diosgenin has been researched along with dioscin in 224 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.79) | 18.7374 |
| 1990's | 3 (1.34) | 18.2507 |
| 2000's | 30 (13.39) | 29.6817 |
| 2010's | 134 (59.82) | 24.3611 |
| 2020's | 53 (23.66) | 2.80 |
| Authors | Studies |
|---|---|
| Chapuis, JC; Doubek, DL; Hoffmann, H; Knight, JC; Pettit, GR; Pettit, RK; Pinilla, V; Schmidt, JM; Zhang, Q | 1 |
| Hong, BN; Hong, HN; Kang, TH; Kim, DH; Kim, TW; Le, HT; Lim, CW; Park, KH | 1 |
| Gao, W; Jing, S; Li, X; Man, S; Sun, J; Wang, Y; Zhao, C | 1 |
| Squibb, RE; Squibb, RL | 1 |
| Aquino, R; Conti, C; De Simone, F; Orsi, N; Pizza, C; Stein, ML | 1 |
| Aquino, R; Behar, I; De Simone, F; Pizza, C | 1 |
| Dong, A; Hu, K; Iwasaki, S; Kobayashi, H; Yao, X | 1 |
| Deng, S; Han, X; Hui, Y; Yu, B; Yu, H | 1 |
| Ju, Y; Li, X; Liu, M; Wang, Z; Zhang, H; Zhou, J | 1 |
| Cai, J; Ju, Y; Liu, M; Wang, Z | 1 |
| Chai, H; Cordell, GA; Farnsworth, NR; Hollingshead, MG; Kardono, LB; Kinghorn, AD; Lantvit, D; Lee, IS; Mayo, JG; Mi, Q; Ngassapa, O; Peraza-Sánchez, S; Pezzuto, JM; Reyes-Lim, E; Riswan, S; Zhao, W | 1 |
| Garegg, PJ; Gybäck, H; Lahmann, M; Oscarson, S; Suhr, R; Thiem, J | 1 |
| Han, X; Li, M; Yu, B | 1 |
| Hou, SJ; Lei, PS; Liang, XT; Shi, Y; Zou, CC | 1 |
| Sun, W; Tu, G; Zhang, Y | 1 |
| Kim, JH; Kim, JS; Kim, SH; Kwon, CS; Lee, JS; Lim, JK; Sohn, HY; Son, KH | 1 |
| Cai, B; Cui, CB; Liu, HW; Wang, SL; Wu, CF; Yao, XS | 1 |
| KAWASAKI, T; TSUKAMOTO, T; YAMAUCHI, T | 1 |
| KAWASAKI, T; YAMAUCHI, T | 1 |
| Du, Q; Li, B; Liu, Z; Wang, A; Wang, F; Wang, Y; Wang, Z | 1 |
| Chen, X; Gu, J; Li, K; Wang, Y; Zhong, D | 1 |
| Che, CM; Hui, Y; Shum, TY; Wong, EL; Yang, Z | 1 |
| Balick, MJ; Bills, GF; Borris, RP; DeMartino, J; DiSalvo, J; Dombrowski, AW; Guan, Z; Herath, KB; Jayasuriya, H; Koch, G; Mojena, M; Morenberg, CM; Nanakorn, W; Ondeykal, JG; Polishook, JD; Singh, SB; Slattery, M; Stevenson, DW | 1 |
| Liu, XK; Ma, YH; Yang, SL | 1 |
| Fawcett, JP; Gu, J; Li, K; Tang, Y; Zhong, D | 1 |
| Jin, F; Lu, M; Qian, S; Wang, H; Yu, H; Zhang, C | 1 |
| Che, CM; Cheung, YH; Chiu, JF; He, QY; Wang, Y; Yang, Z | 1 |
| Jeon, JR; Kim, JY; Kim, SD; Lee, CH; Lee, JS; Nam, DH | 1 |
| Li, M; Yu, B | 1 |
| Li, M; Li, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, S | 1 |
| Ouyang, PK; Qian, SH; Yang, NY; Yuan, LH | 1 |
| Kang, LP; Lü, N; Ma, BP; Tan, DW; Zhang, J | 1 |
| Asao, Y; Kumahara, A; Matsuda, H; Morikawa, T; Nakamura, S; Pongpiriyadacha, Y; Xu, F; Yoshikawa, M | 1 |
| Chen, J; Lin, S; Tong, Y; Wang, D; Yang, D; Yao, J | 1 |
| Li, M; Li, W; Qiu, Z; Wang, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, Z | 1 |
| Che, CM; Chiu, JF; He, QY; Wang, Y | 1 |
| Ha, H; Jeon, SJ; Jung, DY; Kim, C; Lee, HY; Son, KH | 1 |
| Dai, CC; Tang, XL; Wang, Q; Xia, B; Xu, ZL; Zhao, YT | 1 |
| Kim, J; Yoon, KD | 1 |
| Lin, F; Wang, R | 1 |
| Han, J; Jiang, DX; Liu, XL; Liu, YT; Wang, GX; Zhao, LW | 1 |
| Fu, Y; Hu, X; Jin, F; Liu, B; Tang, SH; Wang, Y; Yu, C; Yu, H | 1 |
| Lu, B; Peng, J; Xu, L; Yin, L | 1 |
| Bao, YL; Li, YX; Meng, XY; Sun, BT; Wu, Y; Yu, CL; Zheng, LH | 1 |
| Chen, GX; Qin, YZ; Xiong, XY; Yang, DM; Zhao, DW; Zhong, XH | 1 |
| Gao, LL; Jiao, P; Li, FR; Sang, H; Si, YH; Yao, ST | 1 |
| Gao, LL; Jiang, WJ; Jiao, P; Li, FR; Si, YH; Yang, MF; Zheng, TT; Zhou, XJ | 1 |
| Chen, JP; Cheng, Y; Guan, XY; Han, F; Li, YW; Shen, JG; Wang, DM; Wang, N; Wang, Z; Yang, DP | 1 |
| Han, X; Hu, M; Li, H; Peng, J; Qi, Y; Wan, X; Xu, L; Xu, Y; Yin, L | 1 |
| Peng, J; Xu, L; Xu, T; Yin, L; Zhang, S; Zheng, L | 1 |
| Cong, X; Li, H; Lu, B; Peng, J; Xu, L; Xu, Y; Yin, L | 1 |
| Kim, EA; Kim, MS; Kim, YS; Lee, SJ; Lee, TJ; Park, KG; Sohn, HY | 1 |
| Cong, X; Peng, J; Xu, L; Yin, L; Zhao, X; Zheng, L | 1 |
| Kim, DS; Kim, SH; Liang, C; Lim, JH | 1 |
| Chen, S; Chen, X; Liu, C; Pei, R; Song, J; Wang, Y; Wu, C | 1 |
| Cho, J; Choi, H; Kim, MS; Lee, DG; Lee, J; Sohn, HY | 1 |
| Huo, X; Liu, K; Liu, Q; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Zhang, A | 1 |
| Fan, MJ; Hsieh, WT; Liu, FC; Pan, CH; Sheu, MJ; Tsai, CH; Wu, CH | 1 |
| Chiou, HL; Hsieh, MJ; Hsieh, YS; Tsai, TL; Wang, CJ | 1 |
| Li, XZ; Liu, L; Liu, SM; Lu, F; Yu, DH; Zhou, Q | 1 |
| Huo, X; Liu, K; Liu, Q; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Wang, L | 1 |
| Ali, Z; Khan, IA; Smillie, TJ | 1 |
| Han, X; Liu, K; Peng, J; Qi, Y; Sun, H; Wei, Y; Xu, L; Xu, Y; Yin, L | 1 |
| Dong, D; Han, X; Lv, L; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L | 1 |
| Fang, B; Kang, Y; Liu, X; Qin, J; Xu, Z; Zang, C | 1 |
| Ali, Z; Avula, B; Khan, IA; Khan, SI; Manda, VK; Smillie, TJ; Wong, YH | 1 |
| Gao, YX; Guo, YC; Song, HR | 1 |
| Ji, S; Li, Y; Lv, L; Wang, B; Zhang, G; Zhang, H; Zhao, L; Zhou, G | 1 |
| Han, X; Peng, J; Qi, Y; Xu, L; Xu, T; Xu, Y; Yin, L; Zheng, L | 1 |
| Dai, K; Fan, Q; Li, H; Liu, G; Liu, X; Ouyang, Z; Qin, A; Qu, X; Tang, T; Wu, C; Zhai, Z | 1 |
| Chen, H; Han, X; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y | 1 |
| Chen, J; Li, HM; Ruan, JL; Xiong, CM; Zhang, XN | 1 |
| Huo, X; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Wang, L; Yang, X; Zhen, Y | 1 |
| Gao, S; Hao, J; Ren, H; Zhao, X | 1 |
| Jin, Y; Liu, K; Liu, M; Peng, J; Sun, H; Wang, C; Wu, S; Xia, F; Zhang, C | 1 |
| Chiu, JF; He, QY; Wang, Y | 1 |
| Jang, JH; Kim, EA; Kim, JY; Kim, S; Lee, TJ; Lee, YH; Sohn, HY; Song, IH; Sung, EG | 1 |
| Ji, Y; Li, J; Liang, J; Liu, M; Liu, T; Su, J; Wei, Y | 1 |
| Jie, EY; Kim, DJ; Kim, SW; Kwon, YK; Liu, JR; Min, BW; Sartie, A | 1 |
| Han, X; Lin, Y; Peng, J; Qi, Y; Tao, X; Wan, X; Xu, L; Xu, Y; Yin, L | 1 |
| Hu, X; Jiang, L; Qing, Y; Tong, Q; Wu, X; Wu, Y | 1 |
| Ki, HH; Kim, DK; Lee, YM; Lim, SW; Nepali, S; Poudel, B | 1 |
| Jin, Y; Liu, K; Peng, J; Qin, J; Sun, H; Wang, C; Wu, S; Xu, H | 1 |
| Han, X; Lin, Y; Liu, K; Liu, M; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yao, J; Yin, L; Zhao, Y | 1 |
| Chen, JP; Kong, M; Li, SL; Mao, Q; Shen, H; Xu, JD; Zhu, H | 1 |
| Chen, HB; He, XC; Pang, YX; Tang, YN; Yi, T; Zhang, JY; Zhang, YZ; Zhao, ZZ | 1 |
| Han, X; Li, H; Lin, Y; Liu, K; Peng, J; Qi, Y; Sun, X; Tao, X; Xu, L; Xu, Y; Yin, L | 1 |
| Han, X; Lin, Y; Liu, K; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yin, L; Zhang, X | 1 |
| Dong, D; Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y; Zheng, L | 1 |
| Hong, JH; Kim, YS; Lee, CJ; Lee, HJ; Lee, SK; Park, JS; Shin, YJ; Son, KH; Yoon, YP | 1 |
| Peng, JY; Wei, YL; Xu, LN | 1 |
| Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhang, X | 1 |
| Jiang, W; Tao, YH; Wu, ZG | 1 |
| Han, X; Liu, K; Peng, J; Qi, M; Qi, Y; Sun, H; Wang, C; Xu, L; Xu, Y; Yin, L; Zhao, Y; Zheng, L | 1 |
| Ebina, K; Fukatsu, M; Kimura, H; Koketsu, M; Ninomiya, M; Nishina, A; Sato, D; Ukiya, M | 1 |
| Hu, K; Ling, F; Liu, GL; Liu, L; Liu, XY; Shen, YF; Wang, GX; Yang, XL | 1 |
| Li, J; Qi, H; Wang, M; Xu, Y; Zhang, H | 1 |
| Han, X; Liu, K; Liu, M; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, Y | 1 |
| Gao, Y; Liang, QD; Ma, ZC; Tan, HL; Tang, XL; Wang, YG; Xiao, CR; Zhang, YX; Zhao, YH | 1 |
| Ali, Z; Aumsuwan, P; Avula, B; Dasmahapatra, AK; Helferich, WG; Katzenellenbogen, BS; Khan, IA; Khan, SI; Shariat-Madar, Z; Walker, LA | 1 |
| Gu, L; Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yin, L | 2 |
| Han, X; Peng, J; Qi, Y; Si, L; Wang, C; Xu, L; Xu, Y; Yin, L; Zheng, L | 1 |
| Goto, T; Hoshino, S; Kawada, T; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T | 1 |
| Ding, LS; Liang, J; Liao, X; Liu, YM; Qing, LS; Xue, Y | 1 |
| Han, X; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, X; Zheng, L | 1 |
| Han, X; Hu, C; Peng, J; Qi, Y; Tao, X; Wang, C; Xu, L; Xu, Y; Yao, H; Yin, L; Zhao, Y | 1 |
| Han, X; Peng, J; Qi, Y; Sun, H; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L | 1 |
| Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yin, L; Zhao, X | 1 |
| Huo, X; Jia, Y; Liu, K; Liu, Q; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Xu, Q; Zhang, A | 1 |
| Han, X; Peng, J; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhang, W; Zheng, L | 1 |
| Huo, X; Liu, K; Liu, Q; Liu, Z; Meng, Q; Peng, J; Sun, H; Sun, P; Wang, C; Wang, L | 1 |
| Han, X; Liu, K; Peng, J; Qi, M; Qi, Y; Sun, H; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L | 1 |
| An, G; Feng, G; Guo, Y; Liang, X; Song, H; Wang, M; Xing, E; Zhao, X | 1 |
| Chen, P; Jin, HY; Ma, SC; Sun, L | 1 |
| Ji, L; Liang, T; Liang, Y; Liu, R; Shi, L; Xu, L; Yang, F; Yao, N | 1 |
| Han, X; Hu, Y; Peng, J; Qi, Y; Tao, X; Wang, C; Xu, L; Xu, Y; Yin, L; Zhao, Y | 1 |
| Ma, T; Wang, RP; Zou, X | 1 |
| Du, B; Liu, J; Tan, Y; Wu, Y; Wu, Z; Zeng, X; Zhang, G; Zhang, R; Zhang, W; Zhang, X; Zhao, Y | 1 |
| Du, B; Li, B; Liu, X; Tan, Y; Wu, Y; Xiao, J; Zhang, G | 1 |
| Cho, Y; Choi, SZ; Kang, KB; Ryu, J; Son, M; Sung, SH | 1 |
| Chen, W; Dong, X; Du, H; Gao, S; Li, Y; Lu, Y; Yang, R; Yuan, H | 1 |
| Han, X; Liu, K; Ma, X; Peng, J; Qi, Y; Song, S; Tao, X; Xu, L; Xu, Y; Yin, L; Zhang, Y; Zhen, Y | 1 |
| Han, X; Liu, K; Peng, J; Qi, Y; Si, L; Xu, L; Xu, Y; Yin, L; Zhao, Y | 1 |
| He, LY; Li, RL; Shen, GD; Wang, P; Yang, JL | 1 |
| Han, X; Lin, Y; Liu, K; Peng, J; Qi, Y; Song, S; Tao, X; Xu, L; Xu, Y; Yin, L; Zhang, Y; Zhao, Y | 1 |
| Choi, KC; Kim, H; Kim, MK; Kim, YJ; Ko, H; Lee, IH; Lee, KH; Lim, WC | 1 |
| Gu, J; Hu, Y; Li, H; Li, M; Liang, H; Liu, Y; Lu, J; Song, X; Wang, X; Wang, Z; Weng, H; Ye, Y; Zhang, W; Zhang, Y | 1 |
| Du, B; Ji, L; Kou, Y; Liu, L; Liu, Z; Lu, L; Qi, X; Wang, H; Wang, W; Zheng, H; Zou, J | 1 |
| Han, X; Li, L; Peng, J; Qi, Y; Song, S; Sun, P; Tao, X; Xu, L; Xu, Y; Yin, L | 1 |
| Agnihotri, VK; Chand, G; Kumar, A; Maurya, AK | 1 |
| Bao, N; Chen, S; Zhao, J; Zhu, C | 1 |
| Han, X; Li, H; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L | 1 |
| Su, F; Tang, S; Zhu, S | 1 |
| Chen, J; Chen, Y; Du, S; Li, C; Li, S; Liu, F; Lu, Y; Weng, D; Zhang, Y | 1 |
| Han, X; Liu, K; Ma, X; Peng, J; Qi, Y; Qiao, Y; Tang, Z; Tao, X; Xu, L; Xu, Y; Yin, L | 1 |
| Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y | 1 |
| Hu, KX; Jiao, Y; Ju, HY; Song, X; Tang, ZS | 1 |
| Cheng, B; Cui, Y; Hou, L; Huang, L; Li, S; Shen, X; Xu, D | 1 |
| Li, C; Li, J; Liang, Q; Liu, M; Zhang, Y | 1 |
| Chen, CY; Lee, H; Wang, L; Wang, YC; Wu, DW; Wu, TC | 1 |
| Jia, Q; Li, W; Liu, W; Shen, J; Su, Q; Wang, Y; Yin, J; Zhang, J; Zhang, X; Zhao, Z | 1 |
| Cai, J; Chen, Y; Yang, L; Zeng, H; Zhang, X | 1 |
| Peng, J; Qi, Y; Tao, X; Xu, L; Yin, L; Zhao, L | 1 |
| Han, X; Peng, J; Qi, Y; Tao, X; Xu, L; Xu, Y; Yao, H; Yin, L; Zheng, L | 1 |
| Chan, SH; Guh, JH; Liang, PH | 1 |
| Bing, L; Xie, Y; Yu, F; Yu, W | 1 |
| Cao, F; Cao, YK; Li, CW; Li, Y; Wang, YB; Wu, Q; Xu, B; Yang, B; Zhang, J; Zhao, H | 1 |
| Hussain, SS; Ma, YL; Thakur, K; Wang, J; Wei, ZJ; Zhang, JG; Zhang, Q; Zhang, YS | 1 |
| Chen, L; Lei, L; Li, Q; Li, T | 1 |
| Hu, Y; Mao, Z; Peng, J; Qi, Y; Sun, P; Tang, Z; Tao, X; Xu, L; Yin, L | 1 |
| Peng, J; Tao, X; Xu, L; Yin, L | 1 |
| Liu, M; Lu, J; Sun, H; Wang, S; Zhang, T | 1 |
| Fang, L; Liu, K; Peng, J; Sun, P; Xu, L; Xu, M; Yin, L; Zhao, X | 1 |
| Cheng, J; Hao, Q; Sun, C; Xue, Y; Zhang, J; Zou, Q | 1 |
| Li, H; Yu, L; Zhao, C | 1 |
| Han, X; Hu, Y; Liu, K; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zhao, X; Zheng, L | 1 |
| Huang, Y; Liu, X; Ma, T; Quan, G; Sui, Y; Wang, F; Yang, L; Zhong, L | 1 |
| Chen, D; Fang, L; Han, X; Liu, K; Mao, Z; Peng, J; Qi, Y; Sun, H; Xu, L; Xu, Y; Yin, L | 1 |
| Huang, T; Sun, L; Wei, Q; Xiao, X; Zhang, Z; Zhu, T | 1 |
| Cao, YJ; Hou, L; Li, XS; Liu, B; Qi, Y; Sun, YM; Wan, CP; Wen, WB; Wu, J; Xu, Y; Zhang, Y; Zheng, X | 1 |
| An, G; Feng, G; Guo, Y; Song, H; Wang, M; Xing, E; Zhao, X | 1 |
| Han, X; Li, R; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L | 1 |
| Chen, S; Fan, T; He, J; Kang, Y; Li, X; Wen, K; Yin, Y; Zhao, H | 1 |
| Chen, J; Chen, Y; Du, S; Lei, X; Li, C; Li, S; Liu, F; Lu, Y; Weng, D; Zhang, Y | 1 |
| Ao, W; Chen, B; Hou, Y; Ke, J; Liang, Q; Wang, K; Wei, X; Xiao, J; Zhan, Y; Zhou, S; Zhu, P | 1 |
| Fan, L; Fu, M; Li, G; Li, J; Li, X; Liu, J; Pan, W; Wang, X; Wang, Y; Yang, Y; Yu, Y | 1 |
| An, L; Ma, J; Piao, X; Wang, H; Wu, X; Yuan, Y; Zhang, J; Zhou, L | 1 |
| Jin, Y; Liu, K; Ma, X; Sun, H; Wang, C; Wang, J; Xie, T; Yang, Q | 1 |
| Jiang, S; Li, J; Pan, W; Wang, X; Wang, Y; Yang, X; Yang, Y; Yu, Y; Zhang, Z | 1 |
| Liu, X; Ma, Z; Ren, S; Wang, L; Xu, F; Yang, L | 1 |
| Cai, X; Chen, L; Cheng, C; Ding, Q; Liu, X; Mo, F; Peng, G; Wang, J; Yang, S; Zhang, W | 1 |
| Chen, J; Li, H; Li, N; Wang, J; Wu, S; Xia, Y; Zhao, B; Zhao, F; Zhao, J; Zhao, S | 1 |
| Li, Y; Wang, M; Yang, T | 1 |
| Cai, FY; Fu, M; He, SY; Jing, M; Ju, RJ; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Yao, XM; Zhang, L | 1 |
| Bai, L; Li, M; Liu, H; Peng, S; Shi, X; Sun, F; Wang, L | 1 |
| Gao, F; Gong, G; Li, M; Li, T; Li, W; Liu, H; Liu, W; Yu, X; Zhou, L; Zuo, H | 1 |
| Bai, H; Dong, M; Liu, Q; Liu, S; Niu, W; Shi, C; Wang, L; Wang, Q; Yang, X; Yin, W | 1 |
| Han, X; Jin, Y; Liu, KX; Peng, JY; Qi, Y; Xu, LN; Xu, YW; Yin, LH; Zhao, YY | 1 |
| Jiang, W; Lin, M; Wang, Z | 1 |
| Cai, FY; Fu, M; He, SY; Jing, M; Ju, RJ; Kong, L; Li, XT; Liu, JJ; Liu, XZ; Niu, FJ; Yao, XM; Zhang, L | 1 |
| Wang, H; Yang, X; Zhu, H | 1 |
| Chen, W; Du, B; He, Y; Jin, H; Mao, W; Tan, Y; Wu, S; Yin, H; Zhang, R; Zhao, T | 1 |
| Chen, J; Cui, L; Fang, L; Lu, G; Lu, S; Yang, G; Yao, Y; Ye, J; Zhou, J | 1 |
| Choi, SS; de Guzman, ACV; Purevdulam, B; Razzak, MA | 1 |
| Han, K; Jia, N; Sun, C; Wang, C; Zhang, Z | 1 |
| Han, J; Jiang, D; Li, F; Li, W; Shi, G; Xie, Y | 1 |
| Chen, R; Chen, W; Gao, W; Gu, Y; Qi, H; Wang, L; Zhao, H | 1 |
| Liu, X; Ma, Z; Yang, L | 1 |
| Cui, L; Fang, X; Lu, G; Yang, G; Yao, Y; Ye, J; Zeng, Z; Zhou, J | 1 |
| Gao, J; Han, L; Ma, J; Tan, Y; Wang, L; Wang, T; Yu, H; Zhang, Y | 1 |
| Cespedes-Acuña, CL; Li, XL; Ma, RH; Ni, ZJ; Thakur, K; Wang, S; Wei, ZJ; Zhang, JG | 1 |
| Han, X; Peng, JY; Qi, Y; Song, S; Sun, C; Xu, L; Xu, Y; Yang, Y; Yin, L; Zhao, Y; Zhu, M | 1 |
| Fu, S; Guo, W; Hou, S; Hu, G; Kan, X; Liu, J; Ran, X; Yan, Z; Yang, Y | 1 |
| Chen, Y; Huang, Q; Jiang, M; Li, X; Liang, J; Liu, S; Qin, A; Qu, L; Yuan, C; Zou, W | 1 |
| Chen, X; Fu, X; Gu, W; Tian, H; Wang, Y; Wen, Y; Zhang, Y | 1 |
| Gao, M; Li, Y; Peng, JY; Qi, Y; Sun, P; Xu, LN; Yin, LH | 1 |
| Chen, G; Xie, Y | 1 |
| Gao, S; Guo, YT; Hang, CH; Li, W; Liu, C; Lu, Y; Tao, T; Wang, WH; Zhang, XS; Zhou, Y; Zhuang, Z | 1 |
| He, C; Kong, C; Li, R; Lu, Q; Lyu, D | 1 |
| Dong, L; Han, X; Li, R; Qi, Y; Xu, L; Xu, Y; Yin, L | 1 |
| Cai, J; Cao, Y; Dong, X; Fan, P; Liu, J; Liu, X; Zhang, N; Zhu, K | 1 |
| Huang, BY; Mai, CT; Wang, CL; Wang, QM; Wang, TT; Wu, MM; Zhang, XJ | 1 |
| Gao, Y; Li, X; Mi, X; Xu, Z | 1 |
| He, C; Lu, Q; Lyu, D; Qian, H; Shen, T; Tian, Q; Xi, J; Xiao, P | 1 |
| Chen, J; Gao, H; Li, Y; Lin, C; Zhang, J; Zhang, Y | 1 |
| Lu, Z; Peng, JY; Wang, J; Yao, Y | 1 |
| Bai, JX; Chen, YJ; Chou, JY; Fu, XQ; Li, JK; Li, SM; Liu, YX; Niu, XD; Wang, XQ; Wu, JY; Wu, Y; Xu, BW; Yin, CL; Yu, ZL | 1 |
| Azuma, K; Gao, X; Liu, X; Saido, TC; Saito, T; Wang, KY; Wang, X; Zhang, JH; Zhou, Q | 1 |
| Anand, U; Bandopadhyay, S; Behl, T; Dey, A; Gadekar, VS; Gupta, PK; Jha, NK; Kumar, M; Shekhawat, MS | 1 |
| Li, N; Liu, L; Wang, Y; Yue, X; Zhang, Y | 1 |
| Adamski, R; Dworniczek, E; Krzyżek, P; Spiegel, M; Sroka, Z | 1 |
| Li, H; Li, S; Liu, J; Nie, B; Pang, B; Qu, S; Xu, J; Yang, M; Zhang, K | 1 |
| Du, G; Gao, F; Gu, W; Kui, F; Li, W; Liu, Z; Lu, L; Niu, Y; Xi, P; Zhang, Y | 1 |
| Guan, T; Hu, M; Huang, S; Jin, S; Liu, X; Liu, Y; Wang, S | 1 |
| Qi, Y; Shang, Q; Shang, W; Zeng, J; Zhu, L | 1 |
| Chen, W; Chen, X; Dong, L; Jin, R; Shi, L; Zhang, P | 1 |
| Bao, R; Chen, B; Chen, Q; Han, L; Liu, M; Pan, J; Wang, D; Wang, T; Wang, W; Wu, Y; Yu, H; Zhang, Y | 1 |
| Azam, S; Cho, DY; Choi, DK; Haque, ME; Jakaria, M; Kim, IS; Kim, JS | 1 |
| Gao, M; Li, L; Mao, Z; Peng, J; Zhao, X | 1 |
| Gao, M; Qi, Y; Wang, J; Xu, L; Yin, L; Zhang, Z; Zhao, X | 1 |
| Deng, S; Jin, S; Li, D; Li, J; Liu, X; Liu, Y; Zhu, T | 1 |
| Ahn, JY; Azam, S; Choi, DK; Jakaria, M; Kim, IS; Kim, YS; Yu, YJ | 1 |
| Fan, L; Li, J; Liu, B; Ni, R; Song, Y; Wang, A; Wang, H; Zhang, L | 1 |
5 review(s) available for diosgenin and dioscin
| Article | Year |
|---|---|
[Advances in study of dioscin--a natural product].
Topics: Animals; Biological Products; Diosgenin; Humans; Plant Extracts | 2015 |
Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Diosgenin; Humans; Metabolic Diseases; Neoplasms | 2018 |
Recent Advances in the Pharmacological Activities of Dioscin.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Diosgenin; Humans; Saponins | 2019 |
Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases.
Topics: Animals; Cardiotonic Agents; Diosgenin; Heart; Heart Diseases; Humans; Plant Extracts | 2021 |
Dioscin: A review on pharmacological properties and therapeutic values.
Topics: Diosgenin; Humans; Neoplasms; Plant Extracts; Saponins | 2022 |
219 other study(ies) available for diosgenin and dioscin
| Article | Year |
|---|---|
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
Topics: Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Candida albicans; Cryptococcus neoformans; Drug Screening Assays, Antitumor; Humans; Kenya; Leukemia P388; Plants, Medicinal; Sansevieria; Saponins; Spirostans; Tumor Cells, Cultured | 2005 |
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diosgenin; Molecular Structure; Molecular Weight; Polyethylene Glycols | 2012 |
Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae).
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dioscorea; Humans; Isocoumarins; Lung; Lung Neoplasms; Phenanthrenes; Plant Extracts; Rhizome | 2017 |
Effect of food toxicants on voluntary wheel running in rats.
Topics: Animals; Cadmium; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Food Deprivation; Glycosides; Iron; Iron Deficiencies; Liver; Male; Motor Activity; Rats; Sapogenins; Testis | 1979 |
Antiviral activity of constituents of Tamus communis.
Topics: Animals; Antiviral Agents; Cell Division; Cells, Cultured; Diosgenin; HeLa Cells; Humans; Plants, Medicinal; Rhinovirus; RNA, Viral; Spirostans; Vesicular stomatitis Indiana virus; Virus Replication | 1991 |
Steroidal glycosides of Tamus communis.
Topics: Diosgenin; Glycosides; Plants, Medicinal; Sapogenins; Spirostans; Steroids | 1984 |
Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
Topics: Antineoplastic Agents; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drugs, Chinese Herbal; Glycosides; Molecular Sequence Data; Saponins; Spirostans; Tumor Cells, Cultured | 1996 |
Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Glycosylation; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Optical Rotation; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1999 |
Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
Topics: Apoptosis; Cell Differentiation; Cell Division; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Saponins | 2001 |
Apoptosis induced by dioscin in Hela cells.
Topics: Apoptosis; Caspases; Cell Division; Diosgenin; Dose-Response Relationship, Drug; HeLa Cells; Humans; Proto-Oncogene Proteins c-bcl-2 | 2002 |
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Topics: Animals; Biological Factors; Colonic Neoplasms; Diosgenin; Disease Models, Animal; Diterpenes; Drug Screening Assays, Antitumor; Female; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Leukemia P388; Male; Melanoma; Mice; Molecular Structure; Naphthoquinones; Ovarian Neoplasms; Paclitaxel; Polymers; Prostatic Neoplasms; Triterpenes; Tumor Cells, Cultured | 2002 |
A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
Topics: Antineoplastic Agents; Diosgenin; Magnetic Resonance Spectroscopy; Saponins; Tropanes | 2002 |
Synthesis of monomethylated dioscin derivatives and their antitumor activities.
Topics: Animals; Antineoplastic Agents; Cell Division; Diosgenin; Humans; Methylation; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
Topics: Acetylation; Carbohydrate Conformation; Diosgenin; Guanidine; Saponins; Spirostans | 2003 |
A new steroidal saponin from Dioscorea zingiberensis Wright.
Topics: Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Structure; Rhizome; Saponins; Sterols | 2003 |
Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Body Weight; Diet; Dietary Fats; Dioscorea; Diosgenin; Emulsions; Feces; Lipase; Male; Mice; Obesity; Organ Size; Pancreas; Plant Extracts; Rats; Rats, Sprague-Dawley; Triglycerides | 2003 |
[Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Diosgenin; Flow Cytometry; Humans; K562 Cells; Microscopy, Electron, Scanning; Saponins | 2003 |
Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin.
Topics: Dioscoreaceae; Diosgenin; Saponins | 1956 |
Structures of dioscin, gracillin, and kikuba-saponin. 2. (Saponins of Japanese Dioscoreaceae. XI.
Topics: Dioscoreaceae; Diosgenin; Plants; Saponins; Spirostans; Steroids | 1962 |
Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.
Topics: 14-3-3 Proteins; Blotting, Western; Brain Ischemia; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavanones; Flavonoids; Gene Expression; Glycosides; Hippocampus; Maze Learning; Memory Disorders; Oligonucleotide Array Sequence Analysis; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine 3-Monooxygenase | 2004 |
Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
Topics: Carbohydrate Conformation; Cell Survival; Diosgenin; Fluorides; Glycosylation; HeLa Cells; Humans; Models, Molecular; Saponins; Steroids; Trisaccharides | 2005 |
Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
Topics: Animals; Bacteriocins; Biological Factors; Cell Line, Tumor; Diosgenin; Fatty Acids; Models, Molecular; Molecular Conformation; Peptides; Rats; Receptors, Chemokine; Receptors, CXCR3 | 2005 |
[Steroidal constituents from Dioscorea parviflora].
Topics: Dioscorea; Diosgenin; Molecular Conformation; Molecular Structure; Plants, Medicinal; Rhizome; Saponins; Steroids | 2005 |
Characterization of the pharmacokinetics of dioscin in rat.
Topics: Administration, Oral; Animals; Bile; Biological Availability; Biotransformation; Diosgenin; Dose-Response Relationship, Drug; Feces; Female; Injections, Intravenous; Male; Molecular Structure; Rats; Rats, Wistar; Tissue Distribution; Urine | 2005 |
Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.
Topics: Animals; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Diosgenin; Electrophoresis, Polyacrylamide Gel; Glycoside Hydrolases; Hydrolysis; Liver; Molecular Weight; Swine | 2005 |
Proteomic approach to study the cytotoxicity of dioscin (saponin).
Topics: Apoptosis; Diosgenin; Drug Screening Assays, Antitumor; Electrophoresis, Gel, Two-Dimensional; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Models, Chemical; Polygonatum; Proteomics; Saponins; Silver Staining; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.
Topics: Animals; Bacteroides fragilis; Blood Glucose; Cholesterol; Dioscorea; Diosgenin; Feces; Food, Organic; Gastric Acid; Gastrointestinal Agents; Gastrointestinal Motility; Gastrointestinal Tract; Lipids; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome; Time Factors | 2006 |
Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
Topics: Cholestanes; Diosgenin; Hydrocarbons, Iodinated; Molecular Structure; Saponins; Spirostans; Sulfur Compounds | 2006 |
Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
Topics: Cell Line, Tumor; Diosgenin; Humans; Tropanes | 2006 |
[Study on steroidal compounds from Dioscorea zingiberensis].
Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Roots; Plants, Medicinal; Spirostans; Steroids | 2006 |
[Study on steroidal saponins of Dioscorea septemloba thunb].
Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Tubers; Plants, Medicinal; Saponins; Steroids | 2006 |
Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
Topics: Animals; Arecaceae; Blood Glucose; Diosgenin; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Methanol; Molecular Structure; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Time Factors | 2007 |
Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Methanol; Plant Extracts; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
Topics: Cell Death; Cell Line, Tumor; Diosgenin; Erythrocytes; Hemolysis; Humans; Saponins | 2007 |
Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Diosgenin; HL-60 Cells; Humans; Microsomes; Mitochondria; Molecular Sequence Data; Proteomics; Reactive Oxygen Species; Saponins | 2007 |
Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.
Topics: Animals; Cells, Cultured; Dioscorea; Diosgenin; Growth Hormone; Korea; Magnetic Resonance Spectroscopy; Molecular Structure; Pituitary Gland; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone | 2007 |
[Selection of the microorganism for dioscin hydrolyze].
Topics: Alternaria; Aspergillus; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dioscorea; Diosgenin; Hydrolysis; Plants, Medicinal; Rhizome | 2007 |
Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
Topics: Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dioscorea; Diosgenin; Light; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plant Roots; Saponins; Scattering, Radiation; Solvents; Spectrometry, Mass, Electrospray Ionization; Spirostans | 2008 |
Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
Topics: Alkanes; Cholesterol; Diosgenin; Hemolysis; Lipid Bilayers; Membrane Microdomains; Molecular Dynamics Simulation; Molecular Structure; Saponins; Water | 2010 |
Anthelmintic activity of steroidal saponins from Paris polyphylla.
Topics: Animals; Anthelmintics; Diosgenin; Goldfish; Liliaceae; Plant Extracts; Rhizome; Saponins; Trematoda | 2010 |
New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.
Topics: Absidia; Diosgenin; Enzyme Stability; Fungal Proteins; Glycoside Hydrolases; Glycosides; Hydrolysis; Kinetics | 2010 |
Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Diosgenin; Endoplasmic Reticulum Chaperone BiP; Liver; Male; Mice; Necrosis; Protective Agents; Protein Interaction Mapping; Proteomics; Silymarin | 2011 |
Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diosgenin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, MDR; Genetic Vectors; HEK293 Cells; Hep G2 Cells; Hepatocytes; High-Throughput Screening Assays; Humans; Liver Neoplasms; Plasmids; RNA, Messenger | 2011 |
[Effects of organic solvents on proliferation of Hela cells line].
Topics: Apoptosis; Cell Proliferation; Cell Survival; Dimethyl Sulfoxide; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; HeLa Cells; Humans; Solubility; Solvents; Staining and Labeling | 2011 |
Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.
Topics: Apoptosis; Calcium; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; Drugs, Chinese Herbal; Female; Humans; Mitochondria; Mitochondrial Membranes; Ovarian Neoplasms; Permeability; Trillium | 2011 |
Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.
Topics: Animals; Apoptosis; Calcium; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; G2 Phase; Humans; Liliaceae; Plant Extracts; Stomach Neoplasms | 2011 |
Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Diosgenin; Down-Regulation; Gene Expression Profiling; Humans; Membrane Potential, Mitochondrial; Oxidative Stress; Peroxiredoxin VI; Peroxiredoxins; Reactive Oxygen Species | 2012 |
Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Diosgenin; Down-Regulation; Fas Ligand Protein; fas Receptor; Humans; Mitochondria; Radioimmunoassay; RNA, Messenger; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.
Topics: Animals; Body Weight; Diosgenin; Drinking Behavior; Feeding Behavior; Female; Male; Organ Size; Rats; Rats, Sprague-Dawley | 2012 |
Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; Diosgenin; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Protective Agents; Superoxide Dismutase | 2012 |
Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Carcinoma, Renal Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Diosgenin; Down-Regulation; Humans; Kidney Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Biological Products; Chemical and Drug Induced Liver Injury; Comet Assay; Diosgenin; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Mitochondria; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.
Topics: Agaricales; Diosgenin; Enzyme Inhibitors; Fungal Proteins; Kinetics; Monophenol Monooxygenase; Plant Extracts; Plant Roots; Smilax | 2012 |
Dioscin's antiviral effect in vitro.
Topics: Adenoviridae; Antiviral Agents; Cell Line; Dioscorea; Diosgenin; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Plant Extracts; Vesiculovirus; Virus Internalization; Virus Replication | 2013 |
The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.
Topics: Antifungal Agents; Biophysics; Candida albicans; Cell Membrane; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Flow Cytometry; Fluoresceins; Membrane Potentials; Microbial Sensitivity Tests; Microscopy, Fluorescence; Plant Extracts; Propidium; Rhodamines; Time Factors | 2013 |
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
Topics: Animals; Diosgenin; HEK293 Cells; Humans; In Vitro Techniques; Liver; Male; Organic Anion Transporters; Rats; Rats, Wistar | 2013 |
Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Cardiovascular Agents; Cholesterol, Dietary; Diet; Dioscorea; Diosgenin; Disease Models, Animal; Fatty Liver; Food Handling; Functional Food; Hypercholesterolemia; Liver; Male; Nanoparticles; Particle Size; Plant Preparations; Plant Tubers; Rabbits | 2013 |
Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.
Topics: Annexin A5; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Diosgenin; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Oncogene Protein v-akt; Organelles; Phosphatidylinositol 3-Kinases; Signal Transduction | 2013 |
Therapeutic effect of Rhizoma Dioscoreae Nipponicae on gouty arthritis based on the SDF-1/CXCR 4 and p38 MAPK pathway: an in vivo and in vitro study.
Topics: Animals; Arthritis, Gouty; Chemokine CXCL12; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Fibroblasts; Interleukin-1beta; Male; MAP Kinase Kinase 3; MAP Kinase Kinase 6; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptors, CXCR4; Rhizome; Signal Transduction; Synovial Membrane; Uric Acid | 2014 |
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Dioscorea; Diosgenin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; I-kappa B Proteins; K562 Cells; Leukemia, Erythroblastic, Acute; Luciferases; NF-kappa B; NF-KappaB Inhibitor alpha; RNA, Messenger; Signal Transduction | 2013 |
Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
Topics: Dioscorea; Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Saponins; Spirostans | 2013 |
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Large Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytosol; Diosgenin; DNA Damage; Humans; Inhibitory Concentration 50; Lung Neoplasms; Microscopy, Electron, Transmission; Mitochondria; Protein Transport; S Phase; Signal Transduction; Small Cell Lung Carcinoma | 2013 |
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Diosgenin; DNA Damage; Glioblastoma; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Neoplasm Transplantation; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Survival Analysis; Tumor Burden | 2013 |
Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Cell Line; Coloring Agents; Cytochromes c; Diosgenin; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; L-Lactate Dehydrogenase; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Myocardium; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2014 |
Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa.
Topics: Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cytochrome P-450 CYP3A; Dioscorea; Diosgenin; Half-Life; Humans; Inhibitory Concentration 50; Intestinal Absorption; Metabolic Detoxication, Phase II; Parasympatholytics; Permeability; Plant Extracts | 2013 |
[Effects of dioscornin tablet containing serum on NF-kappaB p65, STAT3, and VEGF mRNA expressions in rats' synovial cell strain RSC-364 induced by IL-17 and TNF-alpha].
Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Diosgenin; Interleukin-17; Male; Neovascularization, Pathologic; Rats; Rats, Wistar; RNA, Messenger; Serum; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Ginsenosides; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spirostans; Tandem Mass Spectrometry | 2013 |
Protective effects of dioscin against alcohol-induced liver injury.
Topics: Animals; Cytochrome P-450 CYP2E1; Diosgenin; Disease Models, Animal; Ethanol; Fatty Acids; Fatty Liver, Alcoholic; Liver; Liver Diseases, Alcoholic; Male; Mice, Inbred C57BL; Protective Agents; Rats; Rats, Wistar; Toxicity Tests, Acute; Toxicity Tests, Chronic | 2014 |
Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades.
Topics: Animals; Bone Resorption; Cell Differentiation; Diosgenin; Down-Regulation; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Proto-Oncogene Proteins c-akt; Signal Transduction; Treatment Outcome | 2014 |
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Shape; Cell Survival; Colonic Neoplasms; Diosgenin; DNA Damage; HCT116 Cells; Humans; Isotope Labeling; Nitric Oxide; Nitric Oxide Synthase Type II; Proteins; Proteome; Proteomics; Reactive Oxygen Species | 2014 |
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Humans; Male; Molecular Structure; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Time Factors | 2014 |
Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Drug Resistance, Neoplasm; Enterocytes; Genes, Reporter; Humans; I-kappa B Proteins; Intestinal Absorption; Intestine, Small; Male; Methotrexate; NF-kappa B; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transfection | 2014 |
[Effects of dioscin on apoptosis in pancreatic cancer MiaPaCa-2 cells and its mechanism].
Topics: Apoptosis; Diosgenin; Humans; Pancreatic Neoplasms; Peroxiredoxins; Reactive Oxygen Species | 2014 |
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Diosgenin; Estrogen Receptor alpha; Gene Expression Regulation, Developmental; Humans; Low Density Lipoprotein Receptor-Related Protein-5; Mice; Osteoblasts; Osteoporosis; Receptor Activator of Nuclear Factor-kappa B; RNA Interference; Signal Transduction | 2014 |
Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Diosgenin; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases | 2014 |
Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspases; Cell Line, Tumor; Diosgenin; Female; Humans; Inhibitor of Apoptosis Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2 | 2014 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hypertension; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Uric Acid; Xanthine Oxidase | 2014 |
Rapid metabolic discrimination and prediction of dioscin content from African yam tubers using Fourier transform-infrared spectroscopy combined with multivariate analysis.
Topics: Dioscorea; Diosgenin; Least-Squares Analysis; Multivariate Analysis; Spectroscopy, Fourier Transform Infrared | 2015 |
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Diosgenin; Dose-Response Relationship, Drug; Inflammation; Liver; Male; Nitrogen; Oxidative Stress; Phosphorylation; Rats; Rats, Wistar; Reperfusion Injury; Time Factors; Warm Ischemia | 2014 |
Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; Tumor Burden; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice.
Topics: 3T3-L1 Cells; Acetyl-CoA Carboxylase; Adipocytes; Adipogenesis; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Composition; Cell Differentiation; Cell Survival; Diet, High-Fat; Diosgenin; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Triglycerides; Weight Gain | 2014 |
Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cell Proliferation; Diosgenin; Endothelium, Vascular; Gene Expression Regulation; Humans; I-kappa B Kinase; Intercellular Adhesion Molecule-1; Lipase; Monocytes; NF-kappa B; Proteolysis; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2015 |
Potent effects of dioscin against obesity in mice.
Topics: Animals; Autophagy; Blood Glucose; Body Weight; Cholesterol; Diet, High-Fat; Diosgenin; Energy Metabolism; Fatty Acids; Glucose Tolerance Test; Inflammation; Liver; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Obese; Obesity; Oxidative Stress; Phosphorylation; Signal Transduction; Triglycerides | 2015 |
Metabolic profiles of dioscin in rats revealed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Male; Mass Spectrometry; Molecular Structure; Rats; Rats, Sprague-Dawley | 2015 |
UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Feces; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Saponins | 2015 |
Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Survival; Diosgenin; Gene Expression; HMGB1 Protein; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; PC12 Cells; Protein Transport; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2015 |
Potent effects of dioscin against liver fibrosis.
Topics: Animals; Apoptosis; Cellular Senescence; Diosgenin; Extracellular Matrix; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Signal Transduction; Smad Proteins; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Wnt Signaling Pathway | 2015 |
In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Cycle; Computational Biology; Dioscorea; Diosgenin; DNA Topoisomerases, Type I; Down-Regulation; Drugs, Chinese Herbal; Epidermal Growth Factor; ErbB Receptors; Gene Regulatory Networks; Humans; Male; MAP Kinase Signaling System; Mice; Neoplasms; Phytotherapy; Protein Binding; Rats; Signal Transduction | 2015 |
Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
Topics: Asparagus Plant; Cell Line, Tumor; Diosgenin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Mucin 5AC; Plant Roots; Saponins; Tetradecanoylphorbol Acetate | 2015 |
Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Diosgenin; Liver Cirrhosis; Male; Proteomics; Rats; Rats, Wistar | 2015 |
[New variety breeding of Dioscorea alata, cultivar "Wenshanyao No.1].
Topics: Allantoin; Breeding; Dioscorea; Diosgenin; Polysaccharides | 2015 |
Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70.
Topics: Animals; Cells, Cultured; Diosgenin; Down-Regulation; HSP70 Heat-Shock Proteins; Humans; Kidney; Myeloid Differentiation Factor 88; Rats; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2015 |
Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF.
Topics: alpha-MSH; Animals; Cyclic AMP Response Element-Binding Protein; Diosgenin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Intramolecular Oxidoreductases; Melanins; Melanoma, Experimental; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Phosphorylation; Plant Extracts; Solanum melongena | 2015 |
Inhibition of dioscin on Saprolegnia in vitro.
Topics: Animals; Cell Membrane Permeability; Diosgenin; Fishes; Formaldehyde; Hydrogen Peroxide; Mycelium; Reactive Oxygen Species; Saprolegnia | 2015 |
Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.
Topics: Biological Transport; Carrier Proteins; Diosgenin; Diterpenes, Kaurane; Drug Interactions; Glucuronides; HEK293 Cells; Humans; Molecular Structure; Rosuvastatin Calcium | 2015 |
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
Topics: Animals; Diosgenin; Down-Regulation; Hepatic Stellate Cells; Interleukin-6; Liver Cirrhosis, Alcoholic; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2015 |
[Preliminary study on hepatotoxicity induced by dioscin and its possible mechanism].
Topics: Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Diosgenin; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2015 |
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Neoplasm Invasiveness; Phytosterols; Plant Extracts; Plant Roots; Saponins; Treatment Outcome | 2016 |
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
Topics: Animals; Bile Ducts; Dimethylnitrosamine; Diosgenin; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Humans; Ligation; Liver Cirrhosis; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sirtuin 1 | 2016 |
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; DNA Damage; Humans; Laryngeal Neoplasms; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitochondria; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Protein Kinase Inhibitors; Reactive Oxygen Species | 2016 |
An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
Topics: Animals; Chloroform; Chromatography, High Pressure Liquid; Diosgenin; Male; Methanol; Mice, Obese; Plant Extracts; Saponins; Solid Phase Extraction; Tandem Mass Spectrometry; Trigonella | 2015 |
A Rapid Study of Botanical Drug-Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin-Functionalized Magnetic Nanoparticles.
Topics: Diosgenin; Drug Interactions; Humans; Magnetics; Metal Nanoparticles; Molecular Structure; Protein Binding; Serum Albumin | 2015 |
Potent effects of dioscin against gastric cancer in vitro and in vivo.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Diosgenin; DNA Damage; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Proteome; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms | 2016 |
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cytokines; Dioscorea; Diosgenin; Hep G2 Cells; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2016 |
Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis.
Topics: Animals; Bone and Bones; Cell Differentiation; Cell Line; Cell Proliferation; Dioscorea; Diosgenin; Female; Humans; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis, Postmenopausal; Ovariectomy; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Topics: Apoptosis; Cell Proliferation; Diosgenin; DNA Damage; Female; HeLa Cells; Humans; Mitochondria; Reactive Oxygen Species; Signal Transduction; Uterine Cervical Neoplasms | 2016 |
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Topics: 1-Naphthylisothiocyanate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cholestasis, Intrahepatic; Diosgenin; Estrone; Hepatocytes; Liver; Male; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Protective Agents; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 2016 |
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Dimethylnitrosamine; Dioscorea; Diosgenin; Interferon-Stimulated Gene Factor 3, gamma Subunit; Male; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Toll-Like Receptor 4 | 2016 |
Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1.
Topics: ATP Binding Cassette Transporter, Subfamily B; Autophagy; Breast Neoplasms; Cell Proliferation; Diosgenin; Down-Regulation; Doxorubicin; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; NF-kappa B; Promoter Regions, Genetic; Signal Transduction | 2016 |
Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Caspase 3; Cell Line; Diosgenin; Humans; Kidney Diseases; Lipopolysaccharides; Male; Mice, Inbred C57BL; MicroRNAs; Myeloid Differentiation Factor 88; NF-kappa B; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Toll-Like Receptor 4 | 2016 |
Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Dioscorea; Diosgenin; Disease Models, Animal; Diterpenes; Epoxy Compounds; GATA3 Transcription Factor; Humans; Male; Mice; Mice, Inbred DBA; Phenanthrenes; STAT Transcription Factors; Synovial Membrane; Th1 Cells; Th1-Th2 Balance; Th2 Cells | 2016 |
Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
Topics: Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Liliaceae; Quality Control; Saponins | 2016 |
Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.
Topics: Animals; Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Female; Homeostasis; Humans; Liver; Male; Mitochondria; Oxidative Stress; Rats, Wistar; Rhizome; Saponins; Signal Transduction; Up-Regulation | 2016 |
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Topics: Animals; Diosgenin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Humans; Isoenzymes; Male; Models, Biological; Protective Agents; Protein Kinase C beta; Protein Kinase C-alpha; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Stomach | 2016 |
Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR.
Topics: Aged; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Retrospective Studies; RNA, Long Noncoding; Stomach Neoplasms | 2016 |
Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Diosgenin; DNA Fragmentation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2016 |
Dioscin augments HSV-tk-mediated suicide gene therapy for melanoma by promoting connexin-based intercellular communication.
Topics: Animals; Antiviral Agents; Bystander Effect; Cell Communication; Cell Survival; Connexin 26; Connexin 43; Connexins; Diosgenin; Disease Models, Animal; Drug Synergism; Ganciclovir; Genes, Transgenic, Suicide; Genetic Therapy; Melanoma, Experimental; Mice; Mutation; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 2017 |
Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and
Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Preparations; Quality Control; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization | 2017 |
Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.
Topics: Animals; Diosgenin; Doublecortin Domain Proteins; Doublecortin Protein; Encephalitis; Endotoxemia; Gene Expression Profiling; Glial Fibrillary Acidic Protein; Hippocampus; Ki-67 Antigen; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Real-Time Polymerase Chain Reaction; Serotonin; Serotonin Receptor Agonists | 2017 |
Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Cytokines; Diosgenin; Doxorubicin; Glutathione Transferase; Heme Oxygenase (Decyclizing); Kidney; Kidney Diseases; Male; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear | 2017 |
Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of the Akt1 signalling pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasms, Experimental; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats.
Topics: Animals; Atherosclerosis; Cells, Cultured; Cholesterol; Diosgenin; Foam Cells; Hyperlipidemias; Interleukin-1beta; Interleukin-6; Lipoproteins, LDL; Macrophages; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Scavenger Receptors, Class E | 2017 |
Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cisplatin; Diosgenin; Dose-Response Relationship, Drug; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Sirtuin 1; Structure-Activity Relationship | 2017 |
Dioscin suppresses TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Molecular Structure; Structure-Activity Relationship; Transforming Growth Factor beta1 | 2017 |
Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diosgenin; Gallbladder Neoplasms; Glutathione; Humans; Male; Membrane Potential, Mitochondrial; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization.
Topics: Animals; Connexin 43; Diosgenin; Female; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; RAW 264.7 Cells; Up-Regulation | 2017 |
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Topics: Amino Acids; Animals; Collagen; Diosgenin; Humans; Integrin alpha5; Isotope Labeling; Liver Cirrhosis; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proteomics; Rats; Signal Transduction | 2017 |
Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS.
Topics: Caffeic Acids; Costus; Diosgenin; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Plant Leaves; Plants, Medicinal; Rhizome; Saponins; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Steroids; Sterols; Tandem Mass Spectrometry | 2018 |
Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Diosgenin; Mice; NF-kappa B; Osteoblasts; Signal Transduction | 2017 |
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Topics: AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Diosgenin; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thioacetamide | 2018 |
Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model.
Topics: Animals; Brain Ischemia; Diosgenin; HMGB1 Protein; Humans; Inflammation; Interleukin-1 Receptor-Associated Kinases; Myeloid Differentiation Factor 88; NF-kappa B; Oxidative Stress; Rats; Signal Transduction; Stroke; TNF Receptor-Associated Factor 6; Toll-Like Receptor 4; Transforming Growth Factor beta1 | 2018 |
Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice.
Topics: Animals; Blotting, Western; Diosgenin; Epithelial Cells; Female; Flow Cytometry; Hydroxyproline; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Pulmonary Fibrosis; RAW 264.7 Cells; Silicon Dioxide; Silicosis | 2017 |
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Topics: Animals; Diosgenin; Disease Models, Animal; Fibrosis; Fructose; Inflammation; Kidney; Lipid Metabolism; Male; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2018 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative; HCT116 Cells; Humans; Hyperuricemia; Intestinal Elimination; Intestinal Mucosa; Intestines; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Renal Elimination; Spirostans; Time Factors; Uric Acid; Uricosuric Agents | 2018 |
[Preparation and evaluation of dioscin nanostructured lipid carriers].
Topics: Diosgenin; Drug Carriers; Lipids; Nanostructures; Particle Size | 2017 |
Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Diosgenin; HT29 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitochondria; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species | 2018 |
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway.
Topics: Amyloid Precursor Protein Secretases; Animals; Cell Cycle Proteins; Cell Line; Diosgenin; Hepatectomy; Hepatocytes; Humans; Jagged-1 Protein; Liver; Liver Regeneration; Male; Mice, Inbred C57BL; Mice, Transgenic; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction | 2018 |
Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis.
Topics: China; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Gene Expression Profiling; Molecular Sequence Annotation; Phylogeny; Rhizome; Transcriptome | 2018 |
Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Apoptosis; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Diosgenin; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Reactive Oxygen Species | 2018 |
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; beta Catenin; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Diosgenin; Female; Glycogen Synthase Kinase 3; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplastic Stem Cells; Osteosarcoma; Proto-Oncogene Proteins c-akt; Signal Transduction; Young Adult | 2018 |
Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70.
Topics: Acute Lung Injury; Animals; Cytokines; Diosgenin; HSP70 Heat-Shock Proteins; Lipopolysaccharides; Male; Mice; Myeloid Differentiation Factor 88; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2018 |
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Topics: Animals; Apoptosis; Cardiotoxicity; Cell Survival; Diosgenin; Doxorubicin; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; Myocardium; Neoplasm Proteins; Neoplasms; Oxidative Stress; Rats | 2018 |
Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diosgenin; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Signal Transduction; Sirtuin 1 | 2018 |
An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Diosgenin; Energy Metabolism; Humans; Leukemia, Myeloid, Acute; Proteomics; Signal Transduction | 2018 |
Dioscin Promotes Proliferation of Pancreatic Beta Cells via Wnt/β-Catenin Signaling Pathways.
Topics: Apoptosis; beta Catenin; Cell Line; Cell Proliferation; Cell Survival; Diabetes Mellitus, Type 2; Diosgenin; Glucose; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Secreting Cells; Wnt Signaling Pathway | 2018 |
Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
Topics: Animals; Coronary Disease; Diosgenin; Inflammation; Male; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Sirtuin 1; Swine; Swine, Miniature | 2018 |
Molecular mechanism and inhibitory targets of dioscin in HepG2 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Cycle Proteins; Cell Division; Cell Proliferation; Diosgenin; G2 Phase; Genes, cdc; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mitochondria; Polygonatum; Reactive Oxygen Species; Receptors, Death Domain | 2018 |
Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways.
Topics: Angiotensin II; Animals; Cardiomegaly; Diosgenin; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Vasoconstrictor Agents | 2018 |
Protective effect of dioscin against intestinal ischemia/reperfusion injury via adjusting miR-351-5p-mediated oxidative stress.
Topics: Animals; Cell Line; Cell Survival; Diosgenin; Intestinal Mucosa; Intestines; Male; Malondialdehyde; Mice, Inbred C57BL; MicroRNAs; Oxidative Stress; Peroxidase; Protective Agents; Rats; Reperfusion Injury; Superoxide Dismutase | 2018 |
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model.
Topics: Animals; Apoptosis; beta Catenin; Cartilage, Articular; Diosgenin; Disease Models, Animal; Extracellular Matrix; Inflammation; Iodoacetates; Male; Osteoarthritis; Oxidative Stress; PPAR gamma; Protective Agents; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2018 |
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Topics: Animals; Anti-Inflammatory Agents; Dioscorea; Diosgenin; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Systemic Inflammatory Response Syndrome; THP-1 Cells; Toll-Like Receptor 2; Zymosan | 2018 |
The Protective Effects of Preconditioning With Dioscin on Myocardial Ischemia/Reperfusion-Induced Ventricular Arrhythmias by Increasing Connexin 43 Expression in Rats.
Topics: Animals; Arrhythmias, Cardiac; Biomarkers; Connexin 43; Creatine Kinase, MB Form; Diosgenin; Disease Models, Animal; Heart Rate; Male; Myocardial Reperfusion Injury; Phosphorylation; Protective Agents; Rats, Sprague-Dawley; Tachycardia, Ventricular; Troponin I; Up-Regulation; Ventricular Fibrillation; Ventricular Premature Complexes | 2019 |
Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway.
Topics: Adipose Tissue; Adiposity; Animals; Blood Glucose; Diet, High-Fat; Diosgenin; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2019 |
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Hypoxia; Cell Line; Diosgenin; Intestinal Mucosa; Male; MicroRNAs; Mitogen-Activated Protein Kinase 13; Protective Agents; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Dioscin Inhibits Virulence Factors of
Topics: Animals; Antifungal Agents; Biofilms; Candida albicans; Candidiasis; Cell Line; Diosgenin; Mammary Glands, Animal; Virulence; Virulence Factors | 2018 |
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Diosgenin; DNA Damage; Glycolysis; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Phosphoric Monoester Hydrolases; Rats, Wistar; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2019 |
Dioscin Attenuates Myocardial Damages in Diabetic Rats maybe by Regulating NO-sGC-cGMP-PKG Pathway.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diosgenin; Disease Models, Animal; Fibrosis; Guanylate Cyclase; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Dioscin, a Steroidal Saponin Isolated from Dioscorea nipponica, Attenuates Collagen-Induced Arthritis by Inhibiting Th17 Cell Response.
Topics: Animals; Arthritis; Cell Differentiation; Cells, Cultured; Collagen; Cytokines; Dioscorea; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred BALB C; Mice, Inbred DBA; Phytotherapy; Th17 Cells | 2019 |
Effects of dioscin on T helper 17 and regulatory T-cell subsets in chicken collagen type II-induced arthritis mice.
Topics: Animals; Arthritis, Experimental; Chickens; Collagen Type II; Diosgenin; Interleukin-17; Interleukin-6; Interleukins; Male; Mice; Mice, Inbred DBA; STAT3 Transcription Factor; STAT5 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells | 2019 |
Neuroprotective Effect of Dioscin on the Aging Brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Brain; Cell Survival; Cytokines; Diosgenin; Galactose; Glutathione Peroxidase; Hydrogen Peroxide; Male; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2019 |
Dioscin inhibits intimal hyperplasia in rat carotid artery balloon injury model through inhibition of the MAPK-FoxM1 pathway.
Topics: Animals; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Diosgenin; Down-Regulation; Enzyme Activation; Forkhead Box Protein M1; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phenotype; Rats; Rats, Sprague-Dawley; Tunica Intima | 2019 |
Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Cell Survival; Diosgenin; Female; Macrophages; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Pneumonia; Pulmonary Fibrosis; Reactive Oxygen Species; Silicon Dioxide; Silicosis | 2019 |
Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
Topics: Cell Movement; Cell Proliferation; Diosgenin; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Signal Transduction; Transforming Growth Factor beta1 | 2019 |
Inhibition of tumor metastasis by targeted daunorubicin and dioscin codelivery liposomes modified with PFV for the treatment of non-small-cell lung cancer.
Topics: A549 Cells; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Daunorubicin; Diosgenin; Drug Delivery Systems; Female; Humans; Liposomes; Lung Neoplasms; Matrix Metalloproteinase 2; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Oligopeptides; Particle Size; Static Electricity; Wound Healing | 2019 |
NMR-based metabolomics approach to investigate the distribution characteristics of metabolites in Dioscorea opposita Thunb. cv. Tiegun.
Topics: Cluster Analysis; Dioscorea; Diosgenin; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Plant Exudates; Plants, Medicinal; Principal Component Analysis; Saponins | 2019 |
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Topics: Animals; Apoptosis; Atherosclerosis; Autophagy; Cells, Cultured; Diosgenin; Endothelial Cells; Estrogen Receptor alpha; Female; Humans; Inflammation; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Ovariectomy; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Plant Extracts; Postmenopause; Receptors, LDL; Signal Transduction | 2019 |
Transferrin Modified Dioscin Loaded PEGylated Liposomes: Characterization and
Topics: Diosgenin; Drug Delivery Systems; HeLa Cells; Humans; Liposomes; Particle Size; Polyethylene Glycols; Transferrin | 2020 |
Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Diosgenin; G2 Phase Cell Cycle Checkpoints; Humans; Osteosarcoma; Pyroptosis; Receptors, Estrogen | 2020 |
Dioscin improves postmenopausal osteoporosis through inducing bone formation and inhibiting apoptosis in ovariectomized rats.
Topics: 3T3 Cells; Animals; Apoptosis; Bone Density; Bone Development; Cell Differentiation; Diosgenin; Female; Humans; Mice; Osteoporosis, Postmenopausal; Ovariectomy; Rats; Rats, Sprague-Dawley | 2019 |
Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK.
Topics: Adult; Atherosclerosis; CD36 Antigens; Dendritic Cells; Diosgenin; Female; Gene Expression Regulation; Glucose; Humans; Inflammation; Interleukin-10; Interleukin-12; Interleukin-6; Lipoproteins, LDL; Male; p38 Mitogen-Activated Protein Kinases; Scavenger Receptors, Class A; Scavenger Receptors, Class E | 2020 |
RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply.
Topics: A549 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell-Penetrating Peptides; Diosgenin; Epirubicin; Gene Expression Regulation, Neoplastic; Humans; Liposomes; Lung Neoplasms; Male; Mice; Neovascularization, Pathologic; Rats; Xenograft Model Antitumor Assays | 2020 |
A rapid method for on-line solid-phase extraction and determination of dioscin in human plasma using a homemade monolithic sorbent combined with high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Diosgenin; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Solid Phase Extraction | 2020 |
Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth.
Topics: Aerobiosis; Animals; Antigens, CD; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Diosgenin; Glycolysis; Humans; Mice, Nude; Proteolysis; S-Phase Kinase-Associated Proteins; Ubiquitination; Xenograft Model Antitumor Assays | 2020 |
A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.
Topics: Animals; Cell Line; Diosgenin; Humans; Lipopolysaccharides; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Osteogenesis; Teichoic Acids | 2020 |
Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Diosgenin; Gene Expression Regulation; Gluconeogenesis; Glycolipids; Hep G2 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Lipogenesis; Liver; Male; Mice, Inbred C57BL; MicroRNAs; Rats, Wistar; STAT3 Transcription Factor | 2020 |
Dioscin: A new potential inhibitor of Skp2 for cancer therapy.
Topics: Animals; Biological Products; Cell Line, Tumor; Diosgenin; Humans; Mice; Neoplasms; S-Phase Kinase-Associated Proteins; Xenograft Model Antitumor Assays | 2020 |
GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition.
Topics: Breast Neoplasms; Cell Line, Tumor; Daunorubicin; Diosgenin; Epithelial-Mesenchymal Transition; Humans; Liposomes | 2020 |
Dioscin exhibits anti-inflammatory effects in IL-1β-stimulated human osteoarthritis chondrocytes by activating LXRα.
Topics: Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Chondrocytes; Diosgenin; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-1beta; Liver X Receptors; Osteoarthritis | 2020 |
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2020 |
Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer.
Topics: Animals; Carcinoma, Lewis Lung; Diosgenin; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor; Tumor Microenvironment | 2020 |
Anti-Parkinson's Disease Function of Dioscin-Zein-Carboxymethyl Cellulose Nanocomplex in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Carboxymethylcellulose Sodium; Diosgenin; Disease Models, Animal; Parkinson Disease; Zein | 2020 |
Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Beclin-1; Cell Line; Diosgenin; Down-Regulation; Humans; Neurons; Peptide Fragments; Protective Agents; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirtuin 3; Up-Regulation | 2020 |
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study.
Topics: Animals; Arthritis, Gouty; Diosgenin; Humans; Inflammasomes; Inflammation; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Toll-Like Receptor 4; Uric Acid | 2021 |
Dioscin Attenuates Interleukin 1β (IL-1β)-Induced Catabolism and Apoptosis via Modulating the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling in Human Nucleus Pulposus Cells.
Topics: Apoptosis; Diosgenin; Humans; Inflammation Mediators; Interleukin-1beta; NF-kappa B; Nucleus Pulposus; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
The potential missing links between hepatoprotective dioscin and alcoholic liver disease.
Topics: Cytotoxins; Diosgenin; Enterococcus faecalis; Humans; Liver Diseases, Alcoholic | 2021 |
Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Diosgenin; HSP27 Heat-Shock Proteins; Lung; Mice; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species | 2020 |
Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice.
Topics: Animals; Diosgenin; Hyperuricemia; Male; Metabolomics; Mice; Uric Acid | 2021 |
Dioscin inhibits human endometrial carcinoma proliferation via G0/G1 cell cycle arrest and mitochondrial-dependent signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Diosgenin; Down-Regulation; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2021 |
Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Diosgenin; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Signal Transduction; Vascular Remodeling | 2021 |
Dioscin Improves Pyroptosis in LPS-Induced Mice Mastitis by Activating AMPK/Nrf2 and Inhibiting the NF-
Topics: AMP-Activated Protein Kinases; Animals; Diosgenin; Female; Inflammasomes; Lipopolysaccharides; Male; Mastitis; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Pyroptosis; Signal Transduction | 2020 |
Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Mouth Neoplasms; Protein Serine-Threonine Kinases; Serine-Threonine Kinase 3; Transcription Factors; Tumor Suppressor Proteins; YAP-Signaling Proteins | 2021 |
Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress.
Topics: Animals; Diosgenin; Kelch-Like ECH-Associated Protein 1; Kidney; Liver; Methotrexate; Mice; MicroRNAs; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2021 |
Dioscin induces ferroptosis and synergistic cytotoxicity with chemotherapeutics in melanoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzophenanthridines; Cation Transport Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cyclohexylamines; Diosgenin; Drug Synergism; Ferroptosis; Humans; Iron; Malondialdehyde; Melanoma; Phenylenediamines; Reactive Oxygen Species; RNA, Small Interfering; Transferrin | 2021 |
Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway.
Topics: Animals; Diosgenin; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Sirtuin 1; Subarachnoid Hemorrhage | 2021 |
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases.
Topics: Animals; Diosgenin; Disease Models, Animal; Heart Diseases; Humans; Male; Mice; Neovascularization, Physiologic; RNA, Long Noncoding | 2021 |
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation.
Topics: Animals; Apoptosis; Diosgenin; Mice; Oxidative Stress; Rats; Reperfusion Injury | 2021 |
Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Male; Mice | 2021 |
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Diosgenin; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; PPAR gamma; RAW 264.7 Cells | 2021 |
Dioscin attenuates lipopolysaccharide-induced inflammatory myocardial injury through oxidative stress-related pathway.
Topics: Animals; Diosgenin; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2021 |
Dioscin Attenuates Myocardial Ischemic/Reperfusion-Induced Cardiac Dysfunction through Suppression of Reactive Oxygen Species.
Topics: Animals; Diosgenin; Humans; Male; Mice; Myocardial Reperfusion Injury; Reactive Oxygen Species | 2021 |
Dioscin-loaded zein nanoparticles alleviate lipopolysaccharide-induced acute kidney injury via the microRNA-let 7i signalling pathways.
Topics: Acute Kidney Injury; Diosgenin; Humans; Lipopolysaccharides; MicroRNAs; Nanoparticles; Zein | 2021 |
Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal.
Topics: Animals; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Diosgenin; Disease Models, Animal; Inflammasomes; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Receptors, Purinergic P2X7; Signal Transduction | 2021 |
Inhibition of Src/STAT3 signaling-mediated angiogenesis is involved in the anti-melanoma effects of dioscin.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Diosgenin; Human Umbilical Vein Endothelial Cells; Humans; Male; Melanoma, Experimental; Mice, Inbred C57BL; Neovascularization, Pathologic; src-Family Kinases; STAT3 Transcription Factor; Tumor Burden | 2022 |
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; beta Catenin; Body Weight; Brain; Cytokines; Diosgenin; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Models, Biological; NF-kappa B; Sex Characteristics; Signal Transduction; Synapses | 2021 |
3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs.
Topics: Acetaminophen; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Chemical and Drug Induced Liver Injury; Composite Resins; Cytochrome P-450 Enzyme System; Diosgenin; Drug Evaluation, Preclinical; Glucose; Hep G2 Cells; Humans; Pharmaceutical Preparations; Tissue Scaffolds | 2022 |
In Silico Screening and In Vitro Assessment of Natural Products with Anti-Virulence Activity against
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Biofilms; Biological Products; Catalytic Domain; Clarithromycin; Diosgenin; Drug Evaluation, Preclinical; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Binding; Protein Conformation; Pyrophosphatases; Virulence | 2021 |
Dioscin promotes autophagy by regulating the AMPK-mTOR pathway in ulcerative colitis.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Colitis, Ulcerative; Colon; Dextran Sulfate; Diosgenin; Disease Models, Animal; Mice; TOR Serine-Threonine Kinases | 2022 |
The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation.
Topics: Animals; Diosgenin; Drugs, Chinese Herbal; Lung Neoplasms; Matrix Metalloproteinase 2; Mice; Molecular Docking Simulation; Network Pharmacology; Phosphatidylinositol 3-Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt | 2022 |
Dioscin Alleviates Cisplatin-Induced Mucositis in Rats by Modulating Gut Microbiota, Enhancing Intestinal Barrier Function and Attenuating TLR4/NF-κB Signaling Cascade.
Topics: Animals; Cisplatin; Diosgenin; Gastrointestinal Microbiome; Humans; Inflammation; Mucositis; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4 | 2022 |
Dioscin exhibits protective effects on in vivo and in vitro asthma models via suppressing TGF-β1/Smad2/3 and AKT pathways.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Diosgenin; Disease Models, Animal; Humans; Hyperplasia; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Proto-Oncogene Proteins c-akt; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2022 |
Dioscin ameliorates inflammatory bowel disease by up-regulating miR-125a-5p to regulate macrophage polarization.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Diosgenin; Humans; Inflammatory Bowel Diseases; Lipopolysaccharides; Macrophages; Mice; MicroRNAs | 2022 |
Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diosgenin; Hyperuricemia; Liver; Mice; Signal Transduction | 2022 |
Dioscin-Mediated Autophagy Alleviates MPP
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Diosgenin; Parkinson Disease | 2022 |
Neuroprotective Effect of Dioscin against Parkinson's Disease via Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative Stress.
Topics: Animals; Diosgenin; Dual Specificity Phosphatase 6; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats | 2022 |
Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation.
Topics: Animals; Bone Morphogenetic Protein 4; Diosgenin; Hypoxia; Inflammation; Interleukin-6; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Myocardial Infarction; NADPH Oxidase 1; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2022 |
Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation.
Topics: Animals; Antioxidants; Cisplatin; Diosgenin; Hydrogen Peroxide; Inflammation; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2022 |
Topics: Animals; Brain-Derived Neurotrophic Factor; Dioscorea; Diosgenin; Memory Disorders; Mice; Neurodegenerative Diseases; Neuroinflammatory Diseases; NF-kappa B; Plant Extracts; Scopolamine | 2022 |
Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia.
Topics: Anemia, Aplastic; Animals; Apoptosis; Bone Marrow; Diosgenin; Disease Models, Animal; Mice | 2022 |