diphenhydramine and perphenazine

diphenhydramine has been researched along with perphenazine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199010 (43.48)18.7374
1990's2 (8.70)18.2507
2000's7 (30.43)29.6817
2010's4 (17.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Gralla, EJ; Hayden, DW; Mattsson, JL; Sabo, JP; Yochmowitz, MG1
Chopra, YM; Dandiya, PC2
Sachweh, H1
Dandiya, PC; Patni, SK1
Ushakov, BN1
Bhargava, LP; Dandiya, PC1
Ibrahim, I; Sulman, FG; Weller, CP1
Benjamin, S; Connor, DF; Ozbayrak, KR1
Kuhlman, C; Mehta, NH; Parsons, SK; Reed, CM; Weinstein, HJ1
FRANKL, HD; MILCH, LJ; RENZI, AA1
DENNER, JL; SMITH, MJ1

Reviews

2 review(s) available for diphenhydramine and perphenazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Antiemetics and emetics. 26].
    Pharmazeutische Praxis, 1968, Volume: 6

    Topics: Antiemetics; Benzamides; Chemical Phenomena; Chemistry; Cyclizine; Diphenhydramine; Emetics; Ethylamines; Haloperidol; Histamine H1 Antagonists; Humans; Meclizine; Perphenazine; Phenothiazines; Piperazines; Prochlorperazine; Promethazine; Thiazines; Thiethylperazine; Triflupromazine

1968

Trials

1 trial(s) available for diphenhydramine and perphenazine

ArticleYear
Controlling conditioning-related emesis in children undergoing bone marrow transplantation.
    Oncology nursing forum, 1997, Volume: 24, Issue:9

    Topics: Adolescent; Antiemetics; Bone Marrow Transplantation; Child; Child, Preschool; Cross-Over Studies; Diphenhydramine; Dopamine Antagonists; Drug Therapy, Combination; Female; Humans; Male; Ondansetron; Perphenazine; Prospective Studies; Transplantation Conditioning; Vomiting

1997

Other Studies

20 other study(ies) available for diphenhydramine and perphenazine

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
The effect of selected drugs on first-stage radioemesis in beagle dogs.
    Radiation research, 1979, Volume: 78, Issue:2

    Topics: Amifostine; Amphetamine; Animals; Antiemetics; Body Weight; Chlorpromazine; Dimenhydrinate; Diphenhydramine; Dogs; Drug Combinations; Perphenazine; Phenytoin; Radiation Injuries, Experimental; Scopolamine; Vomiting; X-Rays

1979
The relative role of brain acetylcholine and histamine in perphenazine catatonia and influence of antidepressants and diphenhydramine alone and in combination.
    Neuropharmacology, 1975, Volume: 14, Issue:8

    Topics: Acetylcholine; Animals; Antidepressive Agents; Brain; Brain Chemistry; Catatonia; Diphenhydramine; Drug Interactions; Histamine; Humans; Male; Perphenazine; Rats; Time Factors

1975
The mechanism of the potentiating effect of antidepressant drugs on the protective influenc oe of diphenhydramine in experimental catatonia. The role of histamine.
    Pharmacology, 1974, Volume: 12, Issue:6

    Topics: Animals; Antidepressive Agents; Brain; Brain Chemistry; Catatonia; Diphenhydramine; Drug Synergism; Histamine; Humans; Male; Monoamine Oxidase Inhibitors; Nortriptyline; Perphenazine; Phenelzine; Rats; Time Factors; Tryptamines

1974
The influence of monoamine oxidase inhibitors and some other antidepressants on the anti-parkinsonian activity of sub-effective doses of diphenylhydramine in rats and mice.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:3

    Topics: Animals; Antidepressive Agents; Catatonia; Diphenhydramine; Humans; Mice; Monoamine Oxidase Inhibitors; Nortriptyline; Parasympatholytics; Parkinson Disease; Parkinson Disease, Secondary; Perphenazine; Phenelzine; Rats; Tremorine

1972
[Weakening of the primary reaction to irradiation in curietherapy of patients with cancer of the cervix uteri].
    Akusherstvo i ginekologiia, 1967, Volume: 43, Issue:4

    Topics: Adult; Aged; Amphetamine; Chlorpromazine; Diphenhydramine; Female; Humans; Middle Aged; Perphenazine; Radiation Injuries; Radiotherapy; Uterine Cervical Neoplasms

1967
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1

    Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine Oxidase Inhibitors; Nialamide; Nicotine; Nortropanes; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Perphenazine; Phenelzine; Physostigmine; Rats; Scopolamine; Sulfonic Acids; Tolazoline; Tremor; Tremorine; Trihexyphenidyl; Tryptamines

1968
Analgesic profile of tranquillizers in multiple screening tests in mice.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1

    Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Chlorpromazine; Codeine; Diazepam; Diphenhydramine; Electric Stimulation; Haloperidol; Hot Temperature; Hydroxyzine; Imipramine; Isocarboxazid; Male; Meprobamate; Mice; Morphine; Perphenazine; Phenobarbital; Phenothiazines; Promazine; Promethazine; Reserpine; Tetrabenazine; Thiopental; Time Factors; Tranquilizing Agents

1968
Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:11

    Topics: Antipsychotic Agents; Dextroamphetamine; Diphenhydramine; Fluoxetine; Humans; Male; Mental Disorders; Movement Disorders; Perphenazine; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Videotape Recording

1995
Effectiveness of perphenazine and systral against motion sickness.
    Journal of applied physiology, 1959, Volume: 14, Issue:2

    Topics: Diphenhydramine; Ethylamines; Motion Sickness; Perphenazine; Phenothiazines

1959
Acute dystonic reactions to phenothiazines and response to antihistamines.
    Diseases of the nervous system, 1962, Volume: 23

    Topics: Antipsychotic Agents; Diphenhydramine; Histamine Antagonists; Humans; Monoamine Oxidase Inhibitors; Perphenazine; Phenothiazines; Prochlorperazine

1962