Page last updated: 2024-08-20

diphenhydramine hydrochloride and diphenhydramine

diphenhydramine hydrochloride has been researched along with diphenhydramine in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199015 (31.25)18.7374
1990's2 (4.17)18.2507
2000's15 (31.25)29.6817
2010's12 (25.00)24.3611
2020's4 (8.33)2.80

Authors

AuthorsStudies
Burgi, H; Cosnier, D; Duchêne-Marullaz, P; Rispat, G; Streichenberger, G1
Matts, SG1
de Haen, P1
Lilienfield, LS; Princiotto, JV; Rose, JC1
Mahato, SB; Maitra, SK; Sahu, NP1
Fladung, H1
Kleinschmidt, H1
Weilacher, JS1
Harenko, A1
Weippl, G1
Hao, P1
Diekema, DS; Robertson, WO; Warden, CR1
Baird, TJ; Briscoe, RJ; Carl, KL; Gauvin, DV; Holloway, FA; Sannerud, CA; Vallett, M; Vanecek, SA1
PETERS, G; WAX, J; WINDER, CV1
CASS, LJ; FREDERIK, WS1
LASFARGUES, G; PERNIN, P1
Jun, JH; Schindler, CW; Thorndike, EB1
Berlin, CM; Carlson, LC; Crowell, KR; Dilworth, DA; McMillan, HS; Paul, IM; Shaffer, ML; Yoder, KE1
Bhatt-Mehta, V1
Walburn, J1
Gomez, MR; Martínez, LD; Olsina, RA; Silva, MF; Sombra, L1
Skoner, DP1
El-Gindy, A; Emara, S; Mostafa, A1
Akkaramongkolporn, P; Kulvanich, P; Pathipvanich, M1
Ali, MS; Ghori, M; Khatri, AR; Rafiuddin, S1
La Tournous, SJ; Paul, IM; Shaffer, ML; Yoder, KE1
Chan, SW; Li, P; Lin, G; Rudd, JA1
Mozaffari-Khosravi, H; Mozayan, MR; Shadkam, MN1
Kelkar, PS; Ramanuja, S1
Carter, D; Gabardi, S; Martin, S; Roberts, K1
Fujiwara, K; Namekata, I; Ohtsuki, A; Oka, T; Takahara, A; Tanaka, H1
Katoh, N; Nakai, N; Yokose, C1
Meremikwu, MM; Oduwole, O; Oyo-Ita, A; Udoh, EE2
Brew, J; Caparros-Wanderley, W; Dhar, S; Dicpinigaitis, PV; Gayle, Y; Johnson, A1
Goyal, RN; Karpoormath, R; Patel, H; Patel, R; Thapliyal, N1
Naveed, S; Rehman, H; Usmanghani, K1
Ali, SA; Naveed, S; Rehman, H; Usmanghani, K1
Burnham, RI; Delva-Clark, H; Green, JL; Paul, IM; Reynolds, KM1
Banner, W; Bond, GR; Dart, RC; Green, JL; Kauffman, RE; Palmer, RB; Paul, IM; Reynolds, KM1
Banner, W; Bond, GR; Dart, RC; Green, JL; Kauffman, RE; Palmer, RB; Paul, IM; Rapp-Olsson, M; Reynolds, KM; Wang, GS1
Banner, W; Bond, GR; Dart, RC; Delva-Clark, H; Green, JL; Halmo, LS; Kauffman, RE; Palmer, RB; Paul, IM; Rapp-Olsson, M; Reynolds, KM; Wang, GS1
Abuba, T; Anibasa, FO; Dankyau, M1

Reviews

5 review(s) available for diphenhydramine hydrochloride and diphenhydramine

ArticleYear
The approach to pediatric cough.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010, Volume: 105, Issue:1

    Topics: Adult; Animals; Antitussive Agents; Asthma; Bronchiectasis; Bronchiolitis; Bronchopneumonia; Child, Preschool; Cough; Diagnosis, Differential; Diphenhydramine; Gastroesophageal Reflux; Humans; Vocal Cords

2010
Recommendations for the proper use of nonprescription cough suppressants and expectorants in solid-organ transplant recipients.
    Progress in transplantation (Aliso Viejo, Calif.), 2011, Volume: 21, Issue:1

    Topics: Antitussive Agents; Codeine; Contraindications; Dextromethorphan; Diphenhydramine; Drug Interactions; Drug Monitoring; Drug Utilization; Expectorants; Guaifenesin; Humans; Immunosuppressive Agents; Nonprescription Drugs; Organ Transplantation; Safety

2011
Honey for acute cough in children.
    The Cochrane database of systematic reviews, 2014, Dec-23, Issue:12

    Topics: Adolescent; Antitussive Agents; Apitherapy; Child; Child, Preschool; Cough; Dextromethorphan; Diphenhydramine; Honey; Humans; Infant; Randomized Controlled Trials as Topic

2014
A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs.
    Talanta, 2015, Sep-01, Volume: 142

    Topics: Antitussive Agents; Dextromethorphan; Diphenhydramine; Electrochemical Techniques; Illicit Drugs; Nonprescription Drugs

2015
Honey for acute cough in children.
    The Cochrane database of systematic reviews, 2018, 04-10, Volume: 4

    Topics: Adolescent; Albuterol; Antitussive Agents; Apitherapy; Bromelains; Bronchodilator Agents; Child; Child, Preschool; Cough; Dextromethorphan; Diphenhydramine; Honey; Humans; Infant; Placebos; Randomized Controlled Trials as Topic

2018

Trials

11 trial(s) available for diphenhydramine hydrochloride and diphenhydramine

ArticleYear
A trial of Lotussin and linctus diphenhydramine in patients wth an irritant cough.
    The Journal of international medical research, 1977, Volume: 5, Issue:6

    Topics: Ammonium Chloride; Antitussive Agents; Chloroform; Citrates; Clinical Trials as Topic; Cough; Dextromethorphan; Diphenhydramine; Drug Combinations; Drug Evaluation; Ephedrine; Guaifenesin; Humans; Menthol

1977
Antitussive activity of diphenhydramine in chronic cough.
    Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:4

    Topics: Adult; Aged; Antitussive Agents; Chronic Disease; Clinical Trials as Topic; Cough; Diphenhydramine; Female; Humans; Male; Middle Aged; Smoking; Time Factors

1976
[Attempt to test a new antitussive agent].
    Zeitschrift fur Allgemeinmedizin, 1974, Feb-10, Volume: 50, Issue:4

    Topics: Adolescent; Ammonium Chloride; Antitussive Agents; Child; Child, Preschool; Clinical Trials as Topic; Cough; Diphenhydramine; Drug Combinations; Guaifenesin; Humans; Hypnotics and Sedatives; Oils, Volatile; Sympatholytics

1974
Therapeutic approaches to the common cold in children.
    Clinical therapeutics, 1984, Volume: 6, Issue:4

    Topics: Antitussive Agents; Child; Child, Preschool; Clinical Trials as Topic; Common Cold; Cyproheptadine; Dextromethorphan; Diphenhydramine; Double-Blind Method; Drug Combinations; Ephedrine; Expectorants; Histamine H1 Antagonists; Humans; Levorphanol; Pseudoephedrine

1984
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents.
    Pediatrics, 2004, Volume: 114, Issue:1

    Topics: Adolescent; Antitussive Agents; Child; Child, Preschool; Cough; Dextromethorphan; Diphenhydramine; Double-Blind Method; Female; Humans; Male; Respiratory Tract Infections; Sleep Initiation and Maintenance Disorders; Sleep Stages

2004
Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection.
    Clinical pediatrics, 2006, Volume: 45, Issue:7

    Topics: Adolescent; Antitussive Agents; Child; Cough; Dextromethorphan; Diphenhydramine; Female; Humans; Male; Placebos; Respiratory Tract Infections; Treatment Outcome

2006
A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents.
    Journal of alternative and complementary medicine (New York, N.Y.), 2010, Volume: 16, Issue:7

    Topics: Antitussive Agents; Apitherapy; Child, Preschool; Cough; Dextromethorphan; Diphenhydramine; Female; Honey; Humans; Male; Parents; Respiratory Tract Infections; Sleep; Time Factors

2010
Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection.
    International journal of clinical pharmacy, 2015, Volume: 37, Issue:3

    Topics: Adult; Antitussive Agents; Capsaicin; Cough; Dextromethorphan; Diphenhydramine; Double-Blind Method; Female; Humans; Male; Reflex; Respiratory Tract Infections; Young Adult

2015
Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:3 Suppl

    Topics: Age Factors; Aminophylline; Antitussive Agents; Bronchodilator Agents; Child; Child, Preschool; Cough; Diphenhydramine; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Male; Pakistan; Pharyngitis; Sleep; Sleep Wake Disorders; Theophylline; Time Factors; Treatment Outcome

2016
An interquartile relationship between polyherbal extract based lozenges linkus a phase IV comparative randomised control trial.
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:3(Suppl.)

    Topics: Aminophylline; Antitussive Agents; Child; Cough; Diphenhydramine; Female; Humans; Male; Pakistan; Plant Extracts; Severity of Illness Index; Tablets; Treatment Outcome

2017
Effect of Honey on Cough Symptoms in Children with Upper Respiratory Tract Infection: A Randomised Controlled Trial.
    West African journal of medicine, 2022, Sep-16, Volume: 39, Issue:9

    Topics: Antitussive Agents; Child; Cough; Demulcents; Diphenhydramine; Female; Honey; Humans; Male; Respiratory Tract Infections; Single-Blind Method

2022

Other Studies

32 other study(ies) available for diphenhydramine hydrochloride and diphenhydramine

ArticleYear
General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity.
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:4

    Topics: Administration, Oral; Anesthetics, Local; Animals; Antitussive Agents; Bronchi; Cats; Codeine; Cough; Dextromethorphan; Diphenhydramine; Dogs; Expectorants; Female; Guinea Pigs; Histamine H1 Antagonists; Humans; In Vitro Techniques; Injections, Intravenous; Lethal Dose 50; Male; Mice; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperazines; Rats; Respiration

1976
Drugs released for clinical use.
    Journal of clinical pharmacology, 1978, Volume: 18, Issue:1

    Topics: Analgesics; Anti-Inflammatory Agents; Antitussive Agents; Betamethasone; Cimetidine; Colestipol; Dihydroergotoxine; Diphenhydramine; Drug Therapy; Furosemide; Humans; Isosorbide; Oxycodone; Pharmaceutical Preparations; Salicylates; United States; United States Food and Drug Administration; Vitamins

1978
American Academy of Pediatrics. Committee on Drugs. Use of codeine- and dextromethorphan-containing cough syrups in pediatrics.
    Pediatrics, 1978, Volume: 62, Issue:1

    Topics: Adolescent; Animals; Antitussive Agents; Child; Child, Preschool; Codeine; Cough; Dextromethorphan; Diphenhydramine; Drug Combinations; Drug Packaging; Humans; Infant; Levorphanol; Male; Narcotics; Pediatrics; Societies, Medical; United States

1978
Simultaneous determination of chlorpheniramine and diphenhydramine in cough syrups by reversed-phase ion-pair high-performance liquid chromatography.
    Journal of chromatography, 1986, Jan-31, Volume: 351, Issue:3

    Topics: Antitussive Agents; Chlorpheniramine; Chromatography, High Pressure Liquid; Diphenhydramine

1986
[On the treatment of combined banal infections].
    Der Landarzt, 1968, Nov-20, Volume: 44, Issue:32

    Topics: Anti-Inflammatory Agents; Antitussive Agents; Bronchitis; Caffeine; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Male; Phenacetin; Respiratory Tract Infections; Rhinitis; Salicylamides; Vasoconstrictor Agents

1968
[Cough and its treatment with a new cough-blocking drug].
    Zeitschrift fur Allgemeinmedizin, 1972, Feb-10, Volume: 48, Issue:4

    Topics: Animals; Antitussive Agents; Cough; Diphenhydramine; Drug Combinations; Humans; Mice; Oxadiazoles; Piperidines

1972
[Cough syrup containing diphenhydramine causing toxicomania and acute psychosis].
    Suomen laakarilehti. Finlands lakartidning, 1965, May-20, Volume: 20, Issue:15

    Topics: Antitussive Agents; Diphenhydramine; Humans; Psychoses, Substance-Induced; Substance-Related Disorders

1965
[Treatment of chronic bronchitis with ketanmin--a clinical study of 316 cases and pharmacological experiments].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1982, Volume: 2, Issue:1

    Topics: Adult; Aged; Aminophylline; Animals; Antitussive Agents; Asthma; Bronchitis; Diphenhydramine; Drug Combinations; Expectorants; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Medicine, Chinese Traditional; Mice; Middle Aged; Plant Extracts; Plants, Medicinal

1982
Dystonic reaction associated with dextromethorphan ingestion in a toddler.
    Pediatric emergency care, 1997, Volume: 13, Issue:3

    Topics: Antidotes; Antitussive Agents; Ataxia; Child, Preschool; Dextromethorphan; Diphenhydramine; Dystonia; Female; Humans; Nystagmus, Pathologic; Poisoning

1997
The stimulus properties of two common over-the-counter drug mixtures: dextromethorphan + ephedrine and dextromethorphan + diphenhydramine.
    Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:1

    Topics: Adrenergic Agents; Animals; Antitussive Agents; Dextromethorphan; Diphenhydramine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Combinations; Ephedrine; Hypnotics and Sedatives; Male; Nonprescription Drugs; Psychomotor Performance; Rats; Rats, Sprague-Dawley

1998
Labeling of diphenhydramine-containing drug products for over-the-counter human use. Final rule.
    Federal register, 2002, Dec-02, Volume: 67, Issue:235

    Topics: Administration, Topical; Analgesics; Antiemetics; Antitussive Agents; Chickenpox; Consumer Product Safety; Dermatitis, Toxicodendron; Diphenhydramine; Drug Labeling; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Measles; Nonprescription Drugs; Sunburn; United States; United States Food and Drug Administration

2002
An antitussive property of diphenhydramine in dogs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 110

    Topics: Animals; Antitussive Agents; Cough; Diphenhydramine; Dogs

1962
THE CLINICAL EVALUATION OF SILOMAT AS AN ANTITUSSIVE.
    Current therapeutic research, clinical and experimental, 1964, Volume: 6

    Topics: Amino Alcohols; Antitussive Agents; Codeine; Diphenhydramine; Pharmacology; Placebos

1964
[VALUE OF A NEW SYRUP WITH A DIPHENHYDRAMINE CAMPHORSULFONATE AMINOXIDE BASE IN CHILD PATHOLOGY].
    Le Progres medical, 1964, Jan-10, Volume: 92

    Topics: Antitussive Agents; Camphor; Child; Diphenhydramine; Food; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Pharmacology

1964
Abuse liability and stimulant properties of dextromethorphan and diphenhydramine combinations in rats.
    Psychopharmacology, 2004, Volume: 172, Issue:3

    Topics: Animals; Anti-Allergic Agents; Antitussive Agents; Dextromethorphan; Diphenhydramine; Dose-Response Relationship, Drug; Drug Interactions; Locomotion; Male; Rats; Rats, Sprague-Dawley; Self Administration

2004
Over-the-counter cough and cold medicines: should parents be using them for their children?
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:11

    Topics: Antitussive Agents; Child; Common Cold; Cough; Dextromethorphan; Diphenhydramine; Humans; Nonprescription Drugs; Parents; Randomized Controlled Trials as Topic; Sleep

2004
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents.
    Pediatrics, 2004, Volume: 114, Issue:5

    Topics: Antitussive Agents; Cough; Dextromethorphan; Diphenhydramine; Humans; Placebo Effect; Placebos; Sucrose

2004
Kids' cough drugs may not work.
    Consumer reports, 2004, Volume: 69, Issue:12

    Topics: Adult; Antitussive Agents; Child; Cost-Benefit Analysis; Cough; Dextromethorphan; Diphenhydramine; Humans

2004
Do over-the-counter cough remedies work?
    Child health alert, 2004, Volume: 22

    Topics: Antitussive Agents; Child; Dextromethorphan; Diphenhydramine; Humans; Nonprescription Drugs; Sleep Wake Disorders

2004
Development and validation of a capillary electrophoresis method for the determination of codeine, diphenhydramine, ephedrine and noscapine in pharmaceuticals.
    Farmaco (Societa chimica italiana : 1989), 2005, Volume: 60, Issue:1

    Topics: Antitussive Agents; Codeine; Diphenhydramine; Electrophoresis, Capillary; Ephedrine; Hydrogen-Ion Concentration; Noscapine; Reproducibility of Results

2005
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents.
    Pediatrics, 2005, Volume: 115, Issue:2

    Topics: Adolescent; Antitussive Agents; Child; Child, Preschool; Confounding Factors, Epidemiologic; Cough; Dextromethorphan; Diphenhydramine; Humans; Respiratory Tract Infections; Surveys and Questionnaires; Treatment Failure

2005
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.
    Journal of pharmaceutical and biomedical analysis, 2006, May-03, Volume: 41, Issue:2

    Topics: Antitussive Agents; Bronchodilator Agents; Chromatography, High Pressure Liquid; Complex Mixtures; Diphenhydramine; Expectorants; Guaifenesin; Least-Squares Analysis; Parabens; Preservatives, Pharmaceutical; Principal Component Analysis; Reproducibility of Results; Sodium Benzoate; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical; Theophylline

2006
Preparation and in vitro release of dual-drug resinates containing equivalent content dextromethorphan and diphenhydramine.
    Drug development and industrial pharmacy, 2006, Volume: 32, Issue:4

    Topics: Anti-Allergic Agents; Antitussive Agents; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dextromethorphan; Diphenhydramine; Drug Carriers; Drug Combinations; Drug Compounding; Ion Exchange Resins; Molecular Weight; Solubility; Surface Properties

2006
A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations.
    Journal of pharmaceutical and biomedical analysis, 2007, Jan-04, Volume: 43, Issue:1

    Topics: Acetates; Antitussive Agents; Buffers; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Dextromethorphan; Diphenhydramine; Drug Combinations; Ephedrine; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Indicators and Reagents; Nasal Decongestants; Pharmaceutical Solutions; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet

2007
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper Sulfate; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Motion Sickness; Nicotine; Reflex; Scopolamine; Shrews; Vomiting

2007
FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children?
    Child health alert, 2007, Volume: 25

    Topics: Adolescent; Antiemetics; Antitussive Agents; Benzamides; Child; Child, Preschool; Cough; Dextromethorphan; Diphenhydramine; Drug and Narcotic Control; Humans; Suppositories; Treatment Failure; United States; United States Food and Drug Administration

2007
Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:3

    Topics: Action Potentials; Amino Alcohols; Animals; Animals, Inbred Strains; Anti-Arrhythmia Agents; Antitussive Agents; Diphenhydramine; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; HEK293 Cells; Humans; Long QT Syndrome; Membrane Potentials; Osmolar Concentration; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Recombinant Proteins; Structure-Activity Relationship

2012
Maculopapular-type drug eruption caused by Coughcode(®)-N combination tablets.
    Allergology international : official journal of the Japanese Society of Allergology, 2013, Volume: 62, Issue:4

    Topics: Acetaminophen; Administration, Oral; Adolescent; Antitussive Agents; Bromisovalum; Codeine; Diphenhydramine; Drug Combinations; Drug Eruptions; Dyphylline; Eosinophils; Ephedrine; Female; Humans; Immunization; Skin Tests; Tablets

2013
Flow Restrictors and Reduction of Accidental Ingestions of Over-the-Counter Medications.
    American journal of preventive medicine, 2019, Volume: 56, Issue:6

    Topics: Accidents; Acetaminophen; Age Factors; Antitussive Agents; Child, Preschool; Diphenhydramine; Drug Overdose; Drug Packaging; Female; Humans; Ibuprofen; Infant; Male; Nonprescription Drugs; Poison Control Centers; Seasons; United States

2019
Adverse events associated with diphenhydramine in children, 2008-2015.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Antitussive Agents; Child; Cough; Diphenhydramine; Humans; Nonprescription Drugs

2020
Trends in adverse events and related health-care facility utilization from cough and cold medication exposures in children.
    Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:4

    Topics: Antitussive Agents; Child; Child, Preschool; Dextromethorphan; Diphenhydramine; Humans; Multi-Ingredient Cold, Flu, and Allergy Medications; Nonprescription Drugs; Patient Acceptance of Health Care; Poison Control Centers; United States

2021
Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.
    Pediatrics, 2021, Volume: 148, Issue:5

    Topics: Antitussive Agents; Brompheniramine; Child; Child, Preschool; Chlorpheniramine; Dextromethorphan; Diphenhydramine; Doxylamine; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Female; Guaifenesin; Homicide; Humans; Infant; Male; Nonprescription Drugs; Phenylephrine; Pseudoephedrine

2021