Page last updated: 2024-08-26

diphyllin and lignans

diphyllin has been researched along with lignans in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.13)	18.7374
1990's	1 (3.13)	18.2507
2000's	5 (15.63)	29.6817
2010's	18 (56.25)	24.3611
2020's	7 (21.88)	2.80

Authors

Authors	Studies
Annapoorani, KS; Damodaran, C; Sekharan, PC	1
Asano, J; Chiba, K; Tada, M; Yoshii, T	1
Chung, MI; Day, SH; Ko, HH; Lee, JC; Lin, CN; Lin, YC; Tsai, ML; Tsao, LT; Wang, JP; Won, SJ	1
Das, B; Ram, TS; Ramesh, C; Ravindranath, N	1
Akhmedjanova, V; Bessonova, I; Delmas, F; Di Giorgio, C; Ollivier, E; Riad, E; Timon-David, P	1
Dziegiel, MH; Henriksen, K; Karsdal, MA; Neutzsky-Wulff, AV; Sørensen, MG	1
Akhmedjanova, V; Balansard, G; Barthomeuf, C; Beliveau, R; Debiton, E; Grassi, J; Lim, S	1
Chen, Q; Ding, J; Feng, JM; Geng, M; Gui, M; Huang, M; Li, M; Li, YX; Liu, CH; Shi, DK; Sun, QM; Zhang, J; Zhao, Y	1
Hour, MJ; Kuo, CS; Kuo, YH; Leung, YM; Lin, SY; Tsou, YH; Wu, PY	1
Chen, M; Guo, H; Huang, S; Liu, P; Shen, W; Shen, Y; Zhang, L; Zou, X	1
Ding, N; Li, M; Li, YX; Shi, DK; Zhang, W	1
Ni, C; Zhang, Y; Zhao, Y; Zhu, L	1
Chen, HW; Cheng, JX; King, K; Liu, MT; Liu, YT; Peng, JY; Schooley, RT; Shresta, S; Wang, CH; Zhang, XQ	1
Chai, HB; Deng, Y; Fuchs, JR; Gallucci, JC; Kanagasabai, R; Kinghorn, AD; Lantvit, DD; Ninh, TN; Ren, Y; Soejarto, DD; Swanson, SM; Yalowich, JC; Yu, J	1
Das, S; Hamide, A; Mohanty, MK; Muthusamy, R	1
Li, Y; Lv, JJ; Wang, D; Xu, M; Yang, CR; Yu, S; Zhang, YJ; Zhao, JQ	1
Kant, R; Narender, T; Naresh, G	1
Cuong, NM; Fong, HHS; Guan, YF; Li, WF; Liu, KL; Nguyen, VH; Rong, L; Rumschlag-Booms, E; Soejarto, DD; Wang, DY; Zhang, HJ	1
Chang, WS; Chen, HW; Chen, YT; Chueh, LL; Fang, ZS; Hohdatsu, T; Hu, CJ; Takano, T; Tsai, HH; Wang, WL	1
Chen, H; Gao, Y; Li, X; Liu, P; Shen, W; Shen, X; Zhang, T; Zhang, Y	1
Burdette, JE; Chai, HB; Cole, MS; Fuchs, JR; Herrera, D; Huntsman, AC; Kanagasabai, R; Karmahapatra, S; Kinghorn, AD; Patel, PA; Ren, Y; Woodard, JL; Yalowich, JC; Young, AN	1
Anantpadma, M; Baker, L; Davey, R; Davisson, VJ; Lindstrom, A; Raghavendra, NM	1
Chang, WS; Chen, HW; Chen, YT; Fang, ZS; Hu, CJ	1
Cai, R; Shen, W; Zhao, Y; Zhu, L	1
Chavez, MP; Diaz-Griffero, F; Liu, S; Martinez-Lopez, A; Persaud, M; Rong, L; Sarafianos, SG; Wang, TT; Zhang, H	1
Cui, Q; Du, R; Liu, M; Rong, L	1
Kamalanathan, C; Rajasekharan, SK; Raji, A; Ramaraj, E; Sethupathy, S; Thamburaj, S	1
Chen, H; Shen, W; Wu, M; Zhang, T; Zhao, Y; Zhu, L	1
Nekrakalaya, B; Ramaiah, CK	1
Bartáček, J; Bhosale, DS; Dufková, L; Eyer, L; Fojtíková, M; Haviernik, J; Huvarová, I; Miller, AD; Růžek, D; Salát, J; Sedlák, M; Štefánik, M; Straková, P; Svoboda, J	1
Anantpadma, M; Davey, R; Davisson, VJ; Keiser, P; Lindstrom, AR; Plescia, CB; Quintero, MV; Stahelin, RV	1
Bao, X; Cai, R; Li, Y; Wei, C; Zhao, Y; Zhu, L	1

Reviews

3 review(s) available for diphyllin and lignans

Article	Year
Fatal Cleistanthus collinus toxicity: a case report and review of literature. Journal of forensic sciences, 2014, Volume: 59, Issue:5 Topics: Acidosis; Adult; Benzodioxoles; Euphorbiaceae; Female; Glycosides; Humans; Lignans; Naphthalenes; Plant Leaves; Suicide	2014
Lignans and Their Derivatives from Plants as Antivirals. Molecules (Basel, Switzerland), 2020, Jan-01, Volume: 25, Issue:1 Topics: Antiviral Agents; Benzodioxoles; Biological Products; Biphenyl Compounds; Drug Development; Furans; Lignans; Masoprocol; Plants; Podophyllotoxin	2020
Antiviral, Anticancer and Hypotensive Potential of Diphyllin Glycosides and their Mechanisms of Action. Mini reviews in medicinal chemistry, 2022, Volume: 22, Issue:13 Topics: Antineoplastic Agents; Antiviral Agents; Benzodioxoles; Glycosides; Lignans	2022

Other Studies

29 other study(ies) available for diphyllin and lignans

Article	Year
Spectrofluorodensitometric determination of diphyllin, a cystostatic lignan isolated from Cleistanthus collinus. Die Pharmazie, 1984, Volume: 39, Issue:10 Topics: Benzodioxoles; Chromatography, Thin Layer; Densitometry; Dioxolanes; Dioxoles; Growth Inhibitors; Lignans; Plants, Toxic; Spectrometry, Fluorescence	1984
Antiviral activity of lignans and their glycosides from Justicia procumbens. Phytochemistry, 1996, Volume: 42, Issue:3 Topics: Animals; Antiviral Agents; Benzodioxoles; Cell Line; Cell Survival; China; Dioxolanes; Glycosides; Lignans; Lung; Molecular Structure; Plants, Medicinal; Rabbits; Spectrometry, Mass, Fast Atom Bombardment; Vesicular stomatitis Indiana virus	1996
Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. Journal of natural products, 2002, Volume: 65, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Line, Transformed; Dioxolanes; Drug Screening Assays, Antitumor; Glycosides; Inhibitory Concentration 50; Lignans; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred Strains; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Spectrophotometry, Ultraviolet; Taiwan; Tumor Necrosis Factor-alpha	2002
Arylnaphthalide lignans from Cleistanthus collinus. Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:11 Topics: Acetylation; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Line, Tumor; Chromatography, Thin Layer; Dioxolanes; Euphorbiaceae; Humans; Lignans; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet	2003
In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum. Planta medica, 2005, Volume: 71, Issue:4 Topics: Animals; Antiprotozoal Agents; Benzodioxoles; Cell Cycle; Dioxolanes; Leishmania; Leishmaniasis; Lignans; Macrophages; Parasitic Sensitivity Tests; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rutaceae	2005
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007, Volume: 22, Issue:10 Topics: Acids; Adrenal Medulla; Animals; Benzodioxoles; Biological Transport; Bone Resorption; Cattle; Cell Survival; Cells, Cultured; Dioxolanes; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Lignans; Molecular Structure; Osteoclasts; Vacuolar Proton-Translocating ATPases	2007
Reversal of P-glycoprotein-mediated drug efflux by eudesmin from Haplophyllum perforatum and cytotoxicity pattern versus diphyllin, podophyllotoxin and etoposide. Planta medica, 2007, Volume: 73, Issue:15 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Cell Line, Tumor; Dioxolanes; Drug Resistance, Neoplasm; Etoposide; Furans; Humans; Lignans; Phytotherapy; Plant Extracts; Plant Leaves; Plant Roots; Podophyllotoxin; Rutaceae	2007
D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting topoisomerase IIα. Investigational new drugs, 2011, Volume: 29, Issue:5 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzodioxoles; Biocatalysis; Cell Line, Tumor; Dioxolanes; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Female; Glucosides; Glycosylation; Humans; Hydrolysis; Lignans; Mice; Mice, Inbred BALB C; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays	2011
Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-15, Volume: 18, Issue:1 Topics: Animals; Benzodioxoles; Cell Line, Tumor; Cupressaceae; Dioxolanes; Lignans; Mice; Neuroblastoma; Plant Extracts; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2010
Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma. European journal of pharmacology, 2011, Sep-30, Volume: 667, Issue:1-3 Topics: Adenocarcinoma; Animals; Apoptosis; Benzodioxoles; Cell Line, Tumor; Cell Proliferation; Dioxolanes; Enzyme Inhibitors; Extracellular Space; Humans; Hydrogen-Ion Concentration; Intracellular Space; Lignans; Low Density Lipoprotein Receptor-Related Protein-6; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Stomach Neoplasms; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays	2011
Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors. European journal of medicinal chemistry, 2012, Volume: 47, Issue:1 Topics: Apoptosis; Benzodioxoles; Cell Cycle Checkpoints; Cell Line, Tumor; Dioxolanes; DNA Fragmentation; DNA Topoisomerases, Type II; Drug Design; Drug Resistance, Multiple; Glycosylation; Humans; Lignans; Structure-Activity Relationship; Topoisomerase II Inhibitors	2012
Synthesis and bioevaluation of diphyllin glycosides as novel anticancer agents. Archiv der Pharmazie, 2012, Volume: 345, Issue:8 Topics: Animals; Antineoplastic Agents; Benzodioxoles; Brain; Cell Line, Tumor; Dioxolanes; Drug Screening Assays, Antitumor; Glycosides; Humans; Inhibitory Concentration 50; Lignans; Molecular Structure; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin	2012
Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral research, 2013, Volume: 99, Issue:3 Topics: Amantadine; Animals; Antiviral Agents; Benzodioxoles; Drug Therapy, Combination; Drugs, Chinese Herbal; Endosomes; Enzyme Inhibitors; Humans; Influenza, Human; Lignans; Magnoliopsida; Membrane Fusion; Orthomyxoviridae; Oseltamivir; Vacuolar Proton-Translocating ATPases; Virus Replication	2013
Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei. Journal of natural products, 2014, Jun-27, Volume: 77, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Benzodioxoles; Caspase 3; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Glycosides; HT29 Cells; Humans; Lactones; Lignans; Mice; Molecular Structure; Naphthalenes; Nuclear Magnetic Resonance, Biomolecular; Phyllanthus; Vietnam	2014
New cytotoxic lignan glycosides from Phyllanthus glaucus. Natural product research, 2016, Volume: 30, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disaccharides; Glycosides; Humans; Lignans; Magnetic Resonance Spectroscopy; Monoterpenes; Phenols; Phyllanthus; Plant Extracts; Spectrometry, Mass, Electrospray Ionization	2016
Silver(I)-Catalyzed Regioselective Construction of Highly Substituted α-Naphthols and Its Application toward Expeditious Synthesis of Lignan Natural Products. Organic letters, 2015, Jul-17, Volume: 17, Issue:14 Topics: Alkynes; Antineoplastic Agents; Benzodioxoles; Biological Products; Catalysis; Dioxolanes; Lignans; Molecular Structure; Naphthalenes; Naphthols; Silver; Stereoisomerism	2015
Anti-HIV diphyllin glycosides from Justicia gendarussa. Phytochemistry, 2017, Volume: 136 Topics: Anti-HIV Agents; Benzodioxoles; Drugs, Chinese Herbal; Glycosides; HIV-1; Inhibitory Concentration 50; Justicia; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular	2017
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Scientific reports, 2017, 10-12, Volume: 7, Issue:1 Topics: Animals; Antiviral Agents; Benzodioxoles; Cats; Cell Line; Coronavirus, Feline; Disease Models, Animal; Endosomes; Enzyme Inhibitors; Feline Infectious Peritonitis; Host-Pathogen Interactions; Lignans; Nanoparticles; Polyethylene Glycols; Vacuolar Proton-Translocating ATPases	2017
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells. Oncology reports, 2018, Volume: 39, Issue:3 Topics: Apoptosis; Benzodioxoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Esophageal Neoplasms; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lignans; Mechanistic Target of Rapamycin Complex 1; Signal Transduction; Vacuolar Proton-Translocating ATPases; Vascular Endothelial Growth Factor A	2018
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones. Bioorganic & medicinal chemistry, 2018, 05-15, Volume: 26, Issue:9 Topics: Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; Etoposide; Glycosides; Humans; Lactones; Lignans; Molecular Structure; Naphthalenes; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors	2018
Phenotypic Prioritization of Diphyllin Derivatives That Block Filoviral Cell Entry by Vacuolar (H ChemMedChem, 2018, 12-20, Volume: 13, Issue:24 Topics: Antiviral Agents; Benzodioxoles; Cell Survival; Ebolavirus; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Lignans; Structure-Activity Relationship; Vacuolar Proton-Translocating ATPases; Virus Internalization	2018
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection. International journal of nanomedicine, 2018, Volume: 13 Topics: Animals; Antiviral Agents; Benzodioxoles; Cell Line; Dogs; Drug Liberation; Enzyme Inhibitors; Humans; Influenza, Human; Inhibitory Concentration 50; Kinetics; Lignans; Macrolides; Mice; Nanoparticles; Orthomyxoviridae; Orthomyxoviridae Infections; Vacuolar Proton-Translocating ATPases; Viral Proteins; Virus Replication	2018
Synthesis, cytotoxicity and anti-invasion activity of three natural diphyllin L-arabinopyranosides. Fitoterapia, 2019, Volume: 137 Topics: Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glycosides; Humans; Lignans; Molecular Structure	2019
Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus. EBioMedicine, 2019, Volume: 47 Topics: Animals; Antiviral Agents; Benzodioxoles; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Endosomes; Flavivirus; Glycosylation; Humans; Lignans; Mice; Mice, Knockout; Microbial Sensitivity Tests; Molecular Structure; Molecular Weight; Receptor, Interferon alpha-beta; Vero Cells; Zika Virus; Zika Virus Infection	2019
Antibacterial and antibiofilm activities of diphyllin against fish pathogens. Microbial pathogenesis, 2020, Volume: 145 Topics: Animals; Anti-Bacterial Agents; Benzodioxoles; Biofilms; Lignans; Microbial Sensitivity Tests; Salmonella typhi	2020
Synthesis, Cytotoxicity, Anti-Migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives. Medicinal chemistry (Shariqah (United Arab Emirates)), 2022, Volume: 18, Issue:1 Topics: Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Humans; Lignans; Vacuolar Proton-Translocating ATPases	2022
Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses. Viruses, 2022, 02-09, Volume: 14, Issue:2 Topics: Animals; Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Glucosides; Lignans; Vacuolar Proton-Translocating ATPases; Virus Replication; Viruses	2022
Evaluation of Phenol-Substituted Diphyllin Derivatives as Selective Antagonists for Ebola Virus Entry. ACS infectious diseases, 2022, 05-13, Volume: 8, Issue:5 Topics: Benzodioxoles; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Lignans; Phenol; Virus Internalization	2022
2, 4, 5-Trideoxyhexopyranosides derivatives of diphyllin: Synthesis and anticancer activity. Chemical biology & drug design, 2022, Volume: 100, Issue:2 Topics: Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Drug Screening Assays, Antitumor; Lignans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Vacuolar Proton-Translocating ATPases	2022