disopyramide and flecainide

disopyramide has been researched along with flecainide in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (30.85)	18.7374
1990's	40 (42.55)	18.2507
2000's	18 (19.15)	29.6817
2010's	7 (7.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baizman, ER; Becker, C; Bell, RH; Birsner, NC; Bohnet, EA; Busacca, CA; Carabateas, PM; Chadwick, CC; Gruett, MD; Johnson, RE	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Sen, S; Sinha, N	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Arita, M; Kiyosue, T; Sato, T; Wu, B	1
Ikeda, N; Kamiya, K	1
Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y	1
Campbell, TJ; Pallandi, R; Wyse, KR	1
Asayama, J; Inoue, D; Inoue, M; Katsume, H; Nakagawa, M; Shirayama, T; Tatsumi, T; Yamahara, Y	1
Gullberg, B; Hansen, O; Johansson, BW	1
Fukami, M; Hashimoto, T; Itoh, Y; Koike, H; Kumakura, S; Miyake, S; Mizuno, H; Shiga, H; Shimoji, Y; Yorikane, R	1
Akaike, N; Inomata, N; Ishihara, T	1
Inoue, H; Nozaki, A; Sugimoto, T; Usui, M; Yamashita, T	1
Inoue, H; Nozaki, A; Sugimoto, T; Yamashita, T	1
Kawamura, T; Kodama, I; Toyama, J	1
Camm, AJ; Garratt, CJ; Griffith, MJ; Linker, NJ; Ward, DE	1
Anderson, JL	1
Hayashi, H; Kawamura, T; Kodama, I; Saito, H; Toyama, J; Yamada, K	1
Keefe, DL; Miura, D; Somberg, JC	1
Hoffman, BF; Spinelli, W	1
James, MA; Jones, JV; Papouchado, P	1
Hoffmeister, HM; Krämer, B; Pflug, A; Seipel, L	1
Somberg, J	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Roy, D	1
Echt, DS; Roden, DM; Woosley, RL	1
Morganroth, J; Nestico, PF	2
Huang, SK; Marcus, FI	1
Light, RT; Onrot, J; Robertson, D; Robertson, RM; Tantengco, MV	1
Kates, RE	1
Frais, MA; Hafizullah, M; Jackson, NC; Kalra, PA; Reynolds, GW; Silke, B; Taylor, SH; Verma, SP	1
Bonazzi, O; Facchini, M; Priori, SG; Schwartz, PJ; Varisco, T	1
Gomoll, AW	1
Hepp, A; Hoffmeister, HM; Seipel, L	1
Baedeker, W; Barthel, P; Blömer, H; Goedel-Meinen, L; Hofmann, M; Schmidt, G	1
Camm, AJ; Griffith, MJ; Lau, CP	1
Campbell, TJ; Gavaghan, TP; Kelly, RP; Koegh, AM; Morgan, JJ; Thorburn, C	1
Podrid, PJ	1
Collignon, P; Legrand, V	1
Atarashi, H; Hayakawa, H	1
Camm, AJ; Caplin, JL; Hamer, J; Johnston, A	1
Hillis, WS; Whiting, B	1
Somberg, JC	1
Block, PJ; Winkle, RA	1
Bathen, J; Kjekshus, J; Orning, OM; Storstein, L	1
Bexton, RS; Burnett, PJ; Camm, AJ; Debbas, NM; Hellestrand, KJ; Milne, JR	1
Crijns, HJ; Lie, KI; Posma, JL; Wiesfeld, AC	1
Haruno, A; Hashimoto, K	1
Grey, E; Silverman, DI	1
Ajiki, K; Inoue, H; Iwasawa, K; Murakawa, Y; Oikawa, N; Omata, M; Sezaki, K; Usui, M; Yamashita, T	1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Sakai, R; Shirayama, T	1
Ajiki, K; Inoue, H; Kuo, TT; Murakawa, Y; Nakajima, T; Oikawa, N; Sezaki, K; Sugimoto, T; Usui, M; Yamashita, T	1
Lee, JK; Nonokawa, M; Sugiyama, T; Takanaka, C; Yame, S	1
Campbell, TJ; Martin, DK; Nakaya, Y; Wyse, KR	1
Lüderitz, B; Manz, M	1
Katoh, H; Mitamura, H; Ogawa, S	1
Brechenmacher, C; Chauvin, M; Koenig, A; Theolade, R	1
Asayama, J; Inoue, D; Inoue, M; Ishibashi, K; Nakagawa, M; Omori, I; Sakai, R; Yamahara, Y	1
Akaike, N; Inomata, N; Ishihara, T; Ohno, T	1
Adgey, AA; Allen, JD; Devine, AB; Stewart, AJ	1
Aupetit, JF; Faucon, G; Loufoua-Moundanga, J; Timour, Q	1
Kondo, T; Kubota, I; Tachibana, H; Tomoike, H; Yamaki, M	1
Beurrier, D; Brembilla-Perrot, B; Danchin, N; Houplon, P; Jacquemin, L; Louis, P; Terrier de la Chaise, A	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Akimoto, S; Hanada, K; Hashiguchi, M; Mitsui, K; Ogata, H	1
Akimoto, S; Hanada, K; Mihara, K; Mitsui, K; Ogata, H	1
Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M	2
Camm, AJ; de Jonghe, D; Debbas, NM; Jackson, SH; Robert, A	1
Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S	2
Haruno, A; Hashimoto, K; Sugiyama, A	1
Carboni, M; Chandra, R; Grant, AO; Keller, C; Starmer, CF	1
Aihara, N; Antzelevitch, C; Kamakura, S; Kurita, T; Shimizu, W; Sunagawa, K; Suyama, K; Taguchi, A; Takaki, H	1
Ito, Y; Naito, S; Teramoto, N; Yunoki, T	1
Imai, H; Matoba, Y; Nakagawa, M; Shiraishi, H; Shirayama, T; Yoshida, S	1
Mounsey, JP; VerNooy, RA	1
Scharf, C	1
Hagiwara, N; Haruki, S; Minami, Y; Suzuki, A	1

Reviews

15 review(s) available for disopyramide and flecainide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Comparisons of efficacy and tolerance of moricizine with other antiarrhythmic agents in the treatment of chronic ventricular arrhythmias. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Double-Blind Method; Encainide; Female; Flecainide; Humans; Male; Moricizine; Phenothiazines; Propranolol; Quinidine; Randomized Controlled Trials as Topic	1990
The treatment of ventricular rhythm disturbances. American heart journal, 1986, Volume: 111, Issue:6 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil	1986
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Antiarrhythmic drugs. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2 Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1986
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents. The American journal of cardiology, 1986, Jan-31, Volume: 57, Issue:3 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Digitalis; Disopyramide; Drug Interactions; Encainide; Flecainide; Half-Life; Heart Failure; Hemodynamics; Humans; Kidney; Kinetics; Lidocaine; Liver; Piperidines; Plants, Medicinal; Plants, Toxic; Potassium; Procainamide; Quinidine; Regional Blood Flow; Tocainide	1986
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
Antiarrhythmic agents for chronic ventricular arrhythmias. Comprehensive therapy, 1987, Volume: 13, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide	1987
Hemodynamic effects of antiarrhythmic drugs. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide	1983
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy. European heart journal, 1993, Volume: 14 Suppl E Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil	1993
[Antiarrhythmic treatment after reduction of atrial fibrillation by external shock]. Presse medicale (Paris, France : 1983), 1993, Nov-20, Volume: 22, Issue:36 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Disopyramide; Electric Countershock; Flecainide; Humans; Propafenone; Quinidine; Recurrence; Sotalol	1993
Antiarrhythmic drug therapy of atrial fibrillation. Cardiology clinics, 2004, Volume: 22, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Flecainide; Humans; Phenethylamines; Sotalol; Sulfonamides	2004
[Atrial flutter and fibrillation]. Praxis, 2005, Nov-09, Volume: 94, Issue:45 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Calcium Channel Blockers; Catheter Ablation; Clinical Trials as Topic; Disopyramide; Electric Countershock; Electrocardiography; Emergencies; Flecainide; Heart Rate; Humans; Middle Aged; Pacemaker, Artificial; Propafenone; Quinidine; Recurrence; Sotalol; Sulfonamides; Treatment Outcome; Vasodilator Agents	2005

Trials

7 trial(s) available for disopyramide and flecainide

Article	Year
Relative efficacy and safety of intravenous drugs for termination of sustained ventricular tachycardia. Lancet (London, England), 1990, Sep-15, Volume: 336, Issue:8716 Topics: Adenosine; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Clinical Trials as Topic; Disopyramide; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Flecainide; Humans; Hypotension; Injections, Intravenous; Lidocaine; Middle Aged; Recurrence; Sotalol; Tachycardia	1990
Comparisons of efficacy and tolerance of moricizine with other antiarrhythmic agents in the treatment of chronic ventricular arrhythmias. The American journal of cardiology, 1990, Feb-20, Volume: 65, Issue:8 Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Double-Blind Method; Encainide; Female; Flecainide; Humans; Male; Moricizine; Phenothiazines; Propranolol; Quinidine; Randomized Controlled Trials as Topic	1990
Combined anti-arrhythmic therapy with class 1 and class 3 drugs. Postgraduate medical journal, 1989, Volume: 65, Issue:766 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Randomized Controlled Trials as Topic; Single-Blind Method	1989
Comparative haemodynamic effects of intravenous lignocaine, disopyramide and flecainide in uncomplicated acute myocardial infarction. British journal of clinical pharmacology, 1986, Volume: 22, Issue:6 Topics: Adult; Aged; Disopyramide; Flecainide; Hemodynamics; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Myocardial Infarction; Prospective Studies	1986
[Effect of class I anti-arrhythmia agents on the signal-averaged ECG]. Herz, 1988, Volume: 13, Issue:3 Topics: Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Clinical Trials as Topic; Coronary Disease; Disopyramide; Electrocardiography; Female; Flecainide; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Random Allocation; Signal Processing, Computer-Assisted; Tachycardia; Tocainide	1988
Flecainide compared with a combination of digoxin and disopyramide for acute atrial arrhythmias after cardiopulmonary bypass. British heart journal, 1988, Volume: 60, Issue:6 Topics: Acute Disease; Aged; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Clinical Trials as Topic; Digoxin; Disopyramide; Drug Therapy, Combination; Female; Flecainide; Humans; Male; Middle Aged; Postoperative Complications; Random Allocation	1988
Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. Journal of cardiovascular electrophysiology, 2000, Volume: 11, Issue:12 Topics: Adult; Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Disopyramide; Electrocardiography; Flecainide; Heart Rate; Humans; Infusions, Intravenous; Male; Mexiletine; Middle Aged; Sodium; Sodium Channel Blockers; Sodium Channels; Syndrome; Ventricular Dysfunction; Ventricular Fibrillation	2000

Other Studies

73 other study(ies) available for disopyramide and flecainide

Article	Year
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal; Dogs; Guinea Pigs; Heart Ventricles; Male; Myocardial Contraction; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sodium Channels; Structure-Activity Relationship	1993
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs. Cardiovascular research, 1992, Volume: 26, Issue:11 Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dinitrophenols; Disopyramide; Flecainide; Glyburide; Guinea Pigs; Heart Ventricles; Imidazoles; Lidocaine; Mexiletine; Myocardium; Piperidines; Potassium; Procainamide; Pyridines	1992
[Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction--rate-dependent effects on QRS duration]. Japanese circulation journal, 1992, Volume: 56 Suppl 5 Topics: Anti-Arrhythmia Agents; Aprindine; Depression, Chemical; Disopyramide; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Humans; Lidocaine; Mexiletine; Sodium Channels; Ventricular Function	1992
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels	1992
Differential effects on action potential duration of class IA, B and C antiarrhythmic drugs: modulation by stimulation rate and extracellular K+ concentration. Clinical and experimental pharmacology & physiology, 1991, Volume: 18, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Flecainide; Heart Rate; In Vitro Techniques; Lidocaine; Potassium Channels; Purkinje Fibers; Sodium Channels	1991
Electrophysiological effects of sodium channel blockers on guinea pig left atrium. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Atrial Function; Atrial Function, Left; Diastole; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; Kinetics; Lidocaine; Male; Sodium Channels	1991
Metabolic, hemodynamic, and electrocardiographic responses to increased circulating adrenaline: effects of pretreatment with class 1 antiarrhythmics. Angiology, 1991, Volume: 42, Issue:12 Topics: Adult; Analysis of Variance; Blood Pressure; Disopyramide; Electrocardiography; Epinephrine; Flecainide; Heart Rate; Humans; Magnesium; Male; Mexiletine; Myocardial Infarction; Potassium	1991
Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate. Arzneimittel-Forschung, 1991, Volume: 41, Issue:11 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Conduction System; Hemodynamics; Isoquinolines; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Myocardial Contraction; Ouabain	1991
Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig. British journal of pharmacology, 1991, Volume: 104, Issue:4 Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Parasympatholytics; Potassium Channels; Quinidine; Receptors, Cholinergic	1991
Antiarrhythmic drugs preferentially produce conduction block at the area of slow conduction in the re-entrant circuit of canine atrial flutter: comparative study of disopyramide, flecainide, and E-4031. Cardiovascular research, 1991, Volume: 25, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Disopyramide; Dogs; Flecainide; Heart Conduction System; Piperidines; Pyridines	1991
Effects of antiarrhythmic drugs on canine atrial flutter due to reentry: role of prolongation of refractory period and depression of conduction to excitable gap. Journal of the American College of Cardiology, 1991, Volume: 18, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Atrial Flutter; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electrocardiography; Flecainide; Heart Conduction System; Piperidines; Propafenone; Pyridines; Refractory Period, Electrophysiological	1991
Effects of combined use of class I antiarrhythmic agents on Vmax of guinea-pig ventricular muscles. Cardiovascular drugs and therapy, 1991, Volume: 5 Suppl 4 Topics: Action Potentials; Animals; Disopyramide; Drug Interactions; Electric Stimulation; Female; Flecainide; Guinea Pigs; Male; Mexiletine; Papillary Muscles	1991
Combined application of class I antiarrhythmic drugs causes "additive", "reductive", or "synergistic" sodium channel block in cardiac muscles. Cardiovascular research, 1990, Volume: 24, Issue:11 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Male; Mexiletine; Myocardium; Sodium Channels	1990
Mechanisms of termination of reentrant atrial arrhythmias by class I and class III antiarrhythmic agents. Circulation research, 1989, Volume: 65, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electrocardiography; Flecainide; Heart Conduction System; Heart Rate; Lidocaine; Piperidines; Propafenone; Sotalol	1989
Circulatory and myocardial effects of different sodium antagonistic drugs in comparison to the calcium antagonist verapamil. Arzneimittel-Forschung, 1989, Volume: 39, Issue:11 Topics: Animals; Cardiac Output; Disopyramide; Flecainide; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Quinidine; Rats; Rats, Inbred Strains; Sodium; Verapamil	1989
Orthostatic hypotension: clinical spectrum and approach to treatment. Comprehensive therapy, 1986, Volume: 12, Issue:6 Topics: Adult; Aged; Amiodarone; Disopyramide; Female; Flecainide; Humans; Hypotension, Orthostatic; Lidocaine; Male; Middle Aged; Piperidines; Procainamide; Quinidine; Sympathomimetics; Tocainide	1986
Metabolites of antiarrhythmic drugs: are they clinically important? Rational drug therapy, 1986, Volume: 20, Issue:5 Topics: Anilides; Anti-Arrhythmia Agents; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Procainamide; Quinidine	1986
Antiarrhythmic efficacy of penticainide and comparison with disopyramide, flecainide, propafenone and mexiletine by acute oral drug testing. The American journal of cardiology, 1987, Nov-01, Volume: 60, Issue:13 Topics: Administration, Oral; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Disopyramide; Drug Administration Schedule; Electrocardiography; Electrophysiology; Female; Flecainide; Humans; Male; Mexiletine; Middle Aged; Propafenone; Propylamines; Pyridines	1987
Assessment of drug effects on spontaneous and induced ventricular arrhythmias in a 24-h canine infarction model. Arzneimittel-Forschung, 1987, Volume: 37, Issue:7 Topics: Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Dogs; Electrocardiography; Encainide; Female; Flecainide; Male; Myocardial Infarction; Sotalol	1987
Negative inotropic effect of class-I-antiarrhythmic drugs: comparison of flecainide with disopyramide and quinidine. European heart journal, 1987, Volume: 8, Issue:10 Topics: Animals; Cardiac Volume; Depression, Chemical; Disopyramide; Flecainide; Male; Myocardial Contraction; Pressure; Quinidine; Rats; Rats, Inbred Strains	1987
Ventricular Wenckebach after intravenous therapy with class I antiarrhythmic agents. International journal of cardiology, 1988, Volume: 20, Issue:1 Topics: Adult; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Flecainide; Heart Block; Heart Conduction System; Humans; Male; Middle Aged; Tachycardia, Supraventricular	1988
Aggravation of ventricular arrhythmia. A drug-induced complication. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine	1985
Haemodynamic effects of class I antiarrhythmic agents. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1985
[Anti-arrhythmia agents (I): Quinidine, procainamide, disopyramide, encainide, propafenone and flecainide]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:11 Topics: Anilides; Anti-Arrhythmia Agents; Disopyramide; Encainide; Flecainide; Humans; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine	1985
The acute changes in serum binding of disopyramide and flecainide after myocardial infarction. European journal of clinical pharmacology, 1985, Volume: 28, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Blood Proteins; Disopyramide; Female; Flecainide; Humans; Male; Middle Aged; Myocardial Infarction; Orosomucoid; Piperidines; Protein Binding; Serum Albumin	1985
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
A double-blind, crossover comparison of flecainide acetate and disopyramide phosphate in the treatment of ventricular premature complexes. The American journal of cardiology, 1984, Feb-27, Volume: 53, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disopyramide; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Flecainide; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Piperidines; Random Allocation	1984
Class 1 antiarrhythmic drugs--characteristic electrocardiographic differences when assessed by atrial and ventricular pacing. European heart journal, 1984, Volume: 5, Issue:2 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Coronary Disease; Disopyramide; Electrocardiography; Female; Flecainide; Humans; Lidocaine; Male; Middle Aged; Piperidines	1984
Favourable outcome in idiopathic ventricular fibrillation with treatment aimed at prevention of high sympathetic tone and suppression of inducible arrhythmias. British heart journal, 1995, Volume: 74, Issue:4 Topics: Adult; Anti-Arrhythmia Agents; Clinical Protocols; Combined Modality Therapy; Defibrillators, Implantable; Disopyramide; Electric Stimulation; Electrocardiography; Female; Flecainide; Humans; Male; Middle Aged; Physical Exertion; Stress, Psychological; Ventricular Fibrillation	1995
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. Japanese journal of pharmacology, 1995, Volume: 68, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Chlorobenzenes; Digitalis Glycosides; Disease Models, Animal; Disopyramide; Dogs; Epinephrine; Female; Flecainide; Injections, Intra-Arterial; Lidocaine; Male; Ouabain; Verapamil	1995
Efficacy of type 1C antiarrhythmic agents for treatment of resistant atrial fibrillation. Pacing and clinical electrophysiology : PACE, 1993, Volume: 16, Issue:12 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Encainide; Female; Flecainide; Heart Rate; Humans; Male; Middle Aged; Procainamide; Propafenone; Quinidine; Recurrence; Retrospective Studies	1993
Shock-induced refractory period extension and pharmacologic modulation of defibrillation threshold. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electric Countershock; Electric Stimulation; Flecainide; Heart; Infusions, Intravenous; Piperidines; Pyridines; Reproducibility of Results	1994
Effects of E-4031 on atrial fibrillation threshold in guinea pig atria: comparative study with class I antiarrhythmic drugs. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:4 Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Disopyramide; Electric Stimulation; Female; Flecainide; Guinea Pigs; Heart Atria; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Piperidines; Procainamide; Pyridines; Refractory Period, Electrophysiological	1994
Prolongation of intraventricular conduction time associated with fatal [correction of fetal] impairment of defibrillation efficiency during treatment with class I antiarrhythmic agents. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Defibrillators, Implantable; Disopyramide; Dogs; Electrophysiology; Female; Flecainide; Heart; Heart Conduction System; Male; Mexiletine; Myocardium; Ventricular Fibrillation	1995
Frequency dependent effects of class I antiarrhythmic agents studied in patients with implanted pacemakers. Pacing and clinical electrophysiology : PACE, 1994, Volume: 17, Issue:11 Pt 2 Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cross-Over Studies; Disopyramide; Electrocardiography; Flecainide; Humans; Lidocaine; Pacemaker, Artificial	1994
Effects of disopyramide and flecainide on the kinetics of inward rectifier potassium channels in rabbit heart muscle. British journal of pharmacology, 1994, Volume: 111, Issue:3 Topics: Animals; Cell Membrane; Disopyramide; Dose-Response Relationship, Drug; Female; Flecainide; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Myocardium; Potassium Channels; Rabbits; Ventricular Function	1994
Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias: comparison with conventional class I drugs. Cardiovascular drugs and therapy, 1993, Volume: 7 Suppl 3 Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disease Models, Animal; Disopyramide; Dogs; Electrophysiology; Flecainide; Myocardial Infarction; Piperidines; Potassium Channel Blockers; Pyridines; Tachycardia, Ventricular	1993
Effects of pilsicainide on the atrial fibrillation threshold in guinea pig atria. A comparative study with disopyramide, lidocaine and flecainide. Japanese heart journal, 1993, Volume: 34, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Electrophysiology; Female; Flecainide; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Male	1993
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Disopyramide; Electric Conductivity; Flecainide; Guinea Pigs; Lidocaine; Male; Myocardium; Potassium; Potassium Channels; Propafenone	1993
Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart. Heart (British Cardiac Society), 1996, Volume: 76, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disopyramide; Electrocardiography; Flecainide; Lidocaine; Mexiletine; Models, Biological; Sodium-Potassium-Exchanging ATPase; Swine; Ventricular Fibrillation; Verapamil	1996
Ischaemia-induced loss or reversal of the effects of the class I antiarrhythmic drugs on vulnerability to fibrillation. British journal of pharmacology, 1997, Volume: 120, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Disopyramide; Electric Stimulation; Electrophysiology; Female; Flecainide; Heart Conduction System; In Vitro Techniques; Injections, Intravenous; Lidocaine; Male; Myocardial Ischemia; Swine; Ventricular Fibrillation	1997
Electrophysiologic effects of sodium channel blockade on anisotropic conduction and conduction block in canine myocardium: preferential slowing of longitudinal conduction by flecainide versus disopyramide or lidocaine. Journal of the American College of Cardiology, 1997, Volume: 29, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disopyramide; Dogs; Electric Conductivity; Electrophysiology; Flecainide; Heart Conduction System; Heart Ventricles; Lidocaine; Sodium Channels; Ventricular Fibrillation	1997
[Can 1/1 atrial flutter be foreseen by class I anti-arrhythmics?]. Archives des maladies du coeur et des vaisseaux, 1997, Volume: 90, Issue:7 Topics: Aged; Anti-Arrhythmia Agents; Atrial Flutter; Disopyramide; Electrocardiography; Female; Flecainide; Heart Conduction System; Humans; Imidazoles; Male; Middle Aged; Predictive Value of Tests; Propafenone; Quinidine; Risk Factors	1997
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
Quantitative determination of disopyramide, verapamil and flecainide enantiomers in rat plasma and tissues by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1998, Jun-12, Volume: 710, Issue:1-2 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Male; Rats; Rats, Wistar; Stereoisomerism; Verapamil	1998
Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding. Pharmaceutical research, 1998, Volume: 15, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Blood Proteins; Disopyramide; Flecainide; Male; Phosphatidylserines; Protein Binding; Rats; Rats, Wistar; Stereoisomerism; Tissue Distribution; Verapamil	1998
Decrease in the high frequency QRS components depending on the local conduction delay. Japanese circulation journal, 1998, Volume: 62, Issue:11 Topics: Animals; Disopyramide; Dogs; Electrocardiography; Flecainide; Fourier Analysis; Heart Conduction System; Lidocaine; Sodium Channel Blockers; Time	1998
Human atrial repolarization: effects of sinus rate, pacing and drugs on the surface electrocardiogram. Journal of the American College of Cardiology, 1999, Volume: 33, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atropine; Cardiac Pacing, Artificial; Disopyramide; Electrocardiography; Female; Flecainide; Heart Atria; Heart Block; Heart Rate; Humans; Injections, Intravenous; Male; Middle Aged; Propranolol; Reproducibility of Results	1999
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current. Circulation, 1999, Mar-30, Volume: 99, Issue:12 Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil	1999
Chronotropic, inotropic, dromotropic and coronary vasodilator effects of bisaramil, a new class I antiarrhythmic drug, assessed using canine isolated, blood-perfused heart preparations. Japanese journal of pharmacology, 1999, Volume: 80, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Blood Flow Velocity; Bridged Bicyclo Compounds, Heterocyclic; Chlorobenzenes; Coronary Vessels; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion; Sinoatrial Node; Vasodilation	1999
Direct effects of class I antiarrhythmic drugs on epicardial electrograms in dogs. Japanese heart journal, 1999, Volume: 40, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Disopyramide; Dogs; Electrocardiography; Flecainide; Lidocaine; Pericardium	1999
Anisotropic effects of sodium channel blockers on the wavelength for ventricular excitation in dogs. Japanese circulation journal, 2000, Volume: 64, Issue:9 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Dogs; Electrocardiography; Electrophysiology; Flecainide; Heart Conduction System; Heart Ventricles; Lidocaine; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Ventricular Fibrillation; Ventricular Function	2000
Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophysical journal, 2000, Volume: 79, Issue:6 Topics: Amino Acid Substitution; Anti-Arrhythmia Agents; Cell Line; Cloning, Molecular; Disopyramide; Flecainide; Heart; Humans; Lidocaine; Membrane Potentials; Models, Biological; Myocardium; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels; Transfection	2000
The effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytes. British journal of pharmacology, 2001, Volume: 133, Issue:5 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; COS Cells; Cromakalim; Disopyramide; Dose-Response Relationship, Drug; Female; Flecainide; Hydrogen-Ion Concentration; Membrane Potentials; Muscle, Smooth; Mutation; Potassium Channels; Swine; Urethra; Vasodilator Agents	2001
Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2002, Volume: 4, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Disopyramide; Electrophysiologic Techniques, Cardiac; Female; Flecainide; Humans; Imidazoles; Lidocaine; Male; Middle Aged; Treatment Outcome	2002
Atrial fibrillation: rate control often better than rhythm control. Prescrire international, 2004, Volume: 13, Issue:70 Topics: Adult; Aged; Amiodarone; Anticoagulants; Arrhythmia, Sinus; Atrial Fibrillation; Canada; Disopyramide; Electric Countershock; Flecainide; Heart Rate; Humans; Netherlands; Platelet Aggregation Inhibitors; Propafenone; Quinidine; Sotalol; United States	2004
Effects of flecainide on left ventricular pressure gradient and symptoms in obstructive hypertrophic cardiomyopathy: a comparison of flecainide and disopyramide. Heart and vessels, 2015, Volume: 30, Issue:5 Topics: Administration, Oral; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Disopyramide; Dose-Response Relationship, Drug; Echocardiography; Female; Flecainide; Follow-Up Studies; Heart Ventricles; Humans; Male; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome; Ventricular Outflow Obstruction; Ventricular Pressure	2015