Compounds > diphenhydramine hydrochloride
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diphenhydramine hydrochloride and morphine

diphenhydramine hydrochloride has been researched along with morphine in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199044 (50.00)18.7374
1990's24 (27.27)18.2507
2000's14 (15.91)29.6817
2010's6 (6.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mattila, MJ; Tammisto, T1
Cowan, A; Doxey, JC; Harry, EJ1
Felgenhauer, F; Friderichs, E; Jongschaap, P; Osterloh, G1
Ishii, Y; Kasuya, Y; Miyasaka, K; Watanabe, M1
Donev, N; Nikolov, R; Nikolova, M1
Hosokawa, T; Iwase, H; Nishimura, T; Yanaura, S1
Nichimura, T; Sakamoto, M; Sasao, T; Yanaura, S1
Kamei, J; Kasuya, Y; Katsuma, K1
Weber, W1
Adcock, JJ; Anderson, CW; Shankley, CE1
Kamei, J; Kasuya, Y1
Johansen, M; Rasmussen, KE; Tønnesen, F1
Kamei, J; Kasuya, Y; Tanihara, H3
Boura, AL; Callaway, JK; King, RG1
Englberger, W; Friderichs, E; Reimann, W; Schneider, J1
Masukawa, Y; Misawa, M; Suzuki, T1
Kamei, J; Kasuya, Y; Mori, T; Ogawa, M1
Hosokawa, T; Hukuhara, T; Kamei, J; Yanaura, S1
Adcock, JJ; Schneider, C; Smith, TW1
Ahtee, L; Etemadzadeh, E; Männistö, PT1
Butz, RF; Findlay, JW; Fowle, AS; Jones, EC; Posner, J; Weatherley, BC; Welch, RM1
Evens, RP; Pachter, IJ1
Pachter, IJ1
Barron, DI; Hall, PL; Vallance, DK1
Boura, AL; Haddlesey, DI; Harry, EJ; Lewis, JW; Mayor, PA1
Geisler, LS1
Iwase, H; Nishimura, T; Sato, S; Yanaura, S1
Clarke, PA; Foltz, RL1
Dingledine, R; Goldstein, A; Kendig, J1
Hayashi, H; Henmi, Z; Horii, D; Kawazura, H; Mitsushima, T1
Hayashi, G; Kowa, Y; Kugita, H; Noguchi, Y; Nurimoto, S1
Kas0e, Y; Kito, G; Yuizono, T1
Kasé, Y; Kito, G; Yuizono, T1
Cook, A; Harrison, AJ1
Hasegawa, K; Kobayashi, S; Oshima, T; Takagi, H1
Hofman, G; Kryspin-Exner, K1
Heldt, W; Herrmann, M; Steinbrecher, W1
Danilevskaia, ZE; Ladnyĭ, AIa; Znaevskaia, AV1
Collins, RJ; Weeks, JR1
Bowers, CY; Redding, TW; Schally, AV1
Nakamura, H; Shimizu, M; Yokoyama, Y1
Bru, M; Caillol, V; Cauquil, J; Go, M; Jougla, AM; Lauressergues, H; Pouget, G; Tarayre, JP; Vilain, P1
Carter, FE; Chau, TT; Harris, LS1
Härsing, LG; Knoll, J; Magyar, K; Tekes, K1
Bruce, NC; Caswell, DA; French, CE; Hailes, AM; Long, MT; Willey, DL1
Kamei, J; Morita, K; Nagase, H; Saitoh, A1
Igarashi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Tanihara, H1
Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H; Suzuki, T1
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Suzuki, T2
Hoffmann, O; Wiesenfeld-Hallin, Z1
Baragatti, G; Dematteis, M; Gavend, M; Mallaret, M1
Foss, JF; Goldberg, LI; Orelind, E1
Hedman, U; Plesan, A; Wiesenfeld-Hallin, Z; Xu, XJ1
Kauppila, T; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W1
Cousins, MJ; Grace, RF; Mather, LE; Mersiades, M; Power, I; Umedaly, H; Zammit, A1
Wang, Y; Zeng, J1
D'Olimpio, J1
Su, CH; Tao, PL; Wu, YH; Yeh, GC1
Allen, RM; Dykstra, LA; Granger, AL1
Braithwaite, R; George, S; Meadway, C1
Hsu, CL; Hung, DZ; Yang, DY1
Sun, GX; Sun, YQ; Wang, Y1
Grant, MH; Gray, AI; Jairaj, M; Skellern, GG; Watson, DG1
Epstein, OI; Kovaleva, VL; Zak, MS1
AKUTSU, T; TAKAGI, K; TAKAYANAGI, I1
THALBERG, RE1
CHAPPEL, CI; VONSEEMANN, C1
ELISON, C; ELLIOTT, HW1
KOBAYASHI, S; SEKI, I; TAKAGI, H1
MANNERING, GJ; RUBIN, A; TEPHYL, TR1
CROS, J; FRIEBEL, H; JACOB, R1
TAKAGI, H; YAMATSU, K1
BRAEUNLICH, H1
Degerbeck, F; Dybendal, T; Florvaag, E; Johansson, SG; Lundberg, M; Oman, H; Venemalm, L1
Florvaag, E; Harboe, T; Johansson, SG; Nopp, A; Oman, H1
Chung, KF1
Florvaag, E; Harboe, T; Johansson, SG; Oman, H1
Wee, B1
Auwaerter, V; Dresen, S; Ferreirós, N; Hentschel, R; Hermanns-Clausen, M; Müller, C; Skopp, G; Thierauf, A; Trittler, R; Weinmann, W1
Dybendal, T; Florvaag, E; Garvey, LH; Gerth van Wijk, R; Guttormsen, AB; Halsey, J; Harper, NJ; Irgens, A; Johansson, SG; Mertes, PM; Metso, T; Oman, H; Poulsen, LK; Seneviratne, SL1
Bolser, DC1
Chen, SL; Hsu, KY; Huang, EY; Lu, RB; Tao, PL1
Barbera, N; Busardò, FP; Indorato, F; Romano, G1
Baltserovich, NB; Galustyan, AN; Geppe, NA; Kamaev, AV; Kondyurina, EG; Laleko, SL; Lazareva, SG; Melnikova, IM; Mikhalkova, EV; Pak, TE; Perminova, OA; Sabitov, AU; Spivakovsky, YM; Zhiglinskaya, OV1
Ding, JS; Guo, BB; Wang, SF; Zhang, YQ; Zhou, WH1

Reviews

8 review(s) available for diphenhydramine hydrochloride and morphine

ArticleYear
Butorphanol.
    Drug and alcohol dependence, 1985, Volume: 14, Issue:3-4

    Topics: Anesthesia; Animals; Antitussive Agents; Butorphanol; Chemical Phenomena; Chemistry; Depression, Chemical; Diuretics; Dose-Response Relationship, Drug; Humans; Morphinans; Morphine; Naloxone; Nausea; Oxymorphone; Pain; Pulmonary Wedge Pressure; Rats; Respiration; Substance-Related Disorders

1985
[Breathing disorders as sequelae of therapy].
    Deutsche medizinische Wochenschrift (1946), 1971, Sep-24, Volume: 96, Issue:39

    Topics: Acid-Base Equilibrium; Adrenergic beta-Antagonists; Aged; Anti-Bacterial Agents; Antitussive Agents; Buffers; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Humans; Hypnotics and Sedatives; Male; Middle Aged; Morphine; Respiration; Respiration, Artificial; Respiratory Function Tests; Respiratory Insufficiency

1971
Discriminative stimulus properties of dextromethorphan in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1995, Volume: 49, Issue:10

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Cyclazocine; Cyclopentanes; Dextromethorphan; Dextrorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Neuroprotective Agents; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, sigma

1995
Contemporary drug therapy in palliative care: new directions.
    Cancer investigation, 2001, Volume: 19, Issue:4

    Topics: Adrenal Cortex Hormones; Analgesics; Anorexia; Antiemetics; Antitussive Agents; Cachexia; Cough; Drug Administration Routes; Drug Therapy; Dyspnea; Fentanyl; Gastrointestinal Diseases; Humans; Lidocaine; Megestrol; Morphine; Neoplasms; Pain; Palliative Care; Quality of Life; Terminal Care

2001
ANTITUSSIVE DRUGS.
    Progress in medicinal chemistry, 1963, Volume: 19

    Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Pharmacology; Phenothiazines; Phenylacetates; Piperazines; Piperidines; Research; Thiophenes

1963
Currently available cough suppressants for chronic cough.
    Lung, 2008, Volume: 186 Suppl 1

    Topics: Antitussive Agents; Central Nervous System; Chronic Disease; Codeine; Cough; Dextromethorphan; Humans; Morphine; Narcotics; Reflex; Thiazolidines; Treatment Outcome

2008
Chronic cough.
    Current opinion in supportive and palliative care, 2008, Volume: 2, Issue:2

    Topics: Analgesics, Opioid; Antitussive Agents; Chronic Disease; Codeine; Cough; Dextromethorphan; Humans; Morphine; Palliative Care; Surveys and Questionnaires

2008
Pharmacologic management of cough.
    Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:1

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Chronic Disease; Cough; Deglutition Disorders; Expectorants; Humans; Morphine; Nervous System Diseases; Treatment Outcome

2010

Trials

5 trial(s) available for diphenhydramine hydrochloride and morphine

ArticleYear
Antitussive respiratory depressant effects of dextromoramide, fentanyl, morphine, pentazocine, and pethidine during the N2O-O2 anaesthesia in man.
    Annals of clinical research, 1977, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Antitussive Agents; Atropine; Clinical Trials as Topic; Cough; Dextromoramide; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentanyl; Humans; Intubation, Intratracheal; Male; Meperidine; Middle Aged; Morphine; Nitrous Oxide; Pentazocine; Preanesthetic Medication; Respiration; Succinylcholine; Thiopental

1977
Preoperative dextromethorphan reduces intraoperative but not postoperative morphine requirements after laparotomy.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:5

    Topics: Abdomen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Antitussive Agents; Dextromethorphan; Double-Blind Method; Female; Humans; Intraoperative Period; Laparotomy; Male; Middle Aged; Morphine; Pain, Postoperative

1998
Interpretation of GC-MS opiate results in the presence of pholcodine.
    Forensic science international, 2002, Jun-25, Volume: 127, Issue:1-2

    Topics: Antitussive Agents; Codeine; Drug Interactions; Gas Chromatography-Mass Spectrometry; Humans; Morphine; Morpholines; Substance-Related Disorders

2002
Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents.
    Allergy, 2007, Volume: 62, Issue:12

    Topics: Adult; Allergens; Anaphylaxis; Antitussive Agents; Codeine; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Middle Aged; Morphine; Morpholines; Neuromuscular Blocking Agents; Skin Tests; Succinylcholine; Treatment Outcome

2007
[Rengalin, a novel drug for treatment of cough in children. Intermediate data on multicentre, comparative randomized clinical trial].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2014, Volume: 59, Issue:7-8

    Topics: Administration, Oral; Adolescent; Ambroxol; Antibodies, Neutralizing; Antitussive Agents; Bradykinin; Child; Child, Preschool; Cough; Expectorants; Female; Histamine; Histamine Antagonists; Humans; Male; Morphine; Phenylbutyrates; Respiratory Tract Infections; Russia

2014

Other Studies

75 other study(ies) available for diphenhydramine hydrochloride and morphine

ArticleYear
The animal pharmacology of buprenorphine, an oripavine analgesic agent.
    British journal of pharmacology, 1977, Volume: 60, Issue:4

    Topics: Analgesics; Animals; Antitussive Agents; Behavior, Animal; Cats; Diuresis; Dogs; Female; Gastrointestinal Motility; Guinea Pigs; Haplorhini; Hemodynamics; Lethal Dose 50; Macaca mulatta; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Motor Activity; Rats; Respiration

1977
[Pharmacological studies on analgesia, dependence on and tolerance of tramadol, a potent analgetic drug (author's transl)].
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:1a

    Topics: Administration, Oral; Analgesics; Animals; Antitussive Agents; Cats; Cyclohexanols; Drug Interactions; Drug Tolerance; Female; Guinea Pigs; Haplorhini; Humans; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Morphine; Muscle Contraction; Rabbits; Rats; Substance-Related Disorders; Tramadol

1978
Potentiation of antitussive effect of codeine by some 1-dimethoxyphenyl-3-alkylaminobutanols in guinea pigs.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:7

    Topics: Amino Alcohols; Analgesics; Anesthesia; Animals; Antitussive Agents; Codeine; Dogs; Drug Synergism; Female; Guinea Pigs; Hemodynamics; Hexobarbital; In Vitro Techniques; Lethal Dose 50; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pulmonary Stretch Receptors; Respiration; Trachea

1977
Glaucine: development of tolerance and morphine-like physical dependence in animals.
    Activitas nervosa superior, 1976, Volume: 18, Issue:3

    Topics: Animals; Antitussive Agents; Aporphines; Codeine; Cough; Drug Tolerance; Guinea Pigs; Humans; Morphine; Nalorphine; Rats; Substance-Related Disorders

1976
[Pharmacological studies on the cough reflex].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:2

    Topics: Airway Resistance; Allyl Compounds; Animals; Antitussive Agents; Benzamides; Cats; Chloralose; Chlorobenzenes; Codeine; Cough; Diethylamines; Dimethylphenylpiperazinium Iodide; Dogs; Electric Stimulation; Electrodes, Implanted; Female; Histamine; Humans; Male; Methyl Ethers; Morphine; Pentobarbital; Piperidines; Pyridines; Reflex; Respiratory Tract Diseases; Thebaine; Trachea

1975
The role of bronchoconstriction in cough reflex.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:6

    Topics: Airway Resistance; Animals; Antitussive Agents; Bronchi; Bronchial Spasm; Bronchodilator Agents; Codeine; Cough; Dogs; Ethanolamines; Female; Isoproterenol; Male; Morphine; Phenylacetates; Picolines; Piperidines; Propranolol

1975
Involvement of mu-opioid receptors in the antitussive effects of pentazocine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Benzomorphans; Capsaicin; Cough; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu

1992
[Respiratory problems in cancer--causes and treatment].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1992, Jan-07, Volume: 81, Issue:1-2

    Topics: Anti-Anxiety Agents; Antitussive Agents; Breathing Exercises; Dyspnea; Humans; Life Style; Morphine; Neoplasms; Oxygen Inhalation Therapy; Palliative Care

1992
Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig.
    Agents and actions, 1992, Volume: 36, Issue:1-2

    Topics: Anesthesia; Animals; Antitussive Agents; Bronchi; Bronchoconstrictor Agents; Guinea Pigs; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Neurons, Afferent; Oligopeptides; Respiration, Artificial

1992
Antitussive effects of Ca2+ channel antagonists.
    European journal of pharmacology, 1992, Feb-25, Volume: 212, Issue:1

    Topics: Animals; Antitussive Agents; Calcium Channel Blockers; Capsaicin; Codeine; Cough; Dextromethorphan; Drug Interactions; Drug Synergism; Flunarizine; Guinea Pigs; Male; Morphine; Nifedipine; Verapamil

1992
Column-switching high-performance liquid chromatographic detection of pholcodine and its metabolites in urine with fluorescence and electrochemical detection.
    Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2

    Topics: Antitussive Agents; Chromatography, High Pressure Liquid; Codeine; Electrochemistry; Humans; Morphine; Morpholines; Spectrometry, Fluorescence

1992
Modulation of mu-mediated antitussive activity in rats by a delta agonist.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Cisterna Magna; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Indoles; Injections; Male; Morphinans; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1991
The abilities of specific kappa-opioid agonists, U-50,488H and U-62,066E, to cause antitussive tolerance were lower than that of morphine.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antitussive Agents; Binding Sites; Brain Stem; Drug Tolerance; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin

1991
Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig.
    General pharmacology, 1991, Volume: 22, Issue:6

    Topics: Administration, Inhalation; Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Dextromethorphan; Female; Guinea Pigs; Injections, Intraperitoneal; Morphine; Naloxone; Narcotics; Oligopeptides; Oxymorphone; Peripheral Nerves

1991
Analgesic and antitussive properties of EM 405.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: Analgesia; Animals; Antitussive Agents; Brain; Cell Membrane; Cough; Cyclohexanes; Cyclohexenes; Guinea Pigs; Hypothalamus; Morphine; Naloxone; Norepinephrine; Rats; Synaptosomes; Yohimbine

1991
Drug interactions in the reinforcing effects of over-the-counter cough syrups.
    Psychopharmacology, 1990, Volume: 102, Issue:4

    Topics: Animals; Antitussive Agents; Benzazepines; Chlorpheniramine; Codeine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Morphine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Substance-Related Disorders

1990
Antitussive effects of two specific kappa-opioid agonists, U-50,488H and U-62,066E, in rats.
    European journal of pharmacology, 1990, Oct-09, Volume: 187, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Cisterna Magna; Cough; Injections; Ketanserin; Male; Methysergide; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Reflex

1990
Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:3

    Topics: Animals; Antitussive Agents; Brain Stem; Codeine; Cough; Dextromethorphan; Levorphanol; Male; Morphine; Noscapine; Rats; Rats, Inbred Strains; Receptors, Serotonin

1989
[Effects of naloxone on the cough depressant activities of antitussive drugs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 87, Issue:6

    Topics: Animals; Antitussive Agents; Cats; Dextromethorphan; Endorphins; Female; Male; Morphine; Morpholines; Naloxone; Respiration

1986
Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig.
    British journal of pharmacology, 1988, Volume: 93, Issue:1

    Topics: Animals; Antitussive Agents; Codeine; Guinea Pigs; Male; Morphine; Nalorphine; Nociceptors; Oligopeptides; Respiration

1988
Comparative studies on the dependence liability of morphine hydrochloride, codeine phosphate and two novel antitussive compounds vadocaine hydrochloride and N-(2',4'-dimethyl-6'-methoxyphenyl)-4-(diethylamine) butanamide hydrochloride in mice.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A

    Topics: Animals; Antitussive Agents; Behavior, Animal; Body Temperature; Body Weight; Codeine; Female; Mice; Morphine; Piperidines; Substance Withdrawal Syndrome; Substance-Related Disorders

1988
Comparative disposition of codeine and pholcodine in man after single oral doses.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:1

    Topics: Administration, Oral; Adult; Antitussive Agents; Codeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Kinetics; Male; Morphine; Morpholines; Pupil; Radioimmunoassay

1986
Synthetic 14-hydroxymorphinan narcotic antagonists.
    Advances in biochemical psychopharmacology, 1973, Volume: 8, Issue:0

    Topics: Analgesics; Animals; Antitussive Agents; Codeine; Cyclazocine; Dextromethorphan; Dogs; Electric Stimulation; Guinea Pigs; Heroin; Humans; Hydroxylation; In Vitro Techniques; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Rats; Trachea

1973
The analgesic and related properties of 6-deoxy-6,6-ethylenedioxy-7,8-dihydro-14-hydroxycodeine hydrochloride.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:4

    Topics: Analgesics; Animals; Antitussive Agents; Blood Pressure; Codeine; Female; Intestines; Lens, Crystalline; Mice; Morphine; Mydriatics; Rabbits; Respiration

1966
Structural requirement for antitussive activity in some novel 16-substituted derivatives of 6,14-endoethenotetrahydrothebaine.
    The Journal of pharmacy and pharmacology, 1968, Volume: 20, Issue:12

    Topics: Analgesia; Animals; Antitussive Agents; Cats; Codeine; Cough; Guinea Pigs; Methadone; Morphinans; Morphine; Rats

1968
A new method for induction of the cough reflex.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:3

    Topics: Animals; Antitussive Agents; Chlorobenzenes; Codeine; Cough; Disease Models, Animal; Dogs; Electric Stimulation; Electrodes; Electrodes, Implanted; Guinea Pigs; Methyl Ethers; Morphine; Mucous Membrane; Piperidines; Pyridines; Reflex; Species Specificity; Thebaine; Time Factors; Trachea

1974
Quantitative analysis of morphine in urine by gas chromatography-chemical ionization-mass spectrometry, with (N-C2H3)morphine as an internal standard.
    Clinical chemistry, 1974, Volume: 20, Issue:4

    Topics: Antitussive Agents; Chromatography, Gas; Codeine; Computers; Deuterium; Evaluation Studies as Topic; Humans; Mass Spectrometry; Methods; Microchemistry; Morphine; Time Factors

1974
Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus.
    Life sciences, 1974, Jun-01, Volume: 14, Issue:11

    Topics: Acetylcholine; Action Potentials; Animals; Antitussive Agents; Dextromethorphan; Electric Stimulation; Guinea Pigs; Ileum; Levorphanol; Lidocaine; Male; Morphinans; Morphine; Muscle, Smooth; Naloxone; Neurons; Serotonin; Structure-Activity Relationship

1974
[Pharmacological studies of a new analgesic, 1-(m-methoxyphenyl)-2-dimethylaminomethylcyclohexanol(1) hydrochloride (K-315). 1. Analgesic effects and general pharmacological action].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:1

    Topics: Action Potentials; Alcohols; Aminopyrine; Analgesics; Animals; Antitussive Agents; Blood Pressure; Body Temperature; Cats; Cyclohexanes; Cyclohexanols; Dogs; Female; Ganglia, Autonomic; Guinea Pigs; Intestines; Male; Meperidine; Methylamines; Mice; Morphine; Muscle Contraction; Nictitating Membrane; Pentazocine; Respiration

1972
Pharmacological studies of 1-phenacyl-2,3-dimethyl-3-(3-hydroxyphenyl) piperidine hydrochloride (TA-306), an analgesic and antitussive agent.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antitussive Agents; Barbiturates; Behavior, Animal; Blood Pressure; Body Temperature; Dogs; Drug Synergism; Intestine, Small; Male; Meperidine; Mice; Morphine; Nalorphine; Piperidines; Rabbits; Rats; Respiration

1968
The influence of anesthesia on the evaluation of antitussive effect.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Analgesics; Anesthesia; Animals; Antitussive Agents; Benzoates; Cats; Codeine; Cough; Dogs; Electric Stimulation; Female; Gases; Guinea Pigs; Laryngeal Nerves; Male; Morphine; Noscapine; Oxides; Sulfur

1969
The influence of anesthesia on the evaluation of antitussive effected.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Analgesics; Anesthesia; Animals; Antitussive Agents; Benzoates; Cats; Codeine; Cough; Dogs; Electric Stimulation; Female; Gases; Guinea Pigs; Laryngeal Nerves; Male; Morphine; Noscapine; Oxides; Sulfur

1969
A case history of drug addiction and a T.L.C. system for the separation and identification of some drugs of addiction in sub-microgramme amounts.
    Journal - Forensic Science Society, 1969, Volume: 9, Issue:3

    Topics: Acute Kidney Injury; Adult; Ammonia; Antitussive Agents; Chloroform; Chromatography, Thin Layer; Cocaine; Cyclizine; Heroin; Humans; Hypotension; Ketones; Male; Methods; Morphine; Pharmaceutical Preparations; Substance-Related Disorders

1969
The pharmacology of azabicyclane, a new analgesic agent.
    Toxicology and applied pharmacology, 1970, Volume: 17, Issue:2

    Topics: Analgesics; Animals; Antitussive Agents; Body Weight; Cardiovascular System; Constriction; Digestive System; Drug Synergism; Drug Tolerance; Humans; Hypotension; Male; Meperidine; Methods; Mice; Morphine; Nalorphine; Piperidines; Pupil; Rats; Respiration; Substance-Related Disorders; Thiopental

1970
[Drug dependence and addiction among patients of the Vienna Psychiatric-Neurological University Hospital with special reference to psychotropic drugs].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:7

    Topics: Analgesics; Antidepressive Agents; Antitussive Agents; Austria; Barbiturates; Cannabis; Chlordiazepoxide; Diazepam; Female; Hallucinogens; Hospitals, Psychiatric; Humans; Hypnotics and Sedatives; Male; Meprobamate; Morphine; Psychopharmacology; Sex Factors; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents

1970
[Pharmacology of a new potent analgesic].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:8

    Topics: Analgesics; Anesthesia; Animals; Antitussive Agents; Blood Pressure; Carotid Arteries; Cats; Central Nervous System; Cyclohexanecarboxylic Acids; Depression, Chemical; Dogs; Female; Guinea Pigs; Heart Rate; Humans; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Intestines; Male; Meperidine; Mice; Morphine; Muscle, Smooth; Rabbits; Rats; Regional Blood Flow; Respiration; Stimulation, Chemical; Substance-Related Disorders; Venous Pressure

1970
[Use of hydrocodon phosphate tablets with expectorants in the treatment of pulmonary tuberculosis].
    Vrachebnoe delo, 1971, Issue:1

    Topics: Adult; Antitussive Agents; Humans; Middle Aged; Morphine; Tuberculosis, Pulmonary

1971
Lack of effect of dexoxadrol in self-maintained morphine dependence in rats.
    Psychopharmacologia, 1967, Volume: 11, Issue:4

    Topics: Analgesics; Animals; Antitussive Agents; Dioxoles; Humans; Meperidine; Morphine; Psychopharmacology; Rats; Reinforcement Schedule; Sodium Chloride; Substance-Related Disorders

1967
The effects of morphine and other narcotics on thyroid function in mice.
    Acta endocrinologica, 1966, Volume: 51, Issue:3

    Topics: Animals; Antitussive Agents; Codeine; Iodine Isotopes; Levorphanol; Mice; Morphine; Pituitary Gland; Thyroid Gland; Thyrotropin

1966
Quantitative assessment of jumping behaviour of morphine-like analgesics in mice.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 263, Issue:1

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Antitussive Agents; Apomorphine; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mice; Morphine; Motor Activity

1983
Pharmacological study of the antitussive and respiratory-analeptic properties of N-(2'-ethylpyrrolidino)diphenylacetamide hydrochloride (F 1459).
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:7

    Topics: Anesthetics, Local; Animals; Antitussive Agents; Blood Gas Analysis; Cats; Dogs; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Hemodynamics; In Vitro Techniques; Lactates; Lactic Acid; Laryngeal Nerves; Male; Mice; Morphine; Pyrrolidines; Respiration; Stimulation, Chemical; Trachea

1983
Antitussive effect of the optical isomers of mu, kappa and sigma opiate agonists/antagonists in the cat.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1

    Topics: Animals; Antitussive Agents; Blood Pressure; Cats; Codeine; Cyclazocine; Dextromethorphan; Female; Heart Rate; Male; Methadone; Morphine; Narcotics; Phenazocine; Stereoisomerism

1983
The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 4

    Topics: Analgesics; Animals; Antitussive Agents; Central Nervous System; Cough; Drug Interactions; In Vitro Techniques; Microsomes, Liver; Morphine; Narcotics; Pyrimidinones; Rats

1980
Towards engineering pathways for the synthesis of analgesics and antitussives.
    Annals of the New York Academy of Sciences, 1994, May-02, Volume: 721

    Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Amino Acid Sequence; Analgesics; Antitussive Agents; Bacterial Proteins; Base Sequence; Biotransformation; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genetic Engineering; Hydrocodone; Hydromorphone; Molecular Sequence Data; Morphine; Oxidoreductases; Pseudomonas putida; Sequence Homology, Amino Acid

1994
Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.
    Life sciences, 1995, Volume: 57, Issue:16

    Topics: Animals; Antitussive Agents; Buprenorphine; Capsaicin; Cough; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Receptors, Opioid, mu; Time Factors

1995
Antitussive effect of captopril, an angiotensin converting enzyme inhibitor, in the rat.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 81, Issue:3

    Topics: Animals; Antitussive Agents; Capsaicin; Captopril; Cough; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley

1993
Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse.
    Neuroscience letters, 1993, Jan-12, Volume: 149, Issue:2

    Topics: Analgesics; Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Reaction Time; Receptors, Opioid, mu

1993
Antitussive effects of mu- and kappa-agonists in diabetic rats.
    Neuroscience letters, 1993, May-14, Volume: 154, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antitussive Agents; Diabetes Mellitus, Experimental; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
The role of the mu 2-opioid receptor in the antitussive effect of morphine in mu 1-opioid receptor-deficient CXBK mice.
    European journal of pharmacology, 1993, Aug-10, Volume: 240, Issue:1

    Topics: Animals; Antitussive Agents; Male; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid, mu

1993
Dextromethorphan potentiates morphine antinociception, but does not reverse tolerance in rats.
    Neuroreport, 1996, Feb-29, Volume: 7, Issue:3

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Dextromethorphan; Drug Synergism; Drug Tolerance; Hormone Antagonists; Indoles; Male; Meglumine; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley

1996
Effects of methylnaltrexone on morphine-induced cough suppression in guinea pigs.
    Life sciences, 1996, Volume: 59, Issue:15

    Topics: Analgesia; Animals; Antitussive Agents; Guinea Pigs; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds

1996
Comparison of ketamine and dextromethorphan in potentiating the antinociceptive effect of morphine in rats.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:4

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Antitussive Agents; Consciousness; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Injections, Subcutaneous; Ketamine; Male; Morphine; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Time Factors

1998
Dextromethorphan potentiates the effect of morphine in rats with peripheral neuropathy.
    Neuroreport, 1998, Apr-20, Volume: 9, Issue:6

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Dextromethorphan; Drug Synergism; Drug Therapy, Combination; Male; Morphine; Naloxone; Narcotic Antagonists; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley

1998
[Determination of morphine in compound liquorice tablets by high performance liquid chromatography with SEP-PAK C18 cartridge pretreatment].
    Se pu = Chinese journal of chromatography, 1998, Volume: 16, Issue:3

    Topics: Antitussive Agents; Drug Compounding; Drugs, Chinese Herbal; Expectorants; Morphine; Tablets

1998
Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring.
    Life sciences, 2001, Oct-05, Volume: 69, Issue:20

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Body Weight; Dextromethorphan; Drug Combinations; Drug Tolerance; Female; Hippocampus; Injections, Subcutaneous; Lactation; Longevity; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pain Measurement; Pain Threshold; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley

2001
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri

2002
The effect of codeine in anti-cough syrup on morphine screen.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 2002, Volume: 65, Issue:6

    Topics: Adult; Antitussive Agents; Codeine; Female; Humans; Immunoenzyme Techniques; Male; Morphine; Opioid-Related Disorders

2002
[Quantitative determinations of glycyrrhizic acid, glycyrrhetinic acid, morphine and sodium benzoate in compound liquorice tablets by capillary zone electrophoresis].
    Se pu = Chinese journal of chromatography, 2002, Volume: 20, Issue:1

    Topics: Antitussive Agents; Drug Compounding; Electrophoresis, Capillary; Expectorants; Glycyrrhetinic Acid; Glycyrrhizic Acid; Morphine; Sodium Benzoate; Tablets

2002
Comparative biotransformation of morphine, codeine and pholcodine in rat hepatocytes: identification of a novel metabolite of pholcodine.
    Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:12

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Chromatography, Liquid; Codeine; Glucuronidase; Hepatocytes; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Chemical; Morphine; Morpholines; Oxygen; Rats; Spectrometry, Mass, Electrospray Ionization; Time Factors

2002
Antitussive activity of Anar.
    Bulletin of experimental biology and medicine, 2003, Volume: 135 Suppl 7

    Topics: Animals; Antibodies; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Lung; Male; Morphine

2003
[Pharmacological studies on repeated administration of drugs. I. On cross-test of drugs].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1963, Volume: 83

    Topics: Antitussive Agents; Body Weight; Codeine; Humans; Morphine; Pharmaceutical Preparations; Promethazine; Research

1963
Clinical trial of a new antitussive agent.
    Western medicine; the medical journal of the west, 1962, Volume: 3

    Topics: Antitussive Agents; Humans; Morphine; Morpholines

1962
STUDIES ON THE ENZYMATIC N- AND O-DEMETHYLATION OF NARCOTIC ANALGESICS AND EVIDENCE FOR THE FORMATION OF CODEINE FROM MORPHINE IN RATS AND DOGS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 144

    Topics: Adenosine Triphosphate; Antitussive Agents; Autoradiography; Carbon Isotopes; Chlorides; Chromatography; Codeine; Dogs; Folic Acid; Glutathione; Liver; Metabolism; Methionine; Methylation; Morphine; NADP; Narcotics; Pharmacology; Rats; Research; Urine

1964
[PHARMACOLOGICAL STUDIES ON MORPHINE DERIVATIVES. 3. ON THE CHEMICAL STRUCTURE-ACTIVITY RELATIONSHIPS OF 14-HYDROXYMORPHINE DERIVATIVES].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1964, Volume: 84

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antitussive Agents; Codeine; Hydromorphone; Morphine; Morphine Derivatives; Nalorphine; Oxymorphone; Pharmacology; Research; Structure-Activity Relationship; Toxicology

1964
INHIBITION OF HEXOBARBITAL METABOLISM BY ETHYLMORPHINE AND CODEINE IN THE INTACT RAT.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Acetanilides; Antimetabolites; Antitussive Agents; Blood; Codeine; Ethylmorphine; Hexobarbital; Meprobamate; Morphine; Pharmacology; Proadifen; Rats; Research

1964
[HABITUATION OF GUINEA PIGS TO THE ANTITUSSIVE AND ANALGESIC EFFECT OF MORPHINE].
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1965, Volume: 12

    Topics: Analgesics; Animals; Antitussive Agents; Cough; Drug Tolerance; Guinea Pigs; Morphine; Morphine Dependence; Research; Substance-Related Disorders; Toxicology; Urine

1965
[A COMPARATIVE STUDY IN DOGS ON THEIR ACQUIRED TOLERANCE TO VARIOUS ANTITUSSIVES].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1965, Volume: 61

    Topics: Animals; Antitussive Agents; Codeine; Dogs; Drug Tolerance; Morphine; Research

1965
[ON THE MORPHINE-LIKE PROPERTIES OF A NEW ANTITUSSIVE (ISOAMINIL; PERACON, MULLATUSS)].
    Die Pharmazie, 1964, Volume: 19

    Topics: Acetonitriles; Antitussive Agents; Codeine; Cyanides; Electron Transport Complex IV; Methadone; Mice; Morphine; Nalorphine; Pharmacology; Rats; Research; Respiration; Toxicology

1964
Prevalence of IgE antibodies to morphine. Relation to the high and low incidences of NMBA anaphylaxis in Norway and Sweden, respectively.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:4

    Topics: Algorithms; Analgesics, Opioid; Anaphylaxis; Antitussive Agents; Blood Donors; Codeine; Cross Reactions; Environmental Pollutants; Humans; Immunoglobulin E; Morphine; Morpholines; Neuromuscular Blocking Agents; Neuromuscular Depolarizing Agents; Norway; Succinylcholine; Sweden

2005
Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study.
    Allergy, 2006, Volume: 61, Issue:1

    Topics: Adult; Allergens; Antitussive Agents; Codeine; Enzyme-Linked Immunosorbent Assay; Female; Galectin 3; Humans; Hypersensitivity; Immunization; Immunoglobulin E; Leukocytes, Mononuclear; Male; Morphine; Morpholines; Neuromuscular Blocking Agents; Pilot Projects; Sensitivity and Specificity; Succinylcholine

2006
Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations.
    International journal of legal medicine, 2009, Volume: 123, Issue:5

    Topics: Antitussive Agents; Brain Chemistry; Brain Edema; Child, Preschool; Chromatography, Liquid; Codeine; Cytochrome P-450 CYP2D6; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Forensic Toxicology; Genotype; Glucuronides; Humans; Medication Errors; Morphine; Morphine Derivatives; Polymorphism, Genetic; Respiratory Aspiration; Tandem Mass Spectrometry; Tissue Distribution; Twins, Monozygotic

2009
National pholcodine consumption and prevalence of IgE-sensitization: a multicentre study.
    Allergy, 2010, Volume: 65, Issue:4

    Topics: Anaphylaxis; Antitussive Agents; Codeine; Cross Reactions; Drug Hypersensitivity; Humans; Immunoglobulin E; Morphine; Morpholines; Neuromuscular Agents; Phosphorylcholine; Prevalence; Quaternary Ammonium Compounds; Succinylcholine

2010
Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats.
    Drug and alcohol dependence, 2011, Sep-01, Volume: 117, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Behavior, Animal; Conditioning, Psychological; Dextromethorphan; Dose-Response Relationship, Drug; Ethylenediamines; Male; Morphine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reward; Sigma-1 Receptor; Ventral Tegmental Area

2011
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
    Forensic science international, 2013, Apr-10, Volume: 227, Issue:1-3

    Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body

2013
The Pharmacokinetics of Morphine and Codeine in Human Plasma and Urine after Oral Administration of Qiangli Pipa Syrup.
    Journal of forensic sciences, 2018, Volume: 63, Issue:4

    Topics: Administration, Oral; Adult; Antitussive Agents; China; Chromatography, High Pressure Liquid; Codeine; Cross-Over Studies; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Male; Medicine, Chinese Traditional; Morphine; Random Allocation; Tandem Mass Spectrometry; Young Adult

2018