discodermolide and cyclopropane

discodermolide has been researched along with cyclopropane* in 1 studies

Other Studies

1 other study(ies) available for discodermolide and cyclopropane

Article	Year
Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide. Organic letters, 2005, Oct-13, Volume: 7, Issue:21 [structure: see text] The design, total synthesis, and biological evaluation of two C13-C14-cyclopropyl analogues [(+)-1 and (+)-2] of (+)-discodermolide have been achieved. Key features of the syntheses include highly stereoselective, hydroxyl-directed cyclopropanations of vinyl iodides and higher order cuprate-mediated cross-coupling reactions between cyclopropyl iodides and alkyl iodides. Biological evaluation revealed that neither orientation of the cyclopropyl methylene completely substitutes for the C14 methyl found in (+)-discodermolide (3). Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Survival; Cyclopropanes; Drug Design; Humans; Lactones; Molecular Structure; Pyrones; Stereoisomerism; Structure-Activity Relationship	2005

Article

Year

Design, total synthesis, and evaluation of C13-C14 cyclopropane analogues of (+)-discodermolide.

Organic letters, 2005, Oct-13, Volume: 7, Issue:21

[structure: see text] The design, total synthesis, and biological evaluation of two C13-C14-cyclopropyl analogues [(+)-1 and (+)-2] of (+)-discodermolide have been achieved. Key features of the syntheses include highly stereoselective, hydroxyl-directed cyclopropanations of vinyl iodides and higher order cuprate-mediated cross-coupling reactions between cyclopropyl iodides and alkyl iodides. Biological evaluation revealed that neither orientation of the cyclopropyl methylene completely substitutes for the C14 methyl found in (+)-discodermolide (3).

Topics: Alkanes; Antineoplastic Agents; Carbamates; Cell Survival; Cyclopropanes; Drug Design; Humans; Lactones; Molecular Structure; Pyrones; Stereoisomerism; Structure-Activity Relationship

2005