diphenhydramine hydrochloride and piperidines

diphenhydramine hydrochloride has been researched along with piperidines in 112 studies

Research

Studies (112)

Timeframe	Studies, this research(%)	All Research%
pre-1990	70 (62.50)	18.7374
1990's	8 (7.14)	18.2507
2000's	16 (14.29)	29.6817
2010's	13 (11.61)	24.3611
2020's	5 (4.46)	2.80

Authors

Authors	Studies
Ferro, AM; Munno, R; Ravieli, E; Valentini, G; Vianelli, MT	1
Alesina, R; Caliandro, L; Cerveri, I; Scala, C	1
Gergely, I	1
Gyarmati, L; Plachy, J; Rácz, I	1
Abramova, VG; Shul'gin, AV; Votchal, OA	1
Duhault, J; Regnier, G; Tisserand, F	1
Hosokawa, T; Iwase, H; Nishimura, T; Yanaura, S	1
Nichimura, T; Sakamoto, M; Sasao, T; Yanaura, S	1
Klein, M; Musacchio, JM	1
Kamikawa, Y; Shimo, Y	1
Karttunen, P; Mykkänen, M; Ottoila, P; Silvasti, M; Tukiainen, H	1
Hänninen, U; Karttunen, P; Mykkänen, M; Silvasti, M; Tukiainen, H; Välttilä, S	1
Aasen, AJ; Schjelderup, L	1
Csürös, L	1
Kangasaho, M	1
Borzani, M; Scotti, L	1
Allegra, L; Bossi, R	1
Algate, DR; Baines, MW; Davies, JE; Karttunen, P; Lahovaara, S; Männistö, PT; Nissinen, E	1
Havas, A; Karttunen, P; Lahovaara, S; Männistö, PT	1
Salonen, RO	1
Paakkari, I; Svartström-Fraser, M	1
Ahtee, L; Etemadzadeh, E; Männistö, PT	1
Männistö, PT; Mäntylä, R; Nissinen, E; Vuorela, A	1
Männistö, PT; Mäntylä, R; Vuorela, A	1
Karttunen, P; Männistö, PT; Tukiainen, H; Uusitupa, M	1
Karttunen, P; Männistö, PT; Nissinen, E; Tukiainen, H; Uusitupa, M	1
Karttunen, P	1
Helin, M; Karttunen, P; Silvasti, M; Tukiainen, H; Uusitupa, M	1
Bandella, M; Fioretti, M; Rimoldi, R	1
Kasé, Y; Kataoka, M; Kawano, A; Okubo, H; Yuizono, T	1
Hadwiger, LA	1
Kamoshita, T; Ohashi, Y; Oida, S; Oki, E; Yoshida, A	1
Iwase, H; Nishimura, T; Sato, S; Yanaura, S	1
Gürbüz, L; Oswald, WD; Stresemann, E	1
Kimura, Y; Noguchi, Y; Oki, K	1
Fehér, I; Harsányi, K; Nagy, G; Tardos, L	1
Weilacher, JS	1
Kowa, Y	1
Kase, Y; Miyata, T; Otsu, K; Yamatsu, K; Yuizono, T	1
Hayashi, G; Kowa, Y; Kugita, H; Noguchi, Y; Nurimoto, S	1
Kase, Y; Kataoka, M; Katsuragi, T; Miyata, T; Nishi, H	1
Del Prete, D; Rinaldi, G	1
Fontaine, G; Gnamey, DK	1
Guerrin, F; Macquet, V	1
Fornaroli, E; Zacco, R	1
De Fina, V; Tellini, N	1
Hasegawa, K; Kobayashi, S; Oshima, T; Takagi, H	1
Fossati, C	1
Takagi, K; Yuizono T Kasé, Y	1
Contini, P	1
Babanassi, E; Keszler, P	1
Otsuka, M; Sakuma, M; Sasaki, Y; Sugihara, J; Watanabe, A	1
Sasaki, Y; Sugihara, Z; Tsuruoka, M; Watanabe, A	1
Schmidt, OP	1
Canti, G; Franco, P; Nicolin, A	1
Schweiger, O	1
Männistö, P; Nissinen, E	1
Korpás, J; Nosál'ová, G; Strapková, A	1
Bolser, DC; Chapman, RW; DeGennaro, FC; Hey, JA; O'Reilly, S	1
Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P	2
Bolser, DC; DeGennaro, FC; Hey, JA; McLeod, RL; O'Reilly, S	1
Dong, F; Hasegawa, S; Iijima, H; Nomura, A; Uchida, Y; Xiang, A; Zhang, MJ	1
Blin, O; Bouhours, P; Lacarelle, B; Le Moing, JP; Levron, JC; Micallef, J; Nataf, MB; Pageaux, GP	1
Bolser, DC; Hey, JA; McLeod, RL; Tulshian, DB	1
Kamei, J; Miyata, S; Morita, K; Onodera, K	1
Chen, XY; Du, ZM; Kang, Y; Zhong, DF	1
Chen, XY; Du, ZM; Huang, HH; Zhong, DF	1
KAKU, T; KASE, Y; NAGAO, K; TAKASAKI, Y; TANAKA, M; YAMAMOTO, Y	1
BINON, F; CHARLIER, R; DELTOUR, G; PROST, M	1
FUKUDA, H; FUKUSHIMA, H; MASUDA, M; ONODERA, T; OZAWA, H; UEMATSU, T	1
GROSS, A; MALLARDE, D	1
SOREL, R	1
POZZETTO, H; TRAMIER, J	1
BINON, F; CHARLIER, R; DELTOUR, G; ETZENSPERGER, P; MERCIER, J; PROST, M	1
DYRBERG, V; JOHANSEN, SH; JORGENSEN, M	1
CHAPPEL, CI; VONSEEMANN, C	1
KASE, Y; MUTO, M; YUIZONO, T	1
IMAMURA, H; TAKAGI, K; TAKAYANAGI, I	1
HERMANSEN, K; HINT, H; OPRESNIK, J; PEDERSEN, JG; RUBINSTEIN, K	1
Celly, C; Chapman, RW; Hey, JA; House, A; Liu, F; Mei, H	1
Chen, S; Kong, W; Li, W; Li, Y; Min, L; Zhong, D	1
Aliprandi, P; Bernorio, S; Carrara, M; Castelli, C; Dell'Abate, E	1
Dong, Y; Li, Y; Sun, Y; Zhang, Y; Zhong, D	1
Chen, SW; Li, Y; Maeba, I; Zhong, DF	1
Otsuka, M; Sakata, Y; Shiraishi, S; Sumikawa, T; Tanabe, E; Tokudome, Y	1
Bercovici, A; Fawzi, A; Fernandez, X; Greenlee, WJ; Ho, GD; McLeod, RL; Smith Torhan, A; Tulshian, D; Zhang, H	1
Liu, MY; Meng, Y; Ren, YL; Zhang, HQ	1
Bongianni, F; Cinelli, E; Fontana, GA; Mutolo, D; Pantaleo, T	1
Nakamura, M; Namekata, I; Sakurai, Y; Sasaki, R; Sendo, A; Takahara, A; Tanaka, H	1
Shirasaki, T; Soeda, F; Takahama, K; Yamamoto, G	2
Itoh, M; Iwabuchi, C; Kanto, H; Ohashi, N	1
Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T	1
Jeong, JJ; Kim, HS; Koo, BN; Lee, JH; Lee, JR	1
Arakawa, C; Endo, A; Fuchigami, T; Fujita, Y; Imai, Y; Ishii, W; Kohira, R; Mugishima, H	1
Hirakawa, E; Inoue, M; Shirasaki, T; Soeda, F; Takahama, K	1
Cho, HB; Kim, DH; Kim, JY; Min, SK; Moon, BK	1
Hayek, LF; Perez-Dueñas, B; Sanz-Cuesta, M; Serrano, M; Villaronga, M	1
Choi, SH; Choi, YS; Kim, H; Kim, NO; Lee, JH; Lee, JR	1
Fujiwara, K; Namekata, I; Ohtsuki, A; Oka, T; Takahara, A; Tanaka, H	1
Choi, SH; Choi, YS; Lee, B; Lee, JH; Lee, JR; Yang, SJ	1
Ghosh, K; Khawas, S; Majee, SK; Nosáľová, G; Raja, W; Ray, B; Sivová, V	1
Hamasaki, R; Honda, I; Kawahara, R; Miki, R; Misumi, S; Shirasaki, T; Soeda, F; Takahama, K	1
Allman, D; Badri, H; K Trower, M; Miller, R; Morris, J; Satia, I; Smith, J; Wood, A	1
Hayashi, M; Hirasawa-Inoue, A; Matsumoto, N; Matsumura, Y; Mizuguchi, T; Shirai, K; Sugai, K; Takase, C; Watanabe, A; Watanabe, T	1
Cui, N; Jiang, C; Johnson, CM; Wu, Y; Xing, H	1
Canning, BJ; Dicpinigaitis, PV; McGarvey, LP	1
Huang, Y; Li, Q; Liu, J; Lu, Y; Ma, L; Qin, S; Weng, N; Yang, M; Zhang, H; Zhang, X; Zhang, Z; Zheng, S; Zhou, L	1

Reviews

5 review(s) available for diphenhydramine hydrochloride and piperidines

Article	Year
Fifteen years of experience on the use of Libexin tablets. Therapia Hungarica (English edition), 1989, Volume: 37, Issue:1 Topics: Antitussive Agents; Humans; Hungary; Piperidines; Respiratory Tract Diseases; Tablets	1989
ANTITUSSIVE DRUGS. Progress in medicinal chemistry, 1963, Volume: 19 Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Pharmacology; Phenothiazines; Phenylacetates; Piperazines; Piperidines; Research; Thiophenes	1963
Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents. Drugs under experimental and clinical research, 2004, Volume: 30, Issue:4 Topics: Adolescent; Adult; Aged; Antitussive Agents; Bronchitis; Chronic Disease; Clinical Trials as Topic; Codeine; Cough; Female; Humans; Lung Diseases; Male; Middle Aged; Patient Selection; Piperidines; Propylene Glycols; Stereoisomerism; Treatment Outcome	2004
[Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:4 Topics: Animals; Antitussive Agents; Brain; Cerebral Infarction; Dextromethorphan; Drug Design; Dysuria; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Molecular Targeted Therapy; Piperidines; Rats; Serotonin; Urinary Bladder, Overactive	2011
P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough. Lung, 2020, Volume: 198, Issue:4 Topics: Ageusia; Antitussive Agents; Chronic Disease; Clinical Trials as Topic; Cough; Humans; Imidazoles; Piperidines; Purinergic P2X Receptor Antagonists; Pyridines; Pyrimidines; Receptors, Purinergic P2X3; Sulfonamides	2020

Trials

17 trial(s) available for diphenhydramine hydrochloride and piperidines

Article	Year
[Clinical evaluation of a synthetic cough sedative: guaiapate]. La Clinica terapeutica, 1978, Aug-31, Volume: 86, Issue:4 Topics: Administration, Oral; Antitussive Agents; Benzhydryl Compounds; Clinical Trials as Topic; Cough; Double-Blind Method; Drug Evaluation; Ethers; Humans; Piperidines; Propanolamines; Time Factors	1978
[Clinical use of the combination prenoxidiazine-S-carboxy-methyl-cysteine]. Giornale di clinica medica, 1979, Volume: 60, Issue:2 Topics: Adult; Aged; Antitussive Agents; Bromhexine; Bronchial Diseases; Bronchial Spasm; Carbocysteine; Clinical Trials as Topic; Cough; Cysteine; Drug Combinations; Drug Evaluation; Female; Humans; Male; Middle Aged; Oxadiazoles; Piperidines	1979
[Clinical evaluation of the antitussive action of libexin and baltix]. Terapevticheskii arkhiv, 1975, Volume: 47, Issue:3 Topics: Acute Disease; Adult; Aged; Antitussive Agents; Benzhydryl Compounds; Chronic Disease; Clinical Trials as Topic; Codeine; Cough; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Oxadiazoles; Piperidines; Propanolamines	1975
The single dose and steady-state pharmacokinetics of a vadocaine tablet in healthy human volunteers. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:11 Topics: Adult; Antitussive Agents; Humans; Male; Piperidines; Random Allocation; Solutions; Tablets	1989
[Cloperastine fendizoate in the treatment of cough-producing diseases in pediatrics]. Minerva pediatrica, 1988, Volume: 40, Issue:5 Topics: Acute Disease; Antitussive Agents; Bronchitis; Child; Child, Preschool; Clinical Trials as Topic; Cough; Double-Blind Method; Female; Humans; Male; Piperidines; Random Allocation	1988
Clinical trials with the new antitussive levodropropizine in adult bronchitic patients. Arzneimittel-Forschung, 1988, Volume: 38, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitussive Agents; Benzophenones; Bronchitis; Clinical Trials as Topic; Cough; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Propylene Glycols	1988
First human studies on the safety and antitussive activity of vadocaine hydrochloride. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adult; Antitussive Agents; Blood Chemical Analysis; Blood Pressure; Cough; Drug Evaluation; Electrocardiography; Heart Rate; Humans; Male; Piperidines	1988
Assessment of the antitussive effect of vadocaine hydrochloride using citric acid-induced cough in healthy volunteers. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adult; Antitussive Agents; Citrates; Citric Acid; Cough; Double-Blind Method; Humans; Male; Piperidines	1988
[Sputum viscosimetric studies of an antitussive dihydrobenzoxazine derivative]. Arzneimittel-Forschung, 1974, Volume: 24, Issue:12 Topics: Analysis of Variance; Antitussive Agents; Bronchitis; Chronic Disease; Cough; Densitometry; Humans; Oxazines; Piperidines; Placebos; Sputum; Viscosity	1974
[Clinical controlled trials of a new synthetic drug with antitussive action]. La Clinica terapeutica, 1968, Jul-31, Volume: 46, Issue:2 Topics: Aged; Antitussive Agents; Cough; Female; Humans; Male; Piperidines; Placebos; Respiratory Tract Diseases	1968
Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. British journal of clinical pharmacology, 2001, Volume: 51, Issue:2 Topics: Adult; Antitussive Agents; Cytochrome P-450 CYP2D6; Dextromethorphan; Humans; Liver; Liver Diseases; Male; Middle Aged; Oxidation-Reduction; Piperidines; Thiazoles	2001
[Enantioselective pharmacokinetics of benproperine in healthy volunteers]. Yao xue xue bao = Acta pharmaceutica Sinica, 2000, Volume: 35, Issue:12 Topics: Administration, Oral; Adult; Antitussive Agents; Area Under Curve; Benzhydryl Compounds; Humans; Male; Piperidines; Stereoisomerism	2000
Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia. British journal of anaesthesia, 2011, Volume: 106, Issue:3 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Antitussive Agents; Cough; Device Removal; Female; Humans; Infusions, Intravenous; Intubation, Intratracheal; Lidocaine; Middle Aged; Piperidines; Postoperative Complications; Remifentanil; Thyroidectomy; Treatment Outcome; Young Adult	2011
Limited maximal flow rate of target-controlled remifentanil infusion and induced cough. Anaesthesia, 2012, Volume: 67, Issue:2 Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Antitussive Agents; Cough; Drug Delivery Systems; Female; Humans; Infusion Pumps; Infusions, Intravenous; Male; Middle Aged; Pain, Postoperative; Piperidines; Remifentanil; Young Adult	2012
Comparison of the antitussive effect of remifentanil during recovery from propofol and sevoflurane anaesthesia. Anaesthesia, 2012, Volume: 67, Issue:7 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Antitussive Agents; Blood Pressure; Cough; Device Removal; Female; Heart Rate; Humans; Intubation, Intratracheal; Methyl Ethers; Middle Aged; Piperidines; Postoperative Complications; Propofol; Prospective Studies; Remifentanil; Sevoflurane; Single-Blind Method; Thyroidectomy; Young Adult	2012
Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane. Journal of clinical anesthesia, 2014, Volume: 26, Issue:6 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, General; Antitussive Agents; Cough; Desflurane; Female; Humans; Intubation, Intratracheal; Isoflurane; Methyl Ethers; Middle Aged; Piperidines; Postoperative Complications; Propofol; Prospective Studies; Remifentanil; Sevoflurane; Thyroid Neoplasms; Thyroidectomy; Young Adult	2014
The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1). Chest, 2020, Volume: 157, Issue:1 Topics: Aged; Antitussive Agents; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; Cough; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Pilot Projects; Piperidines; Quality of Life; Respiratory Function Tests; Severity of Illness Index; Surveys and Questionnaires	2020

Other Studies

90 other study(ies) available for diphenhydramine hydrochloride and piperidines

Article	Year
Libexin combinatum in the treatment of patients suffering from chronic respiratory tract diseases. Therapia Hungarica (English edition), 1978, Volume: 26, Issue:3 Topics: Adolescent; Adult; Antitussive Agents; Chronic Disease; Female; Humans; Male; Middle Aged; Oxadiazoles; Piperidines; Respiratory Tract Diseases	1978
[Libexin metabolism]. Acta pharmaceutica Hungarica, 1978, Volume: 48 Suppl Topics: Animals; Antitussive Agents; Oxadiazoles; Piperidines; Rats	1978
[Pharmacological studies of a new antitussive, 1-phenethyl-4-hydroxy-salicylamido-4-methyl-piperidine-hydrochloride (S 1592) (author's transl)]. Arzneimittel-Forschung, 1976, Volume: 26, Issue:4 Topics: Analgesia; Anaphylaxis; Animals; Antitussive Agents; Body Temperature; Bronchi; Cats; Cough; Dogs; Gastrointestinal Motility; Guinea Pigs; Hemodynamics; Lethal Dose 50; Male; Mice; Motor Activity; Motor Skills; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Piperidines; Rats; Respiration; Salicylamides; Seizures; Sleep	1976
[Pharmacological studies on the cough reflex]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:2 Topics: Airway Resistance; Allyl Compounds; Animals; Antitussive Agents; Benzamides; Cats; Chloralose; Chlorobenzenes; Codeine; Cough; Diethylamines; Dimethylphenylpiperazinium Iodide; Dogs; Electric Stimulation; Electrodes, Implanted; Female; Histamine; Humans; Male; Methyl Ethers; Morphine; Pentobarbital; Piperidines; Pyridines; Reflex; Respiratory Tract Diseases; Thebaine; Trachea	1975
The role of bronchoconstriction in cough reflex. Japanese journal of pharmacology, 1975, Volume: 25, Issue:6 Topics: Airway Resistance; Animals; Antitussive Agents; Bronchi; Bronchial Spasm; Bronchodilator Agents; Codeine; Cough; Dogs; Ethanolamines; Female; Isoproterenol; Male; Morphine; Phenylacetates; Picolines; Piperidines; Propranolol	1975
High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3 Topics: Allosteric Regulation; Animals; Antitussive Agents; Binding Sites; Brain; Computer Simulation; Dextromethorphan; Guinea Pigs; Hydrogen-Ion Concentration; Male; Pentazocine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma	1992
Inhibitory effects of non-narcotic antitussive drugs on cholinergically and non-cholinergically mediated neurogenic contractions of guinea-pig isolated bronchial muscle. The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:4 Topics: Animals; Antitussive Agents; Bronchi; Dextromethorphan; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Noscapine; Parasympathetic Nervous System; Piperidines	1991
Steady state pharmacokinetics of the new antitussive compound vadocaine hydrochloride. Arzneimittel-Forschung, 1990, Volume: 40, Issue:4 Topics: Adult; Antitussive Agents; Biotransformation; Electrocardiography; Humans; Male; Piperidines	1990
The absolute configuration of benproperinium dihydrogen phosphate, an antitussive drug. Chirality, 1989, Volume: 1, Issue:1 Topics: Antitussive Agents; Indicators and Reagents; Molecular Conformation; Piperidines; Stereoisomerism	1989
Effects of lidocaine, codeine and vadocaine hydrochloride on platelet aggregation in human platelet-rich plasma. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adenosine Diphosphate; Alprostadil; Antitussive Agents; Bucladesine; Codeine; Female; Humans; In Vitro Techniques; Lidocaine; Male; Piperidines; Platelet Aggregation; Thromboxane B2	1988
Vadocaine hydrochloride. A novel antitussive compound. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Animals; Antitussive Agents; Humans; Piperidines	1988
Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Anesthetics, Local; Animals; Antitussive Agents; Cats; Codeine; Cornea; Dogs; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Irritants; Male; Piperidines; Reflex	1988
Studies on the nonspecific central nervous system effects of the novel antitussive compound vadocaine hydrochloride. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Analgesics; Animals; Anticonvulsants; Antitussive Agents; Barbiturates; Brain; Female; Male; Mice; Motor Activity; Piperidines; Psychomotor Performance; Rats; Rats, Inbred Strains; Reaction Time; Sleep; Time Factors	1988
Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Amino Alcohols; Animals; Antitussive Agents; Blood Pressure; Female; Guinea Pigs; Heart Rate; Hemodynamics; Lidocaine; Lung; Methacholine Compounds; Piperidines; Respiratory Function Tests	1988
Cardiovascular and ventilator effects of vadocaine hydrochloride in urethane-anaesthetized rats and guinea-pigs. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Anesthesia; Animals; Antitussive Agents; Blood Pressure; Electrocardiography; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Piperidines; Rats; Rats, Inbred Strains; Respiration; Urethane	1988
Comparative studies on the dependence liability of morphine hydrochloride, codeine phosphate and two novel antitussive compounds vadocaine hydrochloride and N-(2',4'-dimethyl-6'-methoxyphenyl)-4-(diethylamine) butanamide hydrochloride in mice. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Animals; Antitussive Agents; Behavior, Animal; Body Temperature; Body Weight; Codeine; Female; Mice; Morphine; Piperidines; Substance Withdrawal Syndrome; Substance-Related Disorders	1988
Preliminary pharmacokinetics of the new antitussive compound vadocaine hydrochloride in animals. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Administration, Oral; Animals; Antitussive Agents; Biological Availability; Dogs; Female; Half-Life; Male; Piperidines; Rabbits; Rats	1988
Tissue distribution of the novel antitussive compound vadocaine hydrochloride in white female mice studied by whole-body autoradiography. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Animals; Antitussive Agents; Autoradiography; Chromatography, Thin Layer; Female; Mice; Piperidines; Tissue Distribution	1988
Pharmacokinetics of graded single doses of the novel antitussive compound vadocaine hydrochloride in healthy male volunteers. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adult; Antitussive Agents; Half-Life; Humans; Male; Piperidines; Reference Values	1988
Assessment of the safety margin of vadocaine hydrochloride in man. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adult; Antitussive Agents; Blood Pressure; Electrocardiography; Heart Rate; Humans; Male; Piperidines	1988
[Use of an antitussive drug in pulmonary pathology]. Bollettino chimico farmaceutico, 1985, Volume: 124, Issue:2 Topics: Antitussive Agents; Codeine; Humans; Lung Diseases; Piperidines	1985
Determination of micro amounts of 3-(dithien-2-ylmethylene)-1-methylpiperidine, a non-narcotic antitussive. The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:2 Topics: Antitussive Agents; Colorimetry; Microchemistry; Piperidines	1966
Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs. Biochemical and biophysical research communications, 1972, Jan-14, Volume: 46, Issue:1 Topics: Antidepressive Agents; Antitussive Agents; Antiviral Agents; Chloroquine; Deamination; Ethylamines; Fluorenes; Histamine H1 Antagonists; Imipramine; Ketones; Lectins; Leucine; Lyases; Parasympatholytics; Phenothiazines; Phenylalanine; Piperidines; Plant Lectins; Plant Proteins; Plants, Edible; Propantheline; Quinacrine; Stimulation, Chemical; Tranquilizing Agents; Trimeprazine	1972
3,5-Propanopiperidine derivatives as potential analgesics. Chemical & pharmaceutical bulletin, 1974, Volume: 22, Issue:5 Topics: Analgesics; Animals; Antitussive Agents; Guinea Pigs; Lethal Dose 50; Male; Mice; Piperidines; Reaction Time	1974
A new method for induction of the cough reflex. Japanese journal of pharmacology, 1974, Volume: 24, Issue:3 Topics: Animals; Antitussive Agents; Chlorobenzenes; Codeine; Cough; Disease Models, Animal; Dogs; Electric Stimulation; Electrodes; Electrodes, Implanted; Guinea Pigs; Methyl Ethers; Morphine; Mucous Membrane; Piperidines; Pyridines; Reflex; Species Specificity; Thebaine; Time Factors; Trachea	1974
A colorimetric determination of 1-(2-benzylphenoxy)-2-piperidinopropane phosphate (pirexyl), and its application to biological materials. The Japanese journal of experimental medicine, 1973, Volume: 43, Issue:1 Topics: Animals; Antitussive Agents; Benzyl Compounds; Colorimetry; Dogs; Ethers; Feces; Humans; Indicators and Reagents; Piperidines	1973
Pharmacologic, clinico-pharmacologic and clinical effects of Libexin. Bollettino chimico farmaceutico, 1973, Volume: 112, Issue:10 Topics: Animals; Antitussive Agents; Codeine; Cough; Guinea Pigs; Humans; Lethal Dose 50; Mice; Oxadiazoles; Piperidines; Rabbits; Rats	1973
[Cough and its treatment with a new cough-blocking drug]. Zeitschrift fur Allgemeinmedizin, 1972, Feb-10, Volume: 48, Issue:4 Topics: Animals; Antitussive Agents; Cough; Diphenhydramine; Drug Combinations; Humans; Mice; Oxadiazoles; Piperidines	1972
[Teratological study of a non-narcotic antitussive agent, Asverin]. Bollettino chimico farmaceutico, 1972, Volume: 111, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Antitussive Agents; Female; Fetus; Gestational Age; Piperidines; Pregnancy; Pregnancy, Animal; Rats	1972
On the site of antitussive action of 1-(2-benzylphenoxy)-2-piperidinopropane phosphate (Pirexyl). Japanese journal of pharmacology, 1967, Volume: 17, Issue:4 Topics: Anesthesia, Conduction; Anesthesia, Local; Animals; Antitussive Agents; Blood Pressure; Brain Stem; Bronchi; Cats; Codeine; Cough; Decerebrate State; Depression, Chemical; Dogs; Electric Stimulation; Female; Laryngeal Nerves; Male; Mice; Muscles; Nalorphine; Piperidines; Respiratory System; Sensory Receptor Cells	1967
Pharmacological studies of 1-phenacyl-2,3-dimethyl-3-(3-hydroxyphenyl) piperidine hydrochloride (TA-306), an analgesic and antitussive agent. Japanese journal of pharmacology, 1968, Volume: 18, Issue:4 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antitussive Agents; Barbiturates; Behavior, Animal; Blood Pressure; Body Temperature; Dogs; Drug Synergism; Intestine, Small; Male; Meperidine; Mice; Morphine; Nalorphine; Piperidines; Rabbits; Rats; Respiration	1968
Antitussive activity and other related pharmacological properties of 2-allyloxy-4-chloro-N-(2-piperidinoethyl) benzamide and its congeners. Japanese journal of pharmacology, 1970, Volume: 20, Issue:1 Topics: Animals; Antitussive Agents; Benzoates; Blood Pressure; Cats; Central Nervous System; Dogs; Female; Guinea Pigs; In Vitro Techniques; Intestines; Male; Mice; Piperidines; Respiration	1970
[On a new synthetic anti-tussive agent, M.G. 5454, in ocular surgery]. Annali di ottalmologia e clinica oculistica, 1969, Volume: 95, Issue:2 Topics: Adult; Aged; Antitussive Agents; Cataract Extraction; Cough; Female; Humans; Male; Middle Aged; Piperidines; Preanesthetic Medication; Preoperative Care	1969
[Therapeutic trial with children of an antitussive active on the tussigenic center: Tussucal. 30 cases]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1969 Topics: 1-Propanol; Age Factors; Antitussive Agents; Child; Child, Preschool; Cough; Female; Humans; Infant; Male; Piperidines	1969
[Methods applied to the study of antitussive drugs. A preparation with pimetixene base]. Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1969, Volume: 14, Issue:2 Topics: Antitussive Agents; Bronchitis; Bronchoscopy; Chronic Disease; Cough; Humans; Piperidines; Tuberculosis; Xanthenes	1969
[Clinico-pharmacological considerations on antitussive preparations. Observations on a new synthetic product]. Minerva medica, 1970, May-12, Volume: 61, Issue:38 Topics: Adult; Aged; Antitussive Agents; Bronchiectasis; Bronchitis; Bronchopneumonia; Cough; Female; Humans; Hypertension, Pulmonary; Lung Neoplasms; Male; Middle Aged; Piperidines; Tracheitis	1970
[Pharmaco-toxicologic study of Pirexyl, a drug with antitussive activity]. Bollettino chimico farmaceutico, 1970, Volume: 109, Issue:8 Topics: Animals; Antitussive Agents; Dogs; Piperidines; Rabbits; Rats	1970
The pharmacology of azabicyclane, a new analgesic agent. Toxicology and applied pharmacology, 1970, Volume: 17, Issue:2 Topics: Analgesics; Animals; Antitussive Agents; Body Weight; Cardiovascular System; Constriction; Digestive System; Drug Synergism; Drug Tolerance; Humans; Hypotension; Male; Meperidine; Methods; Mice; Morphine; Nalorphine; Piperidines; Pupil; Rats; Respiration; Substance-Related Disorders; Thiopental	1970
[Clinical results obtained with a new antitussive drug: 1-(2-methoxy-phenoxy) -3,6-dioxa-8-(N-piperidyl)-octane (MG 5454)]. La Clinica terapeutica, 1967, Oct-15, Volume: 43, Issue:1 Topics: Antitussive Agents; Bronchopneumonia; Codeine; Cough; Humans; Piperidines	1967
[On the site of antitussive action of 1-[2-(alpha-(p-chlorophenyl)-benzyloxy)-ethyl]piperidine (HT-11)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1967, Volume: 87, Issue:8 Topics: Animals; Antitussive Agents; Cats; Dogs; Guinea Pigs; Injections, Intravenous; Piperidines; Rabbits	1967
Libexin in pulmonary surgery. Therapia Hungarica (English edition), 1968, Volume: 16, Issue:3 Topics: Antitussive Agents; Humans; Lung Diseases; Piperidines	1968
[1-(2,methoxy-phenoxy)-3,6-dioxa-8-(N-piperidyl)-octane]. La Clinica terapeutica, 1968, Jan-15, Volume: 44, Issue:1 Topics: Animals; Antitussive Agents; Humans; Mice; Piperidines; Rats	1968
[Studies on the metabolism of 1-methyl-3-[di(2-thienyl)-methylene]piperidine citrate. II]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1969, Volume: 89, Issue:3 Topics: Animals; Antitussive Agents; Autoradiography; Carbon Isotopes; Chromatography, Thin Layer; Citrates; In Vitro Techniques; Kidney; Liver; Lung; Male; Mice; Piperidines; Rabbits; Rats; Time Factors; Tritium	1969
[Studies on the metabolism of 1-methyl-3-(di(2-thienyl)methylene)piperidine citrate. I. Fractional determination of 1-methyl-3-(di(2-thienyl)methylene)piperidine and its N-demethylated derivative]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1969, Volume: 89, Issue:1 Topics: Animals; Antitussive Agents; Chromatography, Thin Layer; Colorimetry; Liver; Methods; Piperidines; Rats	1969
Qualitative and quantitative tests for pipazethate hydrochloride. Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:9 Topics: Antitussive Agents; Chemistry, Pharmaceutical; Piperidines; Thiazines	1965
["Bronchitis"-therapy today]. Medizinische Klinik, 1981, Jun-19, Volume: 76, Issue:13 Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Antitussive Agents; Bronchitis; Expectorants; Histamine H1 Antagonists; Humans; Ketotifen; Parasympatholytics; Physical Therapy Modalities; Piperidines; Thiophenes; Xanthines	1981
[The pharmacologic activity of 1(2-(p-chloro-alpha-phenylbenzyloxy)ethyl)piperidine (cloperastine)]. Bollettino chimico farmaceutico, 1983, Volume: 122, Issue:8 Topics: Animals; Antitussive Agents; Female; Guinea Pigs; Histamine H1 Antagonists; Male; Mice; Piperidines; Rats; Rats, Inbred Strains; Sleep	1983
The role of Libexin combination in the symptomatic treatment of different pulmonary diseases. Therapia Hungarica (English edition), 1984, Volume: 32, Issue:2 Topics: Antitussive Agents; Cough; Humans; Lung Diseases; Piperidines	1984
Determination of a novel antitussive agent 2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl)-propionaldehyde in plasma by high-performance liquid chromatography. Journal of chromatography, 1983, Nov-11, Volume: 278, Issue:1 Topics: Animals; Antitussive Agents; Chromatography, High Pressure Liquid; Piperidines; Rabbits	1983
[Studies of the antitussive effect of prenoxdiazine of experimentally induced cough]. Bratislavske lekarske listy, 1982, Volume: 78, Issue:1 Topics: Animals; Antitussive Agents; Cats; Cough; Piperidines	1982
Pharmacological studies of allergic cough in the guinea pig. European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3 Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsaicin; Chlorpheniramine; Cimetidine; Codeine; Cough; Drug Hypersensitivity; Guinea Pigs; Hexamethonium; Histamine Antagonists; Indomethacin; Injections, Subcutaneous; Ipratropium; Loratadine; Male; Ovalbumin; Piperidines; Receptors, Histamine H1; Receptors, Histamine H2	1995
Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig. The European respiratory journal, 1995, Volume: 8, Issue:7 Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Codeine; Cough; Drug Synergism; Female; Guinea Pigs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism	1995
Antitussive effect of SR 48968, a non-peptide tachykinin NK2 receptor antagonist. European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1 Topics: Animals; Antitussive Agents; Benzamides; Citrates; Citric Acid; Codeine; Cough; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Male; Naloxone; Piperidines; Receptors, Neurokinin-2	1993
Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat. British journal of pharmacology, 1997, Volume: 121, Issue:2 Topics: Animals; Antitussive Agents; Benzamides; Cats; Central Nervous System; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Piperidines	1997
Effects of airway inflammation on cough response in the guinea pig. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:5 Topics: Animals; Antitussive Agents; Benzamides; Bronchoalveolar Lavage Fluid; Capsaicin; Codeine; Cough; Dipeptides; Female; Guinea Pigs; Indoles; Inflammation; Peptides, Cyclic; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Receptors, Tachykinin; Respiratory Hypersensitivity; Respiratory Tract Diseases	1998
Antitussive action of nociceptin in the cat. European journal of pharmacology, 2001, Oct-26, Volume: 430, Issue:1 Topics: Abdominal Muscles; Animals; Antitussive Agents; Benzimidazoles; Cats; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Injections, Intravenous; Nociceptin; Opioid Peptides; Piperidines	2001
Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice. Psychopharmacology, 2003, Volume: 166, Issue:2 Topics: Animals; Antitussive Agents; Butyrophenones; Cetirizine; Codeine; Dopamine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Limbic System; Male; Mice; Mice, Inbred ICR; Piperidines; Receptors, Dopamine D1; Reward	2003
[Study on hydroxylated metabolites of benproperine in human urine]. Yao xue xue bao = Acta pharmaceutica Sinica, 2000, Volume: 35, Issue:12 Topics: Adult; Antitussive Agents; Benzhydryl Compounds; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Molecular Structure; Piperidines; Spectrometry, Mass, Electrospray Ionization	2000
3-Piperidyl-1, 1-di(2'-thienyl)-but-1-ene as a potent antitussive. Pharmaceutical bulletin, 1955, Volume: 3, Issue:5 Topics: Alkenes; Antitussive Agents; Cough; Piperidines	1955
[Pharmacological study of an antitussive agent, 1-phenethyl-4-(2-propynyl)-4-propionoxypiperidine acid fumarate]. Archives internationales de pharmacodynamie et de therapie, 1961, Dec-01, Volume: 134 Topics: Antitussive Agents; Cough; Fumarates; Humans; Piperidines; Research	1961
[Pharmacological assays of 4-phenylpiperidine derivatives]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1962, Volume: 82 Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Antipyretics; Antitussive Agents; Piperidines	1962
[Experimental study of the antitussive properties of o-benzylphenoxyl-beta-N-piperidinopropane (ASA-158-5) phosphate]. Journal de physiologie, 1963, Volume: 55 Topics: Antitubercular Agents; Antitussive Agents; Mesalamine; Phosphates; Piperidines	1963
[Study of a new antitussive agent]. Vie medicale (Paris, France : 1920), 1962, Volume: 43 Topics: Antitubercular Agents; Antitussive Agents; Humans; Phenylacetates; Piperidines	1962
Diphenylpiperidinopropanol, new therapeutic antitussive agent Lyon medical, 1963, Apr-07, Volume: 209 Topics: Antitussive Agents; Humans; Piperidines	1963
[Influence of replacement of the phenyl radical by a propargyl radical on the toxic effects of 1-phenethyl-4-phenyl-4-propionoxypiperidine]. Archives internationales de pharmacodynamie et de therapie, 1963, Apr-01, Volume: 142 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antitussive Agents; Leadership; Piperidines; Replantation	1963
THE EFFECT OF PIREXYL ON NORMAL AND DEPRESSED RESPIRATION. Acta pharmacologica et toxicologica, 1963, Volume: 20 Topics: Antitussive Agents; Carbon Dioxide; Cell Respiration; Central Nervous System; Meperidine; Nervous System; Pharmacology; Piperidines; Respiration	1963
PIPERIDINO GROUPS IN ANTITUSSIVE ACTIVITY. Journal of medicinal chemistry, 1963, Volume: 6 Topics: Anti-Allergic Agents; Antitussive Agents; Camphor; Cats; Chemistry, Pharmaceutical; Dogs; Histamine H1 Antagonists; Morpholines; Pharmacology; Phenethylamines; Phenothiazines; Piperidines; Pyrroles; Research; Sympatholytics; Toxicology	1963
[STUDIES ON APPEARANCE OF PHYSICAL DEPENDENCE OF 1-(2-ALPHA-(P-CHLOROPHENYL)BENZYLOXY-ETHYL)PIPERIDINE]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1965, Volume: 85 Topics: Antitussive Agents; Pharmacology; Piperidines; Rats; Research; Substance-Related Disorders; Toxicology	1965
[Pirexyl--a new antitussive preparation]. Ugeskrift for laeger, 1962, Feb-09, Volume: 124 Topics: Antitussive Agents; Cough; Piperidines	1962
Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs. European journal of pharmacology, 2004, Feb-06, Volume: 485, Issue:1-3 Topics: Animals; Antitussive Agents; Cough; Dogs; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1	2004
Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2 Topics: Animals; Antitussive Agents; Benzhydryl Compounds; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Piperidines; Stereoisomerism; Time Factors	2004
Identification and quantitative determination of benproperine metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jan-02, Volume: 830, Issue:1 Topics: Antitussive Agents; Benzhydryl Compounds; Calibration; Chromatography, Liquid; Humans; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2006
Identification of some benproperine metabolites in humans and investigation of their antitussive effect. Acta pharmacologica Sinica, 2005, Volume: 26, Issue:12 Topics: Adult; Animals; Antitussive Agents; Benzhydryl Compounds; Chromatography, Liquid; Citric Acid; Cough; Female; Guinea Pigs; Humans; Male; Piperidines; Spectrometry, Mass, Electrospray Ionization	2005
Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations. International journal of pharmaceutics, 2007, Apr-20, Volume: 335, Issue:1-2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitussive Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Combinations; Drug Stability; Hardness; Hydrogen Bonding; Microscopy, Electron, Scanning; Phase Transition; Piperidines; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Technology, Pharmaceutical; Temperature; Time Factors	2007
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. Bioorganic & medicinal chemistry letters, 2007, Jun-01, Volume: 17, Issue:11 Topics: Animals; Antitussive Agents; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Ligands; Nociceptin Receptor; Piperidines; Receptors, Opioid; Structure-Activity Relationship	2007
[Nondestructive quantitative analysis of Cofrel medicines by improved partial least squares-NIR spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu, 2007, Volume: 27, Issue:6 Topics: Algorithms; Antitussive Agents; Benzhydryl Compounds; Chromatography, High Pressure Liquid; Least-Squares Analysis; Piperidines; Principal Component Analysis; Reproducibility of Results; Spectroscopy, Near-Infrared; Technology, Pharmaceutical	2007
Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:1 Topics: Animals; Antitussive Agents; Baclofen; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naloxone; Neurokinin A; Organophosphorus Compounds; Peptide Fragments; Piperidines; Rabbits; Reflex; Solitary Nucleus	2008
Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:6 Topics: Action Potentials; Amino Alcohols; Anesthesia; Animals; Antitussive Agents; Blood Pressure; Electric Stimulation; Electrocardiography; Electrophysiological Phenomena; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Guinea Pigs; Halothane; Heart; Heart Rate; Male; Membrane Potentials; Piperidines; Pyridines; Ventricular Function; Ventricular Function, Right	2009
Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats. Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:11 Topics: Animals; Antitussive Agents; Ataxia; Dextromethorphan; Diagnostic Techniques, Urological; Infarction, Middle Cerebral Artery; Male; Piperidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Bladder, Overactive; Urination	2009
Fixed drug eruption induced by tipepidine hibenzate. The Journal of dermatology, 2010, Volume: 37, Issue:5 Topics: Antitussive Agents; Child; Drug Eruptions; Erythema; Humans; Japan; Male; Piperidines	2010
Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit. Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:4 Topics: Abdominal Muscles; Animals; Antitussive Agents; Baclofen; Cough; Diaphragm; Electromyography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hemodynamics; Male; Microinjections; Neurokinin A; Peptide Fragments; Phrenic Nerve; Physical Stimulation; Piperidines; Rabbits; Reflex; Respiratory Center; Respiratory Mechanics; Solitary Nucleus	2010
Tipepidine hibenzate intoxication. Pediatrics international : official journal of the Japan Pediatric Society, 2011, Volume: 53, Issue:5 Topics: Antitussive Agents; Child, Preschool; Delirium; Drug Overdose; Humans; Male; Piperidines	2011
Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol. Environmental toxicology, 2014, Volume: 29, Issue:2 Topics: Animals; Antitussive Agents; Avoidance Learning; Brain-Derived Neurotrophic Factor; Diethylstilbestrol; Endocrine Disruptors; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hippocampus; Learning Disabilities; Male; Mice; Neuroprotective Agents; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Serotonin, 5-HT1A	2014
Cloperastine-based cough syrup and acute dystonic reactions. Developmental medicine and child neurology, 2012, Volume: 54, Issue:3 Topics: Antitussive Agents; Child; Cough; Dystonia; Female; Humans; Piperidines	2012
Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. Journal of pharmacological sciences, 2012, Volume: 120, Issue:3 Topics: Action Potentials; Amino Alcohols; Animals; Animals, Inbred Strains; Anti-Arrhythmia Agents; Antitussive Agents; Diphenhydramine; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; HEK293 Cells; Humans; Long QT Syndrome; Membrane Potentials; Osmolar Concentration; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Recombinant Proteins; Structure-Activity Relationship	2012
In vivo cough suppressive activity of pectic polysaccharide with arabinogalactan type II side chains of Piper nigrum fruits and its synergistic effect with piperine. International journal of biological macromolecules, 2017, Volume: 99 Topics: Animals; Antitussive Agents; Cough; Drug Synergism; Ethanol; Fruit; Galactans; Guinea Pigs; Male; Monosaccharides; Pectins; Piper nigrum; Piperidines; Reflex; Respiratory System; Solubility; Water	2017
Effects of tipepidine on MK-801-induced cognitive impairment in mice. Brain research, 2019, 05-01, Volume: 1710 Topics: Animals; Antidepressive Agents; Antitussive Agents; Clozapine; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Dopaminergic Neurons; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Schizophrenia; Ventral Tegmental Area	2019
KCNT1-positive epilepsy of infancy with migrating focal seizures successfully treated with nonnarcotic antitussive drugs after treatment failure with quinidine: A case report. Brain & development, 2020, Volume: 42, Issue:8 Topics: Antitussive Agents; Dextromethorphan; Electroencephalography; Epilepsy; Humans; Infant; Magnetic Resonance Imaging; Male; Mutation; Nerve Tissue Proteins; Piperidines; Potassium Channels, Sodium-Activated; Quinidine; Seizures; Treatment Failure; Treatment Outcome	2020
The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology, 2020, 10-01, Volume: 176 Topics: Animals; Antitussive Agents; Brain Stem; Dose-Response Relationship, Drug; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Mice; Mice, Transgenic; Organ Culture Techniques; Piperidines; Potassium Channel Blockers; Presynaptic Terminals; Rats; Respiration; Rett Syndrome	2020
Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest. Molecular oncology, 2021, Volume: 15, Issue:2 Topics: Animals; Antitussive Agents; Autophagy; Benzhydryl Compounds; Cell Line, Tumor; Drug Repositioning; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Piperidines; Xenograft Model Antitumor Assays	2021