Page last updated: 2024-08-20

diphenhydramine hydrochloride and benzonatate

diphenhydramine hydrochloride has been researched along with benzonatate in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19906 (27.27)18.7374
1990's2 (9.09)18.2507
2000's1 (4.55)29.6817
2010's10 (45.45)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Cohan, JA; Conradi, SE; Long, C; Lukash, L; Manning, TJ; Ziminski, KR1
Sant'Ambrogio, FB; Sant'Ambrogio, G1
Oberg, B; Thorén, P1
Doona, M; Walsh, D1
Crouch, BI; Crouch, DJ; Knick, KA; Matsumura, KS; Rollins, DE1
BUCHER, K1
HERZOG, H1
LANGREHR, D1
Dicpinigaitis, PV; Gayle, YE; Gilbert, RD; Solomon, G1
Baseluos, C; Cohen, V; Jellinek, SP; Marshall, JP; Stansfield, L; Truong, H1
Griffith, JR; Spiller, HA; Winter, ML1
Colling, L; Hendershot, AJ; Mauger, TF1
Danesh, M; Murase, JE1
Evans, MS; Fletcher, AM; Johnson, SR; Maglinger, GB1
Beuhler, MC; Bishop-Freeman, SC; Friederich, LW; Shonsey, EM; Winecker, RE1
Brown, T; LaRock, R; Lee, S; Mann, P; Mckeon, M; Paranjpe, M; Teo, S1
Levi, ME1
Bedi, P; Jin, C; Majumder, MR; Sherazi, A; Zahid, E1
Leonard, JB; Minhaj, FS1
Baumgartner, KT; Filip, AB; Liss, DB; Schwarz, ES; Stephens, RJ1
Biehl, A; Cheng, C; Goulding, M; Karami, S; Kim, I; Muñoz, M; Pham, T; Tian, F1

Reviews

2 review(s) available for diphenhydramine hydrochloride and benzonatate

ArticleYear
In brief: benzonatate warning.
    The Medical letter on drugs and therapeutics, 2011, Feb-07, Volume: 53, Issue:1357

    Topics: Age Factors; Animals; Antitussive Agents; Arrhythmias, Cardiac; Butylamines; Drug Overdose; Humans; Seizures; United States; United States Food and Drug Administration

2011
A description of the clinical course of severe benzonatate poisonings reported in the literature and to NPDS: A systematic review supplemented with NPDS cases.
    Human & experimental toxicology, 2021, Volume: 40, Issue:12_suppl

    Topics: Antitussive Agents; Butylamines; Humans; Poison Control Centers

2021

Trials

1 trial(s) available for diphenhydramine hydrochloride and benzonatate

ArticleYear
Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough.
    Respiratory medicine, 2009, Volume: 103, Issue:6

    Topics: Administration, Inhalation; Administration, Oral; Adult; Antitussive Agents; Butylamines; Capsaicin; Common Cold; Cough; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Guaifenesin; Humans; Male; Middle Aged; Reflex; Sensory System Agents

2009

Other Studies

19 other study(ies) available for diphenhydramine hydrochloride and benzonatate

ArticleYear
Two fatalities resulting from Tessalon (benzonatate).
    Veterinary and human toxicology, 1986, Volume: 28, Issue:6

    Topics: Adolescent; Antitussive Agents; Butylamines; Chromatography, High Pressure Liquid; Female; Humans; Infant; Male; Phenytoin; Spectrophotometry, Ultraviolet; Suicide

1986
Circulatory accessibility of nervous receptors localized in the tracheobronchial tree.
    Respiration physiology, 1982, Volume: 49, Issue:1

    Topics: Animals; Antitussive Agents; Arteries; Biomechanical Phenomena; Bronchi; Butylamines; Dogs; Female; Ligation; Lung; Male; Mechanoreceptors; Pulmonary Circulation; Respiration; Respiration, Artificial; Time Factors; Trachea; Veratridine

1982
Studies on the endoanesthetic effects of lidocaine and benzonatate on non-medullated nerve endings in the left ventricle.
    Acta physiologica Scandinavica, 1981, Volume: 111, Issue:1

    Topics: Animals; Antitussive Agents; Blood Pressure; Butylamines; Cats; Heart Rate; Heart Ventricles; Lidocaine; Mechanoreceptors; Nerve Endings; Reflex

1981
Benzonatate for opioid-resistant cough in advanced cancer.
    Palliative medicine, 1998, Volume: 12, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antitussive Agents; Butylamines; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Cough; Drug Resistance; Female; Humans; Lung Neoplasms; Male; Neoplasms, Unknown Primary; Treatment Outcome

1998
Benzonatate overdose associated with seizures and arrhythmias.
    Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:7

    Topics: Adult; Antitussive Agents; Arrhythmias, Cardiac; Butylamines; Chromatography, High Pressure Liquid; Drug Overdose; Fatal Outcome; Humans; Infant; Male; Mass Spectrometry; Seizures; Suicide, Attempted

1998
[New effect mechanism of the antitussive drug tessalon].
    Schweizerische medizinische Wochenschrift, 1956, Jan-28, Volume: 86, Issue:4

    Topics: Anesthetics; Antitussive Agents; Butylamines; Cough

1956
[Polyethyleneglycol derivatives with antitussive effects, especially tessalon].
    Schweizerische medizinische Wochenschrift, 1956, Jan-28, Volume: 86, Issue:4

    Topics: Anesthetics; Antitussive Agents; Butylamines; Cough; para-Aminobenzoates; Polyethylene Glycols

1956
[On the problem of receptor specificity of endoanesthetic effects based on the example of benzononatin (Tessalon)].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1963, Volume: 245

    Topics: Antitussive Agents; Butylamines; Electrophysiological Phenomena; Electrophysiology; Humans; Sensory Receptor Cells

1963
Cardiac arrest with residual blindness after overdose of Tessalon® (benzonatate) perles.
    The Journal of emergency medicine, 2011, Volume: 41, Issue:2

    Topics: Adolescent; Antitussive Agents; Blindness; Butylamines; Drug Overdose; Female; Heart Arrest; Humans; Suicide, Attempted; Treatment Outcome

2011
Benzonatate Ingestion Reported to the National Poison Center Database System (NPDS).
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitussive Agents; Arrhythmias, Cardiac; Butylamines; Child; Child, Preschool; Databases, Factual; Female; Humans; Infant; Male; Middle Aged; Poison Control Centers; Poisoning; Retrospective Studies; Survival Rate; United States; Young Adult

2010
Corneal anesthetic abuse from the use of topical benzonatate (Tessalon Perle).
    Cornea, 2011, Volume: 30, Issue:12

    Topics: Administration, Topical; Anesthetics, Local; Antitussive Agents; Butylamines; Cornea; Eye Injuries; Female; Humans; Middle Aged; Visual Acuity

2011
Use of a nonnarcotic antitussive for severe, treatment-resistant oral ulcers.
    Journal of the American Academy of Dermatology, 2015, Volume: 72, Issue:6

    Topics: Administration, Topical; Antitussive Agents; Butylamines; Chronic Disease; Female; Humans; Male; Oral Ulcer; Pain Measurement; Quality of Life; Risk Assessment; Severity of Illness Index; Treatment Outcome

2015
Benzonatate inhibition of voltage-gated sodium currents.
    Neuropharmacology, 2016, Volume: 101

    Topics: Action Potentials; Analysis of Variance; Animals; Antitussive Agents; Biophysical Phenomena; Butylamines; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electric Stimulation; Mice; NAV1.7 Voltage-Gated Sodium Channel; Neuroblastoma; Patch-Clamp Techniques; Sodium Channel Blockers; Time Factors

2016
Benzonatate Toxicity: Nothing to Cough At.
    Journal of analytical toxicology, 2017, 06-01, Volume: 41, Issue:5

    Topics: Antitussive Agents; Butylamines; Clinical Decision-Making; Consumer Product Safety; Cough; Dose-Response Relationship, Drug; Drug Overdose; Humans; Nonprescription Drugs; Patient Safety; Risk Assessment; Risk Factors

2017
The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies.
    Toxicologic pathology, 2018, Volume: 46, Issue:6

    Topics: Administration, Oral; Animals; Antitussive Agents; Butylamines; Carcinogenicity Tests; Dose-Response Relationship, Drug; Female; Genes, ras; Male; Maximum Tolerated Dose; Mice, Transgenic; Neoplasms, Experimental; Rats, Wistar

2018
Primary Care Management of Upper Respiratory Infections in the Women's Health Care Setting.
    Journal of midwifery & women's health, 2019, Volume: 64, Issue:3

    Topics: Adult; Ambulatory Care; Antitussive Agents; Butylamines; Coinfection; Diagnosis, Differential; Disease Management; Female; Humans; Midwifery; Physical Examination; Primary Health Care; Respiratory Tract Infections; Women's Health

2019
Cardiac Arrest Due to Benzonatate Overdose.
    The American journal of case reports, 2019, May-03, Volume: 20

    Topics: Acidosis; Adult; Antitussive Agents; Butylamines; Drug Overdose; Female; Heart Arrest; Humans

2019
Benzonatate Overdose Presenting as Cardiac Arrest with Rapidly Narrowing QRS Interval.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2022, Volume: 18, Issue:4

    Topics: Adolescent; Anesthetics, Local; Antitussive Agents; Arrhythmias, Cardiac; Butylamines; Child; Drug Overdose; Epinephrine; Female; Heart Arrest; Humans; Naloxone; Sodium Channels

2022
Benzonatate Exposure Trends and Adverse Events.
    Pediatrics, 2022, 12-01, Volume: 150, Issue:6

    Topics: Adolescent; Antitussive Agents; Butylamines; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Poison Control Centers; Retrospective Studies; United States

2022