Compounds > diquafosol
Page last updated: 2024-09-04

diquafosol and uridine triphosphate

diquafosol has been researched along with uridine triphosphate in 9 studies

Compound Research Comparison

Studies
(diquafosol)		Trials
(diquafosol)		Recent Studies (post-2010)
(diquafosol)		Studies
(uridine triphosphate)		Trials
(uridine triphosphate)		Recent Studies (post-2010) (uridine triphosphate)
12638922,42320331

Protein Interaction Comparison

ProteinTaxonomydiquafosol (IC50)uridine triphosphate (IC50)
P2Y purinoceptor 2 Mus musculus (house mouse)1.51

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's6 (66.67)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dougherty, RW; Douglass, JG; Pendergast, W; Redick, CC; Rideout, JL; Shaver, SR; Sims, IF; Yerxa, BR1
Brookings, D; Davenport, RJ; Davis, J; Galvin, FC; Lloyd, S; Mack, SR; Owens, R; Sabin, V; Wynn, J1
Besada, P; Calenbergh, SV; Costanzi, S; Cosyn, L; Fricks, I; Harden, TK; Ivanov, AA; Jacobson, KA; Ko, H; Maddileti, S1
Besada, P; Cappellacci, L; Carter, RL; Cosyn, L; de Castro, S; Franchetti, P; Grifantini, M; Harden, TK; Jacobson, KA; Ko, H; Petrelli, R; Van Calenbergh, S; Zhou, Y1
Hillmann, P; Höltje, HD; Ko, GY; Kostenis, E; Müller, CE; Nicholas, RA; Raulf, A; Spinrath, A; von Kügelgen, I; Wolff, SC1
Fischer, B; Ginsburg-Shmuel, T; Haas, M; Kalid, O; Reiser, G; Schumann, M; Stern, N1
Camden, J; Fischer, B; Weisman, GA; Yelovitch, S1
Abraham, WM; James, MK; Mao, YM; O'Riordan, TG; Sabater, JR; Shaffer, C1
Kellerman, DJ1

Reviews

1 review(s) available for diquafosol and uridine triphosphate

ArticleYear
P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance.
    Chest, 2002, Volume: 121, Issue:5 Suppl

    Topics: Animals; Anti-Asthmatic Agents; Bronchitis, Chronic; Cystic Fibrosis; Dose-Response Relationship, Drug; Humans; Mucociliary Clearance; Ophthalmic Solutions; Polyphosphates; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y2; Uracil Nucleotides; Uridine Triphosphate

2002

Other Studies

8 other study(ies) available for diquafosol and uridine triphosphate

ArticleYear
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: Calcium; Dinucleoside Phosphates; Humans; Protein Binding; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Spectrometry, Fluorescence; Structure-Activity Relationship; Transduction, Genetic; Tumor Cells, Cultured; Uracil Nucleotides

2001
Novel nucleotide triphosphates as potent P2Y2 agonists.
    Bioorganic & medicinal chemistry letters, 2007, Jan-15, Volume: 17, Issue:2

    Topics: Cell Line, Tumor; DNA, Complementary; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nucleotides; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y2; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; Uridine Triphosphate

2007
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
    Journal of medicinal chemistry, 2007, Mar-22, Volume: 50, Issue:6

    Topics: Adenosine Triphosphate; Binding Sites; Cell Line, Tumor; Drug Design; Humans; Models, Molecular; Monte Carlo Method; Protein Conformation; Purinergic P2 Receptor Agonists; Quantitative Structure-Activity Relationship; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Uridine Triphosphate

2007
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
    Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12

    Topics: Humans; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Structure-Activity Relationship; Uracil Nucleotides

2008
Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Amino Acid Sequence; Amino Acids; Animals; Cell Line; Disulfides; Drug Design; Enzyme-Linked Immunosorbent Assay; Extracellular Space; Gene Expression; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotides; Oxidation-Reduction; Protein Structure, Secondary; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Sequence Homology, Amino Acid

2009
5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist.
    Journal of medicinal chemistry, 2010, Feb-25, Volume: 53, Issue:4

    Topics: Calcium; Cell Line, Tumor; Humans; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Structure-Activity Relationship; Transfection; Uridine Diphosphate

2010
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Boranes; Calcium; Cell Line, Tumor; Dinucleoside Phosphates; Drug Stability; Humans; Hydrolysis; Models, Molecular; Molecular Conformation; Phosphoric Diester Hydrolases; Purinergic P2Y Receptor Agonists; Pyrophosphatases; Receptors, Purinergic P2Y; Stereoisomerism; Structure-Activity Relationship; Turkey

2012
Aerosolization of P2Y(2)-receptor agonists enhances mucociliary clearance in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:6

    Topics: Aerosols; Animals; Female; Humans; Mucociliary Clearance; Mucus; Ophthalmic Solutions; Polyphosphates; Purinergic P2 Receptor Agonists; Serum Albumin; Sheep; Time Factors; Trachea; Uracil Nucleotides; Uridine Triphosphate

1999