dipyrone and ampyrone

dipyrone has been researched along with ampyrone in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (25.58)	18.7374
1990's	8 (18.60)	18.2507
2000's	7 (16.28)	29.6817
2010's	12 (27.91)	24.3611
2020's	5 (11.63)	2.80

Authors

Authors	Studies
Bisogno, T; Cascio, MG; Di Marzo, V; Imming, P; Lichtman, AH; Nüsing, R; Podlewski, A; Rogosch, T; Schlosburg, J; Sinning, C; Watzer, B	1
Granit, L; Levy, M; Zylber-Katz, E	2
Bacracheva, N; Badian, M; Verho, M; Vlahov, V	1
Becker, EW; Berg, PA; Federmann, G; Penschuck, C; Tautorat, H	1
Funae, Y; Imaoka, S; Inoue, K	1
Burckart, GJ; D'Souza, MJ; Venkataramanan, R; Zemaitis, MA	1
Drexler, R; Levy, M; Matzner, Y	1
Flusser, D; Granit, L; Levy, M; Zylber-Katz, E	1
Altrogge, G; Pola, W; Sistovaris, N; Wolhoff, H	1
Fujimori, K; Inoue, K; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A	1
Pola, W; Sistovaris, N; Wolhoff, H	1
Sakai, A; Tanimura, A	1
Haustein, KO; Hüller, G	1
Carretero, I; Laserna, JJ; Vadillo, JM	1
Caraco, Y; Granit, L; Levy, M; Zylber-Katz, E	2
Dennhardt, R; Gramm, HJ; Heinemeyer, G; Roots, I; Simgen, W	1
Böcker, R; Geisslinger, G; Levy, M	1
Caraco, Y; Cohen, O; Granit, L; Levy, M; Zylber-Katz, E	1
Caraco, Y; Granit, L; Levy, M; Safadi, R; Zylber-Katz, E	1
Bianchi, L; Büchtemann, A; Herdeg, C; Hilt, F; Klein, R	1
Collares, EF; Vinagre, AM	5
Brenneis, C; Geisslinger, G; Michaelis, M; Pierre, SC; Schmidt, R; Scholich, K	1
Agüera, A; Fernández-Alba, AR; Gómez, MJ; Mezcua, M; Sirtori, C	1
Calzadilla, PC; Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Gómez-Hernández, M; Hurtado Y de la Peña, M; López, JR; López-Muñoz, FJ	1
Kamiyama, N; Kayama, H; Kimura, T; Ma, JS; Machimura, S; Ohshima, J; Saiga, H; Sasai, M; Takeda, K; Ueda, Y; Yamamoto, M	1
Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L	1
Agúndez, JA; Andreu, I; Ariza, A; Blanca, M; Blanca-Lopez, N; García-Martín, E; Mayorga, C; Montañez, MI; Perkins, J; Salas, M; Torres, MJ	1
Burmańczuk, A; Giorgi, M; Grabowski, T; Kowalski, C; Owen, H	1
Chea, B; Giorgi, M; Kim, TW; Lebkowska-Wieruszewska, B; Owen, H; Poapolathep, A	1
De Vito, V; Giorgi, M; Kim, TW; Lisowski, A; Owen, H; Poapolathep, A; Łebkowska-Wieruszewska, B	1
Abilova, Z; Giorgi, M; Kim, TW; Lisowski, A; Owen, H; Poapolathep, A; Sitovs, A; Łebkowska-Wieruszewska, B	1
Collares, EF; Troncon, LEA	1
de Azevedo, WF; Russo, S	1
Baumgartner, C; Behrendt-Wippermann, M; Brandl, J; Feist, M; Fux, D; Metzner, M; von Thaden, A	1
Almeida, LD; Badenoch, B; Beatriz, A; Cristina Toffoli-Kadri, M; da Silva Gomes, R; da Silva Júnior, EN; da Silveira, IOMF; Fernandes, J; Hortelan, CRW; Janaína de Campos, L; Juliano Oliveira, R; Martins, ACF; Mohammad, J; Moslaves, ISB; Muller, JAI; Okuyama, TT	1
Araújo-Silva, G; Arcoverde, KN; de Macêdo, LB; de Paiva, ALC; de Paula, VV; Fernandes, NS; Mouta, AN; Nunes, TL; Urizar, JTP	1
Alves, LSA; Araújo-Silva, G; Arcoverde, KN; Cavalcante, JM; de Paula, VV; Jurema, AP; Maranhão, ACPM; Urizar, JTP	1

Reviews

2 review(s) available for dipyrone and ampyrone

Article	Year
Effects of dipyrone on the digestive tract. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2019, Jan-10, Volume: 52, Issue:2 Topics: Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autonomic Nerve Block; Dipyrone; Gastric Emptying; Rats; Rats, Wistar	2019
Computational Analysis of Dipyrone Metabolite 4-Aminoantipyrine As A Cannabinoid Receptor 1 Agonist. Current medicinal chemistry, 2020, Volume: 27, Issue:28 Topics: Ampyrone; Analgesics; Cannabinoid Receptor Agonists; Cannabinoids; Dipyrone	2020

Trials

5 trial(s) available for dipyrone and ampyrone

Article	Year
Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium. European journal of clinical pharmacology, 1990, Volume: 38, Issue:1 Topics: Administration, Oral; Adult; Aminopyrine; Ampyrone; Antipyrine; Dipyrone; Humans; Male; Pyrazolones; Random Allocation; Time Factors	1990
Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone. European journal of clinical pharmacology, 1998, Volume: 54, Issue:7 Topics: Administration, Oral; Adult; Aged; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Dipyrone; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrazolones; Spinal Puncture	1998
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators. European journal of clinical pharmacology, 2001, Volume: 57, Issue:6-7 Topics: Acetylation; Adult; Algorithms; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Carrier State; Dipyrone; Female; Half-Life; Hepatitis B virus; Humans; Male; Metabolic Clearance Rate; Models, Biological; Pyrazolones	2001
Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration. Journal of veterinary pharmacology and therapeutics, 2018, Volume: 41, Issue:2 Topics: Administration, Oral; Ampyrone; Analgesics; Animals; Cats; Cross-Over Studies; Dipyrone; Injections, Intramuscular; Injections, Intravenous; Male	2018
Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs. Journal of veterinary pharmacology and therapeutics, 2018, Volume: 41, Issue:3 Topics: Administration, Oral; Administration, Rectal; Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cross-Over Studies; Dipyrone; Dogs; Female; Half-Life; Injections, Intramuscular; Injections, Intravenous; Molecular Structure	2018

Other Studies

36 other study(ies) available for dipyrone and ampyrone

Article	Year
Novel bioactive metabolites of dipyrone (metamizol). Bioorganic & medicinal chemistry, 2012, Jan-01, Volume: 20, Issue:1 Topics: Administration, Oral; Aminopyridines; Ampyrone; Animals; Central Nervous System; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dipyrone; Enzyme Activation; Mice; Mice, Inbred C57BL; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reference Standards; Spectrometry, Mass, Electrospray Ionization	2012
Formation and excretion of dipyrone metabolites in man. European journal of clinical pharmacology, 1992, Volume: 42, Issue:2 Topics: Administration, Oral; Adult; Aminopyrine; Ampyrone; Chromatography, High Pressure Liquid; Dipyrone; Half-Life; Humans; Male; Pyrazolones	1992
[Demonstration by lymphocyte transformation test of the allergic genesis in a case of acute hepatitis]. Deutsche medizinische Wochenschrift (1946), 1988, Oct-28, Volume: 113, Issue:43 Topics: Acute Disease; Alanine Transaminase; Alkaline Phosphatase; Aminopyrine; Ampyrone; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Dipyrone; Drug Hypersensitivity; gamma-Glutamyltransferase; Humans; Lymphocyte Activation; Male; Middle Aged; Time Factors	1988
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Archives of biochemistry and biophysics, 1988, Aug-15, Volume: 265, Issue:1 Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains	1988
Simple high-performance liquid chromatographic method for simultaneous determination of aminopyrine and its metabolites. Journal of chromatography, 1987, Oct-09, Volume: 421, Issue:1 Topics: Aminopyrine; Ampyrone; Animals; Chromatography, High Pressure Liquid; Dipyrone; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Pyrazolones; Rabbits	1987
Plasma protein binding of dipyrone metabolites in man. European journal of clinical pharmacology, 1985, Volume: 29, Issue:1 Topics: Acetaminophen; Adult; Aminopyrine; Ampyrone; Aspirin; Blood Proteins; Dipyrone; Female; Humans; Ibuprofen; Male; Protein Binding; Pyrazolones	1985
Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis. European journal of clinical investigation, 1984, Volume: 14, Issue:6 Topics: Acetaminophen; Aminopyrine; Ampyrone; Aspirin; Chemotaxis, Leukocyte; Dipyrone; Dose-Response Relationship, Drug; Humans; Neutrophils; Pyrazolones	1984
Plasma kinetics of dipyrone metabolites in rapid and slow acetylators. European journal of clinical pharmacology, 1984, Volume: 27, Issue:4 Topics: Acetylation; Adult; Aminopyrine; Ampyrone; Chemical Phenomena; Chemistry; Dipyrone; Female; Half-Life; Humans; Kinetics; Male; Pyrazolones	1984
[Metamizol--acute overdose with suicidal intent]. Deutsche medizinische Wochenschrift (1946), 1983, Nov-18, Volume: 108, Issue:46 Topics: Adolescent; Aminopyrine; Ampyrone; Biotransformation; Dipyrone; Female; Furosemide; Humans; Pyrazolones; Suicide, Attempted	1983
Simultaneous determination of aminopyrine hydroxylation and aminopyrine N-demethylation in liver microsomes by high-performance liquid chromatography. Journal of chromatography, 1983, May-13, Volume: 274 Topics: Aminopyrine; Ampyrone; Animals; Biotransformation; Chromatography, High Pressure Liquid; Dipyrone; Hydroxylation; Methylation; Microsomes, Liver; Pyrazolones; Rats	1983
Thin-layer chromatographic determination of major metamizole metabolites in serum and urine. Journal of chromatography, 1983, May-13, Volume: 274 Topics: Adolescent; Aminopyrine; Ampyrone; Chromatography, Thin Layer; Dipyrone; Female; Half-Life; Humans; Kinetics; Pyrazolones	1983
Mutagenicity of N-nitroso compounds formed by the reaction of sulpyrine with nitrite; effects of cysteine and its derivatives. IARC scientific publications, 1982, Issue:41 Topics: Aminopyrine; Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cysteine; Dipyrone; Glutathione; Male; Mutagens; Nitrites; Nitrosamines; Rats; Rats, Inbred Strains; Sulfhydryl Compounds	1982
[Quantitative thin-layer chromatographic estimation of aminophenazone (I.N.N.), 4-methylaminophenazone and 4-aminophenazone in plasma (author's transl)]. Die Pharmazie, 1981, Volume: 36, Issue:8 Topics: Aminopyrine; Ampyrone; Antipyrine; Chromatography, Thin Layer; Dipyrone; Humans; Pyrazolones; Time Factors	1981
Determination of antipyrine metabolites in human plasma by solid-phase extraction and micellar liquid chromatography. The Analyst, 1995, Volume: 120, Issue:6 Topics: Aminopyrine; Ampyrone; Antipyrine; Chromatography, Liquid; Dipyrone; Humans; Micelles; Pyrazolones; Reproducibility of Results	1995
Dipyrone metabolism in liver disease. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2 Topics: Acetylation; Administration, Oral; Adult; Aged; Aged, 80 and over; Ampyrone; Case-Control Studies; Dipyrone; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged	1995
The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction. European journal of clinical pharmacology, 1993, Volume: 45, Issue:5 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Ampyrone; Critical Care; Dipyrone; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pyrazolones; Shock, Septic	1993
Validity of saliva samples for the estimation of dipyrone metabolites pharmacokinetics. Arzneimittel-Forschung, 1993, Volume: 43, Issue:11 Topics: Acetylation; Adult; Aminopyrine; Ampyrone; Dipyrone; Female; Half-Life; Humans; Male; Phenotype; Pyrazolones; Saliva	1993
High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes. Pharmaceutical research, 1996, Volume: 13, Issue:8 Topics: Aminopyrine; Ampyrone; Chromatography, High Pressure Liquid; Dipyrone; Humans; Microsomes, Liver; Pyrazolones; Spectrophotometry, Ultraviolet	1996
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test. Liver, 2002, Volume: 22, Issue:6 Topics: Aged; Aminopyrine; Ampyrone; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dipyrone; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Lymphocyte Activation; Male; Pyrazolones	2002
Evidence of the effect of dipyrone on the central nervous system as a determinant of delayed gastric emptying observed in rats after its administration. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2003, Volume: 36, Issue:10 Topics: Ampyrone; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Dipyrone; Dose-Response Relationship, Drug; Gastric Emptying; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Time Factors; Vagotomy; Vagus Nerve	2003
Inhibition of cyclooxygenases by dipyrone. British journal of pharmacology, 2007, Volume: 151, Issue:4 Topics: Ampyrone; Animals; Cyclooxygenase Inhibitors; Dipyrone; Heme; Hydrogen Peroxide; Iron; Male; Rats; Rats, Sprague-Dawley	2007
Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:7 Topics: Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Gastric Emptying; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Time Factors; Vagus Nerve	2007
Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products. Water research, 2008, Volume: 42, Issue:10-11 Topics: Aminopyrine; Ampyrone; Animals; Daphnia; Dipyrone; Humans; Kinetics; Mass Spectrometry; Molecular Weight; Photolysis; Solutions; Time Factors; Toxicity Tests; Water; Water Pollutants, Chemical	2008
Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-sensitive afferent pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2009, Volume: 42, Issue:11 Topics: Afferent Pathways; Ampyrone; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Capsaicin; Dipyrone; Dose-Response Relationship, Drug; Gastric Emptying; Male; Rats; Rats, Wistar	2009
High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis, 2012, Volume: 71 Topics: Aminopyrine; Ampyrone; Animals; Calibration; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dipyrone; Drug Interactions; Male; Morphine; Rats; Rats, Wistar; Solid Phase Extraction	2012
CREBH determines the severity of sulpyrine-induced fatal shock. PloS one, 2013, Volume: 8, Issue:2 Topics: Ampyrone; Animals; Aryl Hydrocarbon Hydroxylases; Cyclic AMP Response Element-Binding Protein; Cytochrome P-450 CYP2B1; Cytochrome P450 Family 2; Dipyrone; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Liver; Male; Mice; Mice, Knockout; Promoter Regions, Genetic; RNA Interference; Severity of Illness Index; Shock; Steroid Hydroxylases; Transcriptional Activation	2013
Evidence for the involvement of peripheral β-adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:9 Topics: Adrenergic Antagonists; Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Dipyrone; Gastric Emptying; Infusions, Intraventricular; Male; Phenolsulfonphthalein; Prazosin; Propranolol; Rats, Wistar; Receptors, Adrenergic, beta; Yohimbine	2013
Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. British journal of pharmacology, 2014, Volume: 171, Issue:15 Topics: Ampyrone; Animals; Antipyretics; Body Temperature; Dinoprostone; Dipyrone; Fever; Hypothalamus; Hypothermia; Indomethacin; Lipopolysaccharides; Male; Prodrugs; Rats, Wistar; Scorpion Venoms	2014
Effect of selective β-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2016, Volume: 49, Issue:3 Topics: Adrenergic beta-Antagonists; Ampyrone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Atenolol; Butoxamine; Dipyrone; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Ganglionectomy; Gastric Emptying; Male; Models, Animal; Propanolamines; Rats, Wistar; Receptors, Adrenergic, beta; Sympathetic Nervous System	2016
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Scientific reports, 2016, Mar-31, Volume: 6 Topics: Adult; Aged; Aminopyrine; Ampyrone; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Basophil Degranulation Test; Basophils; Biotransformation; Case-Control Studies; Dipyrone; Female; Humans; Male; Middle Aged; Pilot Projects; Primary Cell Culture	2016
Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. Journal of veterinary pharmacology and therapeutics, 2016, Volume: 39, Issue:6 Topics: Ampyrone; Animals; Area Under Curve; Dipyrone; Half-Life; Male; Molecular Structure; Swine	2016
Pharmacokinetic profiles of metamizole (dipyrone) active metabolites in goats and its residues in milk. Journal of veterinary pharmacology and therapeutics, 2018, Volume: 41, Issue:5 Topics: Ampyrone; Analgesics; Animals; Antipyrine; Dipyrone; Drug Residues; Female; Goats; Injections, Intramuscular; Injections, Intravenous; Milk	2018
Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery. PloS one, 2022, Volume: 17, Issue:3 Topics: Ampyrone; Analgesics; Animals; Cattle; Dipyrone; Ketamine; Xylazine	2022
Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype. Bioorganic chemistry, 2022, Volume: 124 Topics: Amines; Ampyrone; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dipyrone; Edema; Humans; Inflammation; Pain	2022
Pharmacokinetic profiles of the two major active metabolites of metamizole, 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), after intravenous injection in cats. Research in veterinary science, 2023, Volume: 155 Topics: Ampyrone; Animals; Cats; Chromatography, Liquid; Dipyrone; Injections, Intravenous; Tandem Mass Spectrometry	2023
Pharmacotherapeutic monitoring of dipyrone in northeastern Brazilian donkeys (Equus asinus). Research in veterinary science, 2023, Volume: 164 Topics: Ampyrone; Animals; Brazil; Dipyrone; Equidae; Male; Tandem Mass Spectrometry	2023

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