diphenhydramine has been researched along with chlorpheniramine in 145 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (51.03) | 18.7374 |
| 1990's | 19 (13.10) | 18.2507 |
| 2000's | 34 (23.45) | 29.6817 |
| 2010's | 16 (11.03) | 24.3611 |
| 2020's | 2 (1.38) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Janssen, M; Janssen, PA; Janssens, F; Luyckx, M; Stokbroekx, RA; Torremans, J | 1 |
| Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Akazawa, M; Inui, K; Masuda, S; Okuda, M; Saito, H; Urakami, Y | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Rocklin, RE | 1 |
| Imanaka, K | 1 |
| Johnson, HL; Maibach, HI | 1 |
| Abdel Badei, MM; Daifullah, AA; el-Shahat, MF | 1 |
| Oishi, R; Saeki, K; Shishido, S | 1 |
| Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM | 1 |
| Winter, JC | 1 |
| Hanig, JP; Hui, FW; Sun, CL | 1 |
| von Maur, K | 1 |
| Goto, S; Inagaki, N; Koda, A; Nagai, H | 1 |
| Katona, PG; Rigel, DF | 1 |
| Bergman, J; Spealman, RD | 1 |
| Castellano, C; D'Amato, FR; Sansone, M | 1 |
| Fleisch, JH; Haisch, KD; Rinkema, LE; Whitesitt, CA | 1 |
| D'Udine, B; Renzi, P; Sansone, M; Vetulani, J | 1 |
| Chumsawat, P; Limsuwan, A; Sriwatanakul, K; Unchern, S | 1 |
| Faanes, R; French, S; Susskind, B; Walker, M | 1 |
| Dressler, WE; Gaffey, MJ; Gwaltney, JM; Hayden, FG; Sastre, A; Sorrentino, JV | 1 |
| Mahato, SB; Maitra, SK; Sahu, NP | 1 |
| Gillespie, E; Henney, CS; Lichtenstein, LM; Plaut, M | 1 |
| Carleton, RA; Susmano, A | 1 |
| Fuenmayor, L; Lentino, A | 1 |
| el-Darawy, ZI; Mobarak, ZM | 1 |
| Taub, SJ | 1 |
| Kuye, JO; Levi, R | 1 |
| Altura, BM; Altura, BT | 1 |
| Dessouky, YM; Mousa, BA; Nour el-Din, HM | 1 |
| Abdel-Aziz, A | 1 |
| Altura, BM; Zweifach, BW | 2 |
| Lish, PM; Peters, EL; Robbins, SI | 1 |
| Wellens, D | 1 |
| Frank, JD; Herrmann, RG | 1 |
| Kanda, Z; Miyake, T; Sekiya, A | 1 |
| de Naranjo, E; Naranjo, P | 1 |
| Furkert, K | 1 |
| Carlsson, A; Lindqvist, M | 1 |
| Colson, SH; Tolson, WW; Umberger, EJ | 1 |
| Altura, BM | 1 |
| Takagi, K; Uchida, M | 2 |
| Abdine, H; Korany, MA; Wahbi, AM | 1 |
| Wigton, RS; Wolf, GL | 1 |
| Gerald, MC; Maickel, RP; Skau, KA | 1 |
| Schrold, J | 1 |
| Karlin, JM | 1 |
| Herman, EH; Lee, IP; Mhatre, RM; Waravdekar, VS | 1 |
| Alonso, A; Colombi, PA | 1 |
| Cook, TJ; Lantos, RL; MacQueen, DM; Thornby, JI; Virtue, CM; Wittig, HJ | 1 |
| Okamura, T; Shina, Y | 1 |
| Amer, MM; Ismaiel, SA; Tawakkol, MS | 1 |
| Doyle, TD; Proctor, JB | 1 |
| el-Asmar, MF; Ibrahim, SA; Ismail, M; Osman, OH | 1 |
| Aschan, G | 1 |
| Berry, CA; Faingold, CL | 1 |
| Doyle, TD | 1 |
| Da Silva, A; Gilbert, EF | 1 |
| Ingram, GI; Mason, DY | 1 |
| French, WN; Matsui, F; Watson, JR | 1 |
| Korduba, CA; Symchowicz, S; Veals, J | 1 |
| Lee, CC | 1 |
| Carson, S; Clemente, E; De Paul Lynch, V | 1 |
| Awouters, F; Janssen, PA; Van den Broeck, WA; Wauquier, A | 1 |
| Suzuki, M; Suzuki, Y; Tomita, Y | 1 |
| Kagey-Sobotka, A; Lichtenstein, LM; Plaut, M; Tung, R | 1 |
| Lijinsky, W | 1 |
| Canestrari, DA; Miller, RD; Riker, DK; Witek, TJ; Yang, JY | 1 |
| Danielson, ND; Holeman, JA | 1 |
| Biegalski, CS; Brooker, AE; Philpot, EE | 1 |
| Burde, R; Dippel, E; Seifert, R | 1 |
| Lang, AE | 1 |
| Cruze, CA; Robinson, MK | 1 |
| Klette, K; Levine, B; Radentz, S; Smialek, JE; Smith, ML | 1 |
| KAMEI, CH | 1 |
| Evans, S; Henningfield, J; Johanson, CE | 1 |
| Chen, X; Fraser, TG; Simons, FE; Simons, KJ | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Matsuda, T; Myou, S; Sasaki, S | 1 |
| Fraser, TG; Maher, J; Pillay, N; Simons, FE; Simons, KJ | 1 |
| Hashimoto, Y; Inui, KI; Katsura, T; Mizuuchi, H; Saito, H | 1 |
| Jenkins, AJ; Steinberg, M; Wogoman, H | 1 |
| Chen, Z; Kamei, C; Kaneko, Y; Saitou, K; Sugimoto, Y | 1 |
| Khalil, S | 1 |
| Hashimoto, Y; Inui, K; Katsura, T; Mizuuchi, H | 1 |
| Attarzadeh, M; Farzin, D | 1 |
| Baryla, NE; Lucy, CA | 1 |
| Hashimoto, Y; Moriya, F | 1 |
| Ihrke, PJ; Kass, PH; White, SD; Zur, G | 1 |
| Fukada, A; Inui, K; Saito, H | 1 |
| Chen, IM; Cheng, CY; Lin, CH; Lin, MS; Lin, PR; Lin, YH; Tsai, MC | 1 |
| WECHSLER, H | 1 |
| TAKIUCHI, T | 1 |
| DASHPUTRA, PG; JOSHI, NK; RAJAPURKAR, MV; SHARMA, ML | 1 |
| DASHPUTRA, PG; RAJAPURKAR, MV; SHARMA, ML | 1 |
| LEVEQUE, PE | 1 |
| MACDONALD, A; PFLAUM, RT | 1 |
| FOLLIS, G; LING, JT; MARSHALL, TR; RUSSELL, M | 1 |
| ERICKSON, RW; GREEN, H | 1 |
| Fujii, Y; Hossen, MA; Kamei, C; Kayasuga, R; Sugimoto, Y | 1 |
| Chen, X; Zhang, Y; Zhong, D | 1 |
| Gupta, A; Gupta, S; Khosla, R; Tiwary, AK | 1 |
| Chen, X; Chen, Y; Dong, Y; Hu, Z | 1 |
| Charlton, BG | 1 |
| Hirase, M; Kamei, C; Shinomiya, K; Takeda, Y; Tokunaga, S | 1 |
| Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Rahman, A; Takechi, K | 1 |
| Katz, JL; Kopajtic, TA; Tanda, G | 1 |
| Elmamly, MY; Halquist, MS; Ismaiel, OA; Shalaby, A; Thomas Karnes, H | 1 |
| Ishida, T; Kamei, C; Obara, Y; Tokunaga, S; Tsutsui, R | 1 |
| Edris-Tabrizi, F; Ganjali, MR; Javanbakht, M; Norouzi, P; Riahi, S | 1 |
| Li, X; Sun, J; You, T; Zhu, D | 1 |
| Castro, C; Catbagan, P; Moore, C; Rodrigues, WC; Wang, G | 1 |
| Beebe, MR; Rider, ME; Semin, DJ; Shaw, BJ | 1 |
| Jiang, JG; Song, GS; Zhang, XR; Zhang, YH | 1 |
| Akkaramongkolporn, P; Ngawhirunpat, T; Nitanan, T; Opanasopit, P; Panomsuk, S; Rojanarata, T | 1 |
| Kim, J; Song, JH | 1 |
| Biagi, C; Calamelli, E; Cipriani, F; Donati, M; Melis, M; Monaco, L; Motola, D; Ricci, G; Vaccheri, A | 1 |
| Endo, S; Fujii, N; Furukawa, C; Ikari, A; Manabe, A; Marunaka, K; Matsunaga, T; Nishiyama, T; Tabuchi, Y | 1 |
| Abe, H; Inoue, H; Iwase, H; Iwata, YT; Kanamori, T; Kuwayama, K; Miyaguchi, H; Nariai, M; Segawa, H; Tsujikawa, K; Yamamuro, T | 1 |
| Mochizuki, T | 1 |
| Banner, W; Bond, GR; Dart, RC; Delva-Clark, H; Green, JL; Halmo, LS; Kauffman, RE; Palmer, RB; Paul, IM; Rapp-Olsson, M; Reynolds, KM; Wang, GS | 1 |
4 review(s) available for diphenhydramine and chlorpheniramine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Antihistaminics. 11].
Topics: Benzimidazoles; Chlorpheniramine; Cyclizine; Diphenhydramine; Ethylenediamines; Histamine H1 Antagonists; Humans; Imidazoles; Pheniramine; Phenothiazines; Piperidines; Promethazine; Propylamines; Tripelennamine | 1967 |
Histamine as an Alert Signal in the Brain.
Topics: Animals; Brain; Chlorpheniramine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Humans; Mice; Mice, Knockout; Sleep; Wakefulness | 2022 |
8 trial(s) available for diphenhydramine and chlorpheniramine
| Article | Year |
|---|---|
Antihistamine selection in patients with allergic rhinitis.
Topics: Chlorpheniramine; Clinical Trials as Topic; Diphenhydramine; Histamine H1 Antagonists; Humans; Hydroxyzine; Patient Participation; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Trimeprazine; Tripelennamine | 1985 |
Intranasally and orally administered antihistamine treatment of experimental rhinovirus colds.
Topics: Administration, Intranasal; Administration, Oral; Adult; Chlorpheniramine; Clinical Trials as Topic; Common Cold; Diphenhydramine; Double-Blind Method; Histamine; Humans; Male; Random Allocation; Time Factors | 1987 |
Degree and duration of skin test suppression and side effects with antihistamines. A double blind controlled study with five antihistamines.
Topics: Adult; Allergens; Chlorpheniramine; Diphenhydramine; Dust; Histamine H1 Antagonists; Humans; Hydroxyzine; Immunosuppression Therapy; Pollen; Promethazine; Skin Tests; Tripelennamine; Yeasts | 1973 |
Habituation to repeated rotatory stimuli (cupulometry) and the effect of antinausea drugs and alcohol on the results.
Topics: Aerospace Medicine; Alcoholic Intoxication; Chlorpheniramine; Clinical Trials as Topic; Dimenhydrinate; Diphenhydramine; Humans; Nausea; Placebos; Rotation; Scopolamine; Vestibular Function Tests | 1967 |
Characterization of daytime sleepiness and psychomotor performance following H1 receptor antagonists.
Topics: Adolescent; Adult; Chlorpheniramine; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Psychomotor Performance; Sleep; Terfenadine; Time Factors | 1995 |
Effects of sedating and nonsedating antihistamines on flying performance.
Topics: Aerospace Medicine; Analysis of Variance; Chlorpheniramine; Diphenhydramine; Double-Blind Method; Humans; Military Personnel; Neuropsychological Tests; Psychological Tests; Psychomotor Performance; Task Performance and Analysis; Terfenadine; United States | 1993 |
Antihistaminics in idiopathic dystonia.
Topics: Adult; Atropine; Benztropine; Chlorpheniramine; Cholinergic Antagonists; Diphenhydramine; Double-Blind Method; Dystonia; Histamine H1 Antagonists; Humans | 1996 |
Central nervous system effects of H1-receptor antagonists in the elderly.
Topics: Aged; Blood Glucose; Brain; Cetirizine; Chlorpheniramine; Cognition Disorders; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Event-Related Potentials, P300; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Loratadine; Male; Memory Disorders; Psychomotor Performance; Safety; Skin Tests; Sleep Stages | 1999 |
133 other study(ies) available for diphenhydramine and chlorpheniramine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines.
Topics: Administration, Oral; Animals; Benzimidazoles; Biological Assay; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine; Histamine Antagonists; Ileum; Male; Muscle Contraction; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.
Topics: Animals; Cell Line; Dogs; Kidney; Kidney Tubules; Kinetics; Membranes; Nephrons; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substrate Specificity; Tetraethylammonium; Transfection | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.
Topics: Animals; Antigens; Burimamide; Cell Division; Chlorpheniramine; Depression, Chemical; Diphenhydramine; gamma-Globulins; Guinea Pigs; Histamine; Hypersensitivity, Delayed; Immunity, Cellular; Lymphocytes; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Metiamide; Receptors, Drug; Skin Tests | 1976 |
[Influence of parotin on the repressing action of cyanylethyl group to histamine stress (author's transl)].
Topics: Animals; Chlorpheniramine; Diphenhydramine; Histamine Antagonists; Histamine Release; Hormones; Rats; Salivary Proteins and Peptides | 1978 |
Contact urticaria syndrome. Contact urticaria to diethyltoluamide (immediate-type hypersensitivity).
Topics: Adult; Ammonium Sulfate; Atropine; Benzamides; Benzocaine; Chlorpheniramine; DEET; Dermatitis, Contact; Diphenhydramine; Female; Histamine; Humans; Hypersensitivity, Immediate; Insect Repellents; Lidocaine; p-Methoxy-N-methylphenethylamine; Patch Tests; Urticaria | 1975 |
Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes.
Topics: Alkaloids; Atropine; Chemistry Techniques, Analytical; Chlorpheniramine; Cinchona Alkaloids; Diphenhydramine; Ephedrine; Ions; Solvents; Spectrophotometry, Infrared; Thiocyanates | 1992 |
In vivo effects of some histamine H1-receptor antagonists on monoamine metabolism in the mouse brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Chlorpheniramine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred Strains | 1991 |
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.
Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine | 1989 |
Sedation and the stimulus properties of antihistamines.
Topics: Animals; Chlorpheniramine; Conditioning, Operant; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Histamine Antagonists; Histamine H1 Antagonists; Hypnotics and Sedatives; Promethazine; Rats; Rats, Inbred Strains | 1985 |
Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice.
Topics: Analgesics; Animals; Chlorpheniramine; Cyclizine; Diphenhydramine; Drug Synergism; Histamine H1 Antagonists; Male; Mice; Morphine; Phenothiazines; Pyrilamine | 1985 |
Pharmacological characterization of mouse ear PCA.
Topics: Albuterol; Animals; Ascaris; Chlorpheniramine; Chromones; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Ear; Female; Histamine H1 Antagonists; Isoproterenol; Ketotifen; Male; Methysergide; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Passive Cutaneous Anaphylaxis; Serotonin Antagonists; Serum Albumin, Bovine; SRS-A; Theophylline; Tissue Extracts | 1985 |
Effects of antihistamines and local anesthetics on excess tachycardia in conscious dogs.
Topics: Anesthetics, Local; Animals; Atropine; Chlorpheniramine; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Histamine; Histamine H1 Antagonists; Lidocaine; Male; Procaine; Promethazine; Pyrilamine; Tachycardia | 1986 |
Some behavioral effects of histamine H1 antagonists in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpheniramine; Cimetidine; Clozapine; Cocaine; Conditioning, Operant; Dextroamphetamine; Diphenhydramine; Electroshock; Feeding Behavior; Histamine H1 Antagonists; Male; Promethazine; Saimiri; Self Administration; Tripelennamine | 1986 |
Enhancement of morphine-induced hyperactivity by antihistaminic drugs in mice.
Topics: Animals; Chlorpheniramine; Diphenhydramine; Histamine H1 Antagonists; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Tripelennamine | 1986 |
Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist.
Topics: Animals; Benzhydryl Compounds; Benzimidazoles; Bronchial Provocation Tests; Chlorpheniramine; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists; Lung; Male; Muscle, Smooth; Promethazine; Pyrilamine; Terfenadine; Triprolidine | 1987 |
Antihistaminics enhance morphine-, but not amphetamine- and scopolamine-induced hyperactivity in mice.
Topics: Animals; Chlorpheniramine; Dextroamphetamine; Diphenhydramine; Drug Synergism; Histamine H1 Antagonists; Hyperkinesis; Male; Mice; Morphine; Scopolamine; Tripelennamine | 1987 |
Psychomotor performances and subjective feeling studies with antihistamine.
Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Cognition; Diphenhydramine; Female; Humans; Male; Nausea; Psychomotor Performance; Terfenadine | 1986 |
Modulation of in vitro cellular immune response by histamine agonists or antagonists in murine species.
Topics: Animals; Cell Line; Cell Survival; Chlorpheniramine; Chromium Radioisotopes; Cimetidine; Dimaprit; Diphenhydramine; Histamine; Histamine Antagonists; Imidazoles; Immunity, Cellular; Impromidine; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ranitidine; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Thiourea | 1985 |
Simultaneous determination of chlorpheniramine and diphenhydramine in cough syrups by reversed-phase ion-pair high-performance liquid chromatography.
Topics: Antitussive Agents; Chlorpheniramine; Chromatography, High Pressure Liquid; Diphenhydramine | 1986 |
Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.
Topics: Animals; Ascitic Fluid; Cell Membrane; Chlorpheniramine; Cyclic AMP; Cyclizine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Histamine Release; Imidazoles; Mast Cells; Mice; Mice, Inbred C57BL; Receptors, Drug; T-Lymphocytes; Thiourea | 1973 |
Effect of antihistaminic drugs on hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Chlorpheniramine; Diphenhydramine; Dogs; Female; Histamine H1 Antagonists; Hypertension, Pulmonary; Hypoxia; Male; Promethazine | 1973 |
Effect of 10 undecen 1-YL thiopseudourea iodide (AHR-1911) on rat arterial pressure and capillary permeability.
Topics: Animals; Anti-Inflammatory Agents; Atropine; Blood Pressure; Capillary Permeability; Chlorpheniramine; Diphenhydramine; Dose-Response Relationship, Drug; Hexamethonium Compounds; Histamine H1 Antagonists; Male; Onium Compounds; Polymyxins; Promethazine; Propranolol; Rats; Thiourea; Undecylenic Acids | 1973 |
The use of modified cellulose papers in routine toxicological analysis. 2. Antidepressives and antihistaminics.
Topics: Antidepressive Agents; Chlorpheniramine; Chlorpromazine; Chromatography, Ion Exchange; Chromatography, Paper; Diphenhydramine; Histamine H1 Antagonists; Imipramine; Iproniazid; Isocarboxazid; Isoniazid; Meclizine; Methods; Methylcellulose; Promethazine; Toxicology; Tranylcypromine | 1973 |
The effect of antihistamines on the suppression of skin tests.
Topics: Chlorpheniramine; Depression, Chemical; Diphenhydramine; Histamine H1 Antagonists; Humans; Promethazine; Skin Tests; Tripelennamine | 1973 |
Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-receptor antagonists.
Topics: Animals; Aorta; Atrioventricular Node; Chlorpheniramine; Coronary Circulation; Cyclizine; Diphenhydramine; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; Heart Block; Heart Rate; Heart Ventricles; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Injections, Intra-Arterial; Male; Perfusion; Promethazine; Receptors, Drug; Stimulation, Chemical; Tripelennamine | 1974 |
Contractile actions of antihistamines on isolated arterial smooth muscle.
Topics: Acetylcholine; Anesthetics, Local; Animals; Aorta, Thoracic; Atropine; Calcium; Chlorpheniramine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium; Promethazine; Rabbits; Serotonin; Tripelennamine | 1974 |
Dye-salt formation as a general method for colorimetric determination of antihistaminics. I. The use of methyl orange for the determination of chlorphenamine, diphenhydramine and chloropyramine in pharmaceutical preparations.
Topics: Benzyl Compounds; Chlorpheniramine; Colorimetry; Coloring Agents; Diphenhydramine; Ethylenediamines; Histamine H1 Antagonists; Pyridines; Salts | 1974 |
Blockade by prostaglandins E2 and F1 alpha of the response of the rabbit ileum to stimulation of sympathetic nerve and its reversal by some antihistamines, dexamphetamine and methylphenidate.
Topics: Aniline Compounds; Animals; Benzyl Compounds; Calcium; Chlorpheniramine; Dextroamphetamine; Diphenhydramine; Electric Stimulation; Histamine H1 Antagonists; Ileum; Imidazoles; In Vitro Techniques; Mesentery; Methylphenidate; Muscle, Smooth; Norepinephrine; Prostaglandin Antagonists; Prostaglandins; Rabbits; Sympathetic Nervous System; Synaptic Transmission | 1974 |
Antihistamines and vascular reactivity.
Topics: Acetylcholine; Animals; Blood Circulation; Blood Vessels; Chlorpheniramine; Diphenhydramine; Epinephrine; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Mesenteric Arteries; Mesenteric Veins; Mesentery; Norepinephrine; Promethazine; Rats; Serotonin; Vasomotor System | 1965 |
Pharmacologic properties of antihistamines in relation to vascular reactivity.
Topics: Adrenalectomy; Animals; Atropine; Blood Circulation; Blood Vessels; Chlorpheniramine; Chlorpromazine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Isoproterenol; Lidocaine; Mesentery; Phenoxybenzamine; Phentolamine; Promethazine; Rats; Serotonin; Vasomotor System; Yohimbine | 1965 |
Specificity of antihistamine drugs and involvement of the adrenergic system in histamine deaths in the guinea pig.
Topics: Adrenal Medulla; Aerosols; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Diphenhydramine; Drug Antagonism; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imipramine; Phenothiazines; Shock, Septic; Sympatholytics; Tripelennamine | 1966 |
Pharmacological reactivity of an isolated tracheal preparation of the guinea-pig.
Topics: Acetylcholine; Animals; Atropine; Barium; Chlorisondamine; Chlorpheniramine; Diphenhydramine; Ethanolamines; Guinea Pigs; Hexamethonium Compounds; Histamine; In Vitro Techniques; Isoproterenol; Muscle Contraction; Papaverine; Scopolamine; Serotonin; Theophylline; Trachea | 1966 |
Effect of adenosine derivatives and antihistaminics on platelet aggregation.
Topics: Adenine Nucleotides; Animals; Blood Platelets; Chlorpheniramine; Collagen; Diphenhydramine; Histamine H1 Antagonists; In Vitro Techniques; Nucleosides; Phenothiazines; Promethazine; Rabbits; Trimeprazine | 1966 |
[Anti-bradykinin action of diphenhydramine on the excised ileum of guinea pigs].
Topics: Animals; Aspirin; Barium; Blood Pressure; Bradykinin; Chlorpheniramine; Diphenhydramine; Ethanol; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oscillometry; Papaverine; Piperazines; Respiration | 1966 |
Embryotoxic effects of antihistamines.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Chlorpheniramine; Diphenhydramine; Ear, External; Embryo, Mammalian; Embryonic and Fetal Development; Eye; Female; Hair; Histamine H1 Antagonists; Mice; Pregnancy; Skin; Vagina | 1968 |
Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines.
Topics: 5-Hydroxytryptophan; Amines; Analgesics; Animals; Biological Transport, Active; Chlorpheniramine; Diphenhydramine; Histamine H1 Antagonists; Meperidine; Methadone; Mice; Neurons; Nialamide; Norepinephrine; Serotonin; Tripelennamine | 1969 |
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.
Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase | 1969 |
Contractile responses of microvascular smooth muscle to antihistamines.
Topics: Animals; Calcium; Capillaries; Chlorpheniramine; Diphenhydramine; Endotoxins; Epinephrine; Female; Histamine H1 Antagonists; Isotonic Solutions; Mesentery; Muscle Contraction; Muscle, Smooth; Norepinephrine; p-Methoxy-N-methylphenethylamine; Promethazine; Rats; Receptors, Drug; Stimulation, Chemical; Vasomotor System | 1970 |
Purification of histamine receptor in cat small intestinal muscle. I. Specificity of labeling histamine receptor with radioactive dibenamine.
Topics: Acetylcholine; Amines; Aniline Compounds; Animals; Carbon Isotopes; Cats; Chlorpheniramine; Dibenzylchlorethamine; Diphenhydramine; Drug Antagonism; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Intestine, Small; Muscle, Smooth; Norepinephrine; Phenethylamines; Receptors, Drug; Serotonin; Toluene; Tritium | 1970 |
Application of orthogonal functions to spectrophotometric analysis of weakly absorbing compounds in tablets.
Topics: Benzyl Compounds; Chlorpheniramine; Diphenhydramine; Ephedrine; Ethers; Histamine H1 Antagonists; Mathematics; Methods; Methylamines; Spectrophotometry; Tablets | 1971 |
Vasodilatation induced by streptomycin in the perfused canine kidney.
Topics: Animals; Chlorpheniramine; Dilatation; Diphenhydramine; Diuresis; Dogs; Histamine H1 Antagonists; Kidney; Muscle, Smooth; Perfusion; Regional Blood Flow; Streptomycin | 1971 |
Effects of various antihistamines on oxotremorine-induced hypothermia in mice.
Topics: Alkynes; Analysis of Variance; Animals; Atropine; Benzyl Compounds; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Ethylenediamines; Evaluation Studies as Topic; Histamine H1 Antagonists; Hypothermia; Male; Mice; Mice, Inbred Strains; Parasympathomimetics; Piperazines; Promethazine; Pyridines; Pyrrolidines; Pyrrolidinones; Tripelennamine | 1972 |
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine | 1972 |
The use of antihistamines in asthma.
Topics: Asthma; Child; Child, Preschool; Chlorpheniramine; Diphenhydramine; Histamine H1 Antagonists; Humans; Promethazine; Respiratory Function Tests; Tripelennamine | 1972 |
Comparison of the cardiovascular actions of NSC-109,724 (ifosfamide) and cyclophosphamide.
Topics: Animals; Antineoplastic Agents; Atropine; Blood Pressure; Bradycardia; Cardiovascular System; Chlorpheniramine; Cyclic N-Oxides; Cyclophosphamide; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Electroencephalography; Ethylamines; Haplorhini; Heart Rate; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Oxazines; Perfusion; Time Factors; Tripelennamine | 1972 |
[Action of diphenhydramine, chlorpheniramine, HS 592 and PB 400 on histamine and SRS-A induced wheals in skin of rats].
Topics: Anaphylaxis; Animals; Chlorpheniramine; Clemastine; Diphenhydramine; Histamine; Histamine H1 Antagonists; Maleates; Piperidines; Promethazine; Pyrrolidines; Rats; Serotonin Antagonists; SRS-A | 1972 |
Inhibitory action of some antihistaminics on the anaphylactic contraction in guinea pig's taenia coli.
Topics: Anaphylaxis; Animals; Antigen-Antibody Reactions; Antigens; Atropine; Barium; Binding, Competitive; Chlorpheniramine; Colon; Depression, Chemical; Diphenhydramine; Epinephrine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Immunodiffusion; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Papaverine; Pyrimidines; Rabbits | 1972 |
Cobalt thiocyanate colorimetric determination of diphenhydramine.
Topics: Benzalkonium Compounds; Chlorpheniramine; Cobalt; Codeine; Colorimetry; Diphenhydramine; Thiocyanates | 1974 |
Purification of histamine receptor. II. Subcellular distribution of specifically bound dibenamine.
Topics: Aniline Compounds; Animals; Binding Sites; Carbon Isotopes; Cats; Centrifugation, Density Gradient; Chlorpheniramine; Chromatography, Ion Exchange; Dibenzylchlorethamine; Diphenhydramine; Histamine; Histocytochemistry; Intestine, Small; Muscle, Smooth; Phenethylamines; Receptors, Drug; Subcellular Fractions; Tritium | 1973 |
Effects of solvent composition on the partition of amines: extraction of the free base.
Topics: Alkanes; Amines; Amphetamine; Brompheniramine; Chloroform; Chlorpheniramine; Codeine; Dextromethorphan; Diphenhydramine; Ions; Mathematics; Mescaline; Methamphetamine; Methylamines; Phenethylamines; Pheniramine; Quinine; Solubility; Water | 1972 |
Effect on the rat uterus of the venom from the scorpion Leiurus quinquestriatus.
Topics: Animals; Atropine; Chlorpheniramine; Cocaine; Diphenhydramine; Estrus; Female; Hexamethonium Compounds; Kinins; Lysergic Acid Diethylamide; Methysergide; Muscle Contraction; ortho-Aminobenzoates; Papaverine; Pregnancy; Promethazine; Rats; Scorpions; Toluene; Tripelennamine; Uterus; Venoms | 1972 |
Effects of antihistaminic agents upon the electrographic activity of the cat brain: a power spectral density study.
Topics: Animals; Brain; Catheterization; Cats; Cerebral Cortex; Chlorpheniramine; Computers; Diphenhydramine; Electrodes, Implanted; Electroencephalography; Electrophysiology; Hippocampus; Reticular Formation; Thalamus; Time Factors; Tracheotomy; Tripelennamine | 1972 |
Effects of solvent composition on the column partition chromatography of amines: computer-generated distribution maps.
Topics: Amines; Chlorides; Chloroform; Chlorpheniramine; Chromatography; Computers; Cyclizine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Hydrogen-Ion Concentration; Methods; Methylamines; Promethazine | 1971 |
Henoch-Schöenlein purpura. Report of a fatal case with gastrointestinal hemorrhage and necrosis.
Topics: Adolescent; Chlorpheniramine; Dexamethasone; Diphenhydramine; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Hydrocortisone; Male; Methoxamine; Necrosis; Norepinephrine; Pentobarbital; Purpura; Tetracycline | 1966 |
Management of the hereditary coagulation disorders.
Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Factors; Cerebral Hemorrhage; Chlorpheniramine; Diphenhydramine; Drainage; Factor VIII; Gastrointestinal Hemorrhage; Hemarthrosis; Hemophilia A; Hemophilia B; Hemostasis; Hepatitis B; Humans; Hypersensitivity; Joint Diseases; Oral Hemorrhage; Spleen; Tooth Extraction; Transfusion Reaction; von Willebrand Diseases | 1971 |
Use of the acid dye technique for quantitation of pharmaceutical amines eluted from thin-layer chromatograms.
Topics: Acids; Chlorpheniramine; Chromatography, Thin Layer; Coloring Agents; Cyclizine; Dextropropoxyphene; Diphenhydramine; Ephedrine; Maleates; Methods; Spectrophotometry; Sulfates | 1969 |
Inhibition of dopamine uptake into synaptosomes of rat corpus striatum by chlorpheniramine and its structural analogs.
Topics: Amantadine; Animals; Apomorphine; Brompheniramine; Chlorpheniramine; Cytoplasmic Granules; Diphenhydramine | 1971 |
Comparative pharmacologic responses to antihistamines in newborn and young rats.
Topics: Animals; Animals, Newborn; Brain; Chlorpheniramine; Diphenhydramine; Injections, Subcutaneous; Liver; Phenytoin; Rats | 1966 |
Effect of mescaline on cardiopulmonary dynamics. Method for determination of right ventricular pressure in the guinea pig.
Topics: Animals; Blood Pressure; Chlorpheniramine; Diphenhydramine; Drug Antagonism; Electrocardiography; Female; Guinea Pigs; Heart; Heart Conduction System; Heart Rate; Heart Ventricles; Histamine; Male; Mescaline; Pulse; Respiration; Respiratory Function Tests | 1967 |
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs.
Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Diphenhydramine; Dogs; Histamine H1 Antagonists; Ketotifen; Male; Periodicity; Pyrilamine; Sleep; Sleep Stages; Sleep, REM; Wakefulness | 1981 |
[Studies on relationship between the repressing action of choline to histamine stress and its chemical structure (author's transl)].
Topics: Arginine; Chlorpheniramine; Choline; Diphenhydramine; Histamine Antagonists; Histamine Release; Structure-Activity Relationship | 1981 |
H2 antihistamines augment antigen-induced histamine release from human basophils in vitro.
Topics: Amodiaquine; Antigens; Basophils; Chlorpheniramine; Cimetidine; Dimaprit; Diphenhydramine; Histamine H2 Antagonists; Histamine N-Methyltransferase; Histamine Release; Humans; Stimulation, Chemical; Thiourea | 1982 |
Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite.
Topics: Allantoin; Amines; Animals; Carcinogens; Chlorpheniramine; Dimethylamines; Diphenhydramine; Drug Interactions; Female; Male; Nitrites; Nitrosamines; Rats; Rats, Inbred F344; Risk; Sodium Nitrite | 1984 |
Liquid chromatography of antihistamines using post-column tris(2,2'-bipyridine) ruthenium(III) chemiluminescence detection.
Topics: 2,2'-Dipyridyl; Brompheniramine; Chlorpheniramine; Chromatography, High Pressure Liquid; Diphenhydramine; Histamine H1 Antagonists; Luminescent Measurements; Organometallic Compounds; Pheniramine; Pyrilamine; Ruthenium; Spectrophotometry, Ultraviolet | 1994 |
Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells.
Topics: Animals; Basophils; Calcium; Cells, Cultured; Chlorpheniramine; Diphenhydramine; GTP-Binding Proteins; Histamine H1 Antagonists; HL-60 Cells; Humans; Mast Cells; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Rats; Serotonin; Time Factors; Transducin; Virulence Factors, Bordetella | 1996 |
Preclinical skin sensitization testing of antihistamines: guinea pig and local lymph node assay responses.
Topics: Animals; Chlorpheniramine; Dermatitis, Allergic Contact; Diphenhydramine; Evaluation Studies as Topic; Guinea Pigs; Histamine H1 Antagonists; Immunologic Tests; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Promethazine; Sensitivity and Specificity; Skin; Toxicity Tests; Triprolidine | 1996 |
Antihistamine concentrations in postmortem blood and liver specimens.
Topics: Blood Chemical Analysis; Chlorpheniramine; Diphenhydramine; Doxylamine; Histamine H1 Antagonists; Humans; Liver | 1996 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; Iris; Lethal Dose 50; Male; Methylhistamines; Muscle Contraction; Muscle, Smooth; p-Methoxy-N-methylphenethylamine; Piperidines; Potassium; Pyrilamine; Ranitidine; Receptors, Histamine H1; Substance P | 1996 |
The discriminative stimulus effects of tripelennamine in humans.
Topics: Adult; Chlorpheniramine; Dextroamphetamine; Diazepam; Diphenhydramine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Male; Placebos; Tripelennamine | 1996 |
Effect of cimetidine on the pharmacokinetics and pharmacodynamics of chlorpheniramine and diphenhydramine in rabbits.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Chlorpheniramine; Cimetidine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Histamine H2 Antagonists; L-Lactate Dehydrogenase; Liver; Rabbits | 1996 |
A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Animals; Atropine; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Chlorpheniramine; Cromolyn Sodium; Diphenhydramine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Leukotriene D4; Male; Sonication; Water | 1998 |
Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system.
Topics: Biological Transport, Active; Caco-2 Cells; Cations; Chlorpheniramine; Chromatography, High Pressure Liquid; Diphenhydramine; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Kinetics; Membrane Potentials; Spectrophotometry, Ultraviolet; Stereoisomerism | 1999 |
Acute intoxication with guaifenesin, diphenhydramine, and chlorpheniramine.
Topics: Chlorpheniramine; Diphenhydramine; Female; Guaifenesin; Humans; Middle Aged; Suicide | 1999 |
Slow wave sleep-inducing effects of first generation H1-antagonists.
Topics: Animals; Azepines; Chlorpheniramine; Diphenhydramine; Electroencephalography; Histamine H1 Antagonists; Hypnotics and Sedatives; Male; Pyrilamine; Rats; Rats, Wistar; Sleep | 1999 |
Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate.
Topics: Atropine; Chlorpheniramine; Chromium; Cinchona Alkaloids; Diphenhydramine; Ephedrine; Hydrogen-Ion Concentration; Osmolar Concentration; Pharmaceutical Preparations; Regression Analysis; Spectrum Analysis; Temperature; Thiocyanates | 1999 |
Transepithelial transport of diphenhydramine across monolayers of the human intestinal epithelial cell line Caco-2.
Topics: Algorithms; Caco-2 Cells; Chlorpheniramine; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Interactions; Epithelial Cells; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa | 2000 |
Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat.
Topics: Animals; Apomorphine; Chlorpheniramine; Dimaprit; Diphenhydramine; Dopamine Agonists; Drug Interactions; Famotidine; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Male; Piperidines; Ranitidine; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Thiourea; Toluidines | 2000 |
pH-independent large-volume sample stacking of positive or negative analytes in capillary electrophoresis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Betaine; Brompheniramine; Catecholamines; Cations; Chlorpheniramine; Dihydroxyphenylalanine; Diphenhydramine; Doxylamine; Electrophoresis, Capillary; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Pheniramine; Surface-Active Agents | 2001 |
Newer antihistamines.
Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Psychomotor Performance; Rhinitis, Allergic, Seasonal; Somnambulism; Terfenadine | 2001 |
Postmortem diffusion of drugs from the bladder into femoral venous blood.
Topics: Adolescent; Chlorpheniramine; Codeine; Diffusion; Diphenhydramine; Drowning; Drug Overdose; Femoral Vein; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Male; Postmortem Changes; Substance-Related Disorders; Urea; Urinary Bladder | 2001 |
Antihistamines in the management of canine atopic dermatitis: a retrospective study of 171 dogs (1992-1998).
Topics: Allergens; Animals; Chlorpheniramine; Clemastine; Dermatitis, Atopic; Diphenhydramine; Dog Diseases; Dogs; Female; Histamine H1 Antagonists; Hydroxyzine; Male; Records; Retrospective Studies; Treatment Outcome | 2002 |
Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2.
Topics: Biological Transport; Caco-2 Cells; Chlorpheniramine; Cyclosporine; Digoxin; Diphenhydramine; Humans; Intestinal Mucosa; Kinetics; Nicotine; Recombinant Proteins; Transfection; Tritium | 2002 |
A new isoquinolinone derivative with noble vasorelaxation activity.
Topics: Acetylcholine; Adrenergic Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Atropine; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Isoquinolines; Magnetic Resonance Spectroscopy; Male; Muscarinic Antagonists; Phenylephrine; Propranolol; Pyridines; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Yohimbine | 2003 |
A comparison of benadryl and chlor-trimeton in intravenous urography.
Topics: Anti-Allergic Agents; Chlorpheniramine; Diphenhydramine; Histamine H1 Antagonists; Humans; Hypersensitivity; Immune System Diseases; Urography | 1958 |
ACTION OF SEVERAL ANTI-HISTAMINICS ON THE ISOLATED RAT PHRENIC-DIAPHRAGM PREPARATION.
Topics: Abdominal Muscles; Anti-Allergic Agents; Chlorpheniramine; Diaphragm; Diphenhydramine; Electrophysiology; Histamine H1 Antagonists; Muscle Relaxants, Central; Neuromuscular Junction; Pharmacology; Phrenic Nerve; Physostigmine; Promethazine; Rats; Research; Tripelennamine; Tubocurarine | 1964 |
EFFECT OF ANTIHISTAMINICS ON SKELETAL MUSCLE.
Topics: Acetylcholine; Animals; Anura; Chlorpheniramine; Dimethindene; Diphenhydramine; Ethylenediamines; Histamine H1 Antagonists; Muscle, Skeletal; Muscles; Neuromuscular Junction; Pharmacology; Phenothiazines; Poultry; Rats; Research; Tripelennamine | 1964 |
MODIFICATION OF INTESTINAL PERISTALSIS BY ANTIHISTAMINE DRUGS.
Topics: Animals; Antipsychotic Agents; Cats; Chlorpheniramine; Digestion; Diphenhydramine; Ethylenediamines; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Ileum; Nictitating Membrane; Peristalsis; Pharmacology; Phenothiazines; Physiology; Promethazine; Research; Tripelennamine | 1964 |
GUANETHIDINE AS AN ANTI-FIBRILLATORY AGENT.
Topics: Acetylcholine; Atrial Fibrillation; Chlorpheniramine; Diphenhydramine; Dogs; Guanethidine; Pharmacology; Procaine; Quinidine; Research; Toxicology; Tripelennamine | 1964 |
GAS CHROMATOGRAPHY OF SOME ANTIHISTAMINES.
Topics: Anti-Allergic Agents; Chemistry, Pharmaceutical; Chlorpheniramine; Chromatography; Chromatography, Gas; Cyclizine; Diphenhydramine; Histamine Antagonists; Histamine H1 Antagonists; Meclizine; Pheniramine; Piperazines; Promethazine; Research; Tripelennamine | 1964 |
PHARMACOLOGICAL INCOMPATIBILITY OF CONTRAST MEDIA WITH VARIOUS DRUGS AND AGENTS.
Topics: Chlorpheniramine; Contrast Media; Diatrizoate; Dimenhydrinate; Diphenhydramine; Drug Incompatibility; Histamine H1 Antagonists; Iodipamide; Iodopyracet; Iothalamic Acid; Pharmacology; Polystyrenes; Syringes | 1965 |
EFFECT OF SOME DRUGS UPON RAT BRAIN HISTAMINE CONTENT.
Topics: Antidepressive Agents; Aspirin; Benactyzine; Brain; Brain Chemistry; Chemistry Techniques, Analytical; Chlorpheniramine; Dextroamphetamine; Diphenhydramine; Fluorescence; Fluorometry; Histamine; Morphine; Pharmacology; Rats; Research; Tranquilizing Agents; Tranylcypromine; Tripelennamine | 1964 |
Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice.
Topics: Animals; Capillary Permeability; Chlorpheniramine; Diphenhydramine; Evans Blue; Female; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Injections, Intradermal; Injections, Intravenous; Isothiuronium; Mast Cells; Mice; Mice, Mutant Strains; Piperidines; Receptors, Histamine H3; Skin; Thiourea; Tryptophan | 2003 |
Simultaneous determination of chlorpheniramine and pseudoephedrine in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Anti-Allergic Agents; Central Nervous System Stimulants; Chlorpheniramine; Chromatography, Liquid; Diphenhydramine; Ephedrine; Humans; Mass Spectrometry; Reference Standards; Reproducibility of Results | 2004 |
Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+.
Topics: Calcium; Cell Survival; Chlorpheniramine; Diphenhydramine; Dose-Response Relationship, Drug; Ejaculation; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Humans; Male; Promethazine; Sperm Motility; Spermatozoa; Time Factors | 2004 |
Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis.
Topics: Chlorpheniramine; Common Cold; Dextromethorphan; Diphenhydramine; Electrophoresis, Capillary; Ephedrine; Reproducibility of Results | 2005 |
Self-management and pregnancy--safe interventions for panic, phobia and other anxiety-disorders might include over-the-counter (OTC) 'SSRI' antihistamines such as diphenhydramine and chlorpheniramine.
Topics: Adult; Chlorpheniramine; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Nonprescription Drugs; Panic Disorder; Phobic Disorders; Pregnancy; Pregnancy Complications; Safety; Selective Serotonin Reuptake Inhibitors; Self Care | 2005 |
Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.
Topics: Animals; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Histamine H1 Antagonists; Hypnotics and Sedatives; Male; Nitrazepam; Rats; Sleep; Sleep Wake Disorders; Sleep, REM; Wakefulness | 2007 |
Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
Topics: Administration, Oral; Animals; Animals, Suckling; Chlorpheniramine; Cyproheptadine; Dibenzazepines; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Rats; Rats, Wistar; Seizures; Terfenadine; Time Factors | 2007 |
Cocaine-like neurochemical effects of antihistaminic medications.
Topics: Animals; Central Nervous System Stimulants; Chlorpheniramine; Cocaine; Diphenhydramine; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Histamine H1 Antagonists; Male; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reward; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Substance-Related Disorders; Synaptic Transmission; Synaptosomes; Triprolidine | 2008 |
Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations.
Topics: Chlorpheniramine; Chromatography, Liquid; Diphenhydramine; Glycerylphosphorylcholine; Histamine H1 Antagonists; Humans; Lysophospholipids; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Effects of histamine H1-antagonists on sleep-awake state in rats placed on a grid suspended over water or on sawdust.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Chlorpheniramine; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Histamine H1 Antagonists; Male; Promethazine; Rats; Rats, Wistar; Reaction Time; Sleep; Time Factors; Wakefulness; Water | 2009 |
A computational approach to studying monomer selectivity towards the template in an imprinted polymer.
Topics: Chlorpheniramine; Computer Simulation; Diphenhydramine; Methacrylates; Models, Chemical; Models, Molecular; Molecular Imprinting; Molecular Structure; Polymers | 2009 |
Best drugs for what ails you: the brands to buy--and those to skip.
Topics: Acetaminophen; Anesthetics, Local; Cetirizine; Chlorpheniramine; Common Cold; Cough; Dextromethorphan; Diphenhydramine; Drug Costs; Drug Therapy; Emergencies; Expectorants; First Aid; Glycerol; Guaifenesin; Histamine Antagonists; Honey; Humans; Hypersensitivity; Ibuprofen; Influenza Vaccines; Influenza, Human; Loratadine; Nonprescription Drugs; Oxymetazoline; Pharyngitis; Propiophenones; Pseudoephedrine; Rhinitis; Sodium Chloride | 2009 |
Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Topics: Buffers; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Doxylamine; Electrochemistry; Electrophoresis, Capillary; Ephedrine; Histamine Antagonists; Humans; Hydrogen-Ion Concentration; Luminescent Measurements; Pyridines; Reproducibility of Results; Sensitivity and Specificity | 2012 |
Immunoassay screening of diphenhydramine (Benadryl®) in urine and blood using a newly developed assay.
Topics: Brompheniramine; Chlorpheniramine; Diphenhydramine; Doxylamine; Enzyme-Linked Immunosorbent Assay; Histamine Antagonists; Humans; Reproducibility of Results; Specimen Handling | 2012 |
Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis.
Topics: Calibration; Catalysis; Chemistry, Pharmaceutical; Chlorpheniramine; Diphenhydramine; Drug Contamination; Ephedrine; Palladium; Pharmaceutical Preparations; Pseudoephedrine; Scopolamine; Spectrometry, X-Ray Emission; Technology, Pharmaceutical; Triprolidine | 2012 |
[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
Topics: Acetaminophen; Acetanilides; Amantadine; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Antipyrine; Caffeine; Chlorpheniramine; Chromatography, Liquid; Diclofenac; Diphenhydramine; Drug Contamination; Drug Stability; Ephedrine; Guaifenesin; Promethazine; Pseudoephedrine; Reproducibility of Results; Salicylates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Fabrication and evaluation of cationic exchange nanofibers for controlled drug delivery systems.
Topics: Albuterol; Chlorpheniramine; Delayed-Action Preparations; Dextromethorphan; Diphenhydramine; Drug Delivery Systems; Gastric Juice; Hydrogen-Ion Concentration; Intestinal Secretions; Ion Exchange; Nanofibers; Polystyrenes; Propranolol | 2013 |
Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells.
Topics: Animals; Cell Line; Chlorpheniramine; Diphenhydramine; Histamine Antagonists; Ion Channels; Kinetics; Mice; Microglia; Protons | 2017 |
Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Cetirizine; Child; Child Mortality; Child, Preschool; Chlorpheniramine; Databases, Factual; Diphenhydramine; Epilepsy; Female; Histamine H1 Antagonists; Humans; Infant; Infant, Newborn; Loratadine; Male; Pharmacovigilance; Stevens-Johnson Syndrome; World Health Organization | 2017 |
Chlorpheniramine Increases Paracellular Permeability to Marker Fluorescein Lucifer Yellow Mediated by Internalization of Occludin in Murine Colonic Epithelial Cells.
Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorpheniramine; Claudins; Colon; Diphenhydramine; Epithelial Cells; Fluorescent Dyes; Histamine H1 Antagonists; Isoquinolines; Mice; Occludin | 2017 |
Micro-segmental hair analysis for proving drug-facilitated crimes: Evidence that a victim ingested a sleeping aid, diphenhydramine, on a specific day.
Topics: Beverages; Biomarkers; Chlorpheniramine; Crime; Diphenhydramine; Ephedrine; Female; Forensic Medicine; Hair; Humans; Male; Reproducibility of Results; Sleep Aids, Pharmaceutical; Substance Abuse Detection; Time Factors | 2018 |
Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.
Topics: Antitussive Agents; Brompheniramine; Child; Child, Preschool; Chlorpheniramine; Dextromethorphan; Diphenhydramine; Doxylamine; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Female; Guaifenesin; Homicide; Humans; Infant; Male; Nonprescription Drugs; Phenylephrine; Pseudoephedrine | 2021 |