diphenhydramine and loratadine

diphenhydramine has been researched along with loratadine in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (9.76)	18.7374
1990's	9 (21.95)	18.2507
2000's	22 (53.66)	29.6817
2010's	6 (14.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cale, AD; Gero, TW; Jaques, LW; Johnson, AF; Johnson, DN; Leonard, CA; Lo, YS; Nolan, JC; Walker, KR; Welstead, WJ	1
Almansa, C; Balsa, D; Bartrolí, J; Carceller, E; Forn, J; García-Rafanell, J; Giral, M; Merlos, M	1
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Keserü, GM	1
Caron, G; Ermondi, G	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Sen, S; Sinha, N	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M	1
Koshorek, G; Roehrs, T; Roth, T; Sicklesteel, J; Zorick, F	1
Barnett, A; Cohen-Winston, M; Iorio, LC	1
O'Hanlon, JF; Ramaekers, JG	1
Leutner, D; O'Hanlon, JF; Uiterwijk, MM; van Veggel, LM; Vuurman, EF	1
Cuss, FM; Del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Lin, CC; Sherwood, J	1
Woosley, RL	1
Berman, B; Harris, AG; Kay, GG; Mockoviak, SH; Morris, CE; Reeves, D; Starbuck, V; Sukenik, E	1
Aelony, Y	1
Fraser, TG; Maher, J; Pillay, N; Simons, FE; Simons, KJ	1
Bender, BG; McCormick, DR; Milgrom, H	1
Marsland, TW; Newton, WP	1
Bender, B; Milgrom, H; Wamboldt, F	1
Adams, JL; Finkle, WD; Greenland, S; Melmon, KL	1
Kavoliūniene, A; Petrauskiene, I; Satkiene, D; Sirvyte, R	1
Fujii, Y; Harada, C; Hirai, T; Kamei, C; Tanaka, T	1
Briscoe, MP; Day, JH; Ellis, AK; Kane, RL; Rafeiro, E; Sullivan, CL; Wilken, JA	1
Rikken, G; Simons, RM; Valk, PJ; Van Roon, DB	1
de Halleux, F; Muntjewerff, ND; Ramaekers, JG; Rikken, GH; Vuurman, EF	1
Holománová, D; Jancinová, V; Májeková, M; Nosál, R; Petríková, M	1
Angello, JT; Druce, HM; Raphael, GD; Wu, MM	1
Blaiss, MS	1
Simons, M; Valk, PJ	1
Bindslev-Jensen, C; Doyle, E; Maurer, M; Metz, M; Watanabe, T; Zuberbier, T	1
Cuervo-Pardo, L; Fernandez, J; Gonzalez-Estrada, A	1
Biagi, C; Calamelli, E; Cipriani, F; Donati, M; Melis, M; Monaco, L; Motola, D; Ricci, G; Vaccheri, A	1

Reviews

2 review(s) available for diphenhydramine and loratadine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Cardiac actions of antihistamines. Annual review of pharmacology and toxicology, 1996, Volume: 36 Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Torsades de Pointes	1996

Trials

12 trial(s) available for diphenhydramine and loratadine

Article	Year
Sedative effects of antihistamines. The Journal of allergy and clinical immunology, 1987, Volume: 80, Issue:1 Topics: Adult; Cyproheptadine; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Male; Sleep	1987
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94. Allergy, 1995, Volume: 50, Issue:3 Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine	1995
Seasonal allergic rhinitis and antihistamine effects on children's learning. Annals of allergy, 1993, Volume: 71, Issue:2 Topics: Child; Cognition; Diphenhydramine; Female; Humans; Hypersensitivity, Immediate; Learning; Loratadine; Male; Rhinitis, Allergic, Seasonal	1993
Initial and steady-state effects of diphenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Archives of internal medicine, 1997, Nov-10, Volume: 157, Issue:20 Topics: Adult; Affect; Cognition; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Male; Middle Aged; Multivariate Analysis; Psychomotor Performance; Reference Values; Time Factors; Volunteers	1997
Central nervous system effects of H1-receptor antagonists in the elderly. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 82, Issue:2 Topics: Aged; Blood Glucose; Brain; Cetirizine; Chlorpheniramine; Cognition Disorders; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Event-Related Potentials, P300; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Loratadine; Male; Memory Disorders; Psychomotor Performance; Safety; Skin Tests; Sleep Stages	1999
Children's school performance is not impaired by short-term administration of diphenhydramine or loratadine. The Journal of pediatrics, 2001, Volume: 138, Issue:5 Topics: Child; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Learning; Loratadine; Male; Rhinitis, Allergic, Seasonal; Sleep Stages	2001
Do antihistamines impair school performance in children? The Journal of family practice, 2001, Volume: 50, Issue:9 Topics: Child; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Learning; Loratadine; Male	2001
A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4 Topics: Allergens; Ambrosia; Anti-Allergic Agents; Arousal; Cognition; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Neuropsychological Tests; Rhinitis, Allergic, Seasonal; Treatment Outcome	2003
Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude. Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aerospace Medicine; Affect; Analysis of Variance; Anti-Allergic Agents; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Oximetry; Psychomotor Performance; Sleep; Statistics, Nonparametric	2004
Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements. European journal of clinical pharmacology, 2004, Volume: 60, Issue:5 Topics: Adult; Automobile Driving; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Psychomotor Performance	2004
Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 96, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Middle Aged; Nasal Decongestants; Nasal Obstruction; Rhinitis, Allergic, Seasonal	2006
Effects of loratadine/montelukast on vigilance and alertness task performance in a simulated cabin environment. Advances in therapy, 2009, Volume: 26, Issue:1 Topics: Acetates; Adult; Altitude; Anti-Allergic Agents; Atmospheric Pressure; Cross-Over Studies; Cyclopropanes; Diphenhydramine; Double-Blind Method; Drug Combinations; Humans; Loratadine; Male; Psychomotor Performance; Quinolines; Sulfides; Young Adult	2009

Other Studies

27 other study(ies) available for diphenhydramine and loratadine

Article	Year
Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines. Journal of medicinal chemistry, 1989, Volume: 32, Issue:9 Topics: Animals; Azepines; Cats; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine H1 Antagonists; Hypnotics and Sedatives; Male; Molecular Conformation; Oxazepines; Structure-Activity Relationship	1989
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine. Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17 Topics: Anaphylaxis; Animals; Benzocycloheptenes; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Muscle Contraction; Muscle, Smooth; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	1994
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water	1998
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Effects of nonsedating histamine H1-antagonists on EEG activity and behavior in the cat. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4 Topics: Animals; Astemizole; Behavior, Animal; Benzhydryl Compounds; Benzimidazoles; Cats; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Histamine Antagonists; Histamine H1 Antagonists; Loratadine; Male; Phenothiazines; Sleep; Terfenadine	1989
Interaction studies in mice of SCH 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents. Agents and actions, 1986, Volume: 18, Issue:5-6 Topics: Animals; Benzhydryl Compounds; Diphenhydramine; Dose-Response Relationship, Drug; Electroshock; Hexobarbital; Histamine Antagonists; Loratadine; Male; Mice; Motor Activity; Piperidines; Reflex; Seizures; Stereotyped Behavior; Terfenadine; Vocalization, Animal	1986
Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:10 Topics: Animals; Cardiovascular System; Central Nervous System; Diphenhydramine; Electrocardiography; Electroencephalography; Guinea Pigs; Histamine H1 Antagonists; Hypnotics and Sedatives; Loratadine; Male; Promethazine; Quinidine; Terfenadine	1995
First-generation vs second-generation antihistamines. Archives of internal medicine, 1998, Sep-28, Volume: 158, Issue:17 Topics: Anti-Allergic Agents; Conflict of Interest; Diphenhydramine; Drug Industry; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Psychomotor Performance; Reference Values; Rhinitis, Allergic, Perennial; Sleep; Urticaria	1998
Newer antihistamines. The Medical letter on drugs and therapeutics, 2001, Apr-30, Volume: 43, Issue:1103 Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Somnambulism; Terfenadine	2001
Of injuries and antihistamines and dosing. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:3 Topics: Anti-Allergic Agents; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Motor Skills; Wounds and Injuries	2002
Increased risk of serious injury following an initial prescription for diphenhydramine. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Cohort Studies; Diphenhydramine; Drug Prescriptions; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Motor Skills; Retrospective Studies; Wounds and Injuries	2002
[Tongue angioedema associated with angiotensin-converting enzyme inhibitor (diagnosis, differential diagnosis, treatment)]. Medicina (Kaunas, Lithuania), 2003, Volume: 39, Issue:6 Topics: Algorithms; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Antihypertensive Agents; Diagnosis, Differential; Diphenhydramine; Drug Therapy, Combination; Glossitis; Histamine H1 Antagonists, Non-Sedating; Humans; Hypnotics and Sedatives; Loratadine; Male; Middle Aged; Prednisolone; Ramipril; Time Factors; Treatment Outcome	2003
Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats. Brain research, 2003, Nov-21, Volume: 991, Issue:1-2 Topics: Amygdala; Animals; Cetirizine; Diphenhydramine; Electroencephalography; Epilepsy; Histamine H1 Antagonists; Injections, Intraperitoneal; Ketotifen; Kindling, Neurologic; Loratadine; Male; Pyrilamine; Rats; Rats, Wistar	2003
H(1)- antihistamines and activated blood platelets. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55 Suppl 1 Topics: Benzothiepins; Diphenhydramine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; In Vitro Techniques; Loratadine; Male; Platelet Activation; Platelet Aggregation	2006
Diphenhydramine vs desloratadine comparisons must consider risk-benefit ratio. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:1 Topics: Cognition Disorders; Diphenhydramine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic, Seasonal; Risk Assessment	2006
Best drugs for what ails you: the brands to buy--and those to skip. Consumer reports, 2009, Volume: 74, Issue:9 Topics: Acetaminophen; Anesthetics, Local; Cetirizine; Chlorpheniramine; Common Cold; Cough; Dextromethorphan; Diphenhydramine; Drug Costs; Drug Therapy; Emergencies; Expectorants; First Aid; Glycerol; Guaifenesin; Histamine Antagonists; Honey; Humans; Hypersensitivity; Ibuprofen; Influenza Vaccines; Influenza, Human; Loratadine; Nonprescription Drugs; Oxymetazoline; Pharyngitis; Propiophenones; Pseudoephedrine; Rhinitis; Sodium Chloride	2009
Ahh-choo! How to sneeze at allergies. Consumer reports, 2010, Volume: 75, Issue:5 Topics: Adrenal Cortex Hormones; Cetirizine; Diphenhydramine; Health Behavior; Health Care Surveys; Histamine Antagonists; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Nasal Decongestants; Nonprescription Drugs; Prescription Drugs; Pseudoephedrine; Rhinitis, Allergic, Seasonal	2010
Effects of antihistamines on innate immune responses to severe bacterial infection in mice. International archives of allergy and immunology, 2011, Volume: 155, Issue:4 Topics: Animals; Anti-Allergic Agents; Bacterial Infections; Diphenhydramine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H3 Antagonists; Humans; Immunity, Innate; Loratadine; Mice; Mice, Inbred C57BL; Peritonitis; Piperidines; Receptors, Histamine; Sepsis	2011
Anaphylaxis after home-made quinoa dinner: hold the mustard. BMJ case reports, 2015, Mar-02, Volume: 2015 Topics: Adult; Anaphylaxis; Anti-Allergic Agents; Chenopodium quinoa; Diphenhydramine; Food Hypersensitivity; Humans; Loratadine; Male; Mustard Plant; Skin Tests	2015
Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase. Pharmacoepidemiology and drug safety, 2017, Volume: 26, Issue:10 Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Cetirizine; Child; Child Mortality; Child, Preschool; Chlorpheniramine; Databases, Factual; Diphenhydramine; Epilepsy; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Loratadine; Male; Pharmacovigilance; Stevens-Johnson Syndrome; World Health Organization	2017