diphenhydramine hydrochloride has been researched along with 3-methoxymorphinan in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorski, JC; Haehner, BD; Hall, SD; Jones, DR; O'Mara, EM | 1 |
| Fogelman, SM; Greenblatt, DJ; Schmider, J; Shader, RI; von Moltke, LL | 1 |
| Abdel-Rahman, SM; Gotschall, RR; Kauffman, RE; Kearns, GL; Leeder, JS | 1 |
| Fleckenstein, LL; Ku, YM; Min, DI; Vichiendilokkul, A | 1 |
| Unadkat, JD; Wang, Y | 1 |
| Haining, RL; Yu, A | 1 |
| Chen, TS; Hsiong, CH; Hu, OY; Hung, CF; Kuo, BP; Pao, LH | 1 |
| Mironidou-Tzouveleki, M; Niopas, I; Spanakis, M; Vizirianakis, IS | 1 |
4 trial(s) available for diphenhydramine hydrochloride and 3-methoxymorphinan
| Article | Year |
|---|---|
Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.
Topics: Administration, Oral; Adolescent; Adult; Antitussive Agents; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Erythromycin; Female; Humans; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenotype; Rifampin | 1996 |
Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Topics: Adult; Antifungal Agents; Antitussive Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Female; Humans; Male; Naphthalenes; Phenotype; Prospective Studies; Reference Values; Terbinafine; Volunteers | 1999 |
A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers.
Topics: Administration, Oral; Adult; Antitussive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Emulsions; Female; Humans; Immunosuppressive Agents; Injections, Intravenous; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Predictive Value of Tests; Reference Values | 1999 |
Single-point plasma or urine dextromethorphan method for determining CYP3A activity.
Topics: Administration, Oral; Adult; Antitussive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Delayed-Action Preparations; Dextromethorphan; Humans; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Phenotype; Saliva | 2003 |
4 other study(ies) available for diphenhydramine hydrochloride and 3-methoxymorphinan
| Article | Year |
|---|---|
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Topics: Animals; Antitussive Agents; Benzoflavones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Ditiocarb; Enzyme Inhibitors; Humans; In Vitro Techniques; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Quinidine; Rats; Sulfaphenazole; Tissue Donors | 1997 |
Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes.
Topics: Antibodies, Blocking; Antitussive Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases | 1999 |
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
Topics: Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases, N-Demethylating | 2001 |
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.
Topics: Antitussive Agents; Calibration; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Dextrorphan; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity | 2009 |