diphenhydramine and valproic acid

diphenhydramine has been researched along with valproic acid in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.26)18.7374
1990's2 (10.53)18.2507
2000's8 (42.11)29.6817
2010's7 (36.84)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Bauman, AW; Hammond, EJ; Karas, BJ; Wilder, BJ1
Buttar, HS; Guest, I; Smith, S; Varma, DR1
Abbott, FS; Axelson, JE; Doroudian, A; Gordon, JG; Riggs, KW; Rurak, DW; Tonn, GR1
Cummings, MR; Miller, BD1
Grosberg, BM; Robbins, MS; Solomon, S; Tarshish, S1
Feltner, DE; Haig, G1
Blatt, J; Bridges, AS; Coulter, DW; Davis, IJ; Deal, AM; Khan, WA; McFadden, A; Moats-Staats, BM; Oesterheld, J; Patel, J; Smith, SV; Walko, C1
Hershey, AD; Kabbouche, M; Maconochie, I; Murphy, B; Qaiser, S; Werner, K1

Reviews

5 review(s) available for diphenhydramine and valproic acid

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
New approaches for drug and kinetic analysis in the maternal-fetal unit.
    NIDA research monograph, 1995, Volume: 154

    Topics: Animals; Diphenhydramine; Female; Fetus; Labetalol; Metoclopramide; Pregnancy; Pregnancy, Animal; Sheep; Stereoisomerism; Valproic Acid

1995
Pharmacologic management of behavioral instability in medically ill pediatric patients.
    Current opinion in pediatrics, 2004, Volume: 16, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Analgesics, Non-Narcotic; Behavior Therapy; Behavioral Medicine; Benzodiazepines; Carbamazepine; Central Nervous System Stimulants; Child; Clonidine; Diphenhydramine; Histamine H1 Antagonists; Humans; Lithium; Methylphenidate; Psychomotor Agitation; Valproic Acid

2004
Intravenous Migraine Treatment in Children and Adolescents.
    Current pain and headache reports, 2020, Jul-08, Volume: 24, Issue:8

    Topics: Administration, Intravenous; Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Basal Ganglia Diseases; Child; Dexamethasone; Dihydroergotamine; Diphenhydramine; Dopamine Antagonists; Emergency Service, Hospital; Enzyme Inhibitors; Fluid Therapy; Glucocorticoids; Hospitalization; Humans; Hypnotics and Sedatives; Ketorolac; Lidocaine; Magnesium; Migraine Disorders; Prochlorperazine; Propofol; Valproic Acid; Vasoconstrictor Agents

2020

Trials

3 trial(s) available for diphenhydramine and valproic acid

ArticleYear
Treatment of valproate tremors.
    Neurology, 1983, Volume: 33, Issue:10

    Topics: Amantadine; Cyproheptadine; Diphenhydramine; Humans; Propranolol; Tremor; Valproic Acid

1983
Evaluation of the subjective and reinforcing effects of diphenhydramine, levetiracetam, and valproic acid.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Affect; Blood Pressure; Diphenhydramine; Female; Heart Rate; Humans; Hypnotics and Sedatives; Levetiracetam; Male; Middle Aged; Pentobarbital; Piracetam; Psychomotor Performance; Reinforcement, Psychology; Respiratory Rate; Self Report; Surveys and Questionnaires; Valproic Acid

2011
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
    Anti-cancer drugs, 2013, Volume: 24, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Early Termination of Clinical Trials; Fatigue; Female; Hematologic Diseases; Histone Deacetylase Inhibitors; Humans; Infusions, Intravenous; Male; Mucositis; Neoplasms; Pain; Sirolimus; Valproic Acid

2013

Other Studies

11 other study(ies) available for diphenhydramine and valproic acid

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Evaluation of the rat embryo culture system as a predictive test for human teratogens.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Captopril; Diphenhydramine; DNA; Embryo, Mammalian; False Negative Reactions; False Positive Reactions; Female; Humans; Ibuprofen; Neural Tube Defects; Organ Culture Techniques; Pregnancy; Rats; Teratogens; Valproic Acid

1994
Pharmaceutical drug overdose case reports. From the World Literature.
    Toxicological reviews, 2003, Volume: 22, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine Maleate; Drug Overdose; Female; Humans; International Normalized Ratio; Lithium; Male; Middle Aged; Paroxetine; Salicylates; Valproic Acid; Warfarin

2003
Cluster attacks responsive to recreational cannabis and dronabinol.
    Headache, 2009, Volume: 49, Issue:6

    Topics: Analgesics, Non-Narcotic; Cannabis; Cluster Headache; Dihydroergotamine; Diphenhydramine; Dronabinol; Drug Resistance; Drug Therapy, Combination; Fructose; Humans; Male; Melatonin; Metoclopramide; Topiramate; Treatment Outcome; Valproic Acid; Young Adult

2009