diphenhydramine and fluoxetine

diphenhydramine has been researched along with fluoxetine in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (12.00)18.2507
2000's8 (32.00)29.6817
2010's14 (56.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Keserü, GM1
Caron, G; Ermondi, G1
Nagashima, R; Nishikawa, T; Tobita, M1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Jia, L; Sun, H1
Ahman, M; Holmén, AG; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Sen, S; Sinha, N1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Choi, Y; Raymer, BK1
Covi, L; Haertzen, CA; Hess, JM; Kreiter, NA1
Benjamin, S; Connor, DF; Ozbayrak, KR1
Berman, R; Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Miller, HL; Salomon, RM1
Danaceau, MA; Murphy, DL; Roca, CA; Rubinow, DR; Schmidt, PJ; Smith, MJ1
Ames, A; Czajkowski, KP; Fang, M; Spongberg, AL; Witter, JD; Wu, C1
Halden, RU; McClellan, K; Walters, E1
Prosser, RS; Sibley, PK; Trapp, S1
Benskin, JP; Butler, H; Chandramouli, B; Cosgrove, JR; Helbing, CC; Huang, SSY; Veldhoen, N1

Reviews

2 review(s) available for diphenhydramine and fluoxetine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Sleep modulating agents.
    Bioorganic & medicinal chemistry letters, 2019, 08-15, Volume: 29, Issue:16

    Topics: Animals; Humans; Sleep; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Wakefulness-Promoting Agents

2019

Trials

3 trial(s) available for diphenhydramine and fluoxetine

ArticleYear
Effects of combined fluoxetine and counseling in the outpatient treatment of cocaine abusers.
    The American journal of drug and alcohol abuse, 1995, Volume: 21, Issue:3

    Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Cocaine; Combined Modality Therapy; Counseling; Diphenhydramine; Dose-Response Relationship, Drug; Female; Fluoxetine; Humans; Hypnotics and Sedatives; Male; Middle Aged; Substance Abuse Detection; Substance Withdrawal Syndrome; Substance-Related Disorders

1995
Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression.
    Archives of general psychiatry, 1996, Volume: 53, Issue:2

    Topics: 1-Naphthylamine; Adrenergic Uptake Inhibitors; Antidepressive Agents; Brain; Brain Chemistry; Depressive Disorder; Desipramine; Diphenhydramine; Dopamine; Fluoxetine; Humans; Mazindol; Methyltyrosines; Norepinephrine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Sertraline

1996
Effects of metergoline on symptoms in women with premenstrual dysphoric disorder.
    The American journal of psychiatry, 2002, Volume: 159, Issue:11

    Topics: Adult; Affect; Depression; Diphenhydramine; Double-Blind Method; Female; Fluoxetine; Humans; Metergoline; Personality Inventory; Premenstrual Syndrome; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Treatment Outcome

2002

Other Studies

20 other study(ies) available for diphenhydramine and fluoxetine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:11

    Topics: Antipsychotic Agents; Dextroamphetamine; Diphenhydramine; Fluoxetine; Humans; Male; Mental Disorders; Movement Disorders; Perphenazine; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome; Videotape Recording

1995
Dissipation and leaching potential of selected pharmaceutically active compounds in soils amended with biosolids.
    Archives of environmental contamination and toxicology, 2010, Volume: 59, Issue:3

    Topics: Carbamazepine; Clindamycin; Diltiazem; Diphenhydramine; Environmental Restoration and Remediation; Fluoxetine; Pharmaceutical Preparations; Sewage; Soil Pollutants

2010
Occurrence and loss over three years of 72 pharmaceuticals and personal care products from biosolids-soil mixtures in outdoor mesocosms.
    Water research, 2010, Volume: 44, Issue:20

    Topics: Antimitotic Agents; Azithromycin; Carbamazepine; Carbanilides; Ciprofloxacin; Diphenhydramine; Doxycycline; Environmental Monitoring; Fluoxetine; Sewage; Soil; Tetracycline; Thiabendazole; Triclosan

2010
Modeling uptake of selected pharmaceuticals and personal care products into food crops from biosolids-amended soil.
    Environmental science & technology, 2014, Oct-07, Volume: 48, Issue:19

    Topics: Agriculture; Carbamazepine; Carbanilides; Cimetidine; Cosmetics; Crops, Agricultural; Diphenhydramine; Fluoxetine; Gemfibrozil; Miconazole; Models, Theoretical; Pharmaceutical Preparations; Plant Roots; Plant Shoots; Sewage; Soil Pollutants; Triclosan

2014
A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae.
    Aquatic toxicology (Amsterdam, Netherlands), 2017, Volume: 182

    Topics: Acetaminophen; Animals; Carbamazepine; Diphenhydramine; Dose-Response Relationship, Drug; Fluoxetine; Larva; Metabolome; Models, Animal; Toxicity Tests; Transcriptome; Water Pollutants, Chemical; Xenobiotics; Zebrafish

2017