diphenhydramine and alprazolam

diphenhydramine has been researched along with alprazolam in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's2 (11.76)18.2507
2000's9 (52.94)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Horio, Y; Iwahara, T; Minami, H; Sakai, S; Shibagaki, T; Shimokata, K; Watanabe, A1
Darius, H; Lefer, AM; Smith, JB1
Darius, H; Lefer, AM; Lefer, DJ; Smith, JB1
Mori, K; Saito, Y; Tominaga, K1
Baas, JM; Ellis, V; Grillon, C; Lawley, M; Levine, J; Lissek, S; Pine, DS1
Baas, JM; Broeyer, F; Kenemans, JL; Mol, N; Niklson, I; Prinssen, EP; van Gerven, J; Xia-Chen, C1
Mullins, ME; Rengarajan, A1
Baas, J; Broeyer, F; Chen, X; Cohen, A; de Kam, M; van Gerven, J1

Reviews

1 review(s) available for diphenhydramine and alprazolam

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for diphenhydramine and alprazolam

ArticleYear
Antiemetic efficacy of alprazolam in the combination of metoclopramide plus methylprednisolone. Double-blind randomized crossover study in patients with cisplatin-induced emesis.
    American journal of clinical oncology, 1993, Volume: 16, Issue:4

    Topics: Adult; Aged; Alprazolam; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Diphenhydramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methylprednisolone; Metoclopramide; Middle Aged; Nausea; Vomiting

1993
The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle.
    Biological psychiatry, 2006, Oct-01, Volume: 60, Issue:7

    Topics: Acoustic Stimulation; Adult; Alprazolam; Analysis of Variance; Anti-Anxiety Agents; Anxiety; Association Learning; Conditioning, Classical; Cross-Over Studies; Diphenhydramine; Dose-Response Relationship, Drug; Double-Blind Method; Environment; Fear; Female; Humans; Hypnotics and Sedatives; Male; Reference Values; Reflex, Startle

2006
Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine.
    Psychopharmacology, 2009, Volume: 205, Issue:1

    Topics: Acoustic Stimulation; Alprazolam; Anti-Anxiety Agents; Anxiety; Conditioning, Classical; Cross-Over Studies; Cues; Diphenhydramine; Dose-Response Relationship, Drug; Double-Blind Method; Fear; gamma-Aminobutyric Acid; Humans; Pregabalin; Reflex, Startle; Reproducibility of Results

2009
Pharmacodynamic response profiles of anxiolytic and sedative drugs.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Alprazolam; Anti-Anxiety Agents; Anxiety; Biomarkers; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Male; Pregabalin; Reflex, Startle; Saccades; Young Adult

2017

Other Studies

12 other study(ies) available for diphenhydramine and alprazolam

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
[A combined anti-emesis therapy of oral prednisolone and alprazolam for cisplatin-induced delayed emesis].
    Gan no rinsho. Japan journal of cancer clinics, 1990, Volume: 36, Issue:8

    Topics: Administration, Oral; Adult; Aged; Alprazolam; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Diphenhydramine; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Methylprednisolone; Metoclopramide; Middle Aged; Mitomycin; Mitomycins; Nausea; Prednisolone; Vinblastine; Vomiting

1990
Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists.
    International archives of allergy and applied immunology, 1986, Volume: 80, Issue:4

    Topics: Alprazolam; Anaphylaxis; Animals; Benzodiazepines; Benzofurans; Benzopyrans; Diphenhydramine; Guinea Pigs; Histamine; Lignans; Male; Muscle Contraction; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; SRS-A

1986
Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis.
    Science (New York, N.Y.), 1986, Apr-04, Volume: 232, Issue:4746

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprazolam; Anaphylaxis; Animals; Anti-Inflammatory Agents; Benzodiazepines; Blood Pressure; Diphenhydramine; Guinea Pigs; In Vitro Techniques; Kinetics; Lung; Male; Ovalbumin; Platelet Activating Factor; Platelet Count; Pyrazoles

1986
How often do false-positive phencyclidine urine screens occur with use of common medications?
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:6

    Topics: Alprazolam; Carbazoles; Carvedilol; Clonazepam; Dextromethorphan; Diphenhydramine; Drug Interactions; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Phencyclidine; Propanolamines; Retrospective Studies; Substance-Related Disorders; Tramadol

2013