disopyramide has been researched along with 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (67.65) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaschke, TF; Cox, BM; Giacomini, JC; Giacomini, KM; Nelson, WL; Sneed, CK; Stauss, J | 1 |
| Lima, JJ | 1 |
| Bergfeldt, L; Dahlqvist, R; Schenck-Gustafsson, K | 1 |
| Chevanne, F; le Corre, P; le Verge, R; Malledant, Y; Sado, P | 1 |
| Del Cont Bernard, A; Rambourg, M; Royer Morrot, MJ; Royer, RJ; Zhiri, A | 1 |
| Chevanne, F; Gibassier, D; Guillouzo, A; Le Corre, P; Le Verge, R; Ratanasavanh, D; Sado, P | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Koike, K; Nakamura, H; Ochiai, K; Ogata, H; Takahashi, H | 1 |
| Krämer, BK; Kühlkamp, V; Liebich, HM; Mayer, F; Ress, KM; Risler, T; Seipel, L | 1 |
| Sasyniuk, BI; Toy, W | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Kato, Y; Ochiai, K | 1 |
| Arimori, K; Nakano, M | 1 |
| Bell, JL; Ellsworth, AJ; Horn, JR; Miyagawa, LA; Raisys, VA | 1 |
| Haughey, DB; Lee, MH; Steinberg, I | 1 |
| Ishizaki, T; Kushida, K; Wang, LH | 1 |
| Donatella, P; Gabriella, C; Raffaella, M; Roberto, P; Sergio, B; Vitaliano, B | 1 |
| Gibassier, D; Le Corre, P; Le Verge, R; Sado, P | 2 |
| Ekelund, LG; Nilsson, E; Walldius, G | 1 |
| Bredesen, JE; Kierulf, P | 2 |
| Doherty, JU; Josephson, ME; Shaw, LM; Waxman, HL | 1 |
| Calissendorff, B; Chiang, WT; Dahlqvist, R; Emilsson, H; Magnusson, A; Schenck-Gustafsson, K; von Bahr, C | 1 |
| Aaltonen, L; Iisalo, E | 2 |
| Lasky, FD; Wesley, JF | 1 |
| Armstrong, PW; Brien, JF; Nakatsu, K | 1 |
| Abbott, FS; Axelson, JE; Edwards, DJ; Kapil, RP; Kerr, CR; Lalka, D | 1 |
| Aitio, ML; Allonen, H; Kanto, J; Mäntylä, R | 1 |
| Bredesen, JE; Lunde, PK; Pike, E | 1 |
| Bredesen, JE | 1 |
| Graffner, C; Lagerström, PO; Lundborg, PN; Rönn, OF | 1 |
| Amano, I; Inagaki, Y; Ito, T; Masamoto, S; Niwa, M; Otsu, T | 1 |
| Bonato, PL; Jabor, VA; Lanchote, VL | 1 |
| Fukumoto, K; Kusumoto, M; Tsuchishita, Y; Ueno, K | 1 |
3 trial(s) available for disopyramide and 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide
| Article | Year |
|---|---|
Comparative class 1 electrophysiologic and anticholinergic effects of disopyramide and its main metabolite (mono-N-dealkylated disopyramide) in healthy humans.
Topics: Adult; Disopyramide; Double-Blind Method; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Humans; Male; Parasympatholytics | 1992 |
Efficacy of and adverse effects of disopyramide. Comparison of capsules, controlled release tablets and placebo in patients with chronic ventricular arrhythmias.
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Capsules; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Disopyramide; Double-Blind Method; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Random Allocation | 1986 |
Kinetics and dynamics of disopyramide and its dealkylated metabolite in healthy subjects.
Topics: Adult; Chromatography, High Pressure Liquid; Disopyramide; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Heart Rate; Humans; Infusions, Parenteral; Kinetics; Male; Pupil; Salivation | 1985 |
31 other study(ies) available for disopyramide and 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide
| Article | Year |
|---|---|
Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.
Topics: Acetylcholine; Animals; Chemical Phenomena; Chemistry; Disopyramide; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyridines; Stereoisomerism | 1981 |
Liquid chromatographic analysis of disopyramide and its mono-N-dealkylated metabolite.
Topics: Chromatography, High Pressure Liquid; Disopyramide; Humans; Kinetics; Pyridines; Saliva | 1979 |
Stereoselective biliary elimination of disopyramide and mono-N-desisopropyldisopyramide in humans.
Topics: Bile; Biliary Tract; Disopyramide; Humans; Parasympatholytics; Stereoisomerism | 1992 |
Automated determination of disopyramide and N-monodealkyldisopyramide in plasma by reversed-phase liquid chromatography with a column switching system.
Topics: Chromatography, High Pressure Liquid; Disopyramide; Parasympatholytics; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1992 |
In vitro assessment of stereoselective hepatic metabolism of disopyramide in humans: comparison with in vivo data.
Topics: Adult; Biotransformation; Disopyramide; Female; Humans; In Vitro Techniques; Kinetics; Liver; Male; Middle Aged; Stereoisomerism | 1991 |
Stereoselective disposition and metabolism of disopyramide in pediatric patients.
Topics: Administration, Oral; Biological Availability; Blood Proteins; Child; Child, Preschool; Disopyramide; Female; Humans; Infusions, Intravenous; Male; Parasympatholytics; Protein Binding; Stereoisomerism | 1991 |
Simplified, rapid and inexpensive extraction procedure for a high-performance liquid chromatographic method for determination of disopyramide and its main metabolite mono-N-dealkylated disopyramide in serum.
Topics: Chromatography, High Pressure Liquid; Disopyramide; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Frequency and voltage-dependent effects of mono-N-dealkyldisopyramide, the major metabolite of disopyramide, in canine ventricular tissue.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Culture Techniques; Disopyramide; Dogs; Electrophysiology; Female; Heart; Heart Ventricles; Kinetics; Male; Myocardium; Neural Conduction; Parasympatholytics; Purkinje Fibers; Sodium; Sodium Channels; Ventricular Function | 1990 |
Simultaneous determination of disopyramide and mono-N-dealkyldisopyramide enantiomers in plasma and urine by use of a chiral cellulose-derivative column.
Topics: Anti-Arrhythmia Agents; Cellulose; Chromatography, High Pressure Liquid; Disopyramide; Humans; Metabolic Clearance Rate; Monitoring, Physiologic; Stereoisomerism | 1990 |
Study on transport of disopyramide into the intestinal lumen aimed at gastrointestinal dialysis by activated charcoal in rats.
Topics: Administration, Oral; Adsorption; Animals; Bile; Charcoal; Chromatography, High Pressure Liquid; Dialysis; Digestive System; Disopyramide; Intestinal Absorption; Male; Rats; Rats, Inbred Strains; Urinary Tract | 1989 |
Disopyramide and N-monodesalkyl disopyramide in serum and breast milk.
Topics: Adult; Disopyramide; Female; Fetal Blood; Humans; Infant, Newborn; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Pregnancy Complications, Cardiovascular; Ventricular Fibrillation | 1989 |
Protein binding of disopyramide--displacement by mono-N-dealkyldisopyramide and variation with source of alpha-1-acid glycoprotein.
Topics: Binding, Competitive; Disopyramide; Humans; Kinetics; Orosomucoid; Protein Binding | 1985 |
Use of silica gel with aqueous eluent for simultaneous high performance liquid chromatographic assay of disopyramide and mono-N-dealkyldisopyramide.
Topics: Chromatography, High Pressure Liquid; Disopyramide; Humans; Indicators and Reagents; Kinetics; Monitoring, Physiologic; Silica Gel; Silicon Dioxide | 1986 |
Disopyramide pharmacokinetics in the elderly after single oral administration.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Disopyramide; Half-Life; Humans; Male; Metabolic Clearance Rate; Protein Binding | 1988 |
Direct enantiomeric resolution of disopyramide and its metabolite using chiral high-performance liquid chromatography. Application to stereoselective metabolism and pharmacokinetics of racemic disopyramide in man.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Disopyramide; Humans; Indicators and Reagents; Stereoisomerism | 1988 |
Simultaneous assay of disopyramide and monodesisopropyldisopyramide enantiomers in biological samples by liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Disopyramide; Humans; Indicators and Reagents; Stereoisomerism | 1988 |
Relationship between alpha 1-acid glycoprotein and distribution of disopyramide and mono-N-dealkyldisopyramide in whole blood.
Topics: Adult; Aged; Blood Proteins; Disopyramide; Female; Humans; Male; Middle Aged; Orosomucoid; Protein Binding | 1986 |
The pharmacokinetic and pharmacodynamic effects of varying the free fraction of disopyramide.
Topics: Blood Proteins; Disopyramide; Humans; Protein Binding | 1987 |
Antimuscarinic side-effects of disopyramide.
Topics: Atropine; Biological Assay; Disopyramide; Humans; Parasympatholytics; Pyridines; Receptors, Muscarinic | 1983 |
High performance liquid chromatographic analysis of the antiarrhythmic drugs procainamide, disopyramide, quinidine, propranolol and metabolites from serum extracts.
Topics: Acecainide; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Disopyramide; Humans; Procainamide; Propranolol; Pyridines; Quinidine; Spectrophotometry, Ultraviolet | 1981 |
Relationship between alpha 1-acid glycoprotein and plasma binding of disopyramide and mono-N-dealkyldisopyramide.
Topics: Adolescent; Adult; Aged; Disopyramide; Female; Humans; Male; Middle Aged; Orosomucoid; Protein Binding; Serum Albumin | 1984 |
Determination of disopyramide and mono-N-desisopropyl-disopyramide in serum by gas-liquid chromatography with nitrogen-selective detection.
Topics: Chromatography, Gas; Disopyramide; Humans; Mass Spectrometry; Protein Binding | 1983 |
Anticholinergic activity in the serum of patients receiving maintenance disopyramide therapy.
Topics: Adult; Chromatography, Gas; Disopyramide; Humans; Parasympatholytics; Radioligand Assay | 1984 |
Simultaneous quantitation of disopyramide and its mono-dealkylated metabolite in human plasma by fused-silica capillary gas chromatography using nitrogen-phosphorus specific detection.
Topics: Chromatography, Gas; Disopyramide; Gas Chromatography-Mass Spectrometry; Humans | 1984 |
The pharmacokinetics of disopyramide and mono-N-dealkyl-disopyramide in humans.
Topics: Administration, Oral; Adult; Disopyramide; Female; Humans; Hydrogen-Ion Concentration; Injections, Intramuscular; Injections, Intravenous; Kidney Diseases; Kinetics; Male; Protein Binding; Pyridines | 1982 |
Plasma binding of disopyramide and mono-N-dealkyldisopyramide.
Topics: Adult; Aged; Blood Proteins; Disopyramide; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Protein Binding; Pyridines | 1982 |
Gas-chromatographic determination of disopyramide and its mono-N-dealkylated metabolite in serum with use of a nitrogen-selective detector.
Topics: Chromatography, Gas; Disopyramide; Humans; Pyridines | 1980 |
Relative absorption of disopyramide as determined by liquid chromatography following acute administration of standard capsules and controlled-release tablets.
Topics: Absorption; Adult; Biotransformation; Capsules; Delayed-Action Preparations; Disopyramide; Heart Rate; Humans; Male; Pyridines | 1981 |
[Accumulation of a disopyramide metabolite in renal failure].
Topics: Adult; Aged; Aged, 80 and over; Disopyramide; Female; Humans; Hypoglycemia; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 1993 |
Simultaneous determination of disopyramide and mono-N-dealkyldisopyramide enantiomers in human plasma by capillary electrophoresis.
Topics: Disopyramide; Electrophoresis, Capillary; Humans | 2001 |
Effects of serum concentrations of disopyramide and its metabolite mono-N-dealkyldisopyramide on the anticholinergic side effects associated with disopyramide.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Chromatography, High Pressure Liquid; Creatinine; Disopyramide; Female; Humans; Male; Middle Aged; Urination Disorders; Xerostomia | 2008 |