diphenhydramine hydrochloride and citric acid, anhydrous

diphenhydramine hydrochloride has been researched along with citric acid, anhydrous in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (12.99)	18.7374
1990's	15 (19.48)	18.2507
2000's	26 (33.77)	29.6817
2010's	25 (32.47)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Balzarotti, C; Caiazzo, G; Camusso, L; Cordaro, CI; Fumagalli, G; Maghini, L; Mazzocchi, M; Vanasia, M; Zennaro, M	1
Forsberg, K; Karlsson, JA; Persson, CG; Zackrisson, C	1
Boura, AL; Callaway, JK; King, RG	1
Eady, RP; Jackson, DM	1
Jackson, DM	1
Chakrabarti, A; Jindal, SK; Malik, SK; Pandhi, P; Sharma, PL	1
Karttunen, P	1
Karttunen, P; Kolonen, S; Silvasti, M; Tukiainen, H	1
Clark, TJ; Rees, PJ	1
Grattan, TJ; Laude, EA; Morice, AH	1
Borghi, A; Ceserani, R; Dalla Rosa, C; Gallico, L; Tognella, S	1
Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH	1
Bossi, R; Braga, PC; Dal Sasso, M; Piatti, G	1
Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P	1
Barnes, PJ; Belvisi, MG; Chung, KF; Fox, AJ; Lalloo, UG	1
Borghi, A; Cavalletti, E; Ceserani, R; Gallico, L; Tognella, S	1
Arányi, P; Korbonits, D; Mikus, EG; Minker, E; Pascal, M; Révész, J; Saano, V	1
Ceserani, R; Furuta, M; Gallico, L; Hashimoto, M; Ishii, R; Naruse, T	1
Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R	1
Hosoe, H; Isohama, Y; Kai, H; Kaise, T; Miyata, T; Ohmori, K; Takahama, K	1
D'Angelo, V; De Pasquale, R; Germano, MP; Keita, A; Occhiuto, F; Sanogo, R	1
Abdul-Manap, R; Morice, AH; Rostami-Hodjegan, A; Tucker, GT; Wright, CE	1
Advenier, C; Gustin, P; Moreaux, B	1
Kastelik, JA; Morice, AH; Thompson, R	1
Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Grugni, M; Hay, DW; Kilian, D; Kotzer, CJ; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Potts, W; Raveglia, LF; Sandhu, P; Sarau, HM; Schmidt, DB; Underwood, DC	1
Adcock, JJ; Beatch, G; Douglas, GJ; Garabette, M; Gascoigne, M; Page, CP; Walker, M	1
Antoniou, CG; Koundourellis, JE; Malliou, ET	1
Epstein, OI; Kovaleva, VL; Zak, MS	1
Dugina, YL; Epstein, OI; Kovaleva, VL; Zak, MS	1
BARACH, AL; BICKERMAN, HA	1
BICKERMAN, HA; COHEN, BM; GERMAN, E	1
BICKERMAN, HA; COHEN, BM; GERMAN, E; ITKIN, SE	1
POZZATTI, C; SILVESTRINI, B	1
But, PP; Chung, HS; Dong, H; Hon, PM; Lin, G	1
Chen, S; Kong, W; Li, W; Li, Y; Min, L; Zhong, D	1
Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS	1
Chen, SW; Li, Y; Maeba, I; Zhong, DF	1
Earis, J; Owen, E; Smith, J; Woodcock, A	1
Goto, H; Haji, A; Minamizawa, K; Shimada, Y; Terasawa, K	1
Ghenaati, J; Hosseinzadeh, H	1
Goto, H; Haji, A; Minamizawa, K; Ohi, Y; Shimada, Y; Terasawa, K	1
Li, PB; Ma, Y; Su, WW; Wang, YG	1
Dicpinigaitis, PV	1
Ambrose, C; Banner, K; Battram, C; Butler, K; Giddings, J; Lewis, CA; Mok, J; Nasra, J; Poll, C; Winny, C	1
Hayashi, SS; Kamei, J; Nozaki, C; Takahashi, Y	1
Belvisi, MG; Birring, SS; Chung, KF; Dicpinigaitis, PV; Fontana, GA; Kastelik, JA; McGarvey, LP; Morice, AH; Smith, JA; Tatar, M; Widdicombe, J	1
Hayashi, S; Itabashi, T; Kamei, J; Kawai, K; Takahashi, Y	1
Beardsmore, C; Houghton, T; Kenia, P	1
Cheng, TY; Ke, CQ; Lin, G; Rudd, JA; Tang, CP; Yang, XZ; Ye, Y; Zhu, JY	1
Franova, S; Sutovska, M; Sutovsky, J	1
Huang, SC; Lai, P; Liu, LF; Lu, DD; Tang, LH; Wang, Y; Ye, MR; Zhou, TN	1
But, PP; Chan, YM; Hon, PM; Jiang, RW; Shaw, PC; Xu, YT	1
But, PP; Chang, YS; Cheng, L; Khan, LA; Lam, H; Li, M; Ling, KH; Shaw, PC; Techen, N	1
Ebringerová, A; Hromádková, Z; Nosáľová, G; Prisenžňáková, L	1
Ebringerová, A; Hromádková, Z; Košťálová, Z; Nosáľová, G; Prisenžňáková, L	1
Ke, CQ; Lin, G; Tan, MJ; Tang, CP; Ye, Y; Yin, C	1
Bandyopadhyay, SS; Flešková, D; Nosál'ová, G; Ray, B; Sinha, S	1
Chung, KF	1
Mokry, J; Nosalova, G	1
Edafiogho, IO; El-Hashim, AZ; Ezeamuzie, CI; Jaffal, SM; Kombian, SB; Yousif, MH	1
Breierová, E; Capek, P; Cepák, V; Flešková, D; Hindák, F; Jureček, L; Lukavský, J; Nosáľová, G; Ray, B; Turjan, J	1
Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA	1
Eze, GI; Okpo, SO; Ozolua, RI; Salami, EO; Uwaya, DO	1
Biringerova, Z; Brozmanova, M; Gavliakova, S; Hanuskova, E; Plevkova, J; Poliacek, I; Tatar, M	1
Aranake, S; Bhosale, V; Ghosh, I; Karnik, P; Khairatkar-Joshi, N; Kulkarni, A; Mukhopadhyay, I; Shetty, M; Thorat, S; Wale, D	1
Capek, P; Czarny, A; Fraňová, S; Gancarz, R; Kočmalová, M; Pawlaczyk, I; Šutovská, M; Uhliariková, I; Zaczyńska, E	1
Flešková, D; Fraňová, S; Nosálová, G; Ondrejka, I; Ray, B; Sivová, V	1
Cheng, X; Gao, Y; Li, S; Liu, W; Ni, J; Qi, S; Wang, C; Wang, G; Wang, J; Wang, Y; Wang, Z; Zheng, T	1
Bouyssou, T; Wex, E	1
Capek, P; Fraňová, S; Gancarz, R; Kocmálová, M; Pawlaczyk, I; Šutovská, M	1
Branà, MP; Clay, E; Page, C; Patacchini, R; Preti, D; Spina, D; Trevisani, M	1
Bera, K; Nosáľ, S; Nosáľová, G; Ray, B; Sivová, V	1
Jiang, RW; Nie, H; Shaw, PC; Shou, JW; Wu, HY; Xia, X; Zhang, RR	1
Cui, S; Ito, I; Iwata, T; Izuhara, H; Kanemitsu, Y; Matsumoto, H; Mishima, M; Nagasaki, T; Nakaji, H; Niimi, A; Oguma, T; Tajiri, T	1
Fujii, H; Higashi, E; Hirayama, S; Honjo, A; Ikeda, H; Kamei, J; Kono, T; Nikaido, J; Shibasaki, M	1
Ang, A; Guiu Hernandez, E; Macrae, P; Wallace, E	1
Fu, JH; Guo, H; Hao, W; Jin, L; Liu, JX; Liu, ZX; Meng, S; Xu, SJ; Zhao, JF	1

Reviews

2 review(s) available for diphenhydramine hydrochloride and citric acid, anhydrous

Article	Year
Cough challenge in the assessment of cough reflex. British journal of clinical pharmacology, 2001, Volume: 52, Issue:4 Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Clinical Trials as Topic; Cough; Humans; Nebulizers and Vaporizers; Reflex	2001
Experimentally induced cough. Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:4 Topics: Antitussive Agents; Capsaicin; Citric Acid; Cough; Humans; Patient Selection; Reflex; Reproducibility of Results; Research Design; Sensitivity and Specificity; Water	2007

Trials

10 trial(s) available for diphenhydramine hydrochloride and citric acid, anhydrous

Article	Year
A comparative study of the antitussive activity of levodropropizine and dropropizine in the citric acid-induced cough model in normal subjects. Drugs under experimental and clinical research, 1992, Volume: 18, Issue:7 Topics: Adult; Antitussive Agents; Citrates; Citric Acid; Cough; Double-Blind Method; Female; Humans; Lung; Male; Patient Compliance; Propylene Glycols; Stereoisomerism	1992
A comparative randomized double-blind clinical trial of hexapneumine and clistine as antitussive agents. International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:6 Topics: Adolescent; Adult; Aged; Antitussive Agents; Citrates; Citric Acid; Clinical Trials as Topic; Cough; Double-Blind Method; Female; Guaifenesin; Humans; Male; Middle Aged; Pyridines; Random Allocation; Respiratory Tract Infections	1987
Assessment of the antitussive effect of vadocaine hydrochloride using citric acid-induced cough in healthy volunteers. Arzneimittel-Forschung, 1988, Volume: 38, Issue:4A Topics: Adult; Antitussive Agents; Citrates; Citric Acid; Cough; Double-Blind Method; Humans; Male; Piperidines	1988
Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. Respiration; international review of thoracic diseases, 1987, Volume: 52, Issue:1 Topics: Adult; Albuterol; Antitussive Agents; Citrates; Citric Acid; Cough; Dextromethorphan; Double-Blind Method; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Female; Humans; Levorphanol; Male; Placebos; Random Allocation	1987
Assessment of antitussive effects by citric acid threshold. British journal of diseases of the chest, 1983, Volume: 77, Issue:1 Topics: Adult; Antitussive Agents; Aporphines; Bronchial Provocation Tests; Citrates; Citric Acid; Clinical Trials as Topic; Codeine; Cough; Double-Blind Method; Humans; Male	1983
Effect of inhaled menthol on citric acid induced cough in normal subjects. Thorax, 1994, Volume: 49, Issue:10 Topics: Administration, Inhalation; Adult; Antitussive Agents; Bronchial Provocation Tests; Citrates; Citric Acid; Cough; Evaluation Studies as Topic; Female; Humans; Menthol; Middle Aged; Models, Biological; Random Allocation	1994
The placebo response to citric acid-induced cough: pharmacodynamics and gender differences. Pulmonary pharmacology & therapeutics, 2001, Volume: 14, Issue:4 Topics: Administration, Inhalation; Adolescent; Adult; Antitussive Agents; Citric Acid; Confounding Factors, Epidemiologic; Cough; Cross-Over Studies; Dextromethorphan; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebo Effect; Sex Factors	2001
Theobromine inhibits sensory nerve activation and cough. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:2 Topics: Adult; Animals; Antitussive Agents; Capsaicin; Citric Acid; Codeine; Cough; Cross-Over Studies; Disease Models, Animal; Double-Blind Method; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Neurons, Afferent; Theobromine; Vagus Nerve	2005
Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease. The Journal of allergy and clinical immunology, 2006, Volume: 117, Issue:4 Topics: Aged; Antitussive Agents; Citric Acid; Codeine; Cough; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Reflex	2006
Does inhaling menthol affect nasal patency or cough? Pediatric pulmonology, 2008, Volume: 43, Issue:6 Topics: Administration, Inhalation; Antitussive Agents; Bronchial Provocation Tests; Child; Citric Acid; Cough; Cross-Over Studies; Female; Humans; Male; Menthol; Nasal Decongestants; Nasal Obstruction; Spirometry	2008

Other Studies

65 other study(ies) available for diphenhydramine hydrochloride and citric acid, anhydrous

Article	Year
Selective inhibition of cough and bronchoconstriction in conscious guinea pigs. Respiration; international review of thoracic diseases, 1992, Volume: 59, Issue:2 Topics: Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Citrates; Citric Acid; Cough; Female; Guinea Pigs; Ipratropium; Lidocaine; Male; Terbutaline; Theophylline; Xanthines	1992
Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig. General pharmacology, 1991, Volume: 22, Issue:6 Topics: Administration, Inhalation; Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Dextromethorphan; Female; Guinea Pigs; Injections, Intraperitoneal; Morphine; Naloxone; Narcotics; Oligopeptides; Oxymorphone; Peripheral Nerves	1991
Effect of nedocromil sodium on SO2-induced airway hyperresponsiveness and citric acid-induced cough in dogs. International archives of allergy and applied immunology, 1989, Volume: 88, Issue:1-2 Topics: Animals; Antitussive Agents; Bronchi; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Citrates; Citric Acid; Cough; Dogs; Nedocromil; Nerve Fibers; Neutrophils; Quinolones; Sulfites	1989
The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs. British journal of pharmacology, 1988, Volume: 93, Issue:3 Topics: Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Cromolyn Sodium; Dogs; Female; Male; Nedocromil; Quinolines	1988
The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulmonary pharmacology, 1994, Volume: 7, Issue:3 Topics: Administration, Inhalation; Animals; Antitussive Agents; Camphor; Citrates; Citric Acid; Cough; Cyclohexanols; Eucalyptol; Guinea Pigs; Menthol; Monoterpenes; Terpenes	1994
Moguisteine: a novel peripheral non-narcotic antitussive drug. British journal of pharmacology, 1994, Volume: 112, Issue:3 Topics: Aerosols; Animals; Antitussive Agents; Binding, Competitive; Capsaicin; Citrates; Citric Acid; Codeine; Cough; Dogs; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Naloxone; Physical Stimulation; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Thiazoles; Thiazolidines	1994
Antitussive effect of oxatomide on citric acid-induced cough in conscious guinea pig. Preliminary communication. Arzneimittel-Forschung, 1993, Volume: 43, Issue:5 Topics: Animals; Antitussive Agents; Citrates; Citric Acid; Cough; Guinea Pigs; Histamine H1 Antagonists; Injections, Intraperitoneal; Piperazines; Regression Analysis	1993
Antitussive effect of SR 48968, a non-peptide tachykinin NK2 receptor antagonist. European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1 Topics: Animals; Antitussive Agents; Benzamides; Citrates; Citric Acid; Codeine; Cough; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Male; Naloxone; Piperidines; Receptors, Neurokinin-2	1993
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:4 Topics: Animals; Antitussive Agents; Bronchodilator Agents; Capsaicin; Citrates; Citric Acid; Cough; Guinea Pigs; Irritants; Male; Protons; Saline Solution, Hypertonic; Terbutaline	1995
Antitussive activity of moguisteine enantiomers in guinea-pigs and rats. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:1 Topics: Administration, Oral; Aerosols; Animals; Antacids; Antitussive Agents; Capsaicin; Citric Acid; Cough; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intraperitoneal; Lethal Dose 50; Male; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Thiazoles; Thiazolidines	1996
Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 1st communication: in vivo demonstration of the effects on animal models of cough and of Arzneimittel-Forschung, 1997, Volume: 47, Issue:4 Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; In Vitro Techniques; Male; Mucociliary Clearance; Oxadiazoles; Physical Stimulation; Purines; Rabbits	1997
Effects of moguisteine on the cough reflex induced by afferent electrical stimulation of the superior laryngeal nerve in guinea pigs. European journal of pharmacology, 1998, Dec-04, Volume: 362, Issue:2-3 Topics: Aerosols; Animals; Anticoagulants; Antitussive Agents; Citric Acid; Codeine; Cough; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Injections, Intravenous; Injections, Intraventricular; Laryngeal Nerves; Reflex; Thiazoles; Thiazolidines	1998
Antitussive effect of K+ channel openers. European journal of pharmacology, 1999, Apr-23, Volume: 371, Issue:1 Topics: Animals; Antitussive Agents; Bronchodilator Agents; Citric Acid; Codeine; Cromakalim; Drug Synergism; Female; Guinea Pigs; Male; Pinacidil; Potassium Channels; Tachykinins	1999
Mucolytic and antitussive effects of erdosteine. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:8 Topics: Animals; Antitussive Agents; Citric Acid; Cough; Drug Interactions; Expectorants; Female; Male; Mucociliary Clearance; Mucus; Physical Stimulation; Quail; Rats; Stimulation, Chemical; Swine; Thioglycolates; Thiophenes; Time Factors; Viscosity	1999
Effects of some Malian medicinal plants on the respiratory tract of guinea-pigs. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:11 Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antitussive Agents; Bronchial Spasm; Bronchoconstriction; Citric Acid; Codeine; Cough; Cromolyn Sodium; Fruit; Guinea Pigs; Histamine Antagonists; Male; Mali; Plant Epidermis; Plant Extracts; Plant Roots; Plants, Medicinal; Respiratory System	1999
Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs. Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:1 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antitussive Agents; Bradykinin; Citric Acid; Cough; Dose-Response Relationship, Drug; Drug Synergism; Enalapril; Female; Male; Receptors, Tachykinin; Swine; Tachykinins	2001
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1 Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central Nervous System; Citric Acid; Cloning, Molecular; Cough; Guinea Pigs; In Vitro Techniques; Iris; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pupil; Quinolines; Rabbits; Radioligand Assay; Rats; Receptors, Neurokinin-3; Receptors, Tachykinin; Recombinant Proteins; Substance P	2002
RSD931, a novel anti-tussive agent acting on airway sensory nerves. British journal of pharmacology, 2003, Volume: 138, Issue:3 Topics: Administration, Inhalation; Aerosols; Animals; Antitussive Agents; Bronchi; Bronchoconstriction; Capsaicin; Carnosine; Citric Acid; Cough; Dose-Response Relationship, Drug; Female; Guinea Pigs; Lidocaine; Lung; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Rabbits; Time Factors	2003
Determination of butamyrate citrate in cough preparations by derivative UV spectrophotometry and high performance liquid chromatography. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2003, Volume: 19, Issue:4 Topics: Antitussive Agents; Chromatography, High Pressure Liquid; Citric Acid; Phenylbutyrates; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	2003
Antitussive activity of Anar. Bulletin of experimental biology and medicine, 2003, Volume: 135 Suppl 7 Topics: Animals; Antibodies; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Lung; Male; Morphine	2003
Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin. Bulletin of experimental biology and medicine, 2003, Volume: 135 Suppl 7 Topics: Animals; Antibodies; Antitussive Agents; Bradykinin; Capsaicin; Citric Acid; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Humans; Male; Serotonin	2003
The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents. The American journal of the medical sciences, 1954, Volume: 228, Issue:2 Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans	1954
The cough response of normal human subjects stimulated experimentally by citric acid aerosol: alterations produced by antitussive agents. I. Methology. The American journal of the medical sciences, 1956, Volume: 232, Issue:1 Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans	1956
The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents. The American journal of the medical sciences, 1957, Volume: 234, Issue:2 Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans	1957
PHARMACOLOGICAL PROPERTIES OF 3-ALPHA-PHENYLPROPYL-5-BETA-DIETHYLAMINOETHYL-1,2,4-OXADIAZOLE CITRATE. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antitussive Agents; Citrates; Citric Acid; Guinea Pigs; Inflammation; Mice; Muscle Relaxants, Central; Muscle, Smooth; Oxadiazoles; Pharmacology; Rats; Research; Toxicology	1963
Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta medica, 2003, Volume: 69, Issue:10 Topics: Alkaloids; Animals; Antitussive Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Guinea Pigs; Male; Phytotherapy; Plant Extracts; Plant Roots; Stemonaceae; Structure-Activity Relationship	2003
Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2 Topics: Animals; Antitussive Agents; Benzhydryl Compounds; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Piperidines; Stereoisomerism; Time Factors	2004
Identification of some benproperine metabolites in humans and investigation of their antitussive effect. Acta pharmacologica Sinica, 2005, Volume: 26, Issue:12 Topics: Adult; Animals; Antitussive Agents; Benzhydryl Compounds; Chromatography, Liquid; Citric Acid; Cough; Female; Guinea Pigs; Humans; Male; Piperidines; Spectrometry, Mass, Electrospray Ionization	2005
Effects of eppikahangeto, a Kampo formula, and Ephedrae herba against citric acid-induced laryngeal cough in guinea pigs. Journal of pharmacological sciences, 2006, Volume: 101, Issue:2 Topics: Animals; Antitussive Agents; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ephedra; Guinea Pigs; Larynx; Male; Medicine, Chinese Traditional; Medicine, Kampo; Microinjections; Plant Extracts	2006
Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Fitoterapia, 2006, Volume: 77, Issue:6 Topics: Animals; Antitussive Agents; Carotenoids; Citric Acid; Cough; Crocus; Cyclohexenes; Female; Flowers; Guinea Pigs; Injections, Intraperitoneal; Male; Phytotherapy; Plant Extracts; Terpenes	2006
Effect of d-pseudoephedrine on cough reflex and its mode of action in guinea pigs. Journal of pharmacological sciences, 2006, Volume: 102, Issue:1 Topics: Animals; Antitussive Agents; Bronchodilator Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Electric Stimulation; Ephedrine; Guinea Pigs; Laryngeal Nerves; Larynx; Male; Microinjections; Mucous Membrane; Reflex; Solitary Nucleus	2006
[Experimental studies on antitussive, expectorant and antiasthmatic effects of extract from Citrus grandis var. tomentosa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:16 Topics: Acetylcholine; Ammonia; Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Citric Acid; Citrus; Cough; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Expectorants; Female; Fruit; Guinea Pigs; Histamine; Male; Mice; Phytotherapy; Plants, Medicinal; Rats; Rats, Sprague-Dawley	2006
Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:4 Topics: Animals; Antitussive Agents; Area Under Curve; Atropine; Capsaicin; Citric Acid; Codeine; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Inhalation Exposure; Male; Plethysmography, Whole Body; Reflex; Smoke; Terbutaline	2007
Role of cyclin-dependent kinase 5 in capsaicin-induced cough. European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3 Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Cough; Cyclin-Dependent Kinase 5; Male; Mice; Mice, Inbred ICR; Protein Kinase Inhibitors; Purines; Roscovitine	2007
ERS guidelines on the assessment of cough. The European respiratory journal, 2007, Volume: 29, Issue:6 Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Citric Acid; Clinical Trials as Topic; Cough; Disease Models, Animal; Humans; Lung Diseases; Practice Guidelines as Topic; Quality of Life; Tachyphylaxis; Treatment Outcome; Water	2007
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17. Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:2 Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Fungal Proteins; Guinea Pigs; Histamine; Histamine Agonists; Histamine H1 Antagonists, Non-Sedating; Male; Methacholine Chloride; Respiratory Hypersensitivity; Terfenadine	2008
Alkaloids from roots of Stemona sessilifolia and their antitussive activities. Planta medica, 2009, Volume: 75, Issue:2 Topics: 4-Butyrolactone; Alkaloids; Animals; Antitussive Agents; Azepines; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Molecular Structure; Phytotherapy; Plant Extracts; Plant Roots; Stemonaceae	2009
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. Bratislavske lekarske listy, 2009, Volume: 110, Issue:5 Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels; Male; Muscle Contraction; Muscle, Smooth; Physical Stimulation; Pinacidil; Potassium Channel Blockers; Potassium Channels; Propylene Glycols; Reflex; Trachea	2009
[Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, Volume: 32, Issue:4 Topics: Acetylcholine; Anaphylaxis; Animals; Antitussive Agents; Asthma; Astragalus propinquus; Citric Acid; Cough; Drugs, Chinese Herbal; Expectorants; Female; Guinea Pigs; Histamine; Male; Mice; Moraceae; Muscle Contraction; Muscle, Smooth; Phytotherapy; Plant Roots; Random Allocation; Trachea	2009
Antitussive and central respiratory depressant effects of Stemona tuberosa. Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3 Topics: Alkaloids; Animals; Antitussive Agents; Central Nervous System Agents; Citric Acid; Cough; Guinea Pigs; Lactones; Laryngeal Nerves; Plant Roots; Pyrrolidines; Respiratory System; Spiro Compounds; Stemonaceae	2010
Cardiocrinum seeds as a replacement for Aristolochia fruits in treating cough. Journal of ethnopharmacology, 2010, Jul-20, Volume: 130, Issue:2 Topics: Animals; Antitussive Agents; Aristolochia; Base Sequence; Citric Acid; Cough; Disease Models, Animal; DNA, Plant; Dose-Response Relationship, Drug; Fruit; Guinea Pigs; Liliaceae; Lilium; Plant Extracts; Seeds; Sequence Analysis, DNA	2010
The pharmacological activity of wheat bran polysaccharides. Fitoterapia, 2010, Volume: 81, Issue:8 Topics: Animals; Antitussive Agents; Citric Acid; Cough; Dietary Fiber; Guinea Pigs; Male; Plant Extracts; Polysaccharides	2010
Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs. Fitoterapia, 2011, Volume: 82, Issue:3 Topics: Animals; Antitussive Agents; Citric Acid; Codeine; Cough; Cucurbita; Drug Synergism; Fruit; Guinea Pigs; Muscle, Smooth; Pectins; Phytotherapy; Plant Extracts; Reflex; Respiratory System; Structure-Activity Relationship	2011
Antitussive indole alkaloids from Kopsia hainanensis. Planta medica, 2011, Volume: 77, Issue:9 Topics: Animals; Antitussive Agents; Apocynaceae; Citric Acid; Cough; Guinea Pigs; Indole Alkaloids; Molecular Structure; Plant Extracts; Plant Stems	2011
In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. Journal of ethnopharmacology, 2011, Mar-24, Volume: 134, Issue:2 Topics: Animals; Antitussive Agents; Behavior, Animal; Citric Acid; Codeine; Cough; Galactans; Guinea Pigs; Phytotherapy; Plant Extracts; Withania	2011
Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough. Pulmonary pharmacology & therapeutics, 2011, Volume: 24, Issue:3 Topics: Animals; Antitussive Agents; Capsaicin; Chronic Disease; Citric Acid; Cough; Humans; Quality of Life; Respiratory Hypersensitivity; Syndrome	2011
The influence of the PDE inhibitors on cough reflex in guinea pigs. Bratislavske lekarske listy, 2011, Volume: 112, Issue:3 Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Citric Acid; Cough; Guinea Pigs; Male; Ovalbumin; Phosphodiesterase Inhibitors; Reflex; Theobromine; Theophylline	2011
Anti-tussive and bronchodilator mechanisms of action for the enaminone E121. Life sciences, 2011, Sep-12, Volume: 89, Issue:11-12 Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Obstruction; Aniline Compounds; Animals; Antitussive Agents; Bronchodilator Agents; Citric Acid; Cough; Cyclic AMP; Cyclohexanecarboxylic Acids; Disease Models, Animal; Eosinophils; Female; Glyburide; Guinea Pigs; Infusions, Intraventricular; KATP Channels; Male; Plethysmography; Propranolol; Random Allocation	2011
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex. International journal of biological macromolecules, 2011, Dec-01, Volume: 49, Issue:5 Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Animals; Antitussive Agents; Biopolymers; Bronchial Hyperreactivity; Citric Acid; Cough; Freeze Drying; Glucuronic Acid; Guinea Pigs; Male; Monosaccharides; Muscle, Smooth; Plant Extracts; Plethysmography; Proteoglycans; Reflex; Respiratory System; Rhodophyta; Viscosity	2011
Antitussive effects of memantine in guinea pigs. Chest, 2012, Volume: 141, Issue:4 Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs; Ketamine; Male; Mecamylamine; Memantine; N-Methylaspartate; Serotonin	2012
Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species. Asian Pacific journal of tropical medicine, 2013, Volume: 6, Issue:6 Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Antitussive Agents; Bronchial Spasm; Citric Acid; Cough; Female; Guinea Pigs; Histamine; Kalanchoe; Lung; Male; Mice; Mucus; Ovalbumin; Plant Extracts; Plant Leaves; Trachea; Viscosity	2013
The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models. Respiratory physiology & neurobiology, 2013, Dec-01, Volume: 189, Issue:3 Topics: Administration, Intranasal; Anesthesia; Animals; Anticoagulants; Antitussive Agents; Citric Acid; Consciousness; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Isothiocyanates; Male; Respiration	2013
Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Antitussive Agents; Biological Transport; Calcium; Calcium Channels; Cell Line; Citric Acid; Cough; Guinea Pigs; Humans; Ligands; Male; Nerve Tissue Proteins; Toll-Like Receptors; Transient Receptor Potential Channels; TRPA1 Cation Channel	2014
Characterization and pharmacodynamic properties of Arnica montana complex. International journal of biological macromolecules, 2014, Volume: 69 Topics: Animals; Antitussive Agents; Arnica; Cell Line; Citric Acid; Cough; Guinea Pigs; Humans; Male; Mice; Muscle, Smooth; Plant Extracts; Reflex; Respiratory System	2014
Antitussive activity of Withania somnifera and opioid receptors. Advances in experimental medicine and biology, 2015, Volume: 838 Topics: Animals; Antitussive Agents; Citric Acid; Codeine; Cough; Galactans; Guinea Pigs; Male; Naloxone; Narcotic Antagonists; Plant Extracts; Plant Roots; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Withania	2015
In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn. Journal of ethnopharmacology, 2015, Mar-13, Volume: 162 Topics: Acetylcholine; Ammonia; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Citric Acid; Cough; Expectorants; Female; Guinea Pigs; Histamine; Male; Medicine, Chinese Traditional; Mice, Inbred ICR; Peganum; Phenolsulfonphthalein; Phytotherapy; Plant Components, Aerial; Plant Extracts; Trachea	2015
Olodaterol attenuates citric acid-induced cough in naïve and ovalbumin-sensitized and challenged guinea pigs. PloS one, 2015, Volume: 10, Issue:3 Topics: Adrenergic beta-2 Receptor Agonists; Animals; Antitussive Agents; Benzoxazines; Citric Acid; Cough; Drug Evaluation, Preclinical; Guinea Pigs; Male	2015
Chemical and pharmacological profiles of Echinacea complex. International journal of biological macromolecules, 2015, Volume: 79 Topics: Albuterol; Animals; Antitussive Agents; Bronchodilator Agents; Chromatography, High Pressure Liquid; Citric Acid; Codeine; Cough; Echinacea; Flowers; Guinea Pigs; Male; Plant Extracts; Plethysmography; Polysaccharides; Respiratory System	2015
Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Benzamides; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Citric Acid; Cough; Cyclopropanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Male; Neutrophil Infiltration; Oxidants, Photochemical; Ozone; Propylene Glycols; Rabbits; Transient Receptor Potential Channels	2016
Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna. Advances in experimental medicine and biology, 2016, Volume: 935 Topics: Administration, Oral; Airway Resistance; Animals; Antitussive Agents; Citric Acid; Cough; Galactans; Guinea Pigs; Male; Plant Bark; Plant Extracts; Terminalia	2016
Isolation of novel biflavonoids from Cardiocrinum giganteum seeds and characterization of their antitussive activities. Journal of ethnopharmacology, 2018, Aug-10, Volume: 222 Topics: Animals; Antitussive Agents; Biflavonoids; Citric Acid; Cough; Electric Stimulation; Female; Guinea Pigs; Laryngeal Nerves; Liliaceae; Male; Phytotherapy; Plant Extracts; Seeds	2018
Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model. Respiratory physiology & neurobiology, 2019, Volume: 263 Topics: Administration, Inhalation; Airway Remodeling; Animals; Antitussive Agents; Basement Membrane; Citric Acid; Codeine; Cough; Disease Models, Animal; Guinea Pigs; Male; Muscle, Smooth; Saline Solution; Stress, Mechanical	2019
Development of Novel δ Opioid Receptor Inverse Agonists without a Basic Nitrogen Atom and Their Antitussive Effects in Mice. ACS chemical neuroscience, 2019, 09-18, Volume: 10, Issue:9 Topics: Analgesics, Opioid; Animals; Antitussive Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Drug Development; Drug Inverse Agonism; Mice; Nitrogen; Receptors, Opioid, delta	2019
Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings. Pulmonary pharmacology & therapeutics, 2019, Volume: 58 Topics: Administration, Inhalation; Adult; Antitussive Agents; Citric Acid; Cough; Female; Humans; Male; Middle Aged; Reflex; Reproducibility of Results	2019
[Optimization of extraction process of Children's Qingfei Zhisou Syrup based on pharmacodynamics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:10 Topics: Animals; Antitussive Agents; Calcium Sulfate; Citric Acid; Cough; Ethanol; Guinea Pigs; Humans; Indigo Carmine; Indigofera; Mice; Water	2022