dipyridamole and 1-methyl-3-isobutylxanthine

dipyridamole has been researched along with 1-methyl-3-isobutylxanthine in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199016 (44.44)18.7374
1990's8 (22.22)18.2507
2000's10 (27.78)29.6817
2010's2 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Bristol, JA; Cain, MH; Weishaar, RE1
Hughes, RA; Manallack, DT; Thompson, PE1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H1
Dembinska-Kiec, A; Rücker, W; Schönhöfer, PS1
Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H1
Moreno, S; Tomes, C1
Abdel-Aleem, S; Badr, M; Frangakis, C1
Hellwig, B; Joost, HG1
Ooi, SO; Wong, EH1
Barraco, RA; DeLong, RE; Phillis, JW; Washington, DO1
Ioannou, P; Talesnik, J1
Belloni, FL; Gerritsen, ME; Liang, BC1
Paes de Carvalho, R; Ventura, AL1
d'Almeida, MS; Lautt, WW; Legare, DJ1
Hertting, G; Jackisch, R; Kasakov, L; Strittmatter, H1
Anton, R; Beretz, A; Cazenave, JP1
Hidaka, H; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, S; Yamamoto, T1
Macfarlane, DE1
Coquil, JF; Franks, DJ; Hamet, P; Tremblay, J1
Bousseau-Lafortune, S; Coquil, JF; Franks, DJ; Hamet, P; Tremblay, J1
Baukal, A; Catt, KJ; Darbon, JM; Knecht, M; Ranta, T1
Hartell, NA1
Fyhrquist, F; Saijonmaa, O1
Joksimović, J; Juranić, I; Juranić, Z; Radulović, S1
Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M1
Gorczyca, WA1
Billah, MM; Egan, RW; Myers, JG; Stamford, A; Wang, P; Wu, P1
Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD1
Baskakov, MB; D'yakova, EY; Kapilevich, LV; Kovalev, IV; Nosarev, AV1
Brocke, S; Dong, H; Epstein, PM; Osmanova, V1
Jackson, EK; Mi, Z; Ren, J; Zacharia, LC1
Jaworski, K; Kopcewicz, J; Szmidt-Jaworska, A1
Alvarez, E; Cairrão, E; Morgado, M; Santos-Silva, AJ; Verde, I1
Guillemette, C; Khan, DR; Richard, FJ; Sirard, MA1

Reviews

2 review(s) available for dipyridamole and 1-methyl-3-isobutylxanthine

ArticleYear
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity

1985
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005

Other Studies

34 other study(ies) available for dipyridamole and 1-methyl-3-isobutylxanthine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
    The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15

    Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi

2012
PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 308, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Dipyridamole; Epoprostenol; In Vitro Techniques; Indomethacin; Prostaglandins; Stimulation, Chemical; Theophylline; Time Factors

1979
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline

1992
cAMP analogs and selective inhibitors used to study low Km Mucor rouxii cAMP phosphodiesterase.
    The International journal of biochemistry, 1990, Volume: 22, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Centrifugation, Density Gradient; Cyclic AMP; Cyclic GMP; Dipyridamole; Hydrolysis; Mucor; Nicotinic Acids; Papaverine; Pyridazines; Theophylline

1990
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues.
    Life sciences, 1991, Volume: 48, Issue:18

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats

1991
Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine.
    Molecular pharmacology, 1991, Volume: 40, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Binding Sites; Colforsin; Cytochalasin B; Dipyridamole; Erythrocytes; Humans; Liver; Monosaccharide Transport Proteins; Myocardium; Rats

1991
Methylxanthine and non-xanthine phosphodiesterase inhibitors. Their effects on adenosine uptake and the low Km cyclic AMP phosphodiesterase in intact rat adipocyte.
    Biochemical pharmacology, 1985, Aug-15, Volume: 34, Issue:16

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adipose Tissue; Animals; Dipyridamole; Guanosine Triphosphate; In Vitro Techniques; Insulin; Kinetics; Lipolysis; Male; Papaverine; Rats; Rats, Inbred Strains; Xanthines

1985
Behavioral characteristics of centrally administered adenosine analogs.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Caffeine; Dilazep; Dipyridamole; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Motor Activity

1986
Platelet antiaggregatory substances inhibit arachidonic acid induced coronary constriction.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Cardiovascular Agents; Coronary Circulation; Dipyridamole; Epoprostenol; Guinea Pigs; Heart; Hydralazine; Iloprost; In Vitro Techniques; Male; Nifedipine; Perfusion; Platelet Aggregation; Rats; Rats, Inbred Strains; Vasoconstriction

1986
Effects of alkylxanthines and calcium antagonists on adenosine uptake by cultured rabbit coronary microvascular endothelium.
    Pharmacology, 1987, Volume: 35, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Dipyridamole; Endothelium; Ethanol; Isoproterenol; Male; Microcirculation; Rabbits; Theophylline; Trifluoperazine; Xanthines

1987
Development of adenosine-dependent cyclic AMP accumulation in the avian optic tectum.
    Brain research, 1987, Volume: 432, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Animals; Chick Embryo; Cyclic AMP; Dipyridamole; Proteins; Superior Colliculi

1987
Adenosine as putative regulator of hepatic arterial flow (the buffer response).
    The American journal of physiology, 1985, Volume: 248, Issue:3 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Blood Pressure; Cats; Dipyridamole; Hepatic Artery; Liver Circulation; Portal System; Rheology; Time Factors; Vasodilation

1985
Endogenous adenosine as a modulator of hippocampal acetylcholine release.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Caudate Nucleus; Dipyridamole; Electric Stimulation; Hippocampus; In Vitro Techniques; Pyrrolidinones; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline

1984
Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: structure-activity relationships.
    Agents and actions, 1982, Volume: 12, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Blood Platelets; Collagen; Dipyridamole; Flavonoids; Humans; In Vitro Techniques; Platelet Aggregation; Quercetin; Serotonin; Structure-Activity Relationship; Thrombin

1982
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
    The Journal of biological chemistry, 1983, Dec-10, Volume: 258, Issue:23

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Dipyridamole; Hydrolysis; Kinetics; Liver; Papaverine; Quinolines; Quinolones; Theophylline

1983
Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets.
    The Journal of biological chemistry, 1984, Jan-25, Volume: 259, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Dipyridamole; Humans; Hydrogen-Ion Concentration; Hydrolysis; Methionine; Mopidamol; Papaverine; Protein Methyltransferases; Protein O-Methyltransferase; S-Adenosylmethionine

1984
Rapid activation of cAMP phosphodiesterase in rat platelets.
    Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1983, Volume: 61, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Animals; Blood Platelets; Calcimycin; Calcium; Dipyridamole; Enzyme Activation; Epoprostenol; Indomethacin; Papaverine; Prostaglandins E; Protein Kinases; Rats

1983
Cyclic GMP binding and phosphodiesterase: implication for platelet function.
    Advances in cyclic nucleotide and protein phosphorylation research, 1984, Volume: 16

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Diphosphate; Blood Platelets; Carrier Proteins; Cyclic GMP; Dipyridamole; Humans; Intracellular Signaling Peptides and Proteins; Nitroprusside; Platelet Aggregation; Receptors, Cyclic AMP

1984
Inhibitory actions of adenosine on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells.
    Biology of reproduction, 1984, Volume: 30, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dipyridamole; Diterpenes; Female; Follicle Stimulating Hormone; Granulosa Cells; Rats; Receptors, Cell Surface; Receptors, LH

1984
Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, May-01, Volume: 16, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cerebellum; Cyclic GMP; Dipyridamole; Long-Term Potentiation; Male; Phosphodiesterase Inhibitors; Purinones; Purkinje Cells; Rats; Rats, Wistar; Synaptic Transmission

1996
Upregulation of angiotensin converting enzyme by atrial natriuretic peptide and cyclic GMP in human endothelial cells.
    Cardiovascular research, 1998, Volume: 40, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Peptidyl-Dipeptidase A; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Purinones; Stimulation, Chemical; Thionucleotides; Umbilical Veins; Vasodilator Agents

1998
The mechanism of 8-Cl-cAMP action.
    Journal of experimental & clinical cancer research : CR, 1998, Volume: 17, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Blood; Cell Division; Cell Survival; Culture Media; Dipyridamole; Enzyme Inhibitors; HeLa Cells; Humans; K562 Cells; Kinetics; Melanoma, Experimental; Mice; Ribavirin; Tumor Cells, Cultured

1998
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
    Multiple sclerosis (Houndmills, Basingstoke, England), 1999, Volume: 5, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines

1999
Use of nucleoside alpha-phosphorothioates in studies of photoreceptor guanylyl cyclase: purification of guanylyl cyclase activating proteins.
    Methods in enzymology, 2000, Volume: 315

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Binding Proteins; Cattle; Cell Membrane; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dipyridamole; Guanosine 5'-O-(3-Thiotriphosphate); Guanylate Cyclase; Guanylate Cyclase-Activating Proteins; Kinetics; Radioisotope Dilution Technique; Rod Cell Outer Segment; Sulfur Radioisotopes; Thionucleotides

2000
Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases.
    Life sciences, 2001, Mar-16, Volume: 68, Issue:17

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Chromatography; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Dogs; Humans; Isoenzymes; Kinetics; Male; Muscle, Smooth; Penis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Purinones; Rabbits; Sildenafil Citrate; Species Specificity; Sulfones

2001
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
    European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents

2001
Role of cyclic nucleotides in regulation of pulmonary artery tone in rabbits.
    Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dipyridamole; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pulmonary Artery; Rabbits; Signal Transduction; Sympathomimetics; Theophylline; Vasodilator Agents

2003
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.
    Biochemical and biophysical research communications, 2006, Jun-30, Volume: 345, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chemotaxis; Colforsin; Concanavalin A; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipyridamole; Inflammation; Lymphocyte Activation; Mice; Phosphodiesterase Inhibitors; RNA, Messenger; Signal Transduction; Spleen; Time Factors

2006
Characterization of renal ecto-phosphodiesterase.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Dipyridamole; Kidney; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats

2007
Involvement of cyclic GMP in phytochrome-controlled flowering of Pharbitis nil.
    Journal of plant physiology, 2008, May-26, Volume: 165, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Cotyledon; Cyclic GMP; Dipyridamole; Flowers; Ipomoea nil; Light; Nitroprusside; Photoperiod; Phytochrome

2008
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
    European journal of pharmacology, 2008, Mar-17, Volume: 582, Issue:1-3

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Female; Guanylate Cyclase; Histamine; Humans; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthyridines; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Serotonin; Umbilical Arteries; Vasodilator Agents

2008
Transcriptomic analysis of cyclic AMP response in bovine cumulus cells.
    Physiological genomics, 2015, Volume: 47, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cattle; Cells, Cultured; Colforsin; Cumulus Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipyridamole; Female; Gene Expression Regulation; In Vitro Oocyte Maturation Techniques; Reproducibility of Results; Signal Transduction

2015