diphenhydramine and caffeine

diphenhydramine has been researched along with caffeine in 62 studies

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-199029 (46.77)18.7374
1990's6 (9.68)18.2507
2000's12 (19.35)29.6817
2010's11 (17.74)24.3611
2020's4 (6.45)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Sen, S; Sinha, N1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bjørndal, N; Nørgaard, P1
Cruccu, G; Ferracuti, S; Innocenti, P; Leardi, MG; Prandi, P1
Weiss, M1
Bi, TX; Xu, BM1
Spealman, RD1
Kalow, W1
Clyne, MJ; Middleton, RS1
Westin, S1
Rall, TW; Zanella, J1
Forney, RB1
Fladung, H1
Frank, GB; Jhamandas, K1
Hata, T; Kita, T; Murakami, T1
Campiglio, A1
Kammerl, E; Schlemmer, W1
Gordon, JL1
Mason, RG; Read, MS; Saba, SR; Shermer, RW1
Kiper, EM1
Hutchins, DA; Rogers, KJ1
Zhukov, BN1
Moskowitz, H1
Guay, DR; Meatherall, RC1
Debova, GA1
Bushnell, PJ; Sarter, M1
Fine, BJ; Kobrick, JL; Lieberman, HR; Marlowe, B; Riley, RH; Tharion, WJ1
Okabe, E; Suyama, N; Todoki, K1
Fine, BJ; Kobrick, JL; Lieberman, HR; Tharion, WJ1
Barbas, C; Castro, M; García, A; Saavedra, L1
Gevins, A; McEvoy, LK; Smith, ME1
RETTERSTØL, N; STUART, ED1
HARTWIG, J1
TOSCH, R1
ROSSIER, M1
HYMAN, JB; LAI, MS; POMERANITZ, N; WALLACH, R1
BREGADZE, IL; KUZNETSOV, IuV1
BARTH, L; MEYER, M; PODLESCH, I1
Alfaya Arias, T; Iglesias Aranzazu, M; Lombardero Vega, M; Mur Gimeno, P; Sastre, B1
Baum, C; Chan, CS; Gevins, A; Ilan, AB; McEvoy, LK; Sam-Vargas, L; Smith, ME1
Gardinali, PR; Wang, J1
Jiang, JG; Song, GS; Zhang, XR; Zhang, YH1
Han, B; Liu, AJ; Liu, HQ; Song, XR; Tian, JS; Yu, XH; Zhang, LL; Zhang, Y1
Hisatsune, A; Katsuki, H; Kurauchi, Y; Seki, T; Yamakawa, T1
Ellison, CA; Wu, S1
Archakam, SC; Koganti, B; Palur, K1
Browne, T; Cervantes, A; Logan, BK; Nelson, BN; Strathmann, FG1
Chen, J; Chen, Y; Dai, X; Gao, F; Geng, B; Gu, J; Li, J; Mao, J; Ren, L; Shi, W; Tian, Y; Wang, H; Yan, L; Zhang, J; Zhang, T; Zhang, X; Zhu, J1

Reviews

2 review(s) available for diphenhydramine and caffeine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Ethnic differences in reactions to drugs and xenobiotics. Caffeine and other drugs.
    Progress in clinical and biological research, 1986, Volume: 214

    Topics: Acetylation; Caffeine; Cytochrome P-450 Enzyme System; Diphenhydramine; Drug-Related Side Effects and Adverse Reactions; Gene Frequency; Genetic Markers; Humans; Kinetics; Methemoglobinemia; Mutagens; Phenylthiourea; Polymorphism, Genetic; Porphyrias; Racial Groups; Superoxide Dismutase; Taste; Xanthine Oxidase

1986

Trials

7 trial(s) available for diphenhydramine and caffeine

ArticleYear
[Electric stimulation of the dental pulp in the evaluation of the central effect of analgesics].
    Bollettino della Societa italiana di biologia sperimentale, 1990, Volume: 66, Issue:6

    Topics: Adult; Analgesics; Antipyrine; Benzocaine; Caffeine; Dental Pulp; Diphenhydramine; Diphenylacetic Acids; Dipyrone; Double-Blind Method; Drug Combinations; Drug Evaluation; Electric Stimulation; Ethylmorphine; Humans; Pain Measurement; Sensory Thresholds

1990
A comparative study of Propain and a dextropropoxyphene/paracetamol combination analgesic.
    The British journal of clinical practice, 1985, Volume: 39, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Caffeine; Codeine; Dextropropoxyphene; Diphenhydramine; Drug Combinations; Female; Humans; Male; Middle Aged; Pain

1985
International seminar research on alcohol, drugs and driving.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1973, Volume: 6, Issue:2

    Topics: Alcohol Drinking; Auditory Perception; Automobile Driving; Caffeine; Chlordiazepoxide; Clinical Trials as Topic; Color Perception Tests; Dextroamphetamine; Diazepam; Diphenhydramine; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Ethanol; Feedback; Glutethimide; Histamine H1 Antagonists; Humans; Meprobamate; Motor Skills; Nortriptyline; Placebos; Postural Balance; Secobarbital; Tripelennamine

1973
Effects of caffeine or diphenhydramine on visual vigilance.
    Psychopharmacology, 1994, Volume: 114, Issue:2

    Topics: Adult; Affect; Arousal; Caffeine; Diphenhydramine; Double-Blind Method; Evoked Potentials, Auditory; Humans; Male; Personality; Reaction Time; Smoking; Vision, Ocular

1994
Effects of caffeine and diphenhydramine on auditory evoked cortical potentials.
    Perceptual and motor skills, 1993, Volume: 76, Issue:3 Pt 1

    Topics: Acoustic Stimulation; Adult; Arousal; Attention; Caffeine; Cerebral Cortex; Diphenhydramine; Double-Blind Method; Evoked Potentials, Auditory; Humans; Male; Reaction Time

1993
Tracking the cognitive pharmacodynamics of psychoactive substances with combinations of behavioral and neurophysiological measures.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:1

    Topics: Adult; Behavior; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Cognition; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Electroencephalography; Ethanol; Female; Humans; Hypnotics and Sedatives; Male; Multivariate Analysis; Neuropsychological Tests; Psychomotor Performance; Psychotropic Drugs; Reaction Time

2002
Long-term and within-day variability of working memory performance and EEG in individuals.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012, Volume: 123, Issue:7

    Topics: Adult; Caffeine; Cannabis; Circadian Rhythm; Cognition; Diphenhydramine; Electroencephalography; Ethanol; Female; Humans; Longitudinal Studies; Male; Memory, Short-Term; Middle Aged; Task Performance and Analysis; Time Factors

2012

Other Studies

53 other study(ies) available for diphenhydramine and caffeine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Determination of log D via automated microfluidic liquid-liquid extraction.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
[Koffinautin abuse: an increasing problem].
    Ugeskrift for laeger, 1979, Jul-30, Volume: 141, Issue:31

    Topics: Adult; Caffeine; Denmark; Diphenhydramine; Drug and Narcotic Control; Humans; Male; Substance-Related Disorders

1979
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
    Clinical pharmacokinetics, 1990, Volume: 18, Issue:5

    Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Ketanserin; Lidocaine; Liver Diseases; Metronidazole; Nomifensine; Triamterene

1990
[Studies on multiwavelength absorbance ratio difference spectrophotometry and its application].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:5

    Topics: Aminopyrine; Caffeine; Diphenhydramine; Drug Combinations; Ephedrine; Spectrophotometry

1989
Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azabicyclo Compounds; Barbital; Benzodiazepines; Benzodiazepinones; Buspirone; Caffeine; Chlordiazepoxide; Cinanserin; Clozapine; Conditioning, Operant; Cyproheptadine; Diazepam; Diphenhydramine; Discrimination Learning; Electroshock; Flumazenil; Male; Midazolam; Muscimol; Nordazepam; Pentobarbital; Piperazines; Pyridazines; Pyrimidines; Saimiri; Tripelennamine

1985
[Abuse of travel sickness remedies among young drug addicts].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972, Nov-10, Volume: 92, Issue:31

    Topics: Adolescent; Adult; Caffeine; Cannabis; Diphenhydramine; Drug Interactions; Drug Prescriptions; Female; Hallucinations; Histamine H1 Antagonists; Humans; Illusions; Lysergic Acid Diethylamide; Male; Motion Sickness; Norway; Social Class; Substance-Related Disorders; Time Factors

1972
Evaluation of electrical pulses and elevated levels of potassium ions as stimulants of adenosine 3', 5'-monophosphate (cyclic AMP) accumulation in guinea-pig brain.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 186, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Brain; Caffeine; Calcium; Cerebellum; Cerebral Cortex; Cyclic AMP; Diphenhydramine; Electric Stimulation; Electrodes; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Norepinephrine; Phosphodiesterase Inhibitors; Potassium; Prostaglandins; Reserpine; Stimulation, Chemical; Theophylline; Xanthenes

1973
[On the treatment of combined banal infections].
    Der Landarzt, 1968, Nov-20, Volume: 44, Issue:32

    Topics: Anti-Inflammatory Agents; Antitussive Agents; Bronchitis; Caffeine; Diphenhydramine; Female; Histamine H1 Antagonists; Humans; Male; Phenacetin; Respiratory Tract Infections; Rhinitis; Salicylamides; Vasoconstrictor Agents

1968
Effects of drugs acting alone and in combination on the motor activity of intact mice.
    British journal of pharmacology, 1970, Volume: 39, Issue:4

    Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central Nervous System Stimulants; Chlorpromazine; Diazepam; Diphenhydramine; Female; Glutamates; Hydroxybutyrates; Lactones; Meperidine; Meprobamate; Mice; Motor Activity; Nikethamide; Phenobarbital; Picrotoxin; Promethazine; Reflex; Scopolamine; Seizures; Strychnine; Tranquilizing Agents

1970
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diphenhydramine; Imipramine; Mice; Nikethamide; Pentylenetetrazole; Rodent Diseases; Seizures; Tranquilizing Agents

1970
[Determination of the N-methyl group in organic substances on the micro and decimomilligram scale].
    Il Farmaco; edizione scientifica, 1973, Volume: 28, Issue:1

    Topics: Acetanilides; Aminopyrine; Antipyrine; Caffeine; Diphenhydramine; Ephedrine; Indicators and Reagents; Methylation; Microchemistry; Theobromine; Theophylline

1973
Application of quantitative thin-layer chromatography in drug assay and stability testing. Determination of codeine phosphate, noscapine, diphenhydramine hydrochloride, phenylephrine hydrochloride, caffeine, etofyllin, phenobarbital and thiamine hydrochlo
    Journal of chromatography, 1973, Jul-18, Volume: 82, Issue:1

    Topics: Autoanalysis; Caffeine; Chromatography, Thin Layer; Codeine; Diphenhydramine; Drug Combinations; Drug Stability; Methods; Noscapine; Pharmaceutical Preparations; Phenobarbital; Phenylephrine; Spectrum Analysis; Theophylline; Thiamine

1973
Differential changes in potency of platelet-aggregation inhibitors after preincubation in platelet-rich plasma.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 7, Issue:1

    Topics: Adenosine Diphosphate; Amitriptyline; Animals; Caffeine; Chlorpromazine; Diphenhydramine; Dipyridamole; Imipramine; Papaverine; Plasma; Platelet Adhesiveness; Swine; Time Factors; Trifluoperazine

1974
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction.
    Thrombosis et diathesis haemorrhagica, 1972, Feb-29, Volume: 27, Issue:1

    Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds

1972
[Quantitative determination of salicylamide, phenacetin, caffeine, diphenhydramine chlorhydrate, luminal combinations].
    Turk hijiyen ve tecrubi biyoloji dergisi, 1969, Volume: 29, Issue:2

    Topics: Caffeine; Diphenhydramine; Drug Combinations; Phenacetin; Phenobarbital; Salicylamides

1969
Physiological and drug-induced changes in the glycogen content of mouse brain.
    British journal of pharmacology, 1970, Volume: 39, Issue:1

    Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circadian Rhythm; Diphenhydramine; Glucose; Glycogen; Hyperglycemia; Insulin; Male; Mice; Motor Activity; Nialamide; Phenytoin; Propranolol; Seizures; Temperature

1970
[Treatment of thrombophlebitis of the lower extremities by means of pelvic blackade according to Shkol'nikov and electrophoresis with sulfanilimide preparations].
    Vestnik khirurgii imeni I. I. Grekova, 1968, Volume: 100, Issue:3

    Topics: Adult; Anesthesia, Conduction; Caffeine; Diphenhydramine; Electrophoresis; Female; Humans; Middle Aged; Pelvis; Procaine; Streptomycin; Sulfanilamides; Thrombophlebitis; Vitamin B Complex

1968
Attention tasks as skills performance measures of drug effects.
    British journal of clinical pharmacology, 1984, Volume: 18 Suppl 1

    Topics: Accidents, Traffic; Attention; Automobile Driving; Behavior; Caffeine; Cannabis; Cognition; Diazepam; Diphenhydramine; Ethanol; Flurazepam; Humans; Perception; Psychomotor Performance; Reaction Time; Time Factors

1984
Isothermal gas chromatographic analysis of diphenhydramine after direct injection onto a fused-silica capillary column.
    Journal of chromatography, 1984, May-11, Volume: 307, Issue:2

    Topics: Caffeine; Chromatography, Gas; Diphenhydramine; Humans; Orphenadrine; Time Factors

1984
[Effect of popular drugs on the frequency of sister chromatid exchange in cultured human lymphocytes].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:12

    Topics: Benzimidazoles; Benzoates; Caffeine; Cells, Cultured; Crossing Over, Genetic; Diphenhydramine; Drug Combinations; Humans; Magnesium Sulfate; Muscle Relaxants, Central; Mutagens; Procaine; Sister Chromatid Exchange

1981
Testing vigilance: validity, reliability and sensitivity in methods development.
    Psychopharmacology, 1995, Volume: 118, Issue:2

    Topics: Attention; Caffeine; Diphenhydramine; Humans; Reproducibility of Results; Research Design; Sensitivity and Specificity; Task Performance and Analysis

1995
[A mechanism underlying histamine-induced contraction in isolated rabbit lingual artery].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:4

    Topics: Animals; Caffeine; Calcium; Diphenhydramine; Histamine; Histamine Antagonists; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Tongue; Type C Phospholipases

1994
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography. Stress test for stability evaluation.
    Journal of chromatography. A, 2000, Feb-18, Volume: 870, Issue:1-2

    Topics: Caffeine; Chromatography, High Pressure Liquid; Diphenhydramine; Drug Stability; Evaluation Studies as Topic; Reproducibility of Results; Theophylline

2000
[Seasickness during journey in small vessels].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1953, Nov-01, Volume: 73, Issue:21

    Topics: Caffeine; Diphenhydramine; Humans; Motion Sickness

1953
[Experiences with the antiemetic rodavan in prevention and therapy of postanesthesia vomiting].
    Zentralblatt fur Chirurgie, 1958, Aug-09, Volume: 83, Issue:32

    Topics: Antiemetics; Biomedical Research; Caffeine; Diphenhydramine; Surgical Procedures, Operative; Theophylline; Vomiting

1958
[Clinical experience with the antiemetic rodavan in the therapy of roentgen intoxication].
    Deutsches medizinisches Journal, 1958, Volume: 9, Issue:11

    Topics: Antiemetics; Caffeine; Diphenhydramine; Radiation Injuries; Radiotherapy; Theophylline

1958
[INDICATIONS, THERAPEUTIC EFFICACY AND TOLERANCE OF AN ANTIHISTAMINIC SYNERGISM (DIVAHISTINE)].
    Therapeutische Umschau. Revue therapeutique, 1963, Volume: 20

    Topics: Ascorbic Acid; Caffeine; Common Cold; Diphenhydramine; Humans; Immune Tolerance; Nasal Decongestants; Pheniramine; Phenylephrine; Rhinitis; Rhinitis, Allergic, Seasonal; Vasoconstrictor Agents

1963
HEMORRHAGIC DIATHESIS DUE TO SALICYLATE-INDUCED HYPOPROTHROMBINEMIA.
    New York state journal of medicine, 1964, Mar-15, Volume: 64

    Topics: Adrenocorticotropic Hormone; Aspirin; Blood Transfusion; Caffeine; Diphenhydramine; Hematoma; Hemorrhagic Disorders; Hypoprothrombinemias; Mouth; Phenacetin; Salicylates; Toxicology; Vitamin K 1

1964
[COMPLICATIONS DURING BROMSULPHALEIN TESTS].
    Klinicheskaia meditsina, 1964, Volume: 42

    Topics: Caffeine; Calcium; Diphenhydramine; Echinococcosis; Echinococcosis, Hepatic; Hemangiosarcoma; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Pharmacology; Procaine; Sulfobromophthalein; Toxicology

1964
[Prophylaxis and therapy of postoperative vomiting with the diphenhydramine derivative combination Rodavan; a clinical-statistical evaluation].
    Der Anaesthesist, 1961, Volume: 10

    Topics: Caffeine; Diphenhydramine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Theophylline; Vomiting

1961
Anaphylactic shock caused by antihistamines.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:4

    Topics: Administration, Oral; Allergens; Anaphylaxis; Antiemetics; Caffeine; Dimenhydrinate; Diphenhydramine; Drug Combinations; Female; Hand Dermatoses; Histamine Antagonists; Humans; Immunoglobulin E; Middle Aged; Nasal Polyps; Respiratory Hypersensitivity; Single-Blind Method; Skin Tests

2011
Uptake and depuration of pharmaceuticals in reclaimed water by mosquito fish (Gambusia holbrooki): a worst-case, multiple-exposure scenario.
    Environmental toxicology and chemistry, 2013, Volume: 32, Issue:8

    Topics: Animals; Caffeine; Carbamazepine; Cyprinodontiformes; Diphenhydramine; Fresh Water; Ibuprofen; Pharmaceutical Preparations; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical

2013
[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:1

    Topics: Acetaminophen; Acetanilides; Amantadine; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Antipyrine; Caffeine; Chlorpheniramine; Chromatography, Liquid; Diclofenac; Diphenhydramine; Drug Contamination; Drug Stability; Ephedrine; Guaifenesin; Promethazine; Pseudoephedrine; Reproducibility of Results; Salicylates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2013
The Combination of Scopolamine and Psychostimulants for the Prevention of Severe Motion Sickness.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:8

    Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cholinergic Antagonists; Dextroamphetamine; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Granisetron; Locomotion; Male; Mice; Mice, Inbred ICR; Modafinil; Motion Sickness; Rotation; Scopolamine

2016
Endogenous Nitric Oxide Inhibits, Whereas Awakening Stimuli Increase, the Activity of a Subset of Orexin Neurons.
    Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:12

    Topics: Animals; Arousal; Caffeine; Central Nervous System Stimulants; Diphenhydramine; Male; Mice, Inbred C57BL; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Orexins; Proto-Oncogene Proteins c-fos; Sleep Deprivation

2018
Application of structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic model development and evaluation.
    Regulatory toxicology and pharmacology : RTP, 2020, Volume: 114

    Topics: Animal Testing Alternatives; Animals; Caffeine; Diphenhydramine; Humans; Models, Biological; Molecular Structure

2020
Chemometric assisted UV spectrophotometric and RP-HPLC methods for simultaneous determination of paracetamol, diphenhydramine, caffeine and phenylephrine in tablet dosage form.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2020, Dec-15, Volume: 243

    Topics: Acetaminophen; Caffeine; Chromatography, High Pressure Liquid; Diphenhydramine; Phenylephrine; Spectrophotometry, Ultraviolet; Tablets

2020
Qualitative LC-Q-TOF Analysis of Umbilical Cord Tissue via Data-Dependent Acquisition as an Indicator of In Utero Exposure to Toxic Adulterating Substances.
    Journal of analytical toxicology, 2022, Jul-14, Volume: 46, Issue:6

    Topics: Analgesics, Opioid; Caffeine; Cocaine; Diphenhydramine; Drug Contamination; Female; Humans; Levamisole; Lidocaine; Phenacetin; Pregnancy; Umbilical Cord; Xylazine

2022
Evaluation of subchronic toxicity of the compound of diphenhydramine hydrochloride and caffeine after 28 days of repeated oral administration in Sprague-Dawley rats and beagle dogs.
    Drug and chemical toxicology, 2023, Volume: 46, Issue:6

    Topics: Administration, Oral; Animals; Caffeine; Diphenhydramine; Dogs; Female; Male; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley

2023