Page last updated: 2024-08-26

diosgenin and dioscin

diosgenin has been researched along with dioscin in 224 studies

Research

Studies (224)

TimeframeStudies, this research(%)All Research%
pre-19904 (1.79)18.7374
1990's3 (1.34)18.2507
2000's30 (13.39)29.6817
2010's134 (59.82)24.3611
2020's53 (23.66)2.80

Authors

AuthorsStudies
Chapuis, JC; Doubek, DL; Hoffmann, H; Knight, JC; Pettit, GR; Pettit, RK; Pinilla, V; Schmidt, JM; Zhang, Q1
Hong, BN; Hong, HN; Kang, TH; Kim, DH; Kim, TW; Le, HT; Lim, CW; Park, KH1
Gao, W; Jing, S; Li, X; Man, S; Sun, J; Wang, Y; Zhao, C1
Squibb, RE; Squibb, RL1
Aquino, R; Conti, C; De Simone, F; Orsi, N; Pizza, C; Stein, ML1
Aquino, R; Behar, I; De Simone, F; Pizza, C1
Dong, A; Hu, K; Iwasaki, S; Kobayashi, H; Yao, X1
Deng, S; Han, X; Hui, Y; Yu, B; Yu, H1
Ju, Y; Li, X; Liu, M; Wang, Z; Zhang, H; Zhou, J1
Cai, J; Ju, Y; Liu, M; Wang, Z1
Chai, H; Cordell, GA; Farnsworth, NR; Hollingshead, MG; Kardono, LB; Kinghorn, AD; Lantvit, D; Lee, IS; Mayo, JG; Mi, Q; Ngassapa, O; Peraza-Sánchez, S; Pezzuto, JM; Reyes-Lim, E; Riswan, S; Zhao, W1
Garegg, PJ; Gybäck, H; Lahmann, M; Oscarson, S; Suhr, R; Thiem, J1
Han, X; Li, M; Yu, B1
Hou, SJ; Lei, PS; Liang, XT; Shi, Y; Zou, CC1
Sun, W; Tu, G; Zhang, Y1
Kim, JH; Kim, JS; Kim, SH; Kwon, CS; Lee, JS; Lim, JK; Sohn, HY; Son, KH1
Cai, B; Cui, CB; Liu, HW; Wang, SL; Wu, CF; Yao, XS1
KAWASAKI, T; TSUKAMOTO, T; YAMAUCHI, T1
KAWASAKI, T; YAMAUCHI, T1
Du, Q; Li, B; Liu, Z; Wang, A; Wang, F; Wang, Y; Wang, Z1
Chen, X; Gu, J; Li, K; Wang, Y; Zhong, D1
Che, CM; Hui, Y; Shum, TY; Wong, EL; Yang, Z1
Balick, MJ; Bills, GF; Borris, RP; DeMartino, J; DiSalvo, J; Dombrowski, AW; Guan, Z; Herath, KB; Jayasuriya, H; Koch, G; Mojena, M; Morenberg, CM; Nanakorn, W; Ondeykal, JG; Polishook, JD; Singh, SB; Slattery, M; Stevenson, DW1
Liu, XK; Ma, YH; Yang, SL1
Fawcett, JP; Gu, J; Li, K; Tang, Y; Zhong, D1
Jin, F; Lu, M; Qian, S; Wang, H; Yu, H; Zhang, C1
Che, CM; Cheung, YH; Chiu, JF; He, QY; Wang, Y; Yang, Z1
Jeon, JR; Kim, JY; Kim, SD; Lee, CH; Lee, JS; Nam, DH1
Li, M; Yu, B1
Li, M; Li, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, S1
Ouyang, PK; Qian, SH; Yang, NY; Yuan, LH1
Kang, LP; Lü, N; Ma, BP; Tan, DW; Zhang, J1
Asao, Y; Kumahara, A; Matsuda, H; Morikawa, T; Nakamura, S; Pongpiriyadacha, Y; Xu, F; Yoshikawa, M1
Chen, J; Lin, S; Tong, Y; Wang, D; Yang, D; Yao, J1
Li, M; Li, W; Qiu, Z; Wang, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, Z1
Che, CM; Chiu, JF; He, QY; Wang, Y1
Ha, H; Jeon, SJ; Jung, DY; Kim, C; Lee, HY; Son, KH1
Dai, CC; Tang, XL; Wang, Q; Xia, B; Xu, ZL; Zhao, YT1
Kim, J; Yoon, KD1
Lin, F; Wang, R1
Han, J; Jiang, DX; Liu, XL; Liu, YT; Wang, GX; Zhao, LW1
Fu, Y; Hu, X; Jin, F; Liu, B; Tang, SH; Wang, Y; Yu, C; Yu, H1
Lu, B; Peng, J; Xu, L; Yin, L1
Bao, YL; Li, YX; Meng, XY; Sun, BT; Wu, Y; Yu, CL; Zheng, LH1
Chen, GX; Qin, YZ; Xiong, XY; Yang, DM; Zhao, DW; Zhong, XH1
Gao, LL; Jiao, P; Li, FR; Sang, H; Si, YH; Yao, ST1
Gao, LL; Jiang, WJ; Jiao, P; Li, FR; Si, YH; Yang, MF; Zheng, TT; Zhou, XJ1
Chen, JP; Cheng, Y; Guan, XY; Han, F; Li, YW; Shen, JG; Wang, DM; Wang, N; Wang, Z; Yang, DP1
Han, X; Hu, M; Li, H; Peng, J; Qi, Y; Wan, X; Xu, L; Xu, Y; Yin, L1
Peng, J; Xu, L; Xu, T; Yin, L; Zhang, S; Zheng, L1
Cong, X; Li, H; Lu, B; Peng, J; Xu, L; Xu, Y; Yin, L1
Kim, EA; Kim, MS; Kim, YS; Lee, SJ; Lee, TJ; Park, KG; Sohn, HY1
Cong, X; Peng, J; Xu, L; Yin, L; Zhao, X; Zheng, L1
Kim, DS; Kim, SH; Liang, C; Lim, JH1
Chen, S; Chen, X; Liu, C; Pei, R; Song, J; Wang, Y; Wu, C1
Cho, J; Choi, H; Kim, MS; Lee, DG; Lee, J; Sohn, HY1
Huo, X; Liu, K; Liu, Q; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Zhang, A1
Fan, MJ; Hsieh, WT; Liu, FC; Pan, CH; Sheu, MJ; Tsai, CH; Wu, CH1
Chiou, HL; Hsieh, MJ; Hsieh, YS; Tsai, TL; Wang, CJ1
Li, XZ; Liu, L; Liu, SM; Lu, F; Yu, DH; Zhou, Q1
Huo, X; Liu, K; Liu, Q; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Wang, L1
Ali, Z; Khan, IA; Smillie, TJ1
Han, X; Liu, K; Peng, J; Qi, Y; Sun, H; Wei, Y; Xu, L; Xu, Y; Yin, L1
Dong, D; Han, X; Lv, L; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L1
Fang, B; Kang, Y; Liu, X; Qin, J; Xu, Z; Zang, C1
Ali, Z; Avula, B; Khan, IA; Khan, SI; Manda, VK; Smillie, TJ; Wong, YH1
Gao, YX; Guo, YC; Song, HR1
Ji, S; Li, Y; Lv, L; Wang, B; Zhang, G; Zhang, H; Zhao, L; Zhou, G1
Han, X; Peng, J; Qi, Y; Xu, L; Xu, T; Xu, Y; Yin, L; Zheng, L1
Dai, K; Fan, Q; Li, H; Liu, G; Liu, X; Ouyang, Z; Qin, A; Qu, X; Tang, T; Wu, C; Zhai, Z1
Chen, H; Han, X; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y1
Chen, J; Li, HM; Ruan, JL; Xiong, CM; Zhang, XN1
Huo, X; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Wang, L; Yang, X; Zhen, Y1
Gao, S; Hao, J; Ren, H; Zhao, X1
Jin, Y; Liu, K; Liu, M; Peng, J; Sun, H; Wang, C; Wu, S; Xia, F; Zhang, C1
Chiu, JF; He, QY; Wang, Y1
Jang, JH; Kim, EA; Kim, JY; Kim, S; Lee, TJ; Lee, YH; Sohn, HY; Song, IH; Sung, EG1
Ji, Y; Li, J; Liang, J; Liu, M; Liu, T; Su, J; Wei, Y1
Jie, EY; Kim, DJ; Kim, SW; Kwon, YK; Liu, JR; Min, BW; Sartie, A1
Han, X; Lin, Y; Peng, J; Qi, Y; Tao, X; Wan, X; Xu, L; Xu, Y; Yin, L1
Hu, X; Jiang, L; Qing, Y; Tong, Q; Wu, X; Wu, Y1
Ki, HH; Kim, DK; Lee, YM; Lim, SW; Nepali, S; Poudel, B1
Jin, Y; Liu, K; Peng, J; Qin, J; Sun, H; Wang, C; Wu, S; Xu, H1
Han, X; Lin, Y; Liu, K; Liu, M; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yao, J; Yin, L; Zhao, Y1
Chen, JP; Kong, M; Li, SL; Mao, Q; Shen, H; Xu, JD; Zhu, H1
Chen, HB; He, XC; Pang, YX; Tang, YN; Yi, T; Zhang, JY; Zhang, YZ; Zhao, ZZ1
Han, X; Li, H; Lin, Y; Liu, K; Peng, J; Qi, Y; Sun, X; Tao, X; Xu, L; Xu, Y; Yin, L1
Han, X; Lin, Y; Liu, K; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yin, L; Zhang, X1
Dong, D; Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y; Zheng, L1
Hong, JH; Kim, YS; Lee, CJ; Lee, HJ; Lee, SK; Park, JS; Shin, YJ; Son, KH; Yoon, YP1
Peng, JY; Wei, YL; Xu, LN1
Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhang, X1
Jiang, W; Tao, YH; Wu, ZG1
Han, X; Liu, K; Peng, J; Qi, M; Qi, Y; Sun, H; Wang, C; Xu, L; Xu, Y; Yin, L; Zhao, Y; Zheng, L1
Ebina, K; Fukatsu, M; Kimura, H; Koketsu, M; Ninomiya, M; Nishina, A; Sato, D; Ukiya, M1
Hu, K; Ling, F; Liu, GL; Liu, L; Liu, XY; Shen, YF; Wang, GX; Yang, XL1
Li, J; Qi, H; Wang, M; Xu, Y; Zhang, H1
Han, X; Liu, K; Liu, M; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y1
Gao, Y; Liang, QD; Ma, ZC; Tan, HL; Tang, XL; Wang, YG; Xiao, CR; Zhang, YX; Zhao, YH1
Ali, Z; Aumsuwan, P; Avula, B; Dasmahapatra, AK; Helferich, WG; Katzenellenbogen, BS; Khan, IA; Khan, SI; Shariat-Madar, Z; Walker, LA1
Gu, L; Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yin, L2
Han, X; Peng, J; Qi, Y; Si, L; Wang, C; Xu, L; Xu, Y; Yin, L; Zheng, L1
Goto, T; Hoshino, S; Kawada, T; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T1
Ding, LS; Liang, J; Liao, X; Liu, YM; Qing, LS; Xue, Y1
Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, X; Zheng, L1
Han, X; Hu, C; Peng, J; Qi, Y; Tao, X; Wang, C; Xu, L; Xu, Y; Yao, H; Yin, L; Zhao, Y1
Han, X; Peng, J; Qi, Y; Sun, H; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L1
Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yin, L; Zhao, X1
Huo, X; Jia, Y; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Xu, Q; Zhang, A1
Han, X; Peng, J; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhang, W; Zheng, L1
Huo, X; Liu, K; Liu, Q; Liu, Z; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Wang, L1
Han, X; Liu, K; Peng, J; Qi, M; Qi, Y; Sun, H; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L1
An, G; Feng, G; Guo, Y; Liang, X; Song, H; Wang, M; Xing, E; Zhao, X1
Chen, P; Jin, HY; Ma, SC; Sun, L1
Ji, L; Liang, T; Liang, Y; Liu, R; Shi, L; Xu, L; Yang, F; Yao, N1
Han, X; Hu, Y; Peng, J; Qi, Y; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhao, Y1
Ma, T; Wang, RP; Zou, X1
Du, B; Liu, J; Tan, Y; Wu, Y; Wu, Z; Zeng, X; Zhang, G; Zhang, R; Zhang, W; Zhang, X; Zhao, Y1
Du, B; Li, B; Liu, X; Tan, Y; Wu, Y; Xiao, J; Zhang, G1
Cho, Y; Choi, SZ; Kang, KB; Ryu, J; Son, M; Sung, SH1
Chen, W; Dong, X; Du, H; Gao, S; Li, Y; Lu, Y; Yang, R; Yuan, H1
Han, X; Liu, K; Ma, X; Peng, J; Qi, Y; Song, S; Tao, X; Xu, L; Xu, Y; Yin, L; Zhang, Y; Zhen, Y1
Han, X; Liu, K; Peng, J; Qi, Y; Si, L; Xu, L; Xu, Y; Yin, L; Zhao, Y1
He, LY; Li, RL; Shen, GD; Wang, P; Yang, JL1
Han, X; Lin, Y; Liu, K; Peng, J; Qi, Y; Song, S; Tao, X; Xu, L; Xu, Y; Yin, L; Zhang, Y; Zhao, Y1
Choi, KC; Kim, H; Kim, MK; Kim, YJ; Ko, H; Lee, IH; Lee, KH; Lim, WC1
Gu, J; Hu, Y; Li, H; Li, M; Liang, H; Liu, Y; Lu, J; Song, X; Wang, X; Wang, Z; Weng, H; Ye, Y; Zhang, W; Zhang, Y1
Du, B; Ji, L; Kou, Y; Liu, L; Liu, Z; Lu, L; Qi, X; Wang, H; Wang, W; Zheng, H; Zou, J1
Han, X; Li, L; Peng, J; Qi, Y; Song, S; Sun, P; Tao, X; Xu, L; Xu, Y; Yin, L1
Agnihotri, VK; Chand, G; Kumar, A; Maurya, AK1
Bao, N; Chen, S; Zhao, J; Zhu, C1
Han, X; Li, H; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L1
Su, F; Tang, S; Zhu, S1
Chen, J; Chen, Y; Du, S; Li, C; Li, S; Liu, F; Lu, Y; Weng, D; Zhang, Y1
Han, X; Liu, K; Ma, X; Peng, J; Qi, Y; Qiao, Y; Tang, Z; Tao, X; Xu, L; Xu, Y; Yin, L1
Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y1
Hu, KX; Jiao, Y; Ju, HY; Song, X; Tang, ZS1
Cheng, B; Cui, Y; Hou, L; Huang, L; Li, S; Shen, X; Xu, D1
Li, C; Li, J; Liang, Q; Liu, M; Zhang, Y1
Chen, CY; Lee, H; Wang, L; Wang, YC; Wu, DW; Wu, TC1
Jia, Q; Li, W; Liu, W; Shen, J; Su, Q; Wang, Y; Yin, J; Zhang, J; Zhang, X; Zhao, Z1
Cai, J; Chen, Y; Yang, L; Zeng, H; Zhang, X1
Peng, J; Qi, Y; Tao, X; Xu, L; Yin, L; Zhao, L1
Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yao, H; Yin, L; Zheng, L1
Chan, SH; Guh, JH; Liang, PH1
Bing, L; Xie, Y; Yu, F; Yu, W1
Cao, F; Cao, YK; Li, CW; Li, Y; Wang, YB; Wu, Q; Xu, B; Yang, B; Zhang, J; Zhao, H1
Hussain, SS; Ma, YL; Thakur, K; Wang, J; Wei, ZJ; Zhang, JG; Zhang, Q; Zhang, YS1
Chen, L; Lei, L; Li, Q; Li, T1
Hu, Y; Mao, Z; Peng, J; Qi, Y; Sun, P; Tang, Z; Tao, X; Xu, L; Yin, L1
Peng, J; Tao, X; Xu, L; Yin, L1
Liu, M; Lu, J; Sun, H; Wang, S; Zhang, T1
Fang, L; Liu, K; Peng, J; Sun, P; Xu, L; Xu, M; Yin, L; Zhao, X1
Cheng, J; Hao, Q; Sun, C; Xue, Y; Zhang, J; Zou, Q1
Li, H; Yu, L; Zhao, C1
Han, X; Hu, Y; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, X; Zheng, L1
Huang, Y; Liu, X; Ma, T; Quan, G; Sui, Y; Wang, F; Yang, L; Zhong, L1
Chen, D; Fang, L; Han, X; Liu, K; Mao, Z; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yin, L1
Huang, T; Sun, L; Wei, Q; Xiao, X; Zhang, Z; Zhu, T1
Cao, YJ; Hou, L; Li, XS; Liu, B; Qi, Y; Sun, YM; Wan, CP; Wen, WB; Wu, J; Xu, Y; Zhang, Y; Zheng, X1
An, G; Feng, G; Guo, Y; Song, H; Wang, M; Xing, E; Zhao, X1
Han, X; Li, R; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L1
Chen, S; Fan, T; He, J; Kang, Y; Li, X; Wen, K; Yin, Y; Zhao, H1
Chen, J; Chen, Y; Du, S; Lei, X; Li, C; Li, S; Liu, F; Lu, Y; Weng, D; Zhang, Y1
Ao, W; Chen, B; Hou, Y; Ke, J; Liang, Q; Wang, K; Wei, X; Xiao, J; Zhan, Y; Zhou, S; Zhu, P1
Fan, L; Fu, M; Li, G; Li, J; Li, X; Liu, J; Pan, W; Wang, X; Wang, Y; Yang, Y; Yu, Y1
An, L; Ma, J; Piao, X; Wang, H; Wu, X; Yuan, Y; Zhang, J; Zhou, L1
Jin, Y; Liu, K; Ma, X; Sun, H; Wang, C; Wang, J; Xie, T; Yang, Q1
Jiang, S; Li, J; Pan, W; Wang, X; Wang, Y; Yang, X; Yang, Y; Yu, Y; Zhang, Z1
Liu, X; Ma, Z; Ren, S; Wang, L; Xu, F; Yang, L1
Cai, X; Chen, L; Cheng, C; Ding, Q; Liu, X; Mo, F; Peng, G; Wang, J; Yang, S; Zhang, W1
Chen, J; Li, H; Li, N; Wang, J; Wu, S; Xia, Y; Zhao, B; Zhao, F; Zhao, J; Zhao, S1
Li, Y; Wang, M; Yang, T1
Cai, FY; Fu, M; He, SY; Jing, M; Ju, RJ; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Yao, XM; Zhang, L1
Bai, L; Li, M; Liu, H; Peng, S; Shi, X; Sun, F; Wang, L1
Gao, F; Gong, G; Li, M; Li, T; Li, W; Liu, H; Liu, W; Yu, X; Zhou, L; Zuo, H1
Bai, H; Dong, M; Liu, Q; Liu, S; Niu, W; Shi, C; Wang, L; Wang, Q; Yang, X; Yin, W1
Han, X; Jin, Y; Liu, KX; Peng, JY; Qi, Y; Xu, LN; Xu, YW; Yin, LH; Zhao, YY1
Jiang, W; Lin, M; Wang, Z1
Cai, FY; Fu, M; He, SY; Jing, M; Ju, RJ; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Niu, FJ; Yao, XM; Zhang, L1
Wang, H; Yang, X; Zhu, H1
Chen, W; Du, B; He, Y; Jin, H; Mao, W; Tan, Y; Wu, S; Yin, H; Zhang, R; Zhao, T1
Chen, J; Cui, L; Fang, L; Lu, G; Lu, S; Yang, G; Yao, Y; Ye, J; Zhou, J1
Choi, SS; de Guzman, ACV; Purevdulam, B; Razzak, MA1
Han, K; Jia, N; Sun, C; Wang, C; Zhang, Z1
Han, J; Jiang, D; Li, F; Li, W; Shi, G; Xie, Y1
Chen, R; Chen, W; Gao, W; Gu, Y; Qi, H; Wang, L; Zhao, H1
Liu, X; Ma, Z; Yang, L1
Cui, L; Fang, X; Lu, G; Yang, G; Yao, Y; Ye, J; Zeng, Z; Zhou, J1
Gao, J; Han, L; Ma, J; Tan, Y; Wang, L; Wang, T; Yu, H; Zhang, Y1
Cespedes-Acuña, CL; Li, XL; Ma, RH; Ni, ZJ; Thakur, K; Wang, S; Wei, ZJ; Zhang, JG1
Han, X; Peng, JY; Qi, Y; Song, S; Sun, C; Xu, L; Xu, Y; Yang, Y; Yin, L; Zhao, Y; Zhu, M1
Fu, S; Guo, W; Hou, S; Hu, G; Kan, X; Liu, J; Ran, X; Yan, Z; Yang, Y1
Chen, Y; Huang, Q; Jiang, M; Li, X; Liang, J; Liu, S; Qin, A; Qu, L; Yuan, C; Zou, W1
Chen, X; Fu, X; Gu, W; Tian, H; Wang, Y; Wen, Y; Zhang, Y1
Gao, M; Li, Y; Peng, JY; Qi, Y; Sun, P; Xu, LN; Yin, LH1
Chen, G; Xie, Y1
Gao, S; Guo, YT; Hang, CH; Li, W; Liu, C; Lu, Y; Tao, T; Wang, WH; Zhang, XS; Zhou, Y; Zhuang, Z1
He, C; Kong, C; Li, R; Lu, Q; Lyu, D1
Dong, L; Han, X; Li, R; Qi, Y; Xu, L; Xu, Y; Yin, L1
Cai, J; Cao, Y; Dong, X; Fan, P; Liu, J; Liu, X; Zhang, N; Zhu, K1
Huang, BY; Mai, CT; Wang, CL; Wang, QM; Wang, TT; Wu, MM; Zhang, XJ1
Gao, Y; Li, X; Mi, X; Xu, Z1
He, C; Lu, Q; Lyu, D; Qian, H; Shen, T; Tian, Q; Xi, J; Xiao, P1
Chen, J; Gao, H; Li, Y; Lin, C; Zhang, J; Zhang, Y1
Lu, Z; Peng, JY; Wang, J; Yao, Y1
Bai, JX; Chen, YJ; Chou, JY; Fu, XQ; Li, JK; Li, SM; Liu, YX; Niu, XD; Wang, XQ; Wu, JY; Wu, Y; Xu, BW; Yin, CL; Yu, ZL1
Azuma, K; Gao, X; Liu, X; Saido, TC; Saito, T; Wang, KY; Wang, X; Zhang, JH; Zhou, Q1
Anand, U; Bandopadhyay, S; Behl, T; Dey, A; Gadekar, VS; Gupta, PK; Jha, NK; Kumar, M; Shekhawat, MS1
Li, N; Liu, L; Wang, Y; Yue, X; Zhang, Y1
Adamski, R; Dworniczek, E; Krzyżek, P; Spiegel, M; Sroka, Z1
Li, H; Li, S; Liu, J; Nie, B; Pang, B; Qu, S; Xu, J; Yang, M; Zhang, K1
Du, G; Gao, F; Gu, W; Kui, F; Li, W; Liu, Z; Lu, L; Niu, Y; Xi, P; Zhang, Y1
Guan, T; Hu, M; Huang, S; Jin, S; Liu, X; Liu, Y; Wang, S1
Qi, Y; Shang, Q; Shang, W; Zeng, J; Zhu, L1
Chen, W; Chen, X; Dong, L; Jin, R; Shi, L; Zhang, P1
Bao, R; Chen, B; Chen, Q; Han, L; Liu, M; Pan, J; Wang, D; Wang, T; Wang, W; Wu, Y; Yu, H; Zhang, Y1
Azam, S; Cho, DY; Choi, DK; Haque, ME; Jakaria, M; Kim, IS; Kim, JS1
Gao, M; Li, L; Mao, Z; Peng, J; Zhao, X1
Gao, M; Qi, Y; Wang, J; Xu, L; Yin, L; Zhang, Z; Zhao, X1
Deng, S; Jin, S; Li, D; Li, J; Liu, X; Liu, Y; Zhu, T1
Ahn, JY; Azam, S; Choi, DK; Jakaria, M; Kim, IS; Kim, YS; Yu, YJ1
Fan, L; Li, J; Liu, B; Ni, R; Song, Y; Wang, A; Wang, H; Zhang, L1

Reviews

5 review(s) available for diosgenin and dioscin

ArticleYear
[Advances in study of dioscin--a natural product].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:1

    Topics: Animals; Biological Products; Diosgenin; Humans; Plant Extracts

2015
Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections.
    Pharmacological research, 2018, Volume: 137

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Diosgenin; Humans; Metabolic Diseases; Neoplasms

2018
Recent Advances in the Pharmacological Activities of Dioscin.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Diosgenin; Humans; Saponins

2019
Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases.
    Journal of ethnopharmacology, 2021, Jun-28, Volume: 274

    Topics: Animals; Cardiotonic Agents; Diosgenin; Heart; Heart Diseases; Humans; Plant Extracts

2021
Dioscin: A review on pharmacological properties and therapeutic values.
    BioFactors (Oxford, England), 2022, Volume: 48, Issue:1

    Topics: Diosgenin; Humans; Neoplasms; Plant Extracts; Saponins

2022

Other Studies

219 other study(ies) available for diosgenin and dioscin

ArticleYear
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
    Journal of natural products, 2005, Volume: 68, Issue:5

    Topics: Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Candida albicans; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Humans; Kenya; Leukemia P388; Plants, Medicinal; Sansevieria; Saponins; Spirostans; Tumor Cells, Cultured

2005
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.
    Bioorganic & medicinal chemistry letters, 2012, Jul-15, Volume: 22, Issue:14

    Topics: Animals; Diabetes Mellitus, Experimental; Diosgenin; Molecular Structure; Molecular Weight; Polyethylene Glycols

2012
Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae).
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dioscorea; Humans; Isocoumarins; Lung; Lung Neoplasms; Phenanthrenes; Plant Extracts; Rhizome

2017
Effect of food toxicants on voluntary wheel running in rats.
    The Journal of nutrition, 1979, Volume: 109, Issue:5

    Topics: Animals; Cadmium; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Food Deprivation; Glycosides; Iron; Iron Deficiencies; Liver; Male; Motor Activity; Rats; Sapogenins; Testis

1979
Antiviral activity of constituents of Tamus communis.
    Journal of chemotherapy (Florence, Italy), 1991, Volume: 3, Issue:5

    Topics: Animals; Antiviral Agents; Cell Division; Cells, Cultured; Diosgenin; HeLa Cells; Humans; Plants, Medicinal; Rhinovirus; RNA, Viral; Spirostans; Vesicular stomatitis Indiana virus; Virus Replication

1991
Steroidal glycosides of Tamus communis.
    Bollettino della Societa italiana di biologia sperimentale, 1984, Dec-30, Volume: 60, Issue:12

    Topics: Diosgenin; Glycosides; Plants, Medicinal; Sapogenins; Spirostans; Steroids

1984
Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
    Planta medica, 1996, Volume: 62, Issue:6

    Topics: Antineoplastic Agents; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drugs, Chinese Herbal; Glycosides; Molecular Sequence Data; Saponins; Spirostans; Tumor Cells, Cultured

1996
Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
    Carbohydrate research, 1999, Apr-30, Volume: 317, Issue:1-4

    Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Glycosylation; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Optical Rotation; Saponins; Spectrometry, Mass, Fast Atom Bombardment

1999
Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:2

    Topics: Apoptosis; Cell Differentiation; Cell Division; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Saponins

2001
Apoptosis induced by dioscin in Hela cells.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:2

    Topics: Apoptosis; Caspases; Cell Division; Diosgenin; Dose-Response Relationship, Drug; HeLa Cells; Humans; Proto-Oncogene Proteins c-bcl-2

2002
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
    Journal of natural products, 2002, Volume: 65, Issue:6

    Topics: Animals; Biological Factors; Colonic Neoplasms; Diosgenin; Disease Models, Animal; Diterpenes; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Leukemia P388; Male; Melanoma; Mice; Molecular Structure; Naphthoquinones; Ovarian Neoplasms; Paclitaxel; Polymers; Prostatic Neoplasms; Triterpenes; Tumor Cells, Cultured

2002
A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
    Carbohydrate research, 2002, Nov-19, Volume: 337, Issue:21-23

    Topics: Antineoplastic Agents; Diosgenin; Magnetic Resonance Spectroscopy; Saponins; Tropanes

2002
Synthesis of monomethylated dioscin derivatives and their antitumor activities.
    Carbohydrate research, 2003, Jan-20, Volume: 338, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Diosgenin; Humans; Methylation; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured

2003
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
    Carbohydrate research, 2003, Apr-04, Volume: 338, Issue:8

    Topics: Acetylation; Carbohydrate Conformation; Diosgenin; Guanidine; Saponins; Spirostans

2003
A new steroidal saponin from Dioscorea zingiberensis Wright.
    Natural product research, 2003, Volume: 17, Issue:4

    Topics: Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Structure; Rhizome; Saponins; Sterols

2003
Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.
    Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:7

    Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Body Weight; Diet; Dietary Fats; Dioscorea; Diosgenin; Emulsions; Feces; Lipase; Male; Mice; Obesity; Organ Size; Pancreas; Plant Extracts; Rats; Rats, Sprague-Dawley; Triglycerides

2003
[Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
    Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Diosgenin; Flow Cytometry; Humans; K562 Cells; Microscopy, Electron, Scanning; Saponins

2003
Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin.
    Pharmaceutical bulletin, 1956, Volume: 4, Issue:1

    Topics: Dioscoreaceae; Diosgenin; Saponins

1956
Structures of dioscin, gracillin, and kikuba-saponin. 2. (Saponins of Japanese Dioscoreaceae. XI.
    Chemical & pharmaceutical bulletin, 1962, Volume: 10

    Topics: Dioscoreaceae; Diosgenin; Plants; Saponins; Spirostans; Steroids

1962
Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.
    Journal of neurochemistry, 2004, Volume: 88, Issue:6

    Topics: 14-3-3 Proteins; Blotting, Western; Brain Ischemia; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavanones; Flavonoids; Gene Expression; Glycosides; Hippocampus; Maze Learning; Memory Disorders; Oligonucleotide Array Sequence Analysis; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine 3-Monooxygenase

2004
Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Mar-25, Volume: 817, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity

2005
Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
    Organic letters, 2005, Feb-17, Volume: 7, Issue:4

    Topics: Carbohydrate Conformation; Cell Survival; Diosgenin; Fluorides; Glycosylation; HeLa Cells; Humans; Models, Molecular; Saponins; Steroids; Trisaccharides

2005
Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
    Molecular diversity, 2005, Volume: 9, Issue:1-3

    Topics: Animals; Bacteriocins; Biological Factors; Cell Line, Tumor; Diosgenin; Fatty Acids; Models, Molecular; Molecular Conformation; Peptides; Rats; Receptors, Chemokine; Receptors, CXCR3

2005
[Steroidal constituents from Dioscorea parviflora].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:2

    Topics: Dioscorea; Diosgenin; Molecular Conformation; Molecular Structure; Plants, Medicinal; Rhizome; Saponins; Steroids

2005
Characterization of the pharmacokinetics of dioscin in rat.
    Steroids, 2005, Volume: 70, Issue:8

    Topics: Administration, Oral; Animals; Bile; Biological Availability; Biotransformation; Diosgenin; Dose-Response Relationship, Drug; Feces; Female; Injections, Intravenous; Male; Molecular Structure; Rats; Rats, Wistar; Tissue Distribution; Urine

2005
Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.
    Chemical & pharmaceutical bulletin, 2005, Volume: 53, Issue:8

    Topics: Animals; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Diosgenin; Electrophoresis, Polyacrylamide Gel; Glycoside Hydrolases; Hydrolysis; Liver; Molecular Weight; Swine

2005
Proteomic approach to study the cytotoxicity of dioscin (saponin).
    Proteomics, 2006, Volume: 6, Issue:8

    Topics: Apoptosis; Diosgenin; Drug Screening Assays, Antitumor; Electrophoresis, Gel, Two-Dimensional; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Models, Chemical; Polygonatum; Proteomics; Saponins; Silver Staining; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.
    Archives of pharmacal research, 2006, Volume: 29, Issue:5

    Topics: Animals; Bacteroides fragilis; Blood Glucose; Cholesterol; Dioscorea; Diosgenin; Feces; Food, Organic; Gastric Acid; Gastrointestinal Agents; Gastrointestinal Motility; Gastrointestinal Tract; Lipids; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome; Time Factors

2006
Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
    Organic letters, 2006, Jun-22, Volume: 8, Issue:13

    Topics: Cholestanes; Diosgenin; Hydrocarbons, Iodinated; Molecular Structure; Saponins; Spirostans; Sulfur Compounds

2006
Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
    Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21

    Topics: Cell Line, Tumor; Diosgenin; Humans; Tropanes

2006
[Study on steroidal compounds from Dioscorea zingiberensis].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006, Volume: 29, Issue:11

    Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Roots; Plants, Medicinal; Spirostans; Steroids

2006
[Study on steroidal saponins of Dioscorea septemloba thunb].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006, Volume: 29, Issue:11

    Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Tubers; Plants, Medicinal; Saponins; Steroids

2006
Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:2

    Topics: Animals; Arecaceae; Blood Glucose; Diosgenin; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Methanol; Molecular Structure; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Time Factors

2007
Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
    Analytica chimica acta, 2007, Sep-05, Volume: 599, Issue:1

    Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Methanol; Plant Extracts; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2007
Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
    Carbohydrate research, 2007, Dec-28, Volume: 342, Issue:18

    Topics: Cell Death; Cell Line, Tumor; Diosgenin; Erythrocytes; Hemolysis; Humans; Saponins

2007
Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
    Journal of proteome research, 2007, Volume: 6, Issue:12

    Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Diosgenin; HL-60 Cells; Humans; Microsomes; Mitochondria; Molecular Sequence Data; Proteomics; Reactive Oxygen Species; Saponins

2007
Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.
    Journal of biochemistry and molecular biology, 2007, Nov-30, Volume: 40, Issue:6

    Topics: Animals; Cells, Cultured; Dioscorea; Diosgenin; Growth Hormone; Korea; Magnetic Resonance Spectroscopy; Molecular Structure; Pituitary Gland; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone

2007
[Selection of the microorganism for dioscin hydrolyze].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2007, Volume: 30, Issue:8

    Topics: Alternaria; Aspergillus; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dioscorea; Diosgenin; Hydrolysis; Plants, Medicinal; Rhizome

2007
Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
    Journal of separation science, 2008, Volume: 31, Issue:13

    Topics: Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dioscorea; Diosgenin; Light; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plant Roots; Saponins; Scattering, Radiation; Solvents; Spectrometry, Mass, Electrospray Ionization; Spirostans

2008
Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
    Journal of molecular modeling, 2010, Volume: 16, Issue:1

    Topics: Alkanes; Cholesterol; Diosgenin; Hemolysis; Lipid Bilayers; Membrane Microdomains; Molecular Dynamics Simulation; Molecular Structure; Saponins; Water

2010
Anthelmintic activity of steroidal saponins from Paris polyphylla.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-01, Volume: 17, Issue:14

    Topics: Animals; Anthelmintics; Diosgenin; Goldfish; Liliaceae; Plant Extracts; Rhizome; Saponins; Trematoda

2010
New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.
    Journal of microbiology and biotechnology, 2010, Volume: 20, Issue:6

    Topics: Absidia; Diosgenin; Enzyme Stability; Fungal Proteins; Glycoside Hydrolases; Glycosides; Hydrolysis; Kinetics

2010
Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
    Planta medica, 2011, Volume: 77, Issue:5

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Diosgenin; Endoplasmic Reticulum Chaperone BiP; Liver; Male; Mice; Necrosis; Protective Agents; Protein Interaction Mapping; Proteomics; Silymarin

2011
Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.
    European journal of pharmacology, 2011, Mar-05, Volume: 654, Issue:2

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diosgenin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, MDR; Genetic Vectors; HEK293 Cells; Hep G2 Cells; Hepatocytes; High-Throughput Screening Assays; Humans; Liver Neoplasms; Plasmids; RNA, Messenger

2011
[Effects of organic solvents on proliferation of Hela cells line].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:4

    Topics: Apoptosis; Cell Proliferation; Cell Survival; Dimethyl Sulfoxide; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; HeLa Cells; Humans; Solubility; Solvents; Staining and Labeling

2011
Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:5

    Topics: Apoptosis; Calcium; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; Drugs, Chinese Herbal; Female; Humans; Mitochondria; Mitochondrial Membranes; Ovarian Neoplasms; Permeability; Trillium

2011
Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.
    World journal of gastroenterology, 2011, Oct-21, Volume: 17, Issue:39

    Topics: Animals; Apoptosis; Calcium; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; G2 Phase; Humans; Liliaceae; Plant Extracts; Stomach Neoplasms

2011
Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.
    Cancer biology & therapy, 2012, Feb-01, Volume: 13, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Diosgenin; Down-Regulation; Gene Expression Profiling; Humans; Membrane Potential, Mitochondrial; Oxidative Stress; Peroxiredoxin VI; Peroxiredoxins; Reactive Oxygen Species

2012
Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.
    Journal of applied toxicology : JAT, 2013, Volume: 33, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Diosgenin; Down-Regulation; Fas Ligand Protein; fas Receptor; Humans; Mitochondria; Radioimmunoassay; RNA, Messenger; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation

2013
A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:5

    Topics: Animals; Body Weight; Diosgenin; Drinking Behavior; Feeding Behavior; Female; Male; Organ Size; Rats; Rats, Sprague-Dawley

2012
Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
    Environmental toxicology and pharmacology, 2012, Volume: 34, Issue:2

    Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Diosgenin; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Protective Agents; Superoxide Dismutase

2012
Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2.
    Oncology reports, 2012, Volume: 28, Issue:5

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Diosgenin; Down-Regulation; Humans; Kidney Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; TNF-Related Apoptosis-Inducing Ligand

2012
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
    Toxicology letters, 2012, Oct-02, Volume: 214, Issue:1

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Biological Products; Chemical and Drug Induced Liver Injury; Comet Assay; Diosgenin; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Mitochondria; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2012
Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
    Food chemistry, 2012, Sep-15, Volume: 134, Issue:2

    Topics: Agaricales; Diosgenin; Enzyme Inhibitors; Fungal Proteins; Kinetics; Monophenol Monooxygenase; Plant Extracts; Plant Roots; Smilax

2012
Dioscin's antiviral effect in vitro.
    Virus research, 2013, Volume: 172, Issue:1-2

    Topics: Adenoviridae; Antiviral Agents; Cell Line; Dioscorea; Diosgenin; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Plant Extracts; Vesiculovirus; Virus Internalization; Virus Replication

2013
The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.
    Biochimica et biophysica acta, 2013, Volume: 1828, Issue:3

    Topics: Antifungal Agents; Biophysics; Candida albicans; Cell Membrane; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Flow Cytometry; Fluoresceins; Membrane Potentials; Microbial Sensitivity Tests; Microscopy, Fluorescence; Plant Extracts; Propidium; Rhodamines; Time Factors

2013
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Animals; Diosgenin; HEK293 Cells; Humans; In Vitro Techniques; Liver; Male; Organic Anion Transporters; Rats; Rats, Wistar

2013
Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model.
    Journal of the science of food and agriculture, 2013, Volume: 93, Issue:6

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Cardiovascular Agents; Cholesterol, Dietary; Diet; Dioscorea; Diosgenin; Disease Models, Animal; Fatty Liver; Food Handling; Functional Food; Hypercholesterolemia; Liver; Male; Nanoparticles; Particle Size; Plant Preparations; Plant Tubers; Rabbits

2013
Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.
    Archives of toxicology, 2013, Volume: 87, Issue:11

    Topics: Annexin A5; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Diosgenin; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Oncogene Protein v-akt; Organelles; Phosphatidylinositol 3-Kinases; Signal Transduction

2013
Therapeutic effect of Rhizoma Dioscoreae Nipponicae on gouty arthritis based on the SDF-1/CXCR 4 and p38 MAPK pathway: an in vivo and in vitro study.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:2

    Topics: Animals; Arthritis, Gouty; Chemokine CXCL12; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Fibroblasts; Interleukin-1beta; Male; MAP Kinase Kinase 3; MAP Kinase Kinase 6; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptors, CXCR4; Rhizome; Signal Transduction; Synovial Membrane; Uric Acid

2014
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.
    Journal of natural products, 2013, May-24, Volume: 76, Issue:5

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Dioscorea; Diosgenin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; I-kappa B Proteins; K562 Cells; Leukemia, Erythroblastic, Acute; Luciferases; NF-kappa B; NF-KappaB Inhibitor alpha; RNA, Messenger; Signal Transduction

2013
Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
    Natural product communications, 2013, Volume: 8, Issue:3

    Topics: Dioscorea; Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Saponins; Spirostans

2013
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 59

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Large Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytosol; Diosgenin; DNA Damage; Humans; Inhibitory Concentration 50; Lung Neoplasms; Microscopy, Electron, Transmission; Mitochondria; Protein Transport; S Phase; Signal Transduction; Small Cell Lung Carcinoma

2013
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 59

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Diosgenin; DNA Damage; Glioblastoma; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Neoplasm Transplantation; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Survival Analysis; Tumor Burden

2013
Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells.
    Drug research, 2014, Volume: 64, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Cell Line; Coloring Agents; Cytochromes c; Diosgenin; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; L-Lactate Dehydrogenase; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Myocardium; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles

2014
Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa.
    Planta medica, 2013, Volume: 79, Issue:15

    Topics: Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cytochrome P-450 CYP3A; Dioscorea; Diosgenin; Half-Life; Humans; Inhibitory Concentration 50; Intestinal Absorption; Metabolic Detoxication, Phase II; Parasympatholytics; Permeability; Plant Extracts

2013
[Effects of dioscornin tablet containing serum on NF-kappaB p65, STAT3, and VEGF mRNA expressions in rats' synovial cell strain RSC-364 induced by IL-17 and TNF-alpha].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2013, Volume: 33, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Diosgenin; Interleukin-17; Male; Neovascularization, Pathologic; Rats; Rats, Wistar; RNA, Messenger; Serum; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2013
Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
    Steroids, 2013, Dec-11, Volume: 78, Issue:12-13

    Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Ginsenosides; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spirostans; Tandem Mass Spectrometry

2013
Protective effects of dioscin against alcohol-induced liver injury.
    Archives of toxicology, 2014, Volume: 88, Issue:3

    Topics: Animals; Cytochrome P-450 CYP2E1; Diosgenin; Disease Models, Animal; Ethanol; Fatty Acids; Fatty Liver, Alcoholic; Liver; Liver Diseases, Alcoholic; Male; Mice, Inbred C57BL; Protective Agents; Rats; Rats, Wistar; Toxicity Tests, Acute; Toxicity Tests, Chronic

2014
Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades.
    Biochemical and biophysical research communications, 2014, Jan-10, Volume: 443, Issue:2

    Topics: Animals; Bone Resorption; Cell Differentiation; Diosgenin; Down-Regulation; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Proto-Oncogene Proteins c-akt; Signal Transduction; Treatment Outcome

2014
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
    Proteomics, 2014, Volume: 14, Issue:1

    Topics: Apoptosis; Cell Cycle; Cell Shape; Cell Survival; Colonic Neoplasms; Diosgenin; DNA Damage; HCT116 Cells; Humans; Isotope Labeling; Nitric Oxide; Nitric Oxide Synthase Type II; Proteins; Proteome; Proteomics; Reactive Oxygen Species

2014
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2014, Volume: 34, Issue:1

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Humans; Male; Molecular Structure; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Time Factors

2014
Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
    Toxicology and applied pharmacology, 2014, Jun-01, Volume: 277, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Drug Resistance, Neoplasm; Enterocytes; Genes, Reporter; Humans; I-kappa B Proteins; Intestinal Absorption; Intestine, Small; Male; Methotrexate; NF-kappa B; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transfection

2014
[Effects of dioscin on apoptosis in pancreatic cancer MiaPaCa-2 cells and its mechanism].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2014, Volume: 36, Issue:1

    Topics: Apoptosis; Diosgenin; Humans; Pancreatic Neoplasms; Peroxiredoxins; Reactive Oxygen Species

2014
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
    Journal of biomedical science, 2014, Apr-17, Volume: 21

    Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Diosgenin; Estrogen Receptor alpha; Gene Expression Regulation, Developmental; Humans; Low Density Lipoprotein Receptor-Related Protein-5; Mice; Osteoblasts; Osteoporosis; Receptor Activator of Nuclear Factor-kappa B; RNA Interference; Signal Transduction

2014
Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.
    European journal of pharmacology, 2014, Jul-15, Volume: 735

    Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Diosgenin; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases

2014
Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells.
    Apoptosis : an international journal on programmed cell death, 2014, Volume: 19, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspases; Cell Line, Tumor; Diosgenin; Female; Humans; Inhibitor of Apoptosis Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2

2014
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
    Archives of pharmacal research, 2014, Volume: 37, Issue:10

    Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hypertension; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Uric Acid; Xanthine Oxidase

2014
Rapid metabolic discrimination and prediction of dioscin content from African yam tubers using Fourier transform-infrared spectroscopy combined with multivariate analysis.
    Food chemistry, 2015, Jan-01, Volume: 166

    Topics: Dioscorea; Diosgenin; Least-Squares Analysis; Multivariate Analysis; Spectroscopy, Fourier Transform Infrared

2015
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
    Transplantation, 2014, Sep-27, Volume: 98, Issue:6

    Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Diosgenin; Dose-Response Relationship, Drug; Inflammation; Liver; Male; Nitrogen; Oxidative Stress; Phosphorylation; Rats; Rats, Wistar; Reperfusion Injury; Time Factors; Warm Ischemia

2014
Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.
    Toxicology and applied pharmacology, 2014, Dec-01, Volume: 281, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2

2014
Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice.
    International journal of molecular medicine, 2014, Volume: 34, Issue:5

    Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adipocytes; Adipogenesis; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Composition; Cell Differentiation; Cell Survival; Diet, High-Fat; Diosgenin; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Triglycerides; Weight Gain

2014
Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway.
    Biochimie, 2015, Volume: 110

    Topics: Anti-Inflammatory Agents; Cell Adhesion; Cell Proliferation; Diosgenin; Endothelium, Vascular; Gene Expression Regulation; Humans; I-kappa B Kinase; Intercellular Adhesion Molecule-1; Lipase; Monocytes; NF-kappa B; Proteolysis; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2015
Potent effects of dioscin against obesity in mice.
    Scientific reports, 2015, Jan-22, Volume: 5

    Topics: Animals; Autophagy; Blood Glucose; Body Weight; Cholesterol; Diet, High-Fat; Diosgenin; Energy Metabolism; Fatty Acids; Glucose Tolerance Test; Inflammation; Liver; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Obese; Obesity; Oxidative Stress; Phosphorylation; Signal Transduction; Triglycerides

2015
Metabolic profiles of dioscin in rats revealed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
    Biomedical chromatography : BMC, 2015, Volume: 29, Issue:9

    Topics: Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Male; Mass Spectrometry; Molecular Structure; Rats; Rats, Sprague-Dawley

2015
UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study.
    Journal of ethnopharmacology, 2015, May-13, Volume: 165

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Feces; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Saponins

2015
Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.
    Free radical biology & medicine, 2015, Volume: 84

    Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Survival; Diosgenin; Gene Expression; HMGB1 Protein; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; PC12 Cells; Protein Transport; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4

2015
Potent effects of dioscin against liver fibrosis.
    Scientific reports, 2015, Apr-08, Volume: 5

    Topics: Animals; Apoptosis; Cellular Senescence; Diosgenin; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Signal Transduction; Smad Proteins; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Wnt Signaling Pathway

2015
In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics.
    BMC complementary and alternative medicine, 2015, Mar-05, Volume: 15

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Cycle; Computational Biology; Dioscorea; Diosgenin; DNA Topoisomerases, Type I; Down-Regulation; Drugs, Chinese Herbal; Epidermal Growth Factor; ErbB Receptors; Gene Regulatory Networks; Humans; Male; MAP Kinase Signaling System; Mice; Neoplasms; Phytotherapy; Protein Binding; Rats; Signal Transduction

2015
Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, May-15, Volume: 22, Issue:5

    Topics: Asparagus Plant; Cell Line, Tumor; Diosgenin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Mucin 5AC; Plant Roots; Saponins; Tetradecanoylphorbol Acetate

2015
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
    Chemical communications (Cambridge, England), 2015, Jul-14, Volume: 51, Issue:55

    Topics: Animals; Biomarkers; Carbon Tetrachloride; Diosgenin; Liver Cirrhosis; Male; Proteomics; Rats; Rats, Wistar

2015
[New variety breeding of Dioscorea alata, cultivar "Wenshanyao No.1].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:9

    Topics: Allantoin; Breeding; Dioscorea; Diosgenin; Polysaccharides

2015
Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70.
    Pharmacological research, 2015, Volume: 100

    Topics: Animals; Cells, Cultured; Diosgenin; Down-Regulation; HSP70 Heat-Shock Proteins; Humans; Kidney; Myeloid Differentiation Factor 88; Rats; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation

2015
Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF.
    Journal of food science, 2015, Volume: 80, Issue:10

    Topics: alpha-MSH; Animals; Cyclic AMP Response Element-Binding Protein; Diosgenin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Intramolecular Oxidoreductases; Melanins; Melanoma, Experimental; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Phosphorylation; Plant Extracts; Solanum melongena

2015
Inhibition of dioscin on Saprolegnia in vitro.
    FEMS microbiology letters, 2015, Volume: 362, Issue:24

    Topics: Animals; Cell Membrane Permeability; Diosgenin; Fishes; Formaldehyde; Hydrogen Peroxide; Mycelium; Reactive Oxygen Species; Saprolegnia

2015
Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 86

    Topics: Biological Transport; Carrier Proteins; Diosgenin; Diterpenes, Kaurane; Drug Interactions; Glucuronides; HEK293 Cells; Humans; Molecular Structure; Rosuvastatin Calcium

2015
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
    Scientific reports, 2015, Dec-10, Volume: 5

    Topics: Animals; Diosgenin; Down-Regulation; Hepatic Stellate Cells; Interleukin-6; Liver Cirrhosis, Alcoholic; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2015
[Preliminary study on hepatotoxicity induced by dioscin and its possible mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:14

    Topics: Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Diosgenin; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; RNA, Messenger

2015
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.
    Archives of biochemistry and biophysics, 2016, Feb-01, Volume: 591

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Neoplasm Invasiveness; Phytosterols; Plant Extracts; Plant Roots; Saponins; Treatment Outcome

2016
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
    Toxicology and applied pharmacology, 2016, Feb-01, Volume: 292

    Topics: Animals; Bile Ducts; Dimethylnitrosamine; Diosgenin; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Ligation; Liver Cirrhosis; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sirtuin 1

2016
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
    European journal of pharmacology, 2016, Mar-05, Volume: 774

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; DNA Damage; Humans; Laryngeal Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitochondria; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Protein Kinase Inhibitors; Reactive Oxygen Species

2016
An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
    Journal of nutritional science and vitaminology, 2015, Volume: 61, Issue:6

    Topics: Animals; Chloroform; Chromatography, High Pressure Liquid; Diosgenin; Male; Methanol; Mice, Obese; Plant Extracts; Saponins; Solid Phase Extraction; Tandem Mass Spectrometry; Trigonella

2015
A Rapid Study of Botanical Drug-Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin-Functionalized Magnetic Nanoparticles.
    Natural product communications, 2015, Volume: 10, Issue:12

    Topics: Diosgenin; Drug Interactions; Humans; Magnetics; Metal Nanoparticles; Molecular Structure; Protein Binding; Serum Albumin

2015
Potent effects of dioscin against gastric cancer in vitro and in vivo.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Mar-15, Volume: 23, Issue:3

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Diosgenin; DNA Damage; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Proteome; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms

2016
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
    International immunopharmacology, 2016, Volume: 36

    Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cytokines; Dioscorea; Diosgenin; Hep G2 Cells; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4

2016
Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis.
    Pharmacological research, 2016, Volume: 108

    Topics: Animals; Bone and Bones; Cell Differentiation; Cell Line; Cell Proliferation; Dioscorea; Diosgenin; Female; Humans; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; Rats, Sprague-Dawley; Signal Transduction

2016
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
    Molecules (Basel, Switzerland), 2016, Jun-04, Volume: 21, Issue:6

    Topics: Apoptosis; Cell Proliferation; Diosgenin; DNA Damage; Female; HeLa Cells; Humans; Mitochondria; Reactive Oxygen Species; Signal Transduction; Uterine Cervical Neoplasms

2016
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
    Toxicology and applied pharmacology, 2016, 08-15, Volume: 305

    Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cholestasis, Intrahepatic; Diosgenin; Estrone; Hepatocytes; Liver; Male; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Protective Agents; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger

2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
    Environmental toxicology and pharmacology, 2016, Volume: 45

    Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Dimethylnitrosamine; Dioscorea; Diosgenin; Interferon-Stimulated Gene Factor 3, gamma Subunit; Male; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Toll-Like Receptor 4

2016
Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1.
    Scientific reports, 2016, 06-22, Volume: 6

    Topics: ATP Binding Cassette Transporter, Subfamily B; Autophagy; Breast Neoplasms; Cell Proliferation; Diosgenin; Down-Regulation; Doxorubicin; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; NF-kappa B; Promoter Regions, Genetic; Signal Transduction

2016
Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway.
    Pharmacological research, 2016, Volume: 111

    Topics: Animals; Anti-Inflammatory Agents; Caspase 3; Cell Line; Diosgenin; Humans; Kidney Diseases; Lipopolysaccharides; Male; Mice, Inbred C57BL; MicroRNAs; Myeloid Differentiation Factor 88; NF-kappa B; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Toll-Like Receptor 4

2016
Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.
    International immunopharmacology, 2016, Volume: 39

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Dioscorea; Diosgenin; Disease Models, Animal; Diterpenes; Epoxy Compounds; GATA3 Transcription Factor; Humans; Male; Mice; Mice, Inbred DBA; Phenanthrenes; STAT Transcription Factors; Synovial Membrane; Th1 Cells; Th1-Th2 Balance; Th2 Cells

2016
Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
    Journal of separation science, 2016, Volume: 39, Issue:18

    Topics: Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Liliaceae; Quality Control; Saponins

2016
Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83

    Topics: Animals; Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Female; Homeostasis; Humans; Liver; Male; Mitochondria; Oxidative Stress; Rats, Wistar; Rhizome; Saponins; Signal Transduction; Up-Regulation

2016
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
    Chemico-biological interactions, 2016, Oct-25, Volume: 258

    Topics: Animals; Diosgenin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Humans; Isoenzymes; Male; Models, Biological; Protective Agents; Protein Kinase C beta; Protein Kinase C-alpha; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Stomach

2016
Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR.
    BMC complementary and alternative medicine, 2016, Sep-30, Volume: 16, Issue:1

    Topics: Aged; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Retrospective Studies; RNA, Long Noncoding; Stomach Neoplasms

2016
Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Diosgenin; DNA Fragmentation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53

2016
Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: Animals; Antiviral Agents; Bystander Effect; Cell Communication; Cell Survival; Connexin 26; Connexin 43; Connexins; Diosgenin; Disease Models, Animal; Drug Synergism; Ganciclovir; Genes, Transgenic, Suicide; Genetic Therapy; Melanoma, Experimental; Mice; Mutation; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured

2017
Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and
    Phytochemical analysis : PCA, 2017, Volume: 28, Issue:3

    Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Preparations; Quality Control; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization

2017
Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.
    Scientific reports, 2017, 01-06, Volume: 7

    Topics: Animals; Diosgenin; Doublecortin Domain Proteins; Doublecortin Protein; Encephalitis; Endotoxemia; Gene Expression Profiling; Glial Fibrillary Acidic Protein; Hippocampus; Ki-67 Antigen; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Real-Time Polymerase Chain Reaction; Serotonin; Serotonin Receptor Agonists

2017
Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.
    Toxicology, 2017, 03-01, Volume: 378

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytokines; Diosgenin; Doxorubicin; Glutathione Transferase; Heme Oxygenase (Decyclizing); Kidney; Kidney Diseases; Male; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear

2017
Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of the Akt1 signalling pathway.
    British journal of pharmacology, 2017, Volume: 174, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasms, Experimental; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Structure-Activity Relationship; Tumor Cells, Cultured

2017
Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats.
    Inflammopharmacology, 2017, Volume: 25, Issue:6

    Topics: Animals; Atherosclerosis; Cells, Cultured; Cholesterol; Diosgenin; Foam Cells; Hyperlipidemias; Interleukin-1beta; Interleukin-6; Lipoproteins, LDL; Macrophages; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Scavenger Receptors, Class E

2017
Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.
    British journal of pharmacology, 2017, Volume: 174, Issue:15

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cisplatin; Diosgenin; Dose-Response Relationship, Drug; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Sirtuin 1; Structure-Activity Relationship

2017
Dioscin suppresses TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion.
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship; Transforming Growth Factor beta1

2017
Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling.
    International journal of biological sciences, 2017, Volume: 13, Issue:6

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diosgenin; Gallbladder Neoplasms; Glutathione; Humans; Male; Membrane Potential, Mitochondrial; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays

2017
Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization.
    International journal of cancer, 2017, 10-15, Volume: 141, Issue:8

    Topics: Animals; Connexin 43; Diosgenin; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; RAW 264.7 Cells; Up-Regulation

2017
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017, Volume: 107, Issue:Pt A

    Topics: Amino Acids; Animals; Collagen; Diosgenin; Humans; Integrin alpha5; Isotope Labeling; Liver Cirrhosis; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proteomics; Rats; Signal Transduction

2017
Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS.
    Natural product research, 2018, Volume: 32, Issue:7

    Topics: Caffeic Acids; Costus; Diosgenin; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Plant Leaves; Plants, Medicinal; Rhizome; Saponins; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Steroids; Sterols; Tandem Mass Spectrometry

2018
Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway.
    Molecular medicine reports, 2017, Volume: 16, Issue:4

    Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Diosgenin; Mice; NF-kappa B; Osteoblasts; Signal Transduction

2017
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Diosgenin; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thioacetamide

2018
Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: Animals; Brain Ischemia; Diosgenin; HMGB1 Protein; Humans; Inflammation; Interleukin-1 Receptor-Associated Kinases; Myeloid Differentiation Factor 88; NF-kappa B; Oxidative Stress; Rats; Signal Transduction; Stroke; TNF Receptor-Associated Factor 6; Toll-Like Receptor 4; Transforming Growth Factor beta1

2018
Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice.
    Theranostics, 2017, Volume: 7, Issue:17

    Topics: Animals; Blotting, Western; Diosgenin; Epithelial Cells; Female; Flow Cytometry; Hydroxyproline; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Pulmonary Fibrosis; RAW 264.7 Cells; Silicon Dioxide; Silicosis

2017
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
    Toxicology letters, 2018, Mar-01, Volume: 284

    Topics: Animals; Diosgenin; Disease Models, Animal; Fibrosis; Fructose; Inflammation; Kidney; Lipid Metabolism; Male; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Renal Insufficiency, Chronic

2018
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
    Journal of ethnopharmacology, 2018, Mar-25, Volume: 214

    Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative; HCT116 Cells; Humans; Hyperuricemia; Intestinal Elimination; Intestinal Mucosa; Intestines; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Renal Elimination; Spirostans; Time Factors; Uric Acid; Uricosuric Agents

2018
[Preparation and evaluation of dioscin nanostructured lipid carriers].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017, Volume: 42, Issue:19

    Topics: Diosgenin; Drug Carriers; Lipids; Nanostructures; Particle Size

2017
Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways.
    Anti-cancer drugs, 2018, Volume: 29, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Diosgenin; HT29 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitochondria; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species

2018
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Jan-01, Volume: 38

    Topics: Amyloid Precursor Protein Secretases; Animals; Cell Cycle Proteins; Cell Line; Diosgenin; Hepatectomy; Hepatocytes; Humans; Jagged-1 Protein; Liver; Liver Regeneration; Male; Mice, Inbred C57BL; Mice, Transgenic; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction

2018
Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis.
    Molecules (Basel, Switzerland), 2018, Feb-18, Volume: 23, Issue:2

    Topics: China; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Gene Expression Profiling; Molecular Sequence Annotation; Phylogeny; Rhizome; Transcriptome

2018
Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression.
    International journal of biological sciences, 2018, Volume: 14, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Apoptosis; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Diosgenin; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Reactive Oxygen Species

2018
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
    Cell death & disease, 2018, 03-01, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Animals; Antineoplastic Agents; beta Catenin; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Diosgenin; Female; Glycogen Synthase Kinase 3; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplastic Stem Cells; Osteosarcoma; Proto-Oncogene Proteins c-akt; Signal Transduction; Young Adult

2018
Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70.
    Molecular medicine reports, 2018, Volume: 17, Issue:5

    Topics: Acute Lung Injury; Animals; Cytokines; Diosgenin; HSP70 Heat-Shock Proteins; Lipopolysaccharides; Male; Mice; Myeloid Differentiation Factor 88; Signal Transduction; Toll-Like Receptor 4; Up-Regulation

2018
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
    Redox biology, 2018, Volume: 16

    Topics: Animals; Apoptosis; Cardiotoxicity; Cell Survival; Diosgenin; Doxorubicin; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; Myocardium; Neoplasm Proteins; Neoplasms; Oxidative Stress; Rats

2018
Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway.
    Pharmacological research, 2018, Volume: 131

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diosgenin; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Signal Transduction; Sirtuin 1

2018
An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Diosgenin; Energy Metabolism; Humans; Leukemia, Myeloid, Acute; Proteomics; Signal Transduction

2018
Dioscin Promotes Proliferation of Pancreatic Beta Cells via Wnt/β-Catenin Signaling Pathways.
    Clinical laboratory, 2018, May-01, Volume: 64, Issue:5

    Topics: Apoptosis; beta Catenin; Cell Line; Cell Proliferation; Cell Survival; Diabetes Mellitus, Type 2; Diosgenin; Glucose; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Secreting Cells; Wnt Signaling Pathway

2018
Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
    Molecular medicine reports, 2018, Volume: 18, Issue:1

    Topics: Animals; Coronary Disease; Diosgenin; Inflammation; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Sirtuin 1; Swine; Swine, Miniature

2018
Molecular mechanism and inhibitory targets of dioscin in HepG2 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 120

    Topics: Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Division; Cell Proliferation; Diosgenin; G2 Phase; Genes, cdc; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mitochondria; Polygonatum; Reactive Oxygen Species; Receptors, Death Domain

2018
Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways.
    Life sciences, 2018, Sep-15, Volume: 209

    Topics: Angiotensin II; Animals; Cardiomegaly; Diosgenin; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Vasoconstrictor Agents

2018
Protective effect of dioscin against intestinal ischemia/reperfusion injury via adjusting miR-351-5p-mediated oxidative stress.
    Pharmacological research, 2018, Volume: 137

    Topics: Animals; Cell Line; Cell Survival; Diosgenin; Intestinal Mucosa; Intestines; Male; Malondialdehyde; Mice, Inbred C57BL; MicroRNAs; Oxidative Stress; Peroxidase; Protective Agents; Rats; Reperfusion Injury; Superoxide Dismutase

2018
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Animals; Apoptosis; beta Catenin; Cartilage, Articular; Diosgenin; Disease Models, Animal; Extracellular Matrix; Inflammation; Iodoacetates; Male; Osteoarthritis; Oxidative Stress; PPAR gamma; Protective Agents; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway

2018
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
    International immunopharmacology, 2018, Volume: 65

    Topics: Animals; Anti-Inflammatory Agents; Dioscorea; Diosgenin; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Systemic Inflammatory Response Syndrome; THP-1 Cells; Toll-Like Receptor 2; Zymosan

2018
The Protective Effects of Preconditioning With Dioscin on Myocardial Ischemia/Reperfusion-Induced Ventricular Arrhythmias by Increasing Connexin 43 Expression in Rats.
    Journal of cardiovascular pharmacology and therapeutics, 2019, Volume: 24, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Biomarkers; Connexin 43; Creatine Kinase, MB Form; Diosgenin; Disease Models, Animal; Heart Rate; Male; Myocardial Reperfusion Injury; Phosphorylation; Protective Agents; Rats, Sprague-Dawley; Tachycardia, Ventricular; Troponin I; Up-Regulation; Ventricular Fibrillation; Ventricular Premature Complexes

2019
Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: Adipose Tissue; Adiposity; Animals; Blood Glucose; Diet, High-Fat; Diosgenin; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction

2019
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
    Pharmacological research, 2019, Volume: 139

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Hypoxia; Cell Line; Diosgenin; Intestinal Mucosa; Male; MicroRNAs; Mitogen-Activated Protein Kinase 13; Protective Agents; Rats, Sprague-Dawley; Reperfusion Injury

2019
Dioscin Inhibits Virulence Factors of
    BioMed research international, 2018, Volume: 2018

    Topics: Animals; Antifungal Agents; Biofilms; Candida albicans; Candidiasis; Cell Line; Diosgenin; Mammary Glands, Animal; Virulence; Virulence Factors

2018
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
    British journal of pharmacology, 2019, Volume: 176, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Diosgenin; DNA Damage; Glycolysis; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Phosphoric Monoester Hydrolases; Rats, Wistar; RNA, Small Interfering; Tumor Suppressor Protein p53

2019
Dioscin Attenuates Myocardial Damages in Diabetic Rats maybe by Regulating NO-sGC-cGMP-PKG Pathway.
    Annals of clinical and laboratory science, 2019, Volume: 49, Issue:1

    Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diosgenin; Disease Models, Animal; Fibrosis; Guanylate Cyclase; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction

2019
Dioscin, a Steroidal Saponin Isolated from Dioscorea nipponica, Attenuates Collagen-Induced Arthritis by Inhibiting Th17 Cell Response.
    The American journal of Chinese medicine, 2019, Volume: 47, Issue:2

    Topics: Animals; Arthritis; Cell Differentiation; Cells, Cultured; Collagen; Cytokines; Dioscorea; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred BALB C; Mice, Inbred DBA; Phytotherapy; Th17 Cells

2019
Effects of dioscin on T helper 17 and regulatory T-cell subsets in chicken collagen type II-induced arthritis mice.
    Journal of the Chinese Medical Association : JCMA, 2019, Volume: 82, Issue:3

    Topics: Animals; Arthritis, Experimental; Chickens; Collagen Type II; Diosgenin; Interleukin-17; Interleukin-6; Interleukins; Male; Mice; Mice, Inbred DBA; STAT3 Transcription Factor; STAT5 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells

2019
Neuroprotective Effect of Dioscin on the Aging Brain.
    Molecules (Basel, Switzerland), 2019, Mar-30, Volume: 24, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Brain; Cell Survival; Cytokines; Diosgenin; Galactose; Glutathione Peroxidase; Hydrogen Peroxide; Male; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase

2019
Dioscin inhibits intimal hyperplasia in rat carotid artery balloon injury model through inhibition of the MAPK-FoxM1 pathway.
    European journal of pharmacology, 2019, Jul-05, Volume: 854

    Topics: Animals; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Diosgenin; Down-Regulation; Enzyme Activation; Forkhead Box Protein M1; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phenotype; Rats; Rats, Sprague-Dawley; Tunica Intima

2019
Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy.
    Theranostics, 2019, Volume: 9, Issue:7

    Topics: Animals; Apoptosis; Autophagy; Cell Line; Cell Survival; Diosgenin; Female; Macrophages; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Pneumonia; Pulmonary Fibrosis; Reactive Oxygen Species; Silicon Dioxide; Silicosis

2019
Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
    Molecules (Basel, Switzerland), 2019, Jun-14, Volume: 24, Issue:12

    Topics: Cell Movement; Cell Proliferation; Diosgenin; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Signal Transduction; Transforming Growth Factor beta1

2019
Inhibition of tumor metastasis by targeted daunorubicin and dioscin codelivery liposomes modified with PFV for the treatment of non-small-cell lung cancer.
    International journal of nanomedicine, 2019, Volume: 14

    Topics: A549 Cells; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Daunorubicin; Diosgenin; Drug Delivery Systems; Female; Humans; Liposomes; Lung Neoplasms; Matrix Metalloproteinase 2; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Oligopeptides; Particle Size; Static Electricity; Wound Healing

2019
NMR-based metabolomics approach to investigate the distribution characteristics of metabolites in Dioscorea opposita Thunb. cv. Tiegun.
    Food chemistry, 2019, Nov-15, Volume: 298

    Topics: Cluster Analysis; Dioscorea; Diosgenin; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Plant Exudates; Plants, Medicinal; Principal Component Analysis; Saponins

2019
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
    Pharmacological research, 2019, Volume: 148

    Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Cells, Cultured; Diosgenin; Endothelial Cells; Estrogen Receptor alpha; Female; Humans; Inflammation; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Ovariectomy; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Plant Extracts; Postmenopause; Receptors, LDL; Signal Transduction

2019
Transferrin Modified Dioscin Loaded PEGylated Liposomes: Characterization and
    Journal of nanoscience and nanotechnology, 2020, 03-01, Volume: 20, Issue:3

    Topics: Diosgenin; Drug Delivery Systems; HeLa Cells; Humans; Liposomes; Particle Size; Polyethylene Glycols; Transferrin

2020
Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.
    Journal of cellular physiology, 2020, Volume: 235, Issue:3

    Topics: Apoptosis; Bone Neoplasms; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Diosgenin; G2 Phase Cell Cycle Checkpoints; Humans; Osteosarcoma; Pyroptosis; Receptors, Estrogen

2020
Dioscin improves postmenopausal osteoporosis through inducing bone formation and inhibiting apoptosis in ovariectomized rats.
    Bioscience trends, 2019, Nov-13, Volume: 13, Issue:5

    Topics: 3T3 Cells; Animals; Apoptosis; Bone Density; Bone Development; Cell Differentiation; Diosgenin; Female; Humans; Mice; Osteoporosis, Postmenopausal; Ovariectomy; Rats; Rats, Sprague-Dawley

2019
Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Adult; Atherosclerosis; CD36 Antigens; Dendritic Cells; Diosgenin; Female; Gene Expression Regulation; Glucose; Humans; Inflammation; Interleukin-10; Interleukin-12; Interleukin-6; Lipoproteins, LDL; Male; p38 Mitogen-Activated Protein Kinases; Scavenger Receptors, Class A; Scavenger Receptors, Class E

2020
RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply.
    Cancer science, 2020, Volume: 111, Issue:2

    Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell-Penetrating Peptides; Diosgenin; Epirubicin; Gene Expression Regulation, Neoplastic; Humans; Liposomes; Lung Neoplasms; Male; Mice; Neovascularization, Pathologic; Rats; Xenograft Model Antitumor Assays

2020
A rapid method for on-line solid-phase extraction and determination of dioscin in human plasma using a homemade monolithic sorbent combined with high-performance liquid chromatography.
    Analytical and bioanalytical chemistry, 2020, Volume: 412, Issue:2

    Topics: Chromatography, High Pressure Liquid; Diosgenin; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Solid Phase Extraction

2020
Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth.
    EBioMedicine, 2020, Volume: 51

    Topics: Aerobiosis; Animals; Antigens, CD; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Diosgenin; Glycolysis; Humans; Mice, Nude; Proteolysis; S-Phase Kinase-Associated Proteins; Ubiquitination; Xenograft Model Antitumor Assays

2020
A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.
    Small (Weinheim an der Bergstrasse, Germany), 2020, Volume: 16, Issue:1

    Topics: Animals; Cell Line; Diosgenin; Humans; Lipopolysaccharides; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Osteogenesis; Teichoic Acids

2020
Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 67

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Diosgenin; Gene Expression Regulation; Gluconeogenesis; Glycolipids; Hep G2 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Lipogenesis; Liver; Male; Mice, Inbred C57BL; MicroRNAs; Rats, Wistar; STAT3 Transcription Factor

2020
Dioscin: A new potential inhibitor of Skp2 for cancer therapy.
    EBioMedicine, 2020, Volume: 51

    Topics: Animals; Biological Products; Cell Line, Tumor; Diosgenin; Humans; Mice; Neoplasms; S-Phase Kinase-Associated Proteins; Xenograft Model Antitumor Assays

2020
GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition.
    Drug development and industrial pharmacy, 2020, Volume: 46, Issue:6

    Topics: Breast Neoplasms; Cell Line, Tumor; Daunorubicin; Diosgenin; Epithelial-Mesenchymal Transition; Humans; Liposomes

2020
Dioscin exhibits anti-inflammatory effects in IL-1β-stimulated human osteoarthritis chondrocytes by activating LXRα.
    Immunopharmacology and immunotoxicology, 2020, Volume: 42, Issue:4

    Topics: Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Diosgenin; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-1beta; Liver X Receptors; Osteoarthritis

2020
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases

2020
Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:16

    Topics: Animals; Carcinoma, Lewis Lung; Diosgenin; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor; Tumor Microenvironment

2020
Anti-Parkinson's Disease Function of Dioscin-Zein-Carboxymethyl Cellulose Nanocomplex in Caenorhabditis elegans.
    Biotechnology journal, 2020, Volume: 15, Issue:12

    Topics: Animals; Caenorhabditis elegans; Carboxymethylcellulose Sodium; Diosgenin; Disease Models, Animal; Parkinson Disease; Zein

2020
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
    Chemical & pharmaceutical bulletin, 2020, Volume: 68, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Beclin-1; Cell Line; Diosgenin; Down-Regulation; Humans; Neurons; Peptide Fragments; Protective Agents; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirtuin 3; Up-Regulation

2020
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study.
    Journal of natural medicines, 2021, Volume: 75, Issue:1

    Topics: Animals; Arthritis, Gouty; Diosgenin; Humans; Inflammasomes; Inflammation; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Toll-Like Receptor 4; Uric Acid

2021
Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Aug-25, Volume: 26

    Topics: Apoptosis; Diosgenin; Humans; Inflammation Mediators; Interleukin-1beta; NF-kappa B; Nucleus Pulposus; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2020
The potential missing links between hepatoprotective dioscin and alcoholic liver disease.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:1

    Topics: Cytotoxins; Diosgenin; Enterococcus faecalis; Humans; Liver Diseases, Alcoholic

2021
Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma.
    International journal of biological sciences, 2020, Volume: 16, Issue:15

    Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Diosgenin; HSP27 Heat-Shock Proteins; Lung; Mice; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species

2020
Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice.
    Journal of proteome research, 2021, 01-01, Volume: 20, Issue:1

    Topics: Animals; Diosgenin; Hyperuricemia; Male; Metabolomics; Mice; Uric Acid

2021
Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 148

    Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Diosgenin; Down-Regulation; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Reactive Oxygen Species; Signal Transduction; Up-Regulation

2021
Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133

    Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Diosgenin; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Vascular Remodeling

2021
Dioscin Improves Pyroptosis in LPS-Induced Mice Mastitis by Activating AMPK/Nrf2 and Inhibiting the NF-
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: AMP-Activated Protein Kinases; Animals; Diosgenin; Female; Inflammasomes; Lipopolysaccharides; Male; Mastitis; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Pyroptosis; Signal Transduction

2020
Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis.
    Molecular medicine reports, 2021, Volume: 23, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Mouth Neoplasms; Protein Serine-Threonine Kinases; Serine-Threonine Kinase 3; Transcription Factors; Tumor Suppressor Proteins; YAP-Signaling Proteins

2021
Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress.
    Free radical biology & medicine, 2021, Volume: 169

    Topics: Animals; Diosgenin; Kelch-Like ECH-Associated Protein 1; Kidney; Liver; Methotrexate; Mice; MicroRNAs; NF-E2-Related Factor 2; Oxidative Stress; Rats

2021
Dioscin induces ferroptosis and synergistic cytotoxicity with chemotherapeutics in melanoma cells.
    Biochemical and biophysical research communications, 2021, 06-11, Volume: 557

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzophenanthridines; Cation Transport Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cyclohexylamines; Diosgenin; Drug Synergism; Ferroptosis; Humans; Iron; Malondialdehyde; Melanoma; Phenylenediamines; Reactive Oxygen Species; RNA, Small Interfering; Transferrin

2021
Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway.
    British journal of pharmacology, 2021, Volume: 178, Issue:18

    Topics: Animals; Diosgenin; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Sirtuin 1; Subarachnoid Hemorrhage

2021
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases.
    Aging cell, 2021, Volume: 20, Issue:7

    Topics: Animals; Diosgenin; Disease Models, Animal; Heart Diseases; Humans; Male; Mice; Neovascularization, Physiologic; RNA, Long Noncoding

2021
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation.
    European journal of pharmacology, 2021, Oct-05, Volume: 908

    Topics: Animals; Apoptosis; Diosgenin; Mice; Oxidative Stress; Rats; Reperfusion Injury

2021
Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation.
    International immunopharmacology, 2021, Volume: 99

    Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Male; Mice

2021
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization.
    Pharmacological research, 2021, Volume: 172

    Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Diosgenin; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; PPAR gamma; RAW 264.7 Cells

2021
Dioscin attenuates lipopolysaccharide-induced inflammatory myocardial injury through oxidative stress-related pathway.
    Annals of palliative medicine, 2021, Volume: 10, Issue:8

    Topics: Animals; Diosgenin; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; NF-E2-Related Factor 2; Oxidative Stress; Rats

2021
Dioscin Attenuates Myocardial Ischemic/Reperfusion-Induced Cardiac Dysfunction through Suppression of Reactive Oxygen Species.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Animals; Diosgenin; Humans; Male; Mice; Myocardial Reperfusion Injury; Reactive Oxygen Species

2021
Dioscin-loaded zein nanoparticles alleviate lipopolysaccharide-induced acute kidney injury via the microRNA-let 7i signalling pathways.
    IET nanobiotechnology, 2021, Volume: 15, Issue:5

    Topics: Acute Kidney Injury; Diosgenin; Humans; Lipopolysaccharides; MicroRNAs; Nanoparticles; Zein

2021
Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal.
    International immunopharmacology, 2021, Volume: 101, Issue:Pt B

    Topics: Animals; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Diosgenin; Disease Models, Animal; Inflammasomes; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Receptors, Purinergic P2X7; Signal Transduction

2021
Inhibition of Src/STAT3 signaling-mediated angiogenesis is involved in the anti-melanoma effects of dioscin.
    Pharmacological research, 2022, Volume: 175

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Diosgenin; Human Umbilical Vein Endothelial Cells; Humans; Male; Melanoma, Experimental; Mice, Inbred C57BL; Neovascularization, Pathologic; src-Family Kinases; STAT3 Transcription Factor; Tumor Burden

2022
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
    Cells, 2021, 11-22, Volume: 10, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; beta Catenin; Body Weight; Brain; Cytokines; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Models, Biological; NF-kappa B; Sex Characteristics; Signal Transduction; Synapses

2021
3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs.
    Toxicology, 2022, 01-30, Volume: 466

    Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Chemical and Drug Induced Liver Injury; Composite Resins; Cytochrome P-450 Enzyme System; Diosgenin; Drug Evaluation, Preclinical; Glucose; Hep G2 Cells; Humans; Pharmaceutical Preparations; Tissue Scaffolds

2022
In Silico Screening and In Vitro Assessment of Natural Products with Anti-Virulence Activity against
    Molecules (Basel, Switzerland), 2021, Dec-21, Volume: 27, Issue:1

    Topics: Amino Acid Sequence; Anti-Bacterial Agents; Biofilms; Biological Products; Catalytic Domain; Clarithromycin; Diosgenin; Drug Evaluation, Preclinical; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Binding; Protein Conformation; Pyrophosphatases; Virulence

2021
Dioscin promotes autophagy by regulating the AMPK-mTOR pathway in ulcerative colitis.
    Immunopharmacology and immunotoxicology, 2022, Volume: 44, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Mice; TOR Serine-Threonine Kinases

2022
The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation.
    Journal of ethnopharmacology, 2022, Jun-28, Volume: 292

    Topics: Animals; Diosgenin; Drugs, Chinese Herbal; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Molecular Docking Simulation; Network Pharmacology; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt

2022
Dioscin Alleviates Cisplatin-Induced Mucositis in Rats by Modulating Gut Microbiota, Enhancing Intestinal Barrier Function and Attenuating TLR4/NF-κB Signaling Cascade.
    International journal of molecular sciences, 2022, Apr-17, Volume: 23, Issue:8

    Topics: Animals; Cisplatin; Diosgenin; Gastrointestinal Microbiome; Humans; Inflammation; Mucositis; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4

2022
Dioscin exhibits protective effects on in vivo and in vitro asthma models via suppressing TGF-β1/Smad2/3 and AKT pathways.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:8

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Diosgenin; Disease Models, Animal; Humans; Hyperplasia; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Proto-Oncogene Proteins c-akt; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1

2022
Dioscin ameliorates inflammatory bowel disease by up-regulating miR-125a-5p to regulate macrophage polarization.
    Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Diosgenin; Humans; Inflammatory Bowel Diseases; Lipopolysaccharides; Macrophages; Mice; MicroRNAs

2022
Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway.
    Nutrients, 2022, May-09, Volume: 14, Issue:9

    Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diosgenin; Hyperuricemia; Liver; Mice; Signal Transduction

2022
Dioscin-Mediated Autophagy Alleviates MPP
    Molecules (Basel, Switzerland), 2022, Apr-29, Volume: 27, Issue:9

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Diosgenin; Parkinson Disease

2022
Neuroprotective Effect of Dioscin against Parkinson's Disease via Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative Stress.
    Molecules (Basel, Switzerland), 2022, May-14, Volume: 27, Issue:10

    Topics: Animals; Diosgenin; Dual Specificity Phosphatase 6; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats

2022
Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 103

    Topics: Animals; Bone Morphogenetic Protein 4; Diosgenin; Hypoxia; Inflammation; Interleukin-6; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Myocardial Infarction; NADPH Oxidase 1; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2022
Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation.
    International immunopharmacology, 2022, Volume: 111

    Topics: Animals; Antioxidants; Cisplatin; Diosgenin; Hydrogen Peroxide; Inflammation; NF-E2-Related Factor 2; Oxidative Stress; Rats

2022
    International journal of molecular sciences, 2022, Sep-01, Volume: 23, Issue:17

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dioscorea; Diosgenin; Memory Disorders; Mice; Neurodegenerative Diseases; Neuroinflammatory Diseases; NF-kappa B; Plant Extracts; Scopolamine

2022
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Anemia, Aplastic; Animals; Apoptosis; Bone Marrow; Diosgenin; Disease Models, Animal; Mice

2022