diosgenin has been researched along with beta-escin in 237 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (6.33) | 18.7374 |
| 1990's | 12 (5.06) | 18.2507 |
| 2000's | 65 (27.43) | 29.6817 |
| 2010's | 121 (51.05) | 24.3611 |
| 2020's | 24 (10.13) | 2.80 |
| Authors | Studies |
|---|---|
| De Geyter, E; Geelen, D; Rahbé, Y; Smagghe, G | 1 |
| Caliş, I; Hosny, M; Khalifa, T; Sticher, O; Wright, AD | 1 |
| Baccou, JC; Loubatieères-Mariani, MM; Ribes, G; Sauvaire, Y | 1 |
| Chiang, HC; Chung, YM; Horng, LY; Lin, WJ; Wu, RT | 1 |
| Chiang, HC; Chien, KY; Chung, YM; Fu, WC; Horng, LY; Wu, RT | 1 |
| Bridges, CH; Camp, BJ; Hejtmancik, E; Hill, DW; Patamalai, B | 1 |
| Malinow, MR | 1 |
| Hardman, R; Jefferies, TM | 2 |
| Hardman, R; Wood, CN | 1 |
| Gupta, YP; Joshi, GS; Kessar, SV; Mahajan, RK; Rampal, AL | 1 |
| Fukunaga, T; Kato, A; Miura, T | 1 |
| Paczkowski, C; Wojciechowski, ZA | 1 |
| Dong, A; Hu, K; Iwasaki, S; Kobayashi, H; Yao, X | 1 |
| Kintia, PK; Lupashku, GA | 1 |
| Kameyama, A; Kuroda, M; Mimaki, Y; Sashida, Y; Yokosuka, A | 1 |
| Takechi, M; Tanaka, Y; Uno, C | 1 |
| Deng, S; Han, X; Hui, Y; Yu, B; Yu, H | 1 |
| Ju, Y; Li, X; Liu, M; Wang, Z; Zhang, H; Zhou, J | 1 |
| Fung, KP; Han, X; Hui, Y; Li, B; Li, M; Yu, B | 1 |
| Kuroda, M; Mimaki, Y; Sashida, Y; Yokosuka, A | 1 |
| Hu, K; Yao, X | 2 |
| Muranaka, T; Putalun, W; Shoyama, Y; Tanaka, H | 1 |
| Garegg, PJ; Gybäck, H; Lahmann, M; Oscarson, S; Suhr, R; Thiem, J | 1 |
| Hibasami, H; Imai, K; Ishii, Y; Ishikawa, K; Katsuzaki, H; Komiya, T; Moteki, H; Yoshioka, K | 1 |
| Han, X; Li, M; Yu, B | 1 |
| Bednarczyk, D; Kaca, W; Myszka, H; Najder, M | 1 |
| Doi, K; Takechi, M; Wakayama, Y | 1 |
| Hou, SJ; Lei, PS; Liang, XT; Shi, Y; Zou, CC | 1 |
| Cheng, MS; Li, Q; Liu, YX; Miao, HD; Song, HY; Tian, Q; Wang, QL; Xu, X; Yang, Z; Yao, XS | 1 |
| Ma, HY; Wang, BX; Wang, LJ; Wang, Y; Zhao, ZT; Zhou, QL | 1 |
| Ma, HY; Wang, BX; Wang, JY; Zhou, QL | 1 |
| Ganesan, AP; Gauthaman, K; Prasad, RN | 1 |
| Sun, W; Tu, G; Zhang, Y | 1 |
| Cai, B; Cui, CB; Liu, HW; Wang, SL; Wu, CF; Yao, XS | 2 |
| De Combarieu, E; Fuzzati, N; Lovati, M; Mercalli, E | 1 |
| GARBER, JD; ROTHROCK, JW; STOUDT, TH | 1 |
| KAWASAKI, T; TSUKAMOTO, T; YAMAUCHI, T | 1 |
| NAKAMURA, I; YAMAGISHI, M | 1 |
| BENNETT, RD; BONNER, J; HEFTMANN, E | 1 |
| BLUNDEN, G; HARDMAN, R | 1 |
| COLORADO IRIS, R | 1 |
| KAWASAKI, T; YAMAUCHI, T | 1 |
| HUANG, ML; WONG, TW | 1 |
| GATSENKO, LG; LURI, FA; MAKSIMOV, VI; MOROZOVA, LS | 1 |
| LOSHKAREV, PM; PANINA, VV | 1 |
| Chin, CK; Garrison, SA; Simon, JE; Tadmor, Y; Wang, M; Wu, QL | 1 |
| Pfefferkorn, P; Suhr, R; Thiem, J; Weingarten, S | 1 |
| Chen, Y; Kadota, S; Kouda, K; Le Tran, Q; Miyahara, T; Tezuka, Y; Yin, J | 1 |
| Guan, H; Li, Y; Lin, F; Yu, B; Zhang, Y; Zhu, S | 1 |
| Dong, M; Feng, X; Ikejima, T; Wang, BX; Wu, LJ | 1 |
| Du, Y; Gu, G; Linhardt, RJ | 1 |
| Patlolla, JM; Raju, J; Rao, CV; Swamy, MV | 1 |
| Cheung, JY; Fung, KP; Kong, SK; Mak, TC; Ong, RC; Ooi, V; Suen, YK; Wong, HN; Yu, B | 1 |
| Beneytout, JL; Corbière, C; Duroux, JL; Liagre, B; Trouillas, P | 1 |
| Che, CM; Hui, Y; Shum, TY; Wong, EL; Yang, Z | 1 |
| Liu, XK; Ma, YH; Yang, SL | 1 |
| Liu, MJ; Wang, Z; Wong, RN; Yue, PY | 1 |
| Feng, Y; Li, X; Shen, L; Wu, XR; Xu, DS | 1 |
| Chung-Wai, TM; Eng-Choon, VO; Fung, KP; Kong, SK; Lee, MS; Nai-Ching, HW; Yu, B; Yuet-Wa, JC | 1 |
| Huang, X; Kong, L | 1 |
| Huang, HY; Jia, ZY; Li, LL; Wang, YJ; Yang, WX | 1 |
| Cui, XR; Hagiwara, K; Isshiki, Y; Komada, F; Kondo, S; Koyanagi, J; Quan, HJ; Saito, S | 1 |
| Bai, G; Chen, H; Fong, WF; Huang, M; Wang, G; Wang, N; Yang, M; Yao, X; Zhang, J; Zhang, Y | 1 |
| Che, CM; Cheung, YH; Chiu, JF; He, QY; Wang, Y; Yang, Z | 1 |
| He, X; Liu, B; Qu, G; Su, L; Wang, G; Wang, X; Yao, X | 1 |
| Li, M; Yu, B | 1 |
| He, X; Jiang, M; Liu, B; Qiao, A; Su, L; Wang, X; Yao, X | 1 |
| Itharat, A; Tewtrakul, S | 1 |
| Kang, LP; Lü, N; Ma, BP; Tan, DW; Zhang, J | 1 |
| Bi, K; Chen, X; Li, J; Liu, Z; Wang, T; Zhong, M | 1 |
| Asao, Y; Kumahara, A; Matsuda, H; Morikawa, T; Nakamura, S; Pongpiriyadacha, Y; Xu, F; Yoshikawa, M | 1 |
| Bird, RP; Raju, J | 1 |
| Ikeda, T; Miyashita, H; Nohara, T | 1 |
| Chen, J; Lin, S; Tong, Y; Wang, D; Yang, D; Yao, J | 1 |
| Li, M; Li, W; Qiu, Z; Wang, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, Z | 1 |
| Li, B; Wang, FQ; Wang, W; Wei, DZ; Zhang, CG | 1 |
| Che, CM; Chiu, JF; He, QY; Wang, Y | 1 |
| Cao, X; Chen, H; Dai, Y; Sun, P; Yao, X; Yao, Z; Ye, W | 1 |
| Cheung, JY; Fung, KP; Ho, HP; Kong, SK; Lee, RK; Lei, J; Li, M; Lin, C; Ong, RC; Yu, B | 1 |
| De Nève, N; Dubois, J; Duez, P; Gnoula, C; Guissou, P; Ingrassia, L; Kiss, R; Lefranc, F; Mégalizzi, V; Mijatovic, T; Ribaucour, F; Sauvage, S | 1 |
| Jiang, ZH; Kaskiw, MJ; Tassotto, ML; Th'ng, J | 1 |
| Bai, N; Chen, C; Chen, Y; Xue, D; Yin, HX; Zhang, H | 1 |
| Che, CM; Cheung, YW; He, QY; Ko, BC; Lok, CN; Ma, DL; Siu, FM; Xu, S; Yan, K; Yang, M; Yang, Z | 1 |
| Kim, J; Yoon, KD | 1 |
| Srinivas, NR | 1 |
| Cao, XZ; Pan, YM; Shao, M; Yao, XS; Yao, ZH; Ye, WC | 1 |
| Bayet, C; Darbour, N; Di Pietro, A; Dijoux-Franca, MG; Doreau, A; Dumontet, C; Guilet, D; Nguyen, VT; Phung, BH; Raad, I | 1 |
| Mehta, R; Raju, J | 1 |
| Chen, LL; Lee, JC; Su, CL; Won, SJ | 1 |
| Lin, F; Wang, R | 1 |
| Dong, YS; Liu, L; Qi, SS; Wang, H; Xiu, ZL | 1 |
| Huang, W; Li, H; Liu, W; Ni, JR; Zhu, YL | 1 |
| Jiang, ZH; Kaskiw, MJ; Mok, M; Pycko, R; Tassotto, ML; Th'ng, J; Tokar, SL | 1 |
| Ahmad, IA; Kamel, AM; Morsy, AM | 1 |
| Li, Y; Ning, Z; Zhang, R | 1 |
| Beneytout, JL; Cook-Moreau, J; Lepage, C; Liagre, B; Pinon, A | 1 |
| Cao, X; Chen, H; Shao, M; Yao, X; Yao, Z; Ye, W | 1 |
| Bi, CW; Bi, K; Choi, RC; Dong, TT; Li, J; Liu, Z; Tsim, KW; Wang, T; Zang, L | 1 |
| Goto, T; Hirai, S; Hoshino, S; Kawada, T; Lee, JY; Mizoguchi, N; Nakano, Y; Narukami, T; Shono, J; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T | 1 |
| Han, J; Jiang, DX; Liu, XL; Liu, YT; Wang, GX; Zhao, LW | 1 |
| Chen, JP; Cong, YW; Guo, L; Kang, LP; Ma, BP; Shan, YJ; Wang, B; Xiao, H; Yu, ZY; Zhao, ZH | 1 |
| Li, YK; Ning, Z; Zhou, Y | 1 |
| Gao, W; Huang, L; Liu, C; Liu, Z; Man, S; Yan, L; Zhang, Y | 1 |
| Chan, JY; Detmar, M; Fung, KP; Kong, SK; Koon, JC; Liu, X; Yu, B | 1 |
| He, Y; Huang, W; Ma, MH; Wu, XH | 1 |
| Bradshaw, JD; Gray, ME; Lee, ST; Prasifka, JR | 1 |
| Dai, X; Fan, X; He, X; Hu, G; Huang, Z; Xiao, M; Zhang, B; Zhou, R | 1 |
| Chen, C; Chen, T; He, J; Liu, X; Wen, F; Xue, D; Yin, H; Zhang, H | 1 |
| Cheung, KL; Fung, KP; Gao, M; Kong, SK; Lau, IP; Loo, JF; Yu, B; Yu, WS | 1 |
| Delemasure, S; Duchamp, O; Dutartre, P; Lacaille-Dubois, MA; Manase, MJ; Mirjolet, JF; Mitaine-Offer, AC; Miyamoto, T; Pertuit, D; Tanaka, C | 1 |
| Feng, B; Kang, LP; Kang, TG; Ma, BP; Quan, B; Song, XB; Yu, HS; Zhang, LJ | 1 |
| Chiji, H; Kitazawa, H; Maeda, T; Motoki, S; Nishihara, E; Shinohara, Y; Suzuki, T | 1 |
| Huang, W; Lei, J; Li, T; Niu, H | 1 |
| Fu, S; Gao, W; Liu, C; Man, S; Qiu, F; Wu, S | 1 |
| Bai, P; Bui-Nguyen, TM; Chen, X; Gao, L; Liu, J; Liu, S; Wang, H; Xiao, J; Xiao, X; Zhang, X; Zou, J | 1 |
| Dawid, C; Hofmann, T | 1 |
| Balasubramanian, MP; Jagadeesan, J; Nandakumar, N; Rengarajan, T | 1 |
| Bai, P; Chen, XL; Liu, SL; Wang, H; Xiao, X; Yang, M; Zou, J | 1 |
| Chen, Q; Guo, X; He, S; He, Y; Huang, B; Huang, W; Wang, Y; Xin, G; Xing, Z; Zhao, H | 1 |
| Bednarczyk, D; Grzywacz, D; Liberek, B; Myszka, H; Sikorski, A; Walczewska, A | 1 |
| Jin, F; Liu, C; Liu, T; Luo, N; Tang, M; Wang, Q; Wang, Y; Xu, X; Yu, H; Yuan, X | 1 |
| Li, ZH; Wan, JY; Wang, GQ; Wen, JH; Zhao, FG | 1 |
| Ali, Z; Khan, IA; Smillie, TJ | 1 |
| Ni, J; Qiu, M; Zhu, H; Zhu, T; Zhu, Y | 1 |
| Dong, D; Han, X; Lv, L; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L | 1 |
| Ao, M; Bai, Y; Jin, W; Wei, M; Yu, L; Yu, P; Zhu, M | 1 |
| Ji, S; Li, Y; Lv, L; Wang, B; Zhang, G; Zhang, H; Zhao, L; Zhou, G | 1 |
| Ali, Z; Avula, B; Khan, IA; Smillie, TJ; Wang, YH | 1 |
| Li, H; Lu, Z; Shi, J; Xu, Z; Zhang, J | 1 |
| Cheng, MS; Chun, J; Han, L; Kim, YS; Wang, B; Xu, MY | 1 |
| Li, Q; Liu, Y; Wu, L | 1 |
| Barbosa-Ferreira, M; Castro, MB; Gracindo, CV; Louvandini, H; Riet-Correa, F | 1 |
| Hou, Y; Jin, H; Li, W; Shen, T; Wang, Y; Yang, S; Yuan, T; Zhang, J; Zhao, Y | 1 |
| Faccin, TC; Ferreira, R; Itavo, CC; Lemos, RA; Melo, GK; Riet-Correa, F; Rodrigues, FS; Santos, AC; Silva, JA | 1 |
| Song, M; Xiang, T; Xiao, YJ; Yuan, Y; Zhang, JY; Zheng, L; Zhou, Y | 1 |
| Bai, P; Huang, Q; Liu, S; Wang, H; Xiao, J; Xiao, X; Yang, F; Yang, K; Yang, M; Zhang, B; Zou, J | 1 |
| Feng, J; Jiang, H; Ma, SL; Su, D; Zhao, PJ | 1 |
| Chen, L; Dai, Q; Du, J; Hu, J; Pang, W; Zhang, H | 1 |
| Chai, H; Fan, W; Gao, W; Li, J; Li, Y; Liu, Z; Man, S | 1 |
| Chen, Q; Li, Q; Lu, P; Yu, Q | 1 |
| Abbasi, F; Al Sawah, E; Berry, A; Boac, BM; Bou Zgheib, N; Bush, SH; Hakam, A; Judson, PL; Khulpateea, BR; Lancaster, JM; Marchion, DC; McClung, EC; Ramirez, IJ; Wenham, RM; Xiong, Y | 1 |
| Feng, J; Jiang, H; Ma, S; Su, D; Zhao, P; Zhu, X | 1 |
| Fan, L; Li, Y; Mei, Q; Meng, J; Sun, Y; Yue, Z; Zhang, D; Zhang, F; Zhang, R; Zhang, X | 1 |
| Cheung, AK; Gao, M; Kong, SK; Lau, PM; Ngai, BH; Yang, AK; Yu, SS | 1 |
| Ding, CH; Li, SL; Long, MH; Mao, Q; Shakya, S; Zhu, H; Zhu, SC | 1 |
| Chen, HB; He, XC; Pang, YX; Tang, YN; Yi, T; Zhang, JY; Zhang, YZ; Zhao, ZZ | 1 |
| Ding, H; Gong, X; Lin, G; Lin, Y; Liu, Z; Ma, W; Zhang, Z | 1 |
| Bai, P; Liu, S; Wang, H; Xiao, X; Yang, M; Zhu, H; Zou, J | 1 |
| Hong, JH; Kim, YS; Lee, CJ; Lee, HJ; Lee, SK; Park, JS; Shin, YJ; Son, KH; Yoon, YP | 1 |
| Li, F; Lin, Z; Liu, Y; Liu, Z; Lu, L; Wang, Y; Wu, J; Zhang, G | 1 |
| Geng, YD; Kong, LY; Shi, YM; Yang, L; Zhang, C | 1 |
| Ali, Z; Aumsuwan, P; Avula, B; Dasmahapatra, AK; Helferich, WG; Katzenellenbogen, BS; Khan, IA; Khan, SI; Shariat-Madar, Z; Walker, LA | 1 |
| Guo, Z; Ito, Y; Li, J; Sun, W; Zhang, X | 1 |
| Gu, W; Lin, P; Lu, JM; Wang, YF; Yan, HL; Yu, J | 1 |
| Tong, Y; Wang, H; Wang, L; Wei, M; Yu, L | 1 |
| Du, LW; Feng, JG; Jiang, H; Li, JH; Ma, SL; Song, SC; Zhao, PJ; Zhou, GH; Zhu, XH | 1 |
| Goto, T; Hoshino, S; Kawada, T; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T | 1 |
| Cai, H; Meng, X; Yang, C | 1 |
| Herling, VR; Hussain, SM; Kowalczyk, M; Pecio, Ł; Pérez, AJ; Stochmal, A | 1 |
| Chen, HF; Chung, YL; Hsu, KC; Pan, CH; Sheu, MJ; Wang, CC; Wu, CH | 1 |
| Guo, Z; Ito, Y; Sun, W; Xian, L; Xue, X; Zhang, X | 1 |
| Chen, P; Jin, HY; Ma, SC; Sun, L | 1 |
| Ji, L; Liang, T; Liang, Y; Liu, R; Shi, L; Xu, L; Yang, F; Yao, N | 1 |
| Liu, YC; Shakya, S; Wu, JW; Zhu, H | 1 |
| Gao, W; Liu, J; Liu, Z; Ma, L; Man, S | 1 |
| Almasry, M; Faggio, C; Jemaà, M; Lang, F; Mischitelli, M | 1 |
| Moura, ML; Pereira de Oliveira, A; Rolim, HM | 1 |
| Guan, H; Hao, J; Li, M; Wang, C; Wang, P; Zhang, X | 1 |
| Chen, W; Gao, W; Li, X; Liu, Z; Man, S; Pan, G; Teng, Y; Wu, M; Yang, K; Yu, P; Zheng, Q | 1 |
| Tohda, C | 1 |
| Du, L; Jiang, H; Li, J; Song, S; Xu, J; Zhu, X | 1 |
| Guo, C; Meng, Z; Shen, J; Yang, X | 1 |
| Cho, Y; Choi, SZ; Kang, KB; Ryu, J; Son, M; Sung, SH | 1 |
| Gil, J; Guillén-Bejarano, R; Jaramillo-Carmona, S; Jiménez-Araujo, A; López, S; Moreno, R; Rodriguez-Arcos, R | 1 |
| Hwang, DY; Kim, BR; Kim, D; Kim, DS; Kim, M; Kim, WB; Koo, KY; Lee, CY; Lee, H; Lee, S; Son, HJ | 1 |
| Gu, W; Lu, J; Wang, Y; Yan, H; Yang, X; Yu, J | 1 |
| Hara, F; Naoe, A; Suzuki, T; Uga, N; Watanabe, S; Yasui, T | 1 |
| Chang, IL; Chen, CL; Chen, HY; Cheng, CH; Hsieh, CP; Shen, TS; Tseng, SC; Wu, CC | 1 |
| Chen, JC; Chen, MK; Chien, SY; Chuang, YC; Hsi, YT; Hsieh, MJ; Lin, CC; Lin, CW; Lo, YS; Yang, SF | 1 |
| Diaz, GJ; Lozano, MC; Martinez, NM | 1 |
| Agnihotri, VK; Chand, G; Kumar, A; Maurya, AK | 1 |
| Cao, R; Cheng, GH; Hou, YL; Liu, D; Liu, JY; Qiu, HX; Tu, R; Wang, L; Zhang, JL | 1 |
| Wang, YZ; Wu, Z; Xu, FR; Zhang, J; Zhang, JY | 1 |
| Deng, ZK; Wu, J; Zhao, YM | 1 |
| Boudjeniba, M; Krauze-Baranowska, M; Król-Kogus, B; Lamine, KM; Migas, P | 1 |
| Dawgul, MA; Grzywacz, D; Kamysz, W; Liberek, B; Myszka, H | 1 |
| Cheng, P; Fujiwara, Y; Ikeda, T; Komohara, Y; Ohnishi, K; Saito, Y; Shiota, T; Takeya, M | 1 |
| Fang, X; He, F; Li, H; Li, W; Wang, N | 1 |
| Chen, CM; Chen, PN; Cheng, CW; Hsieh, YH; Lee, CH; Lin, CL; Ying, TH | 1 |
| Belli, V; Chambery, A; Ciardiello, F; D'Abrosca, B; Esposito, A; Fiorentino, A; Graziani, V; Panella, M; Potenza, N; Russo, A; Russo, R; Scognamiglio, M; Troiani, T | 1 |
| Cui, J; Gao, W; Ma, L; Man, S; Yang, L; Zhang, L | 1 |
| Liu, H; Ma, B; Pang, X; Wei, Y; Xiang, H; Yu, L; Zhang, T; Zhang, Y | 1 |
| Chen, Y; Chi, Y; Dong, Y; He, Q; Ren, Y; Wu, H | 1 |
| Honda, A; Ishikawa, Y; Miyahara, M; Miyako, K; Oikawa, M; Otsuka, K; Sakai, R; Shiozaki, H; Takamizawa, S; Takasaki, Y; Tukada, H | 1 |
| Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S | 1 |
| Chung, ELT; Jesse, FFA; Loh, TC; Nobilly, F; Predith, M; Samsudin, AA | 1 |
| Cai, MT; Liu, DH; Xu, YL; Zhang, ZL; Zuo, YM | 1 |
| Cui, J; Cui, N; Gao, W; Guo, Q; Ma, L; Man, S; Yang, L | 1 |
| Almeida, JD; Barbosa, MC; Ishii-Iwamoto, EL; Kagami, FL; Kern-Cardoso, KA; Mantovanelli, GC; Mito, MS; Silva, AA | 1 |
| Amorim, RNL; Biscoto, GL; Diamantino, GML; Keller, KM; Melo, MM; Pedroza, HP; Soto-Blanco, B | 1 |
| Dong, Y; Guo, C; Liu, Y; Xie, G; Zhu, H | 1 |
| Chen, M; Kong, AN; Li, P; Wen, X; Xin, Q; Yang, J; Ye, K; Zhang, B | 1 |
| Guo, S; Li, YQ; Liu, WN; Luo, XJ; Peng, J; Peng, JJ; Tang, MX; Yang, J; Zhang, XJ; Zhang, YY | 1 |
| An, L; Ma, J; Piao, X; Wang, H; Wu, X; Yuan, Y; Zhang, J; Zhou, L | 1 |
| Ma, YL; Thakur, K; Wei, ZJ; Zhang, F; Zhang, JG; Zhang, YS; Zhang, YY | 1 |
| Choi, IY; Park, NI; Yeoung, YR; Yi, TG | 1 |
| Shu, K; Zhang, Y | 1 |
| Liu, X; Ma, Z; Ren, S; Wang, L; Xu, F; Yang, L | 1 |
| Chen, J; Gai, Y; Li, Y; Xu, Z | 1 |
| Cheng, P; Feng, FF; Sun, C; Wang, H; Wang, W | 1 |
| Bai, L; Liu, H; Peng, S; Sun, F; Wang, L; Yan, H | 1 |
| Gao, W; Wang, G; Weng, G; Wu, Q; Zheng, B; Zhu, W | 1 |
| Xiao, MF | 1 |
| Diamantino, GML; Ferreira, MIC; Martins, CE; Pierezan, F; Rocha, WSD; Soto-Blanco, B; Veiga, MO; Veiga, VMO | 1 |
| Aharoni, A; Beritza, K; Garagounis, C; Georgopoulou, ME; Goossens, A; Haralampidis, K; Papadopoulou, KK; Sonawane, P | 1 |
| Cui, J; Gao, W; Liu, C; Liu, F; Lv, P; Ma, L; Man, S; Peng, L | 1 |
| Dong, X; Liu, Y; Ni, J; Qu, C; Sun, M; Wang, W; Yin, X; You, L | 1 |
| Ahn, D; Chung, SJ; Kang, HJ; Kwon, SJ; Yang, HM | 1 |
| Akhshi, N; Aneva, IY; Darakhshan, S; Echeverría, J; Farzaei, MH; Ghanbari, A; Liao, P; Mollica, A; Nedaei, SE; Qi, Y; Xiao, J | 1 |
| Buschinelli de Goes, RHT; da Costa, MCM; de Moraes, GJ; de Souza Arco, TFF; de Souza Leal, E; Dias, AM; Dos Santos Difante, G; Gurgel, ALC; Ítavo, CCBF; Ítavo, LCV; Kozerski, ND; Niwa, MVG; Nonato, LM | 1 |
| Abenavoli, MR; Araniti, F; Baldoqui, DC; Constantin, RP; da Costa Menezes, PVM; de Oliveira Junior, RS; de Souza, LA; Ishii-Iwamoto, EL; Mantovanelli, GC; Mito, MS; Oliveira do Carmo, AA; Silva, AA; Silva, RG; Stulp, GF; Wagner, AL | 1 |
| Li, H; Liu, J; Liu, W; Liu, Y; Mao, A; Pan, G; Wei, C | 1 |
| Cao, R; Han, S; Hu, Z; Jin, M; Li, Z; Pan, L; Qin, B; Wang, C; Xiang, Y; Zheng, L | 1 |
| Anand, U; Bandopadhyay, S; Behl, T; Dey, A; Gadekar, VS; Gupta, PK; Jha, NK; Kumar, M; Shekhawat, MS | 1 |
| Corzo-Jiménez, IJ; García-Morales, S; León-Morales, JM; Pardo-Núñez, J; Rodríguez-Mejía, DI; Silva-Córdova, NF; Soto-Cordero, AM | 1 |
| Asai, N; Inoue, M; Kondo, Y; Murayama, M; Naoe, A; Niimi, A; Okada, S; Suzuki, M; Suzuki, T; Takeuchi, T; Tsuchiya, T; Watanabe, S; Yasui, T | 1 |
| Dat, NT; Dung, LV; Duyen, NT; Ha, DT; Hien, TT; Khoi, NM; Lee, KY; Long, PQ; Phong, NV; Vinh, LB | 1 |
| Gu, Y; Hou, L; Li, J; Li, S; Zhang, F | 1 |
| Chen, B; Chen, P; Dong, X; Wu, S; Xu, P; Zhou, M | 1 |
| Araújo, NJS; Coutinho, HDM; da Silva, ARP; de Freitas, TS; de Sousa, EO; de Vasconcelos, JEL; do Socorro Costa, M; Filho, JMB; Maia, FPA; Pereira Junior, FN; Pinheiro, JCA; Tavares, JF | 1 |
| Gao, L; Pan, QD; Yan, XX; Yang, LX; Zhou, D | 1 |
| Dou, J; Guo, Y; Guo, Z; Ito, Y; Xue, P; Xue, Z; Zhang, H; Zhang, X; Zhang, Y | 1 |
| Hua, X; Kou, C; Li, Y; Liu, J; Lu, J; Song, W; Xue, Z; Yin, X; Zhang, H | 1 |
| Hanashima, S; Miyazato, DG; Mukogawa, A; Murata, M; Ondevilla, JC; Umegawa, Y | 1 |
9 review(s) available for diosgenin and beta-escin
| Article | Year |
|---|---|
Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Cell Division; Diosgenin; Humans; Neoplasms; Saponins | 2009 |
Cardioprotector Activity of an Esteroidal Saponin: A Scientific and Technological Prospection.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cardiotonic Agents; Diosgenin; Disease Models, Animal; Dyslipidemias; Humans; Hypertension; Mice; Patents as Topic; Rats; Saponins | 2017 |
New Age Therapy for Alzheimer's Disease by Neuronal Network Reconstruction.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Atrophy; Diosgenin; Humans; Medicine, Traditional; Neurons; Saponins; Withanolides | 2016 |
Can treatment of Brachiaria decumbens (signal grass) improve its utilisation in the diet in small ruminants?-a review.
Topics: Animals; Brachiaria; Diet; Diosgenin; Photosensitivity Disorders; Poaceae; Rumen; Ruminants; Saponins; Sheep; Sheep Diseases; Silage | 2018 |
Recent Advances in the Pharmacological Activities of Dioscin.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Diosgenin; Humans; Saponins | 2019 |
Tribulus terrestris and female reproductive system health: A comprehensive review.
Topics: Diosgenin; Female; Genitalia, Female; Humans; Libido; Male; Plant Extracts; Saponins; Tribulus | 2021 |
Dioscin: A review on pharmacological properties and therapeutic values.
Topics: Diosgenin; Humans; Neoplasms; Plant Extracts; Saponins | 2022 |
[Research progress of steroidal saponins in Paris polyphylla var. yunnanensis and their microbial transformation].
Topics: Diosgenin; Liliaceae; Melanthiaceae; Rhizome; Saponins | 2022 |
Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics.
Topics: Conservation of Natural Resources; Dioscorea; Diosgenin; Fermentation; Humans; Saponins | 2023 |
1 trial(s) available for diosgenin and beta-escin
| Article | Year |
|---|---|
Performance of sheep grazing in pastures of Brachiaria decumbens, Brachiaria brizantha, Panicum maximum, and Andropogon gayanus with different protodioscin concentrations.
Topics: Andropogon; Animals; Brachiaria; Brazil; Diosgenin; Male; Panicum; Plant Poisoning; Saponins; Sheep; Sheep Diseases | 2014 |
227 other study(ies) available for diosgenin and beta-escin
| Article | Year |
|---|---|
Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum.
Topics: Animals; Aphids; Digitonin; Diosgenin; Escin; Insect Control; Insect Repellents; Insecticides; Intestinal Mucosa; Plant Bark; Quillaja; Saponins; Toxicity Tests; Vicia faba | 2012 |
Balanitoside, a furostanol glycoside, and 6-methyldiosgenin from Balanites aegyptiaca.
Topics: Carbohydrate Sequence; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plants, Medicinal; Saponins; Steroids | 1992 |
Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek.
Topics: Alloxan; Animals; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Diosgenin; Dogs; Feces; Gas Chromatography-Mass Spectrometry; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins; Spirostans; Trigonella | 1991 |
Modulation of experimental autoimmune uveitis with formosanin-C in guinea pigs.
Topics: Adjuvants, Immunologic; Animals; Antigens; Arrestin; Autoantibodies; Autoimmune Diseases; Diosgenin; Eye Proteins; Guinea Pigs; Lymph Nodes; Lymphocyte Activation; Male; Saponins; Spleen; Uveitis | 1990 |
Formosanin-C, an immunomodulator with antitumor activity.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Diosgenin; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon Inducers; Killer Cells, Natural; Liver Neoplasms, Experimental; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Plants, Medicinal; Saponins | 1990 |
The isolation and identification of steroidal sapogenins in Kleingrass.
Topics: Chromatography, Thin Layer; Diosgenin; Edible Grain; Hemolysis; Panicum; Sapogenins; Saponins; Spectrophotometry, Infrared | 1990 |
Effects of synthetic glycosides on cholesterol absorption.
Topics: Animals; Cholesterol, Dietary; Diosgenin; Glycosides; Hypercholesterolemia; Intestinal Absorption; Male; Rats; Rats, Inbred Strains; Saponins; Spirostans | 1985 |
The determination of diosgenin and yamogenin in fenugreek seed by combined column chromatography and infrared spectrometry.
Topics: Chromatography; Chromatography, Thin Layer; Diosgenin; Infrared Rays; Saponins; Seeds; Spectrophotometry; Spirostans | 1971 |
The infra-red spectrometric estimation of diosgenin and yamogenin individually and as their mixtures.
Topics: Chromatography, Thin Layer; Diosgenin; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Steroids | 1972 |
The effect of ripening and aqueous incubation on the yield of diosgenin and yamogenin from the fruits of Balanites pedicellaris.
Topics: Diosgenin; Saponins; Seeds; Spirostans | 1971 |
Synthetic studies in steroidal sapogenins and alkaloids. V. Synthesis of kryptogenin, diosgenin and yamogenin.
Topics: Alkaloids; Chemical Phenomena; Chemistry; Diosgenin; Saponins; Steroids | 1968 |
Effects of steroidal glycosides on blood glucose in normal and diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Saponins; Spirostans | 1995 |
The in vitro synthesis of diosgenin mono- and diglucoside by enzyme preparations from Solanum melongena leaves.
Topics: Diosgenin; Glucosides; Glucosyltransferases; Oligosaccharides; Plant Proteins; Plants; Saponins; Spirostans | 1993 |
Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
Topics: Antineoplastic Agents; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drugs, Chinese Herbal; Glycosides; Molecular Sequence Data; Saponins; Spirostans; Tumor Cells, Cultured | 1996 |
Regulatory effects of saponins in the pathogenesis of root rots in cereal crops.
Topics: Diosgenin; Edible Grain; Fusarium; Plant Diseases; Plant Roots; Saponins | 1996 |
Aculeoside B, a new bisdesmosidic spirostanol saponin from the underground parts of Ruscus aculeatus.
Topics: Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Liliaceae; Molecular Sequence Data; Molecular Structure; Saponins | 1998 |
Structure-activity relationships of saponins and cardiac glycosides. III. Beta-L-xylopyranosyl-(1-->6)-alpha- and -beta-D-glucopyranosides.
Topics: Adenosine Triphosphatases; Antifungal Agents; Antiviral Agents; Cardiac Glycosides; Digitoxigenin; Diosgenin; Glycyrrhetinic Acid; Hemolysis; Saponins; Structure-Activity Relationship | 1998 |
Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Glycosylation; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Optical Rotation; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1999 |
Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
Topics: Apoptosis; Cell Differentiation; Cell Division; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Saponins | 2001 |
An improved synthesis of the saponin, polyphyllin D.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Saponins; Trisaccharides | 2001 |
Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins.
Topics: Cell Division; Diosgenin; Growth Inhibitors; HL-60 Cells; Humans; Liliaceae; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.
Topics: Antineoplastic Agents, Phytogenic; Dioscorea; Diosgenin; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; K562 Cells; Neoplasms; Plant Extracts; Plant Stems; Saponins; Tumor Cells, Cultured | 2002 |
Determination of aculeatisides based on immunoassay using a polyclonal antibody against aculeatiside A.
Topics: Antibodies; Diosgenin; Enzyme-Linked Immunosorbent Assay; Ovalbumin; Saponins; Sensitivity and Specificity; Solanum | 2002 |
A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
Topics: Antineoplastic Agents; Diosgenin; Magnetic Resonance Spectroscopy; Saponins; Tropanes | 2002 |
Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.
Topics: Apoptosis; Carbohydrate Conformation; Carbohydrate Sequence; Cell Death; Cell Survival; Diosgenin; DNA, Neoplasm; Drugs, Chinese Herbal; HL-60 Cells; Humans; Kinetics; Lymphocytes; Molecular Sequence Data; Oligosaccharides; Saponins; Stomach Neoplasms; Trigonella; Tumor Cells, Cultured | 2003 |
Synthesis of monomethylated dioscin derivatives and their antitumor activities.
Topics: Animals; Antineoplastic Agents; Cell Division; Diosgenin; Humans; Methylation; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Deoxyadenosines; Diosgenin; Glucosamine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Saponins; Structure-Activity Relationship | 2003 |
Biological activities of synthetic saponins and cardiac glycosides.
Topics: Adenosine Triphosphatases; Antifungal Agents; Antiviral Agents; Diosgenin; Erythrocytes; Glycosides; Glycyrrhetinic Acid; Hemolysis; Humans; Microbial Sensitivity Tests; Phytotherapy; Saponins; Simplexvirus; Structure-Activity Relationship; Trichophyton | 2003 |
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
Topics: Acetylation; Carbohydrate Conformation; Diosgenin; Guanidine; Saponins; Spirostans | 2003 |
Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
Topics: Antineoplastic Agents, Phytogenic; Combinatorial Chemistry Techniques; Diosgenin; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Saponins | 2003 |
[Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of Dioscorea panthaica].
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dioscorea; Diosgenin; Female; Hypercholesterolemia; Male; Mice; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 2002 |
[Intestinal bacteria metabolism of TSDP and characterization of metabolites in rats].
Topics: Animals; Biotransformation; Dioscorea; Diosgenin; Gram-Negative Anaerobic Bacteria; Intestines; Male; Molecular Structure; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Spectrometry, Mass, Electrospray Ionization | 2002 |
Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.
Topics: Analysis of Variance; Androgens; Animals; Aphrodisiacs; Body Weight; Copulation; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ejaculation; Female; Male; Models, Animal; Organ Size; Penis; Random Allocation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Saponins; Sexual Behavior, Animal | 2003 |
A new steroidal saponin from Dioscorea zingiberensis Wright.
Topics: Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Structure; Rhizome; Saponins; Sterols | 2003 |
The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Survival; Central Nervous System Neoplasms; Colonic Neoplasms; Diosgenin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia; Lung Neoplasms; Male; Saponins; Tumor Cells, Cultured | 2003 |
[Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Diosgenin; Flow Cytometry; Humans; K562 Cells; Microscopy, Electron, Scanning; Saponins | 2003 |
Furostanol saponins from Tribulus terrestris.
Topics: Chromatography, High Pressure Liquid; Diosgenin; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phytotherapy; Plant Components, Aerial; Plant Extracts; Saponins; Tribulus | 2003 |
Isolation of diosgenin by microbiological hydrolysis of saponin.
Topics: Diosgenin; Hydrolysis; Plants; Saponins | 1955 |
Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin.
Topics: Dioscoreaceae; Diosgenin; Saponins | 1956 |
Studies on determination of sapogenins in plants belonging to Dioscorea growing in Japan. II. Determination of diosgenin, tokorogenin, and a new genin contained in the roots.
Topics: Dioscorea; Diosgenin; Japan; Plant Roots; Plants; Sapogenins; Saponins | 1958 |
Biosynthesis of diosgenin in Dioscorea tubers.
Topics: Dioscorea; Diosgenin; Plant Tubers; Plants; Saponins; Steroids | 1961 |
Dioscorea belizensis Lundell as a source of diosgenin.
Topics: Dioscorea; Diosgenin; Saponins | 1963 |
[Obtaining diosgenin from the barbasco].
Topics: Diosgenin; Humans; Magnoliopsida; Paullinia; Plants, Medicinal; Saponins | 1962 |
Structures of dioscin, gracillin, and kikuba-saponin. 2. (Saponins of Japanese Dioscoreaceae. XI.
Topics: Dioscoreaceae; Diosgenin; Plants; Saponins; Spirostans; Steroids | 1962 |
[THE INTRODUCTION OF C6-ALPHA-METHYL GROUP INTO DIOSGENIN].
Topics: Chemistry, Pharmaceutical; Diosgenin; Research; Saponins | 1962 |
[ON PSEUDOMERIZATION OF DIOSGENIN IN ACETIC ANHYDRIDE IN THE PRESENCE OF ACETIC ACID].
Topics: Acetates; Acetic Acid; Acetic Anhydrides; Chemistry, Pharmaceutical; Diosgenin; Health Services; Pharmacy; Saponins | 1963 |
[COLORIMETRIC METHOD OF DETERMINING DIOSGENIN IN DIOSCOREA].
Topics: Chemistry, Pharmaceutical; Colorimetry; Dioscorea; Diosgenin; Pharmacy; Plants; Plants, Medicinal; Saponins | 1963 |
Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.
Topics: Asparagus Plant; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diosgenin; Plant Extracts; Rutin; Saponins; Spectrometry, Mass, Electrospray Ionization | 2003 |
Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saindersiae and Galtonia candicans.
Topics: Carbohydrate Conformation; Diosgenin; Glucosides; Glycosylation; Liliaceae; Models, Chemical; Molecular Structure; Saponins; Stereoisomerism | 2003 |
Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway.
Topics: Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Cell Line, Tumor; Colonic Neoplasms; Cytochromes c; Dioscorea; Diosgenin; Down-Regulation; Flow Cytometry; Humans; Membrane Potentials; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Saponins | 2004 |
In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
Topics: Animals; Bone Density; Dioscorea; Diosgenin; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Osteoporosis; Ovariectomy; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Saponins | 2004 |
Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.
Topics: Antineoplastic Agents; Chromatography, Thin Layer; Diosgenin; Magnetic Resonance Spectroscopy; Models, Chemical; Saponins; Silicon; Solvents | 2004 |
Microbial metabolism of pseudoprotodioscin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aspergillus fumigatus; Cell Line, Tumor; Dioscorea; Diosgenin; Drugs, Chinese Herbal; HeLa Cells; Humans; Inhibitory Concentration 50; Mice; Phytotherapy; Rhizome; Saponins | 2004 |
Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.
Topics: Antineoplastic Agents, Phytogenic; Diosgenin; Drug Screening Assays, Antitumor; Glycosylation; Humans; Inhibitory Concentration 50; Medicine, Chinese Traditional; Molecular Structure; Oligosaccharides; Saponins; Solanum; Stereoisomerism; Tumor Cells, Cultured | 2004 |
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Diosgenin; Disease Models, Animal; History, Early Modern 1451-1600; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Reference Values; Saponins; Sensitivity and Specificity; Trigonella; Tumor Cells, Cultured | 2004 |
Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.
Topics: Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochromes c; Diosgenin; Drug Resistance, Neoplasm; Flavoproteins; Flow Cytometry; Humans; Membrane Proteins; Mitochondria; Reactive Oxygen Species; Saponins | 2005 |
Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Diosgenin; Humans; Models, Molecular; Osteosarcoma; Saponins; Structure-Activity Relationship | 2005 |
Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
Topics: Carbohydrate Conformation; Cell Survival; Diosgenin; Fluorides; Glycosylation; HeLa Cells; Humans; Models, Molecular; Saponins; Steroids; Trisaccharides | 2005 |
[Steroidal constituents from Dioscorea parviflora].
Topics: Dioscorea; Diosgenin; Molecular Conformation; Molecular Structure; Plants, Medicinal; Rhizome; Saponins; Steroids | 2005 |
Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.
Topics: Apoptosis; bcl-2-Associated X Protein; Calcium; Cell Cycle; Cell Proliferation; Diosgenin; DNA Damage; Homeostasis; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Saponins; Tumor Cells, Cultured; Up-Regulation | 2005 |
[Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats].
Topics: Administration, Oral; Animals; Bacteria; Biotransformation; Diosgenin; Intestines; Male; Ophiopogon; Rats; Rats, Wistar; Saponins | 2005 |
Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Saponins; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2005 |
Steroidal saponins from roots of Asparagus officinalis.
Topics: Asparagus Plant; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Roots; Saponins; Stereoisomerism; Steroids | 2006 |
[Study on chemical constituents in total saponin from Trigonella foenum-graecum].
Topics: Diosgenin; Plants, Medicinal; Saponins; Seeds; Trigonella | 2005 |
Reactions of 26-iodopseudodiosgenin and 26-iodopseudodiosgenone with various nucleophiles and pharmacological activities of the products.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; Bacteria; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drug Screening Assays, Antitumor; Fungi; Humans; Indicators and Reagents; Microbial Sensitivity Tests; Molecular Sequence Data; Saponins | 2006 |
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; CDC2-CDC28 Kinases; Cell Division; Cell Line, Tumor; Cyclin B; Cyclin B1; Diosgenin; G2 Phase; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins | 2006 |
Proteomic approach to study the cytotoxicity of dioscin (saponin).
Topics: Apoptosis; Diosgenin; Drug Screening Assays, Antitumor; Electrophoresis, Gel, Two-Dimensional; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Models, Chemical; Polygonatum; Proteomics; Saponins; Silver Staining; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.
Topics: Adenocarcinoma; Androstenedione; Aspergillus niger; Biotransformation; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diosgenin; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Lung Neoplasms; Molecular Structure; Saponins; Steroids; Uterine Cervical Neoplasms | 2006 |
Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
Topics: Cholestanes; Diosgenin; Hydrocarbons, Iodinated; Molecular Structure; Saponins; Spirostans; Sulfur Compounds | 2006 |
Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Male; Models, Molecular; Neoplasms; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Anti-allergic substances from the rhizomes of Dioscorea membranacea.
Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Line; Dioscorea; Diosgenin; Heterocyclic Compounds, 4 or More Rings; Interleukin-4; Phenanthrenes; Plant Extracts; Quinones; Rats; Rhizome; Saponins; Structure-Activity Relationship | 2006 |
[Study on steroidal saponins of Dioscorea septemloba thunb].
Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Tubers; Plants, Medicinal; Saponins; Steroids | 2006 |
Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
Topics: Animals; Arecaceae; Blood Glucose; Diosgenin; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Methanol; Molecular Structure; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Time Factors | 2007 |
Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells.
Topics: Apoptosis; beta Catenin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Diosgenin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Oncogene Protein p21(ras); Saponins | 2007 |
Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.
Topics: Animals; Carbohydrate Conformation; Cholesterol; Diosgenin; Glucose; Glycolipids; Glycyrrhetinic Acid; Humans; Hydrogen-Ion Concentration; Models, Chemical; PC12 Cells; Pyrans; Rats; Rhamnose; Saponins; Tropanes | 2007 |
Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Methanol; Plant Extracts; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
Topics: Cell Death; Cell Line, Tumor; Diosgenin; Erythrocytes; Hemolysis; Humans; Saponins | 2007 |
Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.
Topics: Biotransformation; Diosgenin; Genes, Bacterial; Saponins; Soil Microbiology; Spiro Compounds; Steroids; Streptomyces; Triterpenes | 2007 |
Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Diosgenin; HL-60 Cells; Humans; Microsomes; Mitochondria; Molecular Sequence Data; Proteomics; Reactive Oxygen Species; Saponins | 2007 |
Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Drug Evaluation, Preclinical; Molecular Structure; Rats; Reproducibility of Results; Saponins; Tandem Mass Spectrometry | 2008 |
Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Diosgenin; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Mitochondria; Saponins; Tumor Cells, Cultured | 2008 |
Balanitin-6 and -7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Balanites; Cell Cycle; Cell Line, Tumor; Diosgenin; Female; Humans; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Reactive Oxygen Species; Saponins | 2008 |
Synthesis and cytotoxic activity of diosgenyl saponin analogues.
Topics: Cell Cycle; Cell Death; Cell Line, Tumor; Diosgenin; G1 Phase; G2 Phase; Humans; Inhibitory Concentration 50; Saponins | 2008 |
[Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch].
Topics: Diosgenin; Magnoliopsida; Molecular Structure; Plant Extracts; Rhizome; Saponins; Steroids | 2008 |
Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diosgenin; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Lung Neoplasms; Mitochondria; Molecular Chaperones; Proteomics; Saponins; Signal Transduction; Transcription Factor CHOP; Tumor Suppressor Protein p53 | 2008 |
Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
Topics: Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dioscorea; Diosgenin; Light; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plant Roots; Saponins; Scattering, Radiation; Solvents; Spectrometry, Mass, Electrospray Ionization; Spirostans | 2008 |
New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.
Topics: Arylsulfonates; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Polyamines; Quinolines; Reproducibility of Results; Saponins; Sulfonium Compounds; Valproic Acid | 2009 |
[Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].
Topics: Animals; Antineoplastic Agents; Blood Proteins; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Female; Humans; Male; Protein Binding; Rats; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry; Ultrafiltration | 2008 |
Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Diosgenin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ecdysteroids; Ecdysterone; Humans; Immunosuppressive Agents; K562 Cells; Leukemia; Magnoliopsida; Membrane Transport Modulators; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Plant Extracts; Rhizome; Saponins; Spirostans; Steroids | 2009 |
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase 2; Caspase 3; Caspase 9; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; DNA Fragmentation; Enzyme Activation; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Mitochondrial Proteins; Saponins | 2009 |
Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
Topics: Alkanes; Cholesterol; Diosgenin; Hemolysis; Lipid Bilayers; Membrane Microdomains; Molecular Dynamics Simulation; Molecular Structure; Saponins; Water | 2010 |
Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.
Topics: Biotransformation; Buffers; Dioscorea; Diosgenin; Fermentation; Ions; Saponins; Steroids; Surface-Active Agents; Temperature; Time Factors; Trichoderma | 2010 |
Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Culture Media; Dioscorea; Diosgenin; Fermentation; Glucose; Molecular Structure; Plant Tubers; Rhamnose; Saponins; Starch; Trichoderma | 2010 |
Structural analogues of diosgenyl saponins: synthesis and anticancer activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diosgenin; Disaccharides; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Monosaccharides; Saponins; Uterine Cervical Neoplasms | 2009 |
Some biomedical applications of Balanites aegyptiaca grown naturally in radioactive area, Southeastern Desert, Egypt.
Topics: Animals; Balanites; Blood Glucose; Carbohydrate Metabolism; Cholesterol, HDL; Cholesterol, LDL; Diet; Diosgenin; Egypt; Hypoglycemic Agents; Hypolipidemic Agents; Plant Oils; Plants, Medicinal; Radioactivity; Rats; Saponins; Triglycerides; Uranium | 2010 |
[Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Diltiazem; Diosgenin; Enzyme Activation; Female; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Potassium-Exchanging ATPase | 2010 |
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
Topics: Apoptosis; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Diosgenin; Gene Expression Regulation, Neoplastic; Humans; Leukotriene B4; Nitrobenzenes; Saponins; Steroids; Sulfonamides; Time Factors | 2010 |
Pharmacokinetics of methyl protodioscin in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Diosgenin; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Mass Spectrometry; Rats; Saponins; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution | 2010 |
Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.
Topics: Animals; Blood Coagulation; Cholesterol, HDL; Cholesterol, LDL; Dioscorea; Diosgenin; Hypolipidemic Agents; Male; Rats; Rats, Sprague-Dawley; Saponins; Triglycerides | 2010 |
Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Diosgenin; Disease Models, Animal; Glucose; Inflammation; Insulin Resistance; Male; Mice; Mice, Obese; Obesity; Phytotherapy; Plant Extracts; RNA, Messenger; Saponins; Trigonella | 2010 |
Anthelmintic activity of steroidal saponins from Paris polyphylla.
Topics: Animals; Anthelmintics; Diosgenin; Goldfish; Liliaceae; Plant Extracts; Rhizome; Saponins; Trematoda | 2010 |
Structural requirement of spirostanol glycosides for rat uterine contractility and mode of their synergism.
Topics: Animals; Dinoprost; Diosgenin; Drug Synergism; Drugs, Chinese Herbal; Estrogens; Female; Liliaceae; Myometrium; Phytosterols; Pregnancy; Rats; Rats, Wistar; Rhizome; Saponins; Structure-Activity Relationship | 2010 |
[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
Topics: Animals; Cell Hypoxia; Cells, Cultured; Diosgenin; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxygen; Rats; Rats, Sprague-Dawley; Saponins | 2010 |
Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cisplatin; Diosgenin; Disease Models, Animal; Female; Lung Neoplasms; Male; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Saponins; Wound Healing | 2011 |
Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo.
Topics: Angiogenesis Inhibitors; Animals; Cell Cycle; Cell Differentiation; Cell Line; Cell Movement; Cell Proliferation; Diosgenin; DNA Replication; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Embryo, Nonmammalian; Endothelial Cells; Humans; Liliaceae; Neovascularization, Physiologic; Plants, Medicinal; Saponins; Time Factors; Zebrafish | 2011 |
[Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Mice; Random Allocation; Saponins | 2011 |
Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.
Topics: Animals; Biofuels; Diosgenin; Food Preferences; Illinois; Larva; Moths; Panicum; Plant Leaves; Poaceae; Population Density; Saponins; Zea mays | 2011 |
Paris saponin I induces G₂/M cell cycle arrest and apoptosis in human gastric carcinoma SGC7901 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Cell Proliferation; Diosgenin; G2 Phase; Humans; Liliaceae; Plant Extracts; Saponins; Stomach Neoplasms | 2011 |
Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H.
Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Liliaceae; Magnoliopsida; Neoplasms; Phytotherapy; Rhizome; Saponins | 2012 |
Polyphyllin D induces apoptosis in human erythrocytes through Ca²⁺ rise and membrane permeabilization.
Topics: Apoptosis; Calcium; Caspase 3; Cell Membrane Permeability; Cell Size; Cells, Cultured; Cytosol; Diosgenin; Erythrocytes; Humans; Mitochondrial Membranes; Saponins | 2012 |
Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Diosgenin; Glycosides; Humans; Mice; Molecular Structure; Neoplasms; Phytotherapy; Plant Extracts; Saponins; Solanaceous Alkaloids; Solanum; Species Specificity; Spirostans; Steroids | 2012 |
Two new steroidal saponins from the biotransformation product of the rhizomes of Dioscorea nipponica.
Topics: Aspergillus oryzae; Biotransformation; Dioscorea; Diosgenin; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rhizome; Saponins; Stereoisomerism | 2012 |
Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.
Topics: Asparagus Plant; Climate; Diosgenin; Plant Stems; Rutin; Saponins; Soil; Temperature | 2012 |
A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).
Topics: Aspergillus; beta-Glucosidase; Circular Dichroism; Dioscorea; Diosgenin; Enzyme Stability; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Molecular Weight; Protein Structure, Secondary; Saponins; Spirostans; Temperature | 2012 |
Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells.
Topics: Animals; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Diosgenin; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Flow Cytometry; Humans; Mice; Ovarian Neoplasms; Phosphorylation; Rhizome; Saponins; Xenograft Model Antitumor Assays | 2012 |
Structural and Sensory Characterization of Bitter Tasting Steroidal Saponins from Asparagus Spears (Asparagus officinalis L.).
Topics: Adult; Asparagus Plant; Chromatography, Liquid; Diosgenin; Female; Humans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Nontherapeutic Human Experimentation; Saponins; Tandem Mass Spectrometry; Taste | 2012 |
Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma.
Topics: Animals; Antioxidants; Diosgenin; Disease Models, Animal; Down-Regulation; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Saponins; Treatment Outcome; Trigonella | 2012 |
[Observation on anticancer function of PS II isolated from Rhizoma Paridis].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Diosgenin; Female; Humans; Liliaceae; Ovarian Neoplasms; Rhizome; Saponins | 2012 |
Novel organic gelators based on pentose derivatized diosgenyl saponins.
Topics: Crystallography, X-Ray; Diosgenin; Gels; Models, Molecular; Pentoses; Saponins; Solvents; Spectroscopy, Fourier Transform Infrared | 2013 |
Differently N-protected 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranosyl chlorides and their application in the synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside.
Topics: Carbohydrate Sequence; Diosgenin; Molecular Sequence Data; Saponins; X-Ray Diffraction | 2013 |
Protodioscin-glycosidase-1 hydrolyzing 26-O-β-D-glucoside and 3-O-(1 → 4)-α-L-rhamnoside of steroidal saponins from Aspergillus oryzae.
Topics: Aspergillus oryzae; Biotransformation; Cloning, Molecular; Diosgenin; Enzyme Stability; Fungal Proteins; Glycoside Hydrolases; Glycosides; Hydrolysis; Molecular Sequence Data; Saponins; Substrate Specificity | 2013 |
Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius.
Topics: Animals; Anthelmintics; Aquaculture; Biological Assay; Carps; Diosgenin; Fish Diseases; Helminthiasis, Animal; Magnoliopsida; Medicine, Chinese Traditional; Methanol; Parasitic Sensitivity Tests; Plant Extracts; Plants, Medicinal; Platyhelminths; Rhizome; Saponins | 2013 |
Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
Topics: Dioscorea; Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Saponins; Spirostans | 2013 |
Investigation on the mechanisms for biotransformation of saponins to diosgenin.
Topics: Biotransformation; Dioscorea; Diosgenin; Hydrolases; Kinetics; Metabolic Networks and Pathways; Saponins; Spirostans; Trichoderma | 2014 |
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Diosgenin; DNA Damage; Glioblastoma; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Neoplasm Transplantation; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Survival Analysis; Tumor Burden | 2013 |
Novel method utilizing microbial treatment for cleaner production of diosgenin from Dioscorea zingiberensis C.H. Wright (DZW).
Topics: Bacillus; Cell Wall; Dioscorea; Diosgenin; Environmental Pollutants; Enzymes; Hydrolysis; Industry; Lignin; Polygalacturonase; Pressure; Saponins; Solvents; Steam; Temperature; Wastewater; Water; Water Pollutants, Chemical | 2013 |
Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Ginsenosides; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spirostans; Tandem Mass Spectrometry | 2013 |
Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD.
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Dioscorea; Diosgenin; Limit of Detection; Linear Models; Plant Extracts; Reproducibility of Results; Saponins | 2014 |
[Screening and condition optimization of a strain for efficiently biotransformation of saponins in Dioscorea zingiberensis into diosgenin].
Topics: Biotransformation; Culture Media; Dioscorea; Diosgenin; Gibberella; Saponins | 2013 |
The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Survival; Diosgenin; DNA Fragmentation; Electrophoretic Mobility Shift Assay; Estrogen Receptor alpha; Humans; MCF-7 Cells; Molecular Structure; Saponins | 2014 |
Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Diosgenin; Humans; K562 Cells; Leukemia, Myeloid; Liliaceae; Phytotherapy; Plant Extracts; Rhizome; Saponins | 2014 |
Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis.
Topics: China; Chromatography, High Pressure Liquid; Diosgenin; Geography; Magnoliopsida; Models, Biological; Molecular Structure; Multivariate Analysis; Saponins; Species Specificity; Spectroscopy, Near-Infrared | 2014 |
Poisoning by Brachiaria brizantha in flocks of naïve and experienced sheep.
Topics: Animals; Aspartate Aminotransferases; Brachiaria; Brazil; Diosgenin; gamma-Glutamyltransferase; Liver; Liver Function Tests; Plant Leaves; Plant Poisoning; Saponins; Sheep; Sheep Diseases; Sheep, Domestic | 2014 |
Two new steroidal saponins from the rhizomes of Dioscorea zingiberensis.
Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Extracts; Rhizome; Saponins; Spirostans; Steroids | 2014 |
Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Movement; Diosgenin; Female; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Ovarian Neoplasms; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Paris saponin I induces apoptosis via increasing the Bax/Bcl-2 ratio and caspase-3 expression in gefitinib-resistant non-small cell lung cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Diosgenin; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lung Neoplasms; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Saponins; Xenograft Model Antitumor Assays | 2014 |
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
Topics: Antineoplastic Agents; bcl-X Protein; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Computational Biology; Diosgenin; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Interleukin-2; Killer Cells, Natural; Medicine, Chinese Traditional; Molecular Docking Simulation; Protein Conformation; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Diosgenin; DNA Damage; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Saponins | 2014 |
Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Magnoliopsida; MAP Kinase Signaling System; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Saponins | 2014 |
The Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Proliferation; Cisplatin; Diosgenin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Signal Transduction; Tumor Cells, Cultured | 2015 |
Inhibition of cell proliferation by mild hyperthermia at 43˚C with Paris Saponin I in the lung adenocarcinoma cell line PC-9.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Diosgenin; Hot Temperature; Humans; Hyperthermia, Induced; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins | 2015 |
Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Colorectal Neoplasms; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Neoplasm Metastasis; Saponins | 2015 |
Quantitative detection of eryptosis in human erythrocytes using tunable resistive pulse sensing and annexin-V-beads.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Cell Size; Diosgenin; Erythrocytes; Hemolysis; Humans; Phosphatidylserines; Saponins; Toxicity Tests | 2015 |
Study on the pharmacokinetics profiles of polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Chromatography, Liquid; Cyclosporine; Diosgenin; Humans; Male; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Verapamil | 2015 |
UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Feces; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Saponins | 2015 |
Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels.
Topics: ATP Binding Cassette Transporter 1; Cholesterol; Diosgenin; Dose-Response Relationship, Drug; Down-Regulation; Foam Cells; Hep G2 Cells; Humans; Lipid Metabolism; MicroRNAs; Proprotein Convertase 9; Proprotein Convertases; RNA, Messenger; Saponins; Serine Endopeptidases; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Time Factors; Transcription, Genetic; Triglycerides; Up-Regulation | 2015 |
Paris saponin II inhibits human ovarian cancer cell-induced angiogenesis by modulating NF-κB signaling.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line, Tumor; Diosgenin; Electrophoretic Mobility Shift Assay; Female; Heterografts; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Ovarian Neoplasms; Saponins; Signal Transduction | 2015 |
Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
Topics: Asparagus Plant; Cell Line, Tumor; Diosgenin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Mucin 5AC; Plant Roots; Saponins; Tetradecanoylphorbol Acetate | 2015 |
Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin B1; Diosgenin; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Saponins; Tumor Suppressor Protein p53; Up-Regulation | 2015 |
Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Chloroquine; Diosgenin; Drug Synergism; Humans; Liver Neoplasms; Molecular Structure; Saponins; Signal Transduction | 2015 |
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Neoplasm Invasiveness; Phytosterols; Plant Extracts; Plant Roots; Saponins; Treatment Outcome | 2016 |
A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study.
Topics: Administration, Oral; Animals; Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Limit of Detection; Male; Rats; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors | 2016 |
Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Dose-Response Relationship, Drug; Gene Expression; Glucose Transporter Type 4; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Lipids; Liver; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (ATP); Polygonatum; PPAR gamma; Rats; Saponins; Signal Transduction; Streptozocin | 2016 |
Low pressure steam expansion pretreatment as a competitive approach to improve diosgenin yield and the production of fermentable sugar from Dioscorea zingiberensis C.H. Wright.
Topics: Biofuels; Bioreactors; Biotransformation; Curcuma; Dioscorea; Diosgenin; Ethanol; Fermentation; Lignin; Microwaves; Plant Tubers; Pressure; Saponins; Steam; Ultrasonic Waves | 2016 |
Paris Saponins enhance radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Diosgenin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gefitinib; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Saponins | 2016 |
An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
Topics: Animals; Chloroform; Chromatography, High Pressure Liquid; Diosgenin; Male; Methanol; Mice, Obese; Plant Extracts; Saponins; Solid Phase Extraction; Tandem Mass Spectrometry; Trigonella | 2015 |
Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Differentiation; Diosgenin; Genes, abl; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liliaceae; Macrophages; Medicine, Chinese Traditional; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcr; Saponins | 2016 |
Ultrahigh-Performance Liquid Chromatography-High-Resolution Quadrupole Time-of-Flight Mass Spectrometry Based Metabolomics Reveals Key Differences between Brachiaria decumbens and B. brizantha, Two Similar Pastures with Different Toxicities.
Topics: Animal Feed; Animals; Brachiaria; Brazil; Cattle; Chromatography, High Pressure Liquid; Diosgenin; Mass Spectrometry; Metabolomics; Saponins; Seasons; Sterols | 2016 |
Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo.
Topics: ADAM Proteins; Algorithms; Animals; Aorta, Thoracic; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hyperplasia; Membrane Proteins; Models, Theoretical; Molecular Structure; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phosphatidylinositol 3-Kinases; Plant Roots; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction | 2016 |
Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Diosgenin; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Male; Neuroprotection; Neuroprotective Agents; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins | 2016 |
Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
Topics: Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Liliaceae; Quality Control; Saponins | 2016 |
Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.
Topics: Animals; Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Female; Homeostasis; Humans; Liver; Male; Mitochondria; Oxidative Stress; Rats, Wistar; Rhizome; Saponins; Signal Transduction; Up-Regulation | 2016 |
Metabolic profile and pharmacokinetics of polyphyllin I, an anticancer candidate, in rats by UPLC-QTOF-MS/MS and LC-TQ-MS/MS.
Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Male; Metabolome; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2017 |
A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells.
Topics: Apoptosis; Cell Cycle; Diosgenin; Drug Screening Assays, Antitumor; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Saponins | 2016 |
Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment.
Topics: Aniline Compounds; Calcium; Cations, Divalent; Cell Size; Ceramides; Diosgenin; Dose-Response Relationship, Drug; Eryptosis; Erythrocytes; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Hemolysis; Humans; Oxidative Stress; Reactive Oxygen Species; Saponins; Xanthenes | 2016 |
Synthesis of furostanol glycosides: discovery of a potent α-glucosidase inhibitor.
Topics: Diosgenin; Drug Evaluation, Preclinical; Glycoside Hydrolase Inhibitors; Glycosides; Inhibitory Concentration 50; Molecular Structure; Saponins; Sterols; Structure-Activity Relationship | 2016 |
Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.
Topics: Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Survival; Diosgenin; Drug Synergism; Humans; Lung Neoplasms; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction | 2017 |
Paris Saponin I Sensitizes Gastric Cancer Cell Lines to Cisplatin via Cell Cycle Arrest and Apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Diosgenin; Drug Synergism; Humans; Proto-Oncogene Proteins c-bcl-2; Saponins; Stomach Neoplasms | 2016 |
Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway.
Topics: Animals; Diet; Dietary Carbohydrates; Dioscorea; Diosgenin; Extracellular Signal-Regulated MAP Kinases; Fructose; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Male; MAP Kinase Signaling System; Metabolic Syndrome; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Saponins; Tumor Necrosis Factor-alpha; Uric Acid | 2016 |
Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and
Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Preparations; Quality Control; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization | 2017 |
Saponin Profile of Wild Asparagus Species.
Topics: Asparagus Plant; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Saponins; Species Specificity; Vegetables | 2017 |
Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on
Topics: Analysis of Variance; Anti-Inflammatory Agents; Asparagus Plant; Chromatography, High Pressure Liquid; Diosgenin; Fermentation; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Plant Extracts; Saponins; Weissella | 2017 |
Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats.
Topics: Animals; China; Diabetes Mellitus; Diosgenin; Gastrointestinal Microbiome; Hypoglycemic Agents; Male; Plant Extracts; Polygonatum; Polysaccharides; Rats; Rats, Sprague-Dawley; Saponins | 2017 |
Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Diosgenin; Drugs, Chinese Herbal; Humans; Liliaceae; Necrosis; Neuroblastoma; Phytotherapy; Saponins | 2017 |
Methyl Protodioscin Induces Apoptosis in Human Osteosarcoma Cells by Caspase-Dependent and MAPK Signaling Pathways.
Topics: Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Dioscorea; Diosgenin; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Osteosarcoma; Phosphorylation; Plant Extracts; Saponins | 2017 |
Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways.
Topics: Apoptosis; Autophagy; Cathepsins; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Survival; Diosgenin; Humans; MAP Kinase Signaling System; Mouth Neoplasms; Saponins | 2017 |
Content of the Saponin Protodioscin in Brachiaria spp. from the Eastern Plains of Colombia.
Topics: Brachiaria; Colombia; Diosgenin; Environmental Monitoring; Saponins; Seasons | 2017 |
Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS.
Topics: Caffeic Acids; Costus; Diosgenin; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Plant Leaves; Plants, Medicinal; Rhizome; Saponins; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Steroids; Sterols; Tandem Mass Spectrometry | 2018 |
Protodioscin ameliorates oxidative stress, inflammation and histology outcome in Complete Freund's adjuvant induced arthritis rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Experimental; Catalase; Cyclooxygenase 2; Dinoprostone; Diosgenin; Dose-Response Relationship, Drug; Edema; Freund's Adjuvant; Gene Expression Regulation; Glutathione; Hindlimb; Interleukin-1beta; Interleukin-6; Male; Nitric Oxide; Oxidative Stress; Pancreatic Elastase; Peroxidase; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2017 |
[Rapid prediction of the content of polyphyllin in various species of Paris by infrared spectrometry].
Topics: Diosgenin; Least-Squares Analysis; Melanthiaceae; Phytochemicals; Saponins; Spectrophotometry, Infrared; Spectroscopy, Near-Infrared; Steroids | 2017 |
Neuroprotective action and mechanistic evaluation of protodioscin against rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Brain; Cell Line, Tumor; Cognition; Dihydroxyphenylalanine; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Humans; Male; Maze Learning; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinsonian Disorders; Rats, Wistar; Saponins | 2018 |
HPTLC determination of diosgenin in fenugreek seeds.
Topics: Acetates; Chromatography, High Pressure Liquid; Diosgenin; Plant Extracts; Saponins; Seeds; Trigonella | 2018 |
Activity of Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its Hydrochloride, and N,N-dialkyl Derivatives Against Non-albicans Candida Isolates.
Topics: Amphotericin B; Antifungal Agents; Candida; Clotrimazole; Diosgenin; Erythrocytes; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Natamycin; Nystatin; Saponins | 2018 |
Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Diosgenin; Extracellular Matrix Proteins; Flavanones; Humans; Hyaluronan Receptors; Interleukin-12; Interleukin-1beta; Lymph Nodes; Macrophage Activation; Macrophages; Mice; Saponins; Sialic Acid Binding Ig-like Lectin 1 | 2018 |
Purification of the total steroidal saponins from fenugreek seeds ( Trigonella foenum- graecum L.) using aqueous two-phase system and determination of diosgenin content using micellar electrokinetic chromatography method.
Topics: Chromatography, Micellar Electrokinetic Capillary; Diosgenin; Plant Extracts; Saponins; Seeds; Solvents; Trigonella | 2019 |
Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Diosgenin; Down-Regulation; Drugs, Chinese Herbal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Heat-Shock Proteins; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; RNA Interference; Saponins; Transcription Factor CHOP; Up-Regulation; Uterine Cervical Neoplasms | 2018 |
Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Proliferation; Chemical Fractionation; Colorectal Neoplasms; Diosgenin; Fabaceae; Glycosides; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Saponins; Triterpenes | 2018 |
Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Diosgenin; Drug Synergism; Fas Ligand Protein; G2 Phase Cell Cycle Checkpoints; Humans; Insulin-Like Growth Factor Binding Protein 1; Lung Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor; Saponins; Signal Transduction | 2018 |
Isolation of endophytic fungi from Dioscorea zingiberensis C. H. Wright and application for diosgenin production by solid-state fermentation.
Topics: Dioscorea; Diosgenin; Fermentation; Fusarium; Hydrolysis; Industrial Microbiology; Saponins | 2018 |
Eco-friendly microbial production of diosgenin from saponins in Dioscorea zingiberensis tubers in the presence of Aspergillus awamori.
Topics: Aspergillus; Biotechnology; Dioscorea; Diosgenin; Fermentation; Green Chemistry Technology; Hydrolysis; Plant Tubers; Saponins; Temperature | 2018 |
Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N-Terminal Amino Acid of Aculeine B.
Topics: Amino Acid Sequence; Amino Acids; Animals; Diosgenin; Indoles; Mice; Molecular Structure; Polyamines; Saponins | 2018 |
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspase 3; Corpus Striatum; Diosgenin; Disease Models, Animal; Down-Regulation; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Mice; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Saponins; Up-Regulation | 2018 |
[Chemical Constituents from Roots and Rhizome of Trillium tschonoskii( Ⅳ)].
Topics: Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Roots; Rhizome; Saponins; Steroids; Trillium | 2016 |
The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase-mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Diosgenin; Drug Synergism; Humans; Lung Neoplasms; Saponins; Signal Transduction | 2019 |
Responses of the weed Bidens pilosa L. to exogenous application of the steroidal saponin protodioscin and plant growth regulators 24-epibrassinolide, indol-3-acetic acid and abscisic acid.
Topics: Abscisic Acid; Antioxidants; Bidens; Brassinosteroids; Diosgenin; Dose-Response Relationship, Drug; Flowers; Germination; Indoleacetic Acids; Malondialdehyde; Plant Growth Regulators; Plant Proteins; Plant Roots; Saponins; Seedlings; Steroids, Heterocyclic | 2019 |
Liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (QTOF/MS) assay for quantification of protodioscin in Brachiaria grasses.
Topics: Brachiaria; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Saponins | 2018 |
Ameliorative effects of protodioscin on experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Blood Glucose; Blood Urea Nitrogen; Carboxymethylcellulose Sodium; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Diosgenin; Fatty Acids, Nonesterified; Kidney; Male; Metformin; Phospholipids; Proteinuria; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Diosgenin; Female; HCT116 Cells; HT29 Cells; Humans; Mice, Nude; Mitochondrial Dynamics; NF-kappa B; Saponins | 2019 |
Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway.
Topics: Animals; Apoptosis; Biological Products; Brain; Caspase 3; Cell Hypoxia; Cell Line; Cytoprotection; Diosgenin; Gene Knockdown Techniques; Mitochondrial Proteins; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Superoxide Dismutase; Ubiquitin-Protein Ligases | 2019 |
NMR-based metabolomics approach to investigate the distribution characteristics of metabolites in Dioscorea opposita Thunb. cv. Tiegun.
Topics: Cluster Analysis; Dioscorea; Diosgenin; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Plant Exudates; Plants, Medicinal; Principal Component Analysis; Saponins | 2019 |
Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Diosgenin; G2 Phase Cell Cycle Checkpoints; HEK293 Cells; HeLa Cells; Humans; Polygonatum; Reactive Oxygen Species; Saponins | 2019 |
Transcriptome analysis of Asparagus officinalis reveals genes involved in the biosynthesis of rutin and protodioscin.
Topics: Asparagus Plant; Diosgenin; Genes, Plant; Rutin; Saponins; Transcriptome | 2019 |
Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Diosgenin; Heat-Shock Proteins; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Reperfusion Injury; Saponins | 2019 |
Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
Topics: ATP Binding Cassette Transporter 1; Cholesterol; Dioscorea; Diosgenin; Hep G2 Cells; Humans; MicroRNAs; Plant Extracts; Proprotein Convertase 9; Receptors, LDL; Rhizome; Saponins; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; THP-1 Cells; Triglycerides | 2019 |
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cisplatin; Diosgenin; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation | 2019 |
Fabrication of a cycloalkyl-monolith for on-line solid-phase extraction and determination of four polyphyllins in plasma.
Topics: Animals; Cycloparaffins; Diosgenin; Mice; Polymers; Saponins; Solid Phase Extraction; Steroids | 2020 |
SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Diosgenin; Down-Regulation; G1 Phase; Humans; Male; PC-3 Cells; Resting Phase, Cell Cycle; Saponins; SOXF Transcription Factors | 2020 |
[Effect of polyphyllin D on proliferation and apoptosis of human pancreatic cancer cells].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins | 2020 |
Photosensitization by Brachiaria ruziziensis in a sheep herd.
Topics: Animals; Brachiaria; Diosgenin; Liver; Photosensitivity Disorders; Plant Poisoning; Saponins; Sheep; Sheep Diseases; Skin | 2020 |
A hairy-root transformation protocol for Trigonella foenum-graecum L. as a tool for metabolic engineering and specialised metabolite pathway elucidation.
Topics: Agrobacterium; Diosgenin; Humans; Metabolic Engineering; Metabolic Networks and Pathways; Plant Roots; Saponins; Transformation, Genetic; Trigonella | 2020 |
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin.
Topics: Antineoplastic Agents; Autophagy; Cell Death; Cell Line, Tumor; Cisplatin; Diosgenin; Endoplasmic Reticulum Stress; Humans; MAP Kinase Signaling System; Saponins | 2020 |
Inhibitory effects of Paris saponin I, II, Ⅵ and Ⅶ on HUVEC cells through regulation of VEGFR2, PI3K/AKT/mTOR, Src/eNOS, PLCγ/ERK/MERK, and JAK2-STAT3 pathways.
Topics: Angiogenesis Inhibitors; Apoptosis; Cell Proliferation; Cells, Cultured; Diosgenin; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinase 2; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2).
Topics: Antineoplastic Agents; Cell Proliferation; Diosgenin; Enzyme Inhibitors; Humans; Jurkat Cells; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Saponins | 2021 |
Natural intoxication caused by protodioscin in lambs kept in Brachiaria pastures.
Topics: Animal Feed; Animals; Brachiaria; Diet; Digestion; Diosgenin; Rumen; Saponins; Sheep; Sheep, Domestic | 2021 |
Morphogenic responses and biochemical alterations induced by the cover crop Urochloa ruziziensis and its component protodioscin in weed species.
Topics: Diosgenin; Plant Weeds; Poaceae; Saponins | 2021 |
Polyphyllin D induces apoptosis and protective autophagy in breast cancer cells through JNK1-Bcl-2 pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; Female; Humans; MAP Kinase Signaling System; Melanthiaceae; Mitogen-Activated Protein Kinase 8; Proto-Oncogene Proteins c-bcl-2; Saponins | 2022 |
Identification and a phased pH control strategy of diosgenin bio-synthesized by an endogenous Bacillus licheniformis Syt1 derived from Dioscorea zingiberensis C. H. Wright.
Topics: Bacillus licheniformis; Dioscorea; Diosgenin; Hydrogen-Ion Concentration; Saponins | 2021 |
Comparative study of steroidal sapogenins content in leaves of five Agave species.
Topics: Agave; Diosgenin; Plant Leaves; Sapogenins; Saponins | 2022 |
Antitumor effect of polyphyllin D on liver metastases of neuroblastoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Diosgenin; Liver Neoplasms; Mice; Neuroblastoma; Saponins | 2022 |
Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest.
Topics: Breast Neoplasms; Cell Cycle Checkpoints; Diosgenin; Female; Humans; Liliaceae; MCF-7 Cells; Molecular Docking Simulation; Plant Components, Aerial; Plant Extracts; Saponins | 2022 |
Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensis.
Topics: Antioxidants; Cyclopentanes; Dioscorea; Diosgenin; Oxylipins; Phytosterols; Saponins; Steroids | 2022 |
Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Diosgenin; Humans; Multiple Myeloma; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
Evaluation of the antibacterial and inhibitory activity of NorA and MepA efflux pumps from Staphylococcus aureus by diosgenin.
Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Diosgenin; Escherichia coli; Ethidium; Fluoroquinolones; Gentamicins; Humans; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Norfloxacin; Saponins; Staphylococcal Infections; Staphylococcus aureus | 2022 |
Deciphering the network of cholesterol biosynthesis in Paris polyphylla laid a base for efficient diosgenin production in plant chassis.
Topics: Cholesterol; Diosgenin; Liliaceae; Plants; Saponins | 2023 |
Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids.
Topics: Animals; Diosgenin; Lipid Bilayers; Membrane Lipids; Saponins; Sugars; Ursidae | 2023 |