Page last updated: 2024-08-24

dioxadrol and piperidines

dioxadrol has been researched along with piperidines in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199021 (55.26)18.7374
1990's10 (26.32)18.2507
2000's5 (13.16)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agrawal, AK; Greco, NJ; Jacobson, AE; Jamieson, GA; Jones, GD; Rice, KC; Tandon, NN; Tenner, TE; White, JG1
Harrison, EA; Jacobson, AE; Mattson, MV; Mirsadeghi, S; Monn, JA; Ornstein, PL; Rice, KC; Richardson, S; Thurkauf, A1
Pechnick, RN; Vargas, HM1
de Costa, BR; Jacobson, AE; Mattson, MV; Monn, JA; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A1
Boksa, P; Chaudieu, I; Mount, H; Quirion, R1
France, CP; Moerschbaecher, JM; Woods, JH1
Kao, MC; Lee, HK; Wang, Y1
Beinfeld, MC; Brog, JS1
ffrench-Mullen, JM; Pieniek, M; Rogawski, MA; Suzuki, S1
Bourne, GW; Capek, R; Esplin, B2
George, R; Jacobson, AE; Pechnick, RN; Rice, KC; Thurkauf, A; Wong, CA1
Lee, HK; Wang, Y1
Harrison, EA; Jacobson, AE; Lessor, RA; Mattson, MV; Rafferty, MF; Rice, KC; Silverton, JV; Solomon, RE; Winger, G; Woods, JH1
Brocklehurst, C; Devia, C; Faust, WB; Moerschbaecher, JM1
Amrick, CL; Bennett, DA; Bernard, PS1
Haring, R; Kloog, Y; Sokolovsky, M1
Kim, MB; Palmer, MR; Wang, Y1
Coan, EJ; Collingridge, GL1
Bartschat, DK; Blaustein, MP1
Kozlowski, MR1
Contreras, P; O'Donohue, TL; Pilapil, C; Quirion, R1
Creveling, CR; Harrison, EA; Jacobson, AE; Rafferty, MF; Rice, KC; Winger, GD; Woods, JH1
Balster, RL; Brady, KT; Woolverton, WL1
Leander, JD1
Browne, RG; Welch, WM1
Herling, S; Solomon, RE; Woods, JH1
Cone, EJ; McQuinn, RL; Shannon, HE1
Pechnick, RN; Poland, RE1
Colombo, G; Grant, J; Grant, KA; Rogawski, MA1
Carpy, A; Elhallaoui, M; Laguerre, M; Ouazzani, FC1
LASAGNA, L; PEARSON, JW1
Aepkers, M; Wünsch, B2
Sun, W; Wessinger, WD1
Sax, M; Wünsch, B1
Banerjee, A; Schepmann, D; Wünsch, B1
Banerjee, A; Köhler, J; Schepmann, D; Wünsch, B; Würthwein, EU1

Reviews

1 review(s) available for dioxadrol and piperidines

ArticleYear
Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity.
    Current topics in medicinal chemistry, 2006, Volume: 6, Issue:7

    Topics: Animals; Dioxolanes; Excitatory Amino Acid Antagonists; Humans; Models, Molecular; Oxygen; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2006

Other Studies

37 other study(ies) available for dioxadrol and piperidines

ArticleYear
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.
    The Biochemical journal, 1992, Jul-01, Volume: 285 ( Pt 1)

    Topics: Binding, Competitive; Blood Platelets; Cells, Cultured; Chromatography, Gel; Cyclic AMP; Dioxolanes; Dizocilpine Maleate; Epinephrine; Humans; Phencyclidine; Piperidines; Platelet Activation; Receptors, Neurotransmitter; Receptors, Phencyclidine

1992
Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships.
    Journal of medicinal chemistry, 1992, Apr-17, Volume: 35, Issue:8

    Topics: Analgesics; Animals; Binding Sites; Brain; Dioxolanes; Phencyclidine; Piperidines; Rats; Structure-Activity Relationship

1992
Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands.
    European journal of pharmacology, 1991, Mar-19, Volume: 195, Issue:1

    Topics: Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Dioxolanes; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pentazocine; Phosphatidylinositols; Piperidines; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine; Scopolamine Derivatives

1991
Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.
    Neuropharmacology, 1990, Volume: 29, Issue:9

    Topics: Analgesics; Animals; Benzomorphans; Brain; Dioxolanes; Dizocilpine Maleate; Guinea Pigs; In Vitro Techniques; Kinetics; Ligands; Narcotics; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Structure-Activity Relationship

1990
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
    Canadian journal of physiology and pharmacology, 1990, Volume: 68, Issue:9

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium

1990
MK-801 and related compounds in monkeys: discriminative stimulus effects and effects on a conditional discrimination.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Dextrorphan; Dioxolanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Erythrocebus patas; Female; Ketamine; Macaca fascicularis; Macaca mulatta; Male; Phencyclidine; Piperidines; Stereoisomerism

1991
Facilitation of GABA-induced depression with PCP and sigma receptor agonists was mediated through catecholaminergic pathways.
    Life sciences, 1990, Volume: 47, Issue:22

    Topics: Animals; Cerebellum; Dioxolanes; Electrophysiology; gamma-Aminobutyric Acid; Male; Norepinephrine; Phencyclidine; Piperidines; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma

1990
Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Animals; Brain; Carbachol; Culture Techniques; Dibenzocycloheptenes; Dioxolanes; Dizocilpine Maleate; Inositol Phosphates; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sigma Factor; Transcription Factors

1990
Phencyclidine selectively blocks the sustained voltage-dependent potassium conductance in PC12 cells.
    Brain research, 1988, Jul-19, Volume: 456, Issue:1

    Topics: Anesthetics; Animals; Dioxolanes; Electric Stimulation; Ion Channels; Membrane Potentials; Phencyclidine; Pheochromocytoma; Piperidines; Potassium; Rats; Tumor Cells, Cultured

1988
Phencyclidine suppresses hippocampal long-term potentiation through stereospecific activation of phencyclidine receptors.
    Neuropharmacology, 1989, Volume: 28, Issue:1

    Topics: Analgesics; Animals; Dioxolanes; Evoked Potentials; Hippocampus; Male; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine

1989
Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat.
    Neuropharmacology, 1989, Volume: 28, Issue:8

    Topics: Animals; Body Temperature; Dibenzocycloheptenes; Dioxolanes; Dioxoles; Dizocilpine Maleate; Injections, Subcutaneous; Male; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Time Factors

1989
Facilitation of gamma-aminobutyric acid-induced depression by (+)PCMP and dexoxadrol in the cerebellar Purkinje neurons of the rat.
    Neuropharmacology, 1989, Volume: 28, Issue:4

    Topics: Analgesics; Animals; Cerebellum; Depression, Chemical; Dioxolanes; Dioxoles; Electrophysiology; gamma-Aminobutyric Acid; Heart Conduction System; In Vitro Techniques; Male; Neurons; Phencyclidine; Piperidines; Purkinje Fibers; Rats; Rats, Inbred Strains; Stereoisomerism; Sympathomimetics

1989
Enantiomeric and diastereomeric dioxadrols: behavioral, biochemical and chemical determination of the configuration necessary for phencyclidine-like properties.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Analgesics; Animals; Brain; Dioxolanes; Dioxoles; Discrimination, Psychological; Isomerism; Ketamine; Kinetics; Macaca mulatta; Models, Molecular; Molecular Conformation; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Phencyclidine; Self Administration; Stereoisomerism; Structure-Activity Relationship

1987
Effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2

    Topics: Analgesics; Animals; Benzomorphans; Conditioning, Psychological; Cyclazocine; Dioxolanes; Dioxoles; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Female; Macaca fascicularis; Male; Naltrexone; Piperidines; Receptors, Opioid; Receptors, Opioid, kappa

1987
A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.
    Life sciences, 1988, Volume: 42, Issue:4

    Topics: Animals; Aspartic Acid; Behavior, Animal; Dioxolanes; Dioxoles; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures

1988
Disinhibitory effect of phencyclidine in the hippocampus in vitro: PCP receptors implicated.
    European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2

    Topics: Analgesics; Animals; Dioxolanes; Hippocampus; In Vitro Techniques; Male; Phencyclidine; Piperidines; Pressure; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine

1988
Regional heterogeneity of rat brain phencyclidine (PCP) receptors revealed by photoaffinity labeling with [3H] azido phencyclidine.
    Biochemical and biophysical research communications, 1985, Sep-30, Volume: 131, Issue:3

    Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Brain; Dioxolanes; Electrophoresis, Polyacrylamide Gel; Peptides; Phencyclidine; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptosomes

1985
Interactions of metaphit with phencyclidine and sigma agonist actions in rat cerebellum: determination of specificity and selectivity.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Cerebellum; Dioxolanes; Drug Interactions; Electrophysiology; Isomerism; Male; Phencyclidine; Piperidines; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Substrate Specificity

1987
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.
    British journal of pharmacology, 1987, Volume: 91, Issue:3

    Topics: Analgesics; Animals; Dioxolanes; Hallucinogens; Hippocampus; In Vitro Techniques; Ketamine; Kinetics; Magnesium; Neuromuscular Depolarizing Agents; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission

1987
Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.
    The Journal of physiology, 1988, Volume: 403

    Topics: Animals; Brain; Cyclazocine; Dioxolanes; Dioxoles; Dose-Response Relationship, Drug; Hallucinogens; In Vitro Techniques; Naloxone; Phenazocine; Phencyclidine; Piperidines; Potassium Channels; Rats; Synaptosomes

1988
Effects of sigma agonist compounds on local cerebral glucose utilization: relationship to psychotomimetic properties.
    Brain research, 1986, Jun-18, Volume: 376, Issue:1

    Topics: Animals; Brain; Dioxolanes; Dioxoles; Glucose; Hallucinogens; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains

1986
Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain.
    Neuroscience letters, 1985, May-01, Volume: 56, Issue:1

    Topics: Animals; Autoradiography; Binding Sites; Brain; Dioxolanes; Dioxoles; Humans; Membranes; Phencyclidine; Piperidines; Rats

1985
Evidence for separation of anesthetic activity from prototypic phencyclidine action in drug discrimination by molecular modification of dioxadrol, a phencyclidine-like dissociative anesthetic.
    NIDA research monograph, 1984, Volume: 55

    Topics: Anesthetics; Animals; Batrachotoxins; Brain; Chemical Phenomena; Chemistry; Dioxolanes; Dioxoles; Discrimination Learning; Humans; Macaca mulatta; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine

1984
Discriminative stimulus and reinforcing properties of etoxadrol and dexoxadrol in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:1

    Topics: Animals; Conditioning, Operant; Dioxolanes; Dioxoles; Discrimination, Psychological; Macaca mulatta; Male; Phencyclidine; Piperidines; Reinforcement, Psychology; Saimiri; Self Administration

1982
Comparison of phencyclidine, etoxadrol and dexoxadrol in the pigeon.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4

    Topics: Analgesics; Animals; Columbidae; Conditioning, Operant; Cyclazocine; Dioxolanes; Dioxoles; Discrimination Learning; Dose-Response Relationship, Drug; Ketamine; Male; Phencyclidine; Piperidines; Reinforcement Schedule

1982
Stereoselective antagonism of phencyclidine's discriminative properties by adenosine receptor agonists.
    Science (New York, N.Y.), 1982, Sep-17, Volume: 217, Issue:4565

    Topics: Adenosine; Animals; Dioxolanes; Humans; Ketamine; Phencyclidine; Phencyclidine Abuse; Piperidines; Rats; Receptors, Cell Surface; Receptors, Purinergic; Tiletamine

1982
Discriminative stimulus effects of dextrorphan in pigeons.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:3

    Topics: Animals; Bemegride; Binding Sites; Columbidae; Dextrorphan; Dioxolanes; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Generalization, Stimulus; Morphinans; Naltrexone; Pentobarbital; Piperidines; Stereoisomerism; Structure-Activity Relationship

1983
Structure-activity relationship studies of phencyclidine derivatives in rats.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:1

    Topics: Animals; Dioxolanes; Discrimination, Psychological; Male; Phencyclidine; Piperidines; Pupil; Rats; Rats, Inbred F344; Stereoisomerism; Structure-Activity Relationship

1984
Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors.
    European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2

    Topics: Adrenocorticotropic Hormone; Analgesics; Animals; Corticosterone; Dioxolanes; Drug Interactions; Hypothalamo-Hypophyseal System; Injections, Subcutaneous; Male; Phenazocine; Phencyclidine; Piperidines; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism; Sympathomimetics

1994
Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Acetamides; Analysis of Variance; Anesthetics, Dissociative; Animals; Conditioning, Operant; Dextromethorphan; Dioxolanes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Memantine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate

1996
Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.
    Journal of molecular modeling, 2002, Volume: 8, Issue:2

    Topics: Binding Sites; Dioxolanes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Lipids; Models, Molecular; Molecular Structure; N-Methylaspartate; Nitrogen; Phencyclidine; Piperidines; Quinolines; Receptors, N-Methyl-D-Aspartate; Static Electricity

2002
ANALGESIC AND PSYCHOTOMIMETIC PROPERTIES OF DEXOXADROL.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Biomedical Research; Dioxolanes; Drug Therapy; Female; Hallucinogens; Humans; Pain; Pharmacology; Piperidines; Placebos; Puerperal Disorders; Toxicology

1965
Synthesis and NMDA-receptor affinity of ring and side chain homologous dexoxadrol derivatives.
    Archiv der Pharmazie, 2004, Volume: 337, Issue:2

    Topics: Analgesics; Animals; Dioxolanes; Guinea Pigs; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Swine

2004
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats.
    Life sciences, 2004, Aug-06, Volume: 75, Issue:12

    Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium

2004
Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol.
    Bioorganic & medicinal chemistry, 2005, Dec-15, Volume: 13, Issue:24

    Topics: Animals; Dioxolanes; Guinea Pigs; Molecular Structure; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship

2005
Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.
    Bioorganic & medicinal chemistry, 2010, Jun-01, Volume: 18, Issue:11

    Topics: Alcohols; Amines; Analgesics; Binding Sites; Dioxolanes; Halogenation; Humans; Piperidines; Piperidones; Protein Binding; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2010
Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists.
    Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22

    Topics: Animals; Binding Sites; Brain; Dioxolanes; Models, Theoretical; Piperidines; Receptors, N-Methyl-D-Aspartate; Static Electricity; Stereoisomerism; Structure-Activity Relationship; Swine

2010