discodermolide has been researched along with divinyl-sulfone* in 1 studies
1 other study(ies) available for discodermolide and divinyl-sulfone
Article | Year |
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Designer discodermolide segments via ozonolysis of vinyl phosphonates.
To apply our collection of enantiopure 7-ring vinyl sulfones to probe the anticancer SAR of a series of computer-designed (+)-discodermolide analogs, the ozonolytic reactivity of transposed cyclic vinyl phosphonates was explored. Successful preparation of the desired aldehyde-esters and lactones from vinyl phosphonates via an oxidative cleavage-phosphite/methanol exchange sequence is described. Topics: Alkanes; Carbamates; Combinatorial Chemistry Techniques; Lactones; Models, Molecular; Molecular Structure; Organophosphonates; Oxidation-Reduction; Ozone; Pyrones; Structure-Activity Relationship; Sulfones; Vinyl Compounds | 2009 |