; Rudakov, AV | 1 |
| Somberg, J | 1 |
| Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Roy, D | 1 |
| Fisher, JD; Kim, SG; Mercando, AD; Tam, S | 1 |
| Belhassen, B; Laniado, S; Pines, A | 1 |
| Andersson, KE; Wettrell, G | 1 |
| Morganroth, J; Nestico, PF | 2 |
| Huang, SK; Marcus, FI | 1 |
| Bonazzi, O; Facchini, M; Priori, SG; Schwartz, PJ; Varisco, T | 1 |
| Elharrar, V; Nakaya, Y; Surawicz, B | 1 |
| Cody, DV; Denniss, AR; Richards, DA; Ross, DL; Russell, PA; Uther, JB; Young, AA | 1 |
| Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K | 1 |
| Hatta, M; Hattori, Y; Hirose, N; Hirotsu, I; Ishihara, T; Kihara, T; Satoh, F | 1 |
| Garan, H; McElroy, M; McGovern, B; Newell, JB; Ruskin, JN; Schoenfeld, MH; Whitford, EG | 1 |
| Furuya, H; Goto, Y; Tanabe, T; Yoshikawa, H | 1 |
| Elharrar, V | 1 |
| Fukuoka, Y; Ito, S; Nakagawa, M; Nakamura, S; Niwa, H; Saikawa, T; Takaki, R; Takakura, T; Tamura, M; Yonemochi, H | 1 |
| Sakai, K; Takagi, M; Yamazaki, T | 1 |
| Komatsu, Y; Kusumoto, M; Miyazawa, Y; Suwa, J; Tanaka, T; Umemura, J | 1 |
| Boissel, JP; Ferry, S; Galleyrand, J; Piolat, C; Rousson, D | 1 |
| Bardy, GH; Fahrenbruch, CE; Graham, EL; Greene, HL; Poole, JE; Pulaski, WP; Werner, JA | 1 |
| Boissel, JP; Galleyrand, J; Rousson, D; Silie, M | 1 |
| Hirosawa, K; Kasanuki, H; Onishi, S | 1 |
| Collignon, P; Legrand, V | 1 |
| Opie, LH | 1 |
| Lawrie, TD | 1 |
| Schmitz, W | 1 |
| Hillis, WS; Whiting, B | 1 |
| Somberg, JC | 1 |
| Lüderitz, B; Manz, M; Steinbeck, G | 2 |
| Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D | 1 |
| Jahrmärker, H; Theisen, K | 1 |
| Mohiuddin, SM; Ross, WB | 1 |
| Lüderitz, B | 1 |
| Rosen, MR; Wit, AL | 1 |
| Block, PJ; Winkle, RA | 1 |
| Angermann, C; Jahrmärker, H | 1 |
| Ronfeld, RA | 1 |
| Jewitt, DE | 1 |
| Cho, YW; Kuemmerle, HP; Singh, BN | 1 |
| Flouvat, B | 1 |
| Mouselimis, N; Wester, HA | 1 |
| Hirosawa, K; Kasanuki, H; Ohnishi, S | 1 |
| Hata, Y; Ichimaru, Y; Kodama, Y; Okamoto, K; Otsuka, K; Ueno, T; Yanaga, T | 1 |
| Hashimoto, K; Imai, S; Satoh, H; Shibuya, T | 1 |
| Lüderitz, B; Manz, M; Nitsch, J; Steinbeck, G | 1 |
| Funke, H; Grube, E; Neumann, G | 1 |
| Chiariello, M; Condorelli, M; Ferro, G; Tari, MG; Ungaro, B; Vigorito, C | 1 |
| Carlier, J | 1 |
| Van Durme, JP | 1 |
| Condorelli, M; De Luca, N; Rengo, F; Ricciardelli, B; Sacca', L; Trimarco, B; Volpe, M | 1 |
| Abendroth, RR; Breithardt, G; Loogen, F; Seipel, L | 1 |
| Böcker, K; Köhler, E; Loogen, F; Seipel, L | 1 |
| Bonaduce, D; Condorelli, M; D'Ascia, C; De Luca, N; Rengo, F; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Bigger, JT; Giardina, EG; Leahey, EB; Reiffel, JA | 1 |
| Härtel, GU | 1 |
| Ijiri, H; Ishihara, T; Komori, S; Li, BH; Matsumura, K; Mochizuki, S; Naitoh, A; Sano, S; Umetani, K; Watanabe, A | 1 |
| Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T; Yamahara, Y | 1 |
| Awaji, T; Hashimoto, K | 1 |
| Ajiki, K; Inoue, H; Kuo, TT; Murakawa, Y; Nakajima, T; Oikawa, N; Sezaki, K; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| Kane, KA; Komori, S; Parratt, JR; Sawanobori, T; Tamura, K | 1 |
| Fiksinski, E; Martin, D; Venditti, F | 1 |
| Akaishi, M; Handa, S; Iwanaga, S; Ogawa, S; Okada, Y; Sadanaga, T; Tsutsumi, N; Yoshikawa, T | 1 |
| Campbell, TJ; Wyse, KR; Ye, V | 1 |
| Arita, M; Hara, M; Inoue, T; Ito, M; Maeda, T; Nakagawa, M; Saikawa, T; Shimoyama, N; Takaki, R; Yonemochi, H | 1 |
| Aizawa, Y; Mitamura, H; Miyazaki, T; Miyoshi, S; Ogawa, S; Soejima, K | 1 |
| Aizawa, Y; Chinushi, M; Naitoh, N; Shibata, A | 1 |
| Kanazawa, T; Kinukawa, M; Maruyama, K; Miyagi, M; Miyata, H; Murakami, M; Ujiie, A | 1 |
| Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ | 1 |
| Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F | 1 |
| Aizawa, Y; Tanabe, Y; Yamaura, M | 1 |
| Aihara, N; Antzelevitch, C; Kamakura, S; Kurita, T; Shimizu, W; Sunagawa, K; Suyama, K; Taguchi, A; Takaki, H | 1 |
| Hashimoto, K; Homma, N; Tsujimoto, G | 1 |
| Hashimoto, K; Ishida, Y; Kugiyama, K; Satoh, Y; Sugiyama, A; Yoshida, H | 1 |
| Ando, A; Hirai, M; Inden, Y; Isobe, S; Murohara, T; Nonokawa, M; Okada, M; Suzuki, A; Takada, Y; Tomita, Y | 1 |
22 review(s) available for disopyramide and mexiletine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Anti-arrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Anesthetics; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Dogs; Humans; Intraoperative Complications; Lidocaine; Mexiletine; Phenytoin; Procainamide; Succinylcholine | 1979 |
New antiarrhythmic agents: amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Electrophysiology; Humans; Mexiletine; Morpholines; Phenothiazines; Verapamil | 1978 |
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Disopyramide; Drug Evaluation; Humans; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Time Factors; Ventricular Fibrillation | 1978 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Clinical pharmacology of old and new antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide | 1985 |
Antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1986 |
Cardiovascular drugs. I: Antidysrhythmic drugs.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Disopyramide; Drug Interactions; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Tocainide; Verapamil | 1986 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
Antiarrhythmic agents for chronic ventricular arrhythmias.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide | 1987 |
Comparison of newer antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Disopyramide; Humans; Mexiletine; Tocainide; Verapamil | 1980 |
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide | 1980 |
Antiarrhythmic drug therapy for sustained ventricular tachycardia.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide | 1984 |
[Medical treatment of extrasystole and tachycardia (author's transl)].
Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Digoxin; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1980 |
Electropharmacology of antiarrhythmic drugs.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil | 1983 |
Hemodynamic effects of antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide | 1983 |
Comparative pharmacokinetics of new antiarrhythmic drugs.
Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Humans; Kinetics; Mexiletine; Piperidines; Tocainide; Verapamil | 1980 |
Hemodynamic effects of newer antiarrhythmic drugs.
Topics: Acebutolol; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Atenolol; Benzeneacetamides; Disopyramide; Dogs; Hemodynamics; Humans; Mexiletine; Piperidines; Tocainide; Verapamil | 1980 |
[Disopyramide, mexiletine, aprindine].
Topics: Anti-Arrhythmia Agents; Aprindine; Disopyramide; Humans; Methods; Mexiletine | 1995 |
Reentrant ventricular tachycardia. Interpretations of electrophysiologic findings and its applications.
Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiomyopathies; Disopyramide; Electrocardiography; Electrophysiology; Heart Conduction System; Humans; Imidazoles; Mexiletine; Procainamide; Tachycardia, Ventricular | 1998 |
23 trial(s) available for disopyramide and mexiletine
| Article | Year |
|---|---|
Prevention of sudden coronary death by chronic antiarrhythmic therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Disopyramide; Drug Evaluation; Humans; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Time Factors; Ventricular Fibrillation | 1978 |
The anti-arrhythmic efficacy of perhexiline maleate, disopyramide and mexiletine in ventricular ectopic activity.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Disopyramide; Heart Ventricles; Humans; Maleates; Mexiletine; Middle Aged | 1978 |
Mexiletine and disopyramide suppress ventricular premature contractions (VPC) irrespective of the relationship between the VPC and the underlying heart rate.
Topics: Cardiac Complexes, Premature; Disopyramide; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Mexiletine; Middle Aged; Signal Processing, Computer-Assisted | 1992 |
Treatment of myotonia with antiarrhythmic drugs.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Disopyramide; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Myotonia; Myotonia Congenita; Myotonic Dystrophy; Neurologic Examination; Phenytoin; Prospective Studies; Single-Blind Method; Tocainide | 1992 |
[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes].
Topics: Adult; Aged; Aged, 80 and over; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Pre-Excitation Syndromes; Procainamide; Propranolol; Quinidine; Time Factors; Verapamil | 1992 |
[Comparison of the anti-arrhythmic effectiveness of ethacizine, ethmozine, cordarone, mexitil and ritmilen in elderly patients with ventricular extrasystole].
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disopyramide; Heart Ventricles; Humans; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Placebos | 1990 |
[Comparative effectiveness of class I anti-arrhythmia drugs and the algorithms of their selection in patients with ventricular arrhythmia].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disopyramide; Heart Conduction System; Heart Ventricles; Humans; Mexiletine; Middle Aged; Quinidine | 1991 |
Evaluation of disopyramide and mexiletine used alone and in combination for ventricular arrhythmias in patients with and without overt heart disease.
Topics: Administration, Oral; Adult; Aged; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Disopyramide; Drug Combinations; Drug Evaluation; Electrocardiography, Ambulatory; Female; Heart Diseases; Humans; Hypertension; Male; Mexiletine; Middle Aged; Myocardial Infarction; Pulmonary Heart Disease | 1991 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
[Comparative study of the effectiveness of allapinin in patients with frequent and stable extrasystole].
Topics: Aconitine; Aconitum; Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Placebos; Propranolol; Quinidine | 1988 |
[Comparative effectiveness of Na+ channel blockers in ventricular disorders of cardiac rhythm].
Topics: Adult; Aged; Calcium Channel Blockers; Cardiac Complexes, Premature; Clinical Trials as Topic; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Prajmaline; Tachycardia, Paroxysmal | 1989 |
Combined anti-arrhythmic therapy with class 1 and class 3 drugs.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Randomized Controlled Trials as Topic; Single-Blind Method | 1989 |
Randomized controlled trial of prophylactic antiarrhythmic therapy in patients with inducible ventricular tachyarrhythmias after recent myocardial infarction.
Topics: Actuarial Analysis; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Electric Stimulation; Electrocardiography; Heart Ventricles; Humans; Mexiletine; Myocardial Infarction; Prognosis; Quinidine; Random Allocation | 1988 |
Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide.
Topics: Adult; Depression, Chemical; Disopyramide; Dose-Response Relationship, Drug; Heart Rate; Humans; Male; Mexiletine; Myocardial Contraction; Propylamines; Time Factors | 1986 |
[Long-term drug therapy in ventricular cardiac arrhythmias. Is an improvement of the prognosis possible?].
Topics: Adult; Aged; Amiodarone; Aprindine; Arrhythmias, Cardiac; Disopyramide; Humans; Long-Term Care; Mexiletine; Middle Aged; Tachycardia | 1983 |
[Comparative studies on the cardiodepressant effect of disopyramide, mexiletine and propafenon].
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Echocardiography; Female; Heart Rate; Hemodynamics; Humans; Male; Mexiletine; Myocardial Contraction; Propafenone; Propiophenones; Propylamines | 1983 |
[The effect of anti-arrhythmic drugs on myocardial function (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Disopyramide; Echocardiography; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Placebos; Propafenone; Propiophenones; Tocainide | 1982 |
Evaluation of the antiarrhythmic efficacy of mexiletine in patients with chronic ventricular arrhythmias.
Topics: Arrhythmias, Cardiac; Atenolol; Chronic Disease; Clinical Trials as Topic; Disopyramide; Double-Blind Method; Electrocardiography; Exercise Test; Heart Ventricles; Humans; Mexiletine; Propylamines | 1980 |
Disopyramide and mexiletine: which is the agent of choice in the long term-oral treatment of lidocaine-responsive arrhythmias? Efficacy comparison in a randomized trial.
Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Propylamines; Pyridines; Random Allocation | 1980 |
Serial electrophysiological testing of antiarrhythmic drug efficacy in patients with recurrent ventricular tachycardia.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Clinical Trials as Topic; Coronary Disease; Disopyramide; Electrocardiography; Electrophysiology; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Stroke Volume; Tachycardia; Ventricular Fibrillation | 1980 |
Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium.
Topics: Anti-Arrhythmia Agents; Aprindine; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Heart Atria; Heart Conduction System; Humans; Kinetics; Lidocaine; Male; Mexiletine; Middle Aged; Sodium Channels | 1995 |
Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Disopyramide; Electrocardiography; Flecainide; Heart Rate; Humans; Infusions, Intravenous; Male; Mexiletine; Middle Aged; Sodium; Sodium Channel Blockers; Sodium Channels; Syndrome; Ventricular Dysfunction; Ventricular Fibrillation | 2000 |
Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.
Topics: Aged; Anti-Asthmatic Agents; Chronic Disease; Disopyramide; Exercise; Exercise Test; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Radionuclide Imaging; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left | 2004 |
95 other study(ies) available for disopyramide and mexiletine
| Article | Year |
|---|---|
Synthesis and antiarrhythmic activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzoxepins; Chemical Phenomena; Chemistry; Chloroform; Dogs; Female; Heart Ventricles; Male; Mice; Molecular Structure; Ouabain; Pyridines; Receptors, Muscarinic; Structure-Activity Relationship | 1990 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
[Drug therapy of tachyarrhythmias (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil | 1978 |
Paediatric use of mexiletine and disopyramide.
Topics: Disopyramide; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Male; Mexiletine; Propylamines; Pyridines; Tachycardia | 1979 |
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses.
Topics: Acebutolol; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digitalis Glycosides; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1978 |
Prevention of ventricular arrhythmias after myocardial infarction.
Topics: Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Propranolol; Quinidine; Ventricular Fibrillation | 1977 |
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines | 1992 |
Combined class I antiarrhythmic agents have differential effects on tonic and use dependent block of maximum rate of depolarisation of action potentials in guinea pig cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Drug Combinations; Guinea Pigs; Lidocaine; Mexiletine; Myocardium; Quinidine; Sodium Channels | 1992 |
[Clinical significance of the use-dependent sodium channel block and reverse use-dependent potassium channel block of class I and class III antiarrhythmic agents and their values to predict drug efficacy].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Electrophysiology; Exercise Test; Humans; Lidocaine; Mexiletine; Middle Aged; Potassium Channels; Sodium Channels | 1992 |
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration].
Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function | 1992 |
Antiarrhythmic, electrophysiological and haemodynamic effects of prolonged oral dosing with Org 7797 in the anaesthetized rat.
Topics: Action Potentials; Administration, Oral; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Electrocardiography; Electrophysiology; Estrenes; Heart; Hemodynamics; Male; Mexiletine; Pentobarbital; Propafenone; Rats; Rats, Wistar | 1992 |
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels | 1992 |
Inhibitory effect of moricizine on reperfusion induced tachyarrhythmias in rats--a comparison study with disopyramide and mexiletine.
Topics: Animals; Disopyramide; Heart; Hemodynamics; Male; Mexiletine; Moricizine; Myocardial Infarction; Rats; Rats, Inbred Strains; Reperfusion Injury; Tachycardia | 1992 |
The effect of pretreatment with moricizine on early arrhythmia resulting from myocardial ischemia in rats.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Hemodynamics; Male; Mexiletine; Moricizine; Rats; Rats, Inbred Strains | 1992 |
Effects of a combination of disopyramide and mexiletine on the anterograde accessory pathway conduction in patients with Wolff-Parkinson-White syndrome.
Topics: Adult; Atrial Fibrillation; Cardiac Pacing, Artificial; Disopyramide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Heart Conduction System; Humans; Infusions, Intravenous; Male; Mexiletine; Middle Aged; Wolff-Parkinson-White Syndrome | 1992 |
Efficacy of disopyramide and mexiletine used alone or in combination in the treatment of ventricular premature beats.
Topics: Adult; Aged; Cardiac Complexes, Premature; Disopyramide; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Male; Mexiletine; Middle Aged | 1991 |
Clinical study on coupling interval of ventricular premature contraction in patients with organic heart disease.
Topics: Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography, Ambulatory; Female; Heart Diseases; Humans; Hypertension; Male; Mexiletine; Middle Aged; Myocardial Contraction | 1991 |
Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics.
Topics: Adult; Analysis of Variance; Blood Pressure; Disopyramide; Electrocardiography; Epinephrine; Flecainide; Heart Rate; Humans; Magnesium; Male; Mexiletine; Myocardial Infarction; Potassium | 1991 |
Comparison of the electrophysiological effects of Org 7797, disopyramide, mexiletine and propafenone in anaesthetized dogs with myocardial infarcts.
Topics: Anesthetics; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electrocardiography; Estrenes; Female; Male; Mexiletine; Myocardial Infarction; Propafenone; Ventricular Function | 1991 |
Coupling interval-related effects of class I antiarrhythmic drugs, mexiletine, cibenzoline and disopyramide, on ventricular activation in canine myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electric Stimulation; Electrocardiography; Heart Rate; Imidazoles; Injections, Intravenous; Mexiletine; Myocardial Infarction; Ventricular Function, Right | 1991 |
Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Conduction System; Hemodynamics; Isoquinolines; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Myocardial Contraction; Ouabain | 1991 |
Effects of combined use of class I antiarrhythmic agents on Vmax of guinea-pig ventricular muscles.
Topics: Action Potentials; Animals; Disopyramide; Drug Interactions; Electric Stimulation; Female; Flecainide; Guinea Pigs; Male; Mexiletine; Papillary Muscles | 1991 |
Combination antiarrhythmic treatment among class Ia, Ib, and II agents for ventricular arrhythmias.
Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Disopyramide; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propranolol | 1991 |
[Therapeutic drug monitoring of disopyramide, mexiletine, aprindine and beta blockers].
Topics: Adrenergic beta-Antagonists; Aprindine; Arrhythmias, Cardiac; Biological Availability; Chromatography, Gas; Chromatography, High Pressure Liquid; Disopyramide; Fluorescent Antibody Technique; Humans; Indenes; Mexiletine; Spectrometry, Fluorescence | 1990 |
Combined application of class I antiarrhythmic drugs causes "additive", "reductive", or "synergistic" sodium channel block in cardiac muscles.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Male; Mexiletine; Myocardium; Sodium Channels | 1990 |
Analysis of ventricular arrhythmias in patients with dilated cardiomyopathy--relationship between the effects of antiarrhythmic agents and severity of myocardial lesions.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Disopyramide; Electrocardiography, Ambulatory; Female; Fibrosis; Follow-Up Studies; Hemodynamics; Humans; Male; Mexiletine; Middle Aged; Myocardium; Procainamide | 1990 |
Blockage of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide.
Topics: Action Potentials; Animals; Cell Separation; Disopyramide; Heart; Heart Ventricles; Homeostasis; Ion Channels; Mexiletine; Myocardium; Propylamines; Rats; Sodium | 1985 |
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents.
Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action Preparations; Disopyramide; Heart Arrest; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Resuscitation; Tocainide | 1985 |
Negative inotropic effects of tetrodotoxin and seven class 1 antiarrhythmic drugs in relation to sodium channel blockade.
Topics: Action Potentials; Androstanols; Animals; Anti-Arrhythmia Agents; Aprindine; Calcium; Depression, Chemical; Disopyramide; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ion Channels; Isoquinolines; Kinetics; Male; Membrane Potentials; Mexiletine; Microelectrodes; Myocardial Contraction; Myocardium; Potassium; Quinidine; Sodium; Sodium-Potassium-Exchanging ATPase; Sparteine; Tetrodotoxin | 1986 |
Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles.
Topics: Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Complexes, Premature; Disopyramide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Lidocaine; Male; Mexiletine; Papillary Muscles; Piperidines; Sodium | 1988 |
Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Disopyramide; Dogs; Heart; Lidocaine; Mexiletine; Procainamide; Ventricular Fibrillation | 1989 |
Effect of altered repolarization course induced by antiarrhythmic drugs and constant current pulses on duration of premature action potentials in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electric Stimulation; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Mexiletine; Purkinje Fibers | 1989 |
Evaluation of antiarrhythmic drug efficacy using holter electrocardiographic technique.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Coronary Disease; Diltiazem; Disopyramide; Drug Evaluation; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Propranolol | 1985 |
Hemodynamic effects of mexiletine and disopyramide after cardioplegic arrest.
Topics: Animals; Depression, Chemical; Disopyramide; Dogs; Heart Arrest, Induced; Hemodynamics; Mexiletine; Myocardial Contraction; Premedication | 1989 |
[Changes in thrombocyte-vascular hemostasis and cyclic nucleotide levels after anti-arrhythmia therapy in patients with ischemic heart disease].
Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Nucleotides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Propafenone | 1989 |
Combination of disopyramide and mexiletine for better tolerance and additive effects for treatment of ventricular arrhythmias.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Tachycardia | 1989 |
Failure of corticosteroid therapy to prevent induction of ventricular tachycardia in sarcoidosis.
Topics: Adult; Amiodarone; Cardiac Pacing, Artificial; Cardiomyopathies; Disopyramide; Drug Therapy, Combination; Electrophysiology; Fluocortolone; Humans; Male; Mexiletine; Quinidine; Sarcoidosis; Tachycardia | 1989 |
Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing.
Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Disopyramide; Drug Administration Schedule; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Propafenone; Propylamines; Pyridines | 1987 |
Effect of mexiletine, amiodarone and disopyramide on the excitability and refractoriness of canine cardiac fibers: possible relation to antiarrhythmic drug action and classification.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Female; Heart; In Vitro Techniques; Male; Mexiletine; Neurons; Papillary Muscles; Purkinje Fibers; Refractory Period, Electrophysiological | 1987 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Disopyramide; Dogs; Electroencephalography; Female; Hypothermia; Lidocaine; Male; Mexiletine; Mice; Motor Activity; Muscle Relaxation; Pain; Rabbits; Rats; Rats, Inbred Strains; Seizures; Tremor; Vomiting | 1988 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs.
Topics: Animals; Anti-Arrhythmia Agents; Autonomic Nervous System; Capillary Permeability; Chemical Phenomena; Chemistry; Digestive System; Disopyramide; Endocrine Glands; Female; Gastric Mucosa; Gastrointestinal Motility; Guinea Pigs; Ileum; Lidocaine; Male; Mexiletine; Mice; Peripheral Nerves; Pregnancy; Pupil; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder; Urogenital System; Uterus; Vas Deferens | 1988 |
Long-term efficacy of mexiletine alone and in combination with class Ia antiarrhythmic drugs for refractory ventricular arrhythmias.
Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Mexiletine; Middle Aged; Procainamide; Quinidine; Tachycardia; Time Factors | 1988 |
Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Chronic Disease; Disopyramide; Drug Therapy, Combination; Female; Heart Ventricles; Humans; Imidazoles; Male; Mexiletine; Middle Aged | 1988 |
Recovery from use-dependent block of Vmax and restitution of action potential duration in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Disopyramide; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Mexiletine; Microelectrodes; Purkinje Fibers; Sodium; Tetrodotoxin | 1988 |
A case of arrhythmogenic right ventricular dysplasia with prominent late potential.
Topics: Cardiac Pacing, Artificial; Disopyramide; Drug Therapy, Combination; Electrocardiography; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Tachycardia | 1988 |
Antiarrhythmic effects of a novel diamine derivative, AN-132, on several animal models of cardiac arrhythmias.
Topics: Aconitine; Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chloroform; Disopyramide; Dogs; Epinephrine; Ethylenediamines; Female; Guinea Pigs; Halothane; Male; Mexiletine; Ouabain; Propafenone; Rats; Rats, Inbred Strains | 1987 |
[Mexiletine in the treatment of ventricular arrhythmias].
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Disopyramide; Drug Evaluation; Electrocardiography; Exercise Test; Female; Humans; Male; Mexiletine; Middle Aged; Propylamines | 1986 |
Intolerance and ineffectiveness of mexiletine in patients with serious ventricular arrhythmias.
Topics: Cardiac Pacing, Artificial; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Female; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Nausea; Procainamide; Propylamines; Quinidine; Recurrence; Tachycardia; Tremor; Ventricular Fibrillation | 1986 |
Uncorrected pre-ejection period: a simple non-invasive measurement for pharmacodynamic screening of inotropic activity.
Topics: Adult; Cardiotonic Agents; Depression, Chemical; Disopyramide; Drug Evaluation; Heart Rate; Humans; Male; Mexiletine; Myocardial Contraction; Stroke Volume; Systole; Time Factors | 1987 |
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil | 1985 |
Aggravation of ventricular arrhythmia. A drug-induced complication.
Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine | 1985 |
Haemodynamic effects of class I antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1985 |
Drugs and the heart. IV. Antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Heart Conduction System; Hemodynamics; Humans; Lidocaine; Mexiletine; Procainamide; Quinidine; Verapamil | 1980 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
[Sudden heart death in ventricular heart rhythm disorders: possibilities and limits of long-term therapy].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden; Disopyramide; Germany, West; Humans; Mexiletine; Risk; Time Factors; Ventricular Fibrillation | 1984 |
Antiarrhythmic therapy: new additions and future expectations.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Bretylium Tosylate; Disopyramide; Encainide; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil | 1983 |
[Drug therapy of arrhythmia in coronary cardiopathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Tachycardia; Tocainide | 1983 |
Clinical pharmacology of antiarrhythmic drugs: a review and overview, part II.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Propranolol; Tocainide | 1981 |
[Determination of plasma concentrations of anti-arrhythmia agents].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biological Availability; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine | 1981 |
Availability of electrophysiological approach to the selection and assessment of antiarrhythmic drugs for recurrent ventricular tachycardia.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Recurrence; Tachycardia; Verapamil | 1983 |
The usefulness of Holter monitoring in the evaluation of antiarrhythmic drug efficacy for tachycardia.
Topics: Adult; Aged; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Diltiazem; Disopyramide; Female; Heart Defects, Congenital; Heart Valve Diseases; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Myocardial Infarction; Procainamide; Tachycardia; Tachycardia, Paroxysmal | 1983 |
Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Dogs; Female; Lidocaine; Male; Mexiletine; Phenytoin; Verapamil | 1983 |
Treatment of recurrent sustained ventricular tachycardia with mexiletine and disopyramide. Control by programmed ventricular stimulation.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Propylamines; Pyridines; Recurrence; Retrospective Studies; Tachycardia | 1983 |
[The value of antitachycardia pacemaker therapy in patients with Wolff-Parkinson-White syndrome].
Topics: Anti-Arrhythmia Agents; Bundle of His; Digitalis Glycosides; Disopyramide; Electrocardiography; Humans; Mexiletine; Pacemaker, Artificial; Propafenone; Propiophenones; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome | 1983 |
Intropic effects of several antiarrhythmic drugs.
Topics: Ajmaline; Anti-Arrhythmia Agents; Aprindine; Blood Pressure; Bunaftine; Coronary Disease; Disopyramide; Heart Rate; Hemodynamics; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Phenytoin; Procainamide | 1983 |
Hemodynamic, electrocardiographic and toxic effects of the intravenous administration of increasing doses of mexiletine in the dog. Comparison with similar effects produced by other antiarrhythmics.
Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Dogs; Electrocardiography; Hemodynamics; Injections, Intravenous; Mexiletine; Myocardial Contraction; Phenytoin; Procainamide; Propylamines | 1980 |
[The effect of disopyramide, mexiletine and propafenon after intravenous and oral administration on left ventricular function in the M-mode echocardiogram].
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Therapy, Combination; Echocardiography; Female; Heart; Heart Ventricles; Humans; Injections, Intravenous; Male; Mexiletine; Propafenone; Propiophenones | 1982 |
[Efficacy of disopyramide and mexiletine per os in the chronic treatment of ventricular arrhythmias sensitive to lidocaine].
Topics: Arrhythmias, Cardiac; Disopyramide; Humans; Lidocaine; Mexiletine; Middle Aged; Propylamines; Pyridines | 1981 |
The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin. A prospective study.
Topics: Aged; Anorexia; Anti-Arrhythmia Agents; Digoxin; Disopyramide; Drug Interactions; Female; Humans; Male; Mexiletine; Middle Aged; Nausea; Procainamide; Prospective Studies; Quinidine; Vomiting | 1980 |
[The new antiarrhythmia drugs disopyramide and mexiletine].
Topics: Arrhythmias, Cardiac; Disopyramide; Humans; Mexiletine; Propylamines; Pyridines | 1980 |
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Heart Rate; Male; Mexiletine; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation | 1995 |
Antiarrhythmic effects of combined application of class I antiarrhythmic drugs; addition of low-dose mexiletine-enhanced antiarrhythmic effects of disopyramide and aprindine in various-rate canine ventricular tachycardias.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Blood Pressure; Coronary Vessels; Disopyramide; Dogs; Drug Interactions; Drug Synergism; Electrophysiology; Female; Heart Rate; Infusions, Intravenous; Male; Mexiletine; Ouabain; Tachycardia, Ventricular | 1993 |
Prolongation of intraventricular conduction time associated with fatal [correction of fetal] impairment of defibrillation efficiency during treatment with class I antiarrhythmic agents.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Disopyramide; Dogs; Electrophysiology; Female; Flecainide; Heart; Heart Conduction System; Male; Mexiletine; Myocardium; Ventricular Fibrillation | 1995 |
Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine.
Topics: Amino Alcohols; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Disease Models, Animal; Disopyramide; Drug Administration Schedule; Heart Rate; Injections, Intravenous; Male; Mexiletine; Myocardial Ischemia; Myocardial Reperfusion; Rats; Rats, Sprague-Dawley; Ventricular Fibrillation | 1994 |
Electrical proarrhythmia with procainamide: a new ICD-drug interaction.
Topics: Aged; Defibrillators, Implantable; Disopyramide; Humans; Male; Mexiletine; Procainamide; Tachycardia, Ventricular | 1994 |
Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography, Ambulatory; Exercise Test; Female; Heart Rate; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Piperidines; Potassium Channels; Pyridines; Sodium Channels | 1993 |
Effects of hyperkalaemia on the depression of maximum rate of depolarization by class I antiarrhythmic agents in guinea-pig myocardium.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Female; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Male; Mexiletine; Microelectrodes; Potassium; Quinidine | 1993 |
Suppression of ventricular premature contractions continues after the washout of antiarrhythmic drugs.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atenolol; Disopyramide; Electrocardiography, Ambulatory; Female; Humans; Male; Mexiletine; Middle Aged | 1993 |
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Syndrome; Tachycardia, Ventricular; Verapamil | 1996 |
Drug-induced narrowing of the width of the zone of entrainment as a predictor of the subsequent non-inducibility of reentrant ventricular tachycardia after an additional dose of an antiarrhythmic drug.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Drug Administration Schedule; Electrocardiography; Female; Heart; Humans; Imidazoles; Male; Mexiletine; Middle Aged; Procainamide; Tachycardia, Ventricular | 1996 |
Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory act
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclooxygenase Inhibitors; Disopyramide; Dogs; Enzyme Inhibitors; Female; Humans; Male; Methacrylates; Mexiletine; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Aggregation; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil | 1996 |
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley | 1997 |
Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Electrophysiology; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Mexiletine; Myocardium; Patch-Clamp Techniques; Piperidines; Rats; Sodium Channel Blockers; Sodium Channels | 2001 |
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Disopyramide; Dogs; Electrocardiography; Halothane; Heart Rate; Long QT Syndrome; Mexiletine; Ventricular Function, Left | 2002 |