Page last updated: 2024-08-26

diosgenin and beta-escin

diosgenin has been researched along with beta-escin in 237 studies

Research

Studies (237)

TimeframeStudies, this research(%)All Research%
pre-199015 (6.33)18.7374
1990's12 (5.06)18.2507
2000's65 (27.43)29.6817
2010's121 (51.05)24.3611
2020's24 (10.13)2.80

Authors

AuthorsStudies
De Geyter, E; Geelen, D; Rahbé, Y; Smagghe, G1
Caliş, I; Hosny, M; Khalifa, T; Sticher, O; Wright, AD1
Baccou, JC; Loubatieères-Mariani, MM; Ribes, G; Sauvaire, Y1
Chiang, HC; Chung, YM; Horng, LY; Lin, WJ; Wu, RT1
Chiang, HC; Chien, KY; Chung, YM; Fu, WC; Horng, LY; Wu, RT1
Bridges, CH; Camp, BJ; Hejtmancik, E; Hill, DW; Patamalai, B1
Malinow, MR1
Hardman, R; Jefferies, TM2
Hardman, R; Wood, CN1
Gupta, YP; Joshi, GS; Kessar, SV; Mahajan, RK; Rampal, AL1
Fukunaga, T; Kato, A; Miura, T1
Paczkowski, C; Wojciechowski, ZA1
Dong, A; Hu, K; Iwasaki, S; Kobayashi, H; Yao, X1
Kintia, PK; Lupashku, GA1
Kameyama, A; Kuroda, M; Mimaki, Y; Sashida, Y; Yokosuka, A1
Takechi, M; Tanaka, Y; Uno, C1
Deng, S; Han, X; Hui, Y; Yu, B; Yu, H1
Ju, Y; Li, X; Liu, M; Wang, Z; Zhang, H; Zhou, J1
Fung, KP; Han, X; Hui, Y; Li, B; Li, M; Yu, B1
Kuroda, M; Mimaki, Y; Sashida, Y; Yokosuka, A1
Hu, K; Yao, X2
Muranaka, T; Putalun, W; Shoyama, Y; Tanaka, H1
Garegg, PJ; Gybäck, H; Lahmann, M; Oscarson, S; Suhr, R; Thiem, J1
Hibasami, H; Imai, K; Ishii, Y; Ishikawa, K; Katsuzaki, H; Komiya, T; Moteki, H; Yoshioka, K1
Han, X; Li, M; Yu, B1
Bednarczyk, D; Kaca, W; Myszka, H; Najder, M1
Doi, K; Takechi, M; Wakayama, Y1
Hou, SJ; Lei, PS; Liang, XT; Shi, Y; Zou, CC1
Cheng, MS; Li, Q; Liu, YX; Miao, HD; Song, HY; Tian, Q; Wang, QL; Xu, X; Yang, Z; Yao, XS1
Ma, HY; Wang, BX; Wang, LJ; Wang, Y; Zhao, ZT; Zhou, QL1
Ma, HY; Wang, BX; Wang, JY; Zhou, QL1
Ganesan, AP; Gauthaman, K; Prasad, RN1
Sun, W; Tu, G; Zhang, Y1
Cai, B; Cui, CB; Liu, HW; Wang, SL; Wu, CF; Yao, XS2
De Combarieu, E; Fuzzati, N; Lovati, M; Mercalli, E1
GARBER, JD; ROTHROCK, JW; STOUDT, TH1
KAWASAKI, T; TSUKAMOTO, T; YAMAUCHI, T1
NAKAMURA, I; YAMAGISHI, M1
BENNETT, RD; BONNER, J; HEFTMANN, E1
BLUNDEN, G; HARDMAN, R1
COLORADO IRIS, R1
KAWASAKI, T; YAMAUCHI, T1
HUANG, ML; WONG, TW1
GATSENKO, LG; LURI, FA; MAKSIMOV, VI; MOROZOVA, LS1
LOSHKAREV, PM; PANINA, VV1
Chin, CK; Garrison, SA; Simon, JE; Tadmor, Y; Wang, M; Wu, QL1
Pfefferkorn, P; Suhr, R; Thiem, J; Weingarten, S1
Chen, Y; Kadota, S; Kouda, K; Le Tran, Q; Miyahara, T; Tezuka, Y; Yin, J1
Guan, H; Li, Y; Lin, F; Yu, B; Zhang, Y; Zhu, S1
Dong, M; Feng, X; Ikejima, T; Wang, BX; Wu, LJ1
Du, Y; Gu, G; Linhardt, RJ1
Patlolla, JM; Raju, J; Rao, CV; Swamy, MV1
Cheung, JY; Fung, KP; Kong, SK; Mak, TC; Ong, RC; Ooi, V; Suen, YK; Wong, HN; Yu, B1
Beneytout, JL; Corbière, C; Duroux, JL; Liagre, B; Trouillas, P1
Che, CM; Hui, Y; Shum, TY; Wong, EL; Yang, Z1
Liu, XK; Ma, YH; Yang, SL1
Liu, MJ; Wang, Z; Wong, RN; Yue, PY1
Feng, Y; Li, X; Shen, L; Wu, XR; Xu, DS1
Chung-Wai, TM; Eng-Choon, VO; Fung, KP; Kong, SK; Lee, MS; Nai-Ching, HW; Yu, B; Yuet-Wa, JC1
Huang, X; Kong, L1
Huang, HY; Jia, ZY; Li, LL; Wang, YJ; Yang, WX1
Cui, XR; Hagiwara, K; Isshiki, Y; Komada, F; Kondo, S; Koyanagi, J; Quan, HJ; Saito, S1
Bai, G; Chen, H; Fong, WF; Huang, M; Wang, G; Wang, N; Yang, M; Yao, X; Zhang, J; Zhang, Y1
Che, CM; Cheung, YH; Chiu, JF; He, QY; Wang, Y; Yang, Z1
He, X; Liu, B; Qu, G; Su, L; Wang, G; Wang, X; Yao, X1
Li, M; Yu, B1
He, X; Jiang, M; Liu, B; Qiao, A; Su, L; Wang, X; Yao, X1
Itharat, A; Tewtrakul, S1
Kang, LP; Lü, N; Ma, BP; Tan, DW; Zhang, J1
Bi, K; Chen, X; Li, J; Liu, Z; Wang, T; Zhong, M1
Asao, Y; Kumahara, A; Matsuda, H; Morikawa, T; Nakamura, S; Pongpiriyadacha, Y; Xu, F; Yoshikawa, M1
Bird, RP; Raju, J1
Ikeda, T; Miyashita, H; Nohara, T1
Chen, J; Lin, S; Tong, Y; Wang, D; Yang, D; Yao, J1
Li, M; Li, W; Qiu, Z; Wang, Y; Yu, B; Yu, J; Zhang, L; Zhang, Y; Zhu, Z1
Li, B; Wang, FQ; Wang, W; Wei, DZ; Zhang, CG1
Che, CM; Chiu, JF; He, QY; Wang, Y1
Cao, X; Chen, H; Dai, Y; Sun, P; Yao, X; Yao, Z; Ye, W1
Cheung, JY; Fung, KP; Ho, HP; Kong, SK; Lee, RK; Lei, J; Li, M; Lin, C; Ong, RC; Yu, B1
De Nève, N; Dubois, J; Duez, P; Gnoula, C; Guissou, P; Ingrassia, L; Kiss, R; Lefranc, F; Mégalizzi, V; Mijatovic, T; Ribaucour, F; Sauvage, S1
Jiang, ZH; Kaskiw, MJ; Tassotto, ML; Th'ng, J1
Bai, N; Chen, C; Chen, Y; Xue, D; Yin, HX; Zhang, H1
Che, CM; Cheung, YW; He, QY; Ko, BC; Lok, CN; Ma, DL; Siu, FM; Xu, S; Yan, K; Yang, M; Yang, Z1
Kim, J; Yoon, KD1
Srinivas, NR1
Cao, XZ; Pan, YM; Shao, M; Yao, XS; Yao, ZH; Ye, WC1
Bayet, C; Darbour, N; Di Pietro, A; Dijoux-Franca, MG; Doreau, A; Dumontet, C; Guilet, D; Nguyen, VT; Phung, BH; Raad, I1
Mehta, R; Raju, J1
Chen, LL; Lee, JC; Su, CL; Won, SJ1
Lin, F; Wang, R1
Dong, YS; Liu, L; Qi, SS; Wang, H; Xiu, ZL1
Huang, W; Li, H; Liu, W; Ni, JR; Zhu, YL1
Jiang, ZH; Kaskiw, MJ; Mok, M; Pycko, R; Tassotto, ML; Th'ng, J; Tokar, SL1
Ahmad, IA; Kamel, AM; Morsy, AM1
Li, Y; Ning, Z; Zhang, R1
Beneytout, JL; Cook-Moreau, J; Lepage, C; Liagre, B; Pinon, A1
Cao, X; Chen, H; Shao, M; Yao, X; Yao, Z; Ye, W1
Bi, CW; Bi, K; Choi, RC; Dong, TT; Li, J; Liu, Z; Tsim, KW; Wang, T; Zang, L1
Goto, T; Hirai, S; Hoshino, S; Kawada, T; Lee, JY; Mizoguchi, N; Nakano, Y; Narukami, T; Shono, J; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T1
Han, J; Jiang, DX; Liu, XL; Liu, YT; Wang, GX; Zhao, LW1
Chen, JP; Cong, YW; Guo, L; Kang, LP; Ma, BP; Shan, YJ; Wang, B; Xiao, H; Yu, ZY; Zhao, ZH1
Li, YK; Ning, Z; Zhou, Y1
Gao, W; Huang, L; Liu, C; Liu, Z; Man, S; Yan, L; Zhang, Y1
Chan, JY; Detmar, M; Fung, KP; Kong, SK; Koon, JC; Liu, X; Yu, B1
He, Y; Huang, W; Ma, MH; Wu, XH1
Bradshaw, JD; Gray, ME; Lee, ST; Prasifka, JR1
Dai, X; Fan, X; He, X; Hu, G; Huang, Z; Xiao, M; Zhang, B; Zhou, R1
Chen, C; Chen, T; He, J; Liu, X; Wen, F; Xue, D; Yin, H; Zhang, H1
Cheung, KL; Fung, KP; Gao, M; Kong, SK; Lau, IP; Loo, JF; Yu, B; Yu, WS1
Delemasure, S; Duchamp, O; Dutartre, P; Lacaille-Dubois, MA; Manase, MJ; Mirjolet, JF; Mitaine-Offer, AC; Miyamoto, T; Pertuit, D; Tanaka, C1
Feng, B; Kang, LP; Kang, TG; Ma, BP; Quan, B; Song, XB; Yu, HS; Zhang, LJ1
Chiji, H; Kitazawa, H; Maeda, T; Motoki, S; Nishihara, E; Shinohara, Y; Suzuki, T1
Huang, W; Lei, J; Li, T; Niu, H1
Fu, S; Gao, W; Liu, C; Man, S; Qiu, F; Wu, S1
Bai, P; Bui-Nguyen, TM; Chen, X; Gao, L; Liu, J; Liu, S; Wang, H; Xiao, J; Xiao, X; Zhang, X; Zou, J1
Dawid, C; Hofmann, T1
Balasubramanian, MP; Jagadeesan, J; Nandakumar, N; Rengarajan, T1
Bai, P; Chen, XL; Liu, SL; Wang, H; Xiao, X; Yang, M; Zou, J1
Chen, Q; Guo, X; He, S; He, Y; Huang, B; Huang, W; Wang, Y; Xin, G; Xing, Z; Zhao, H1
Bednarczyk, D; Grzywacz, D; Liberek, B; Myszka, H; Sikorski, A; Walczewska, A1
Jin, F; Liu, C; Liu, T; Luo, N; Tang, M; Wang, Q; Wang, Y; Xu, X; Yu, H; Yuan, X1
Li, ZH; Wan, JY; Wang, GQ; Wen, JH; Zhao, FG1
Ali, Z; Khan, IA; Smillie, TJ1
Ni, J; Qiu, M; Zhu, H; Zhu, T; Zhu, Y1
Dong, D; Han, X; Lv, L; Peng, J; Qi, Y; Xu, L; Xu, Y; Yin, L; Zheng, L1
Ao, M; Bai, Y; Jin, W; Wei, M; Yu, L; Yu, P; Zhu, M1
Ji, S; Li, Y; Lv, L; Wang, B; Zhang, G; Zhang, H; Zhao, L; Zhou, G1
Ali, Z; Avula, B; Khan, IA; Smillie, TJ; Wang, YH1
Li, H; Lu, Z; Shi, J; Xu, Z; Zhang, J1
Cheng, MS; Chun, J; Han, L; Kim, YS; Wang, B; Xu, MY1
Li, Q; Liu, Y; Wu, L1
Barbosa-Ferreira, M; Castro, MB; Gracindo, CV; Louvandini, H; Riet-Correa, F1
Hou, Y; Jin, H; Li, W; Shen, T; Wang, Y; Yang, S; Yuan, T; Zhang, J; Zhao, Y1
Faccin, TC; Ferreira, R; Itavo, CC; Lemos, RA; Melo, GK; Riet-Correa, F; Rodrigues, FS; Santos, AC; Silva, JA1
Song, M; Xiang, T; Xiao, YJ; Yuan, Y; Zhang, JY; Zheng, L; Zhou, Y1
Bai, P; Huang, Q; Liu, S; Wang, H; Xiao, J; Xiao, X; Yang, F; Yang, K; Yang, M; Zhang, B; Zou, J1
Feng, J; Jiang, H; Ma, SL; Su, D; Zhao, PJ1
Chen, L; Dai, Q; Du, J; Hu, J; Pang, W; Zhang, H1
Chai, H; Fan, W; Gao, W; Li, J; Li, Y; Liu, Z; Man, S1
Chen, Q; Li, Q; Lu, P; Yu, Q1
Abbasi, F; Al Sawah, E; Berry, A; Boac, BM; Bou Zgheib, N; Bush, SH; Hakam, A; Judson, PL; Khulpateea, BR; Lancaster, JM; Marchion, DC; McClung, EC; Ramirez, IJ; Wenham, RM; Xiong, Y1
Feng, J; Jiang, H; Ma, S; Su, D; Zhao, P; Zhu, X1
Fan, L; Li, Y; Mei, Q; Meng, J; Sun, Y; Yue, Z; Zhang, D; Zhang, F; Zhang, R; Zhang, X1
Cheung, AK; Gao, M; Kong, SK; Lau, PM; Ngai, BH; Yang, AK; Yu, SS1
Ding, CH; Li, SL; Long, MH; Mao, Q; Shakya, S; Zhu, H; Zhu, SC1
Chen, HB; He, XC; Pang, YX; Tang, YN; Yi, T; Zhang, JY; Zhang, YZ; Zhao, ZZ1
Ding, H; Gong, X; Lin, G; Lin, Y; Liu, Z; Ma, W; Zhang, Z1
Bai, P; Liu, S; Wang, H; Xiao, X; Yang, M; Zhu, H; Zou, J1
Hong, JH; Kim, YS; Lee, CJ; Lee, HJ; Lee, SK; Park, JS; Shin, YJ; Son, KH; Yoon, YP1
Li, F; Lin, Z; Liu, Y; Liu, Z; Lu, L; Wang, Y; Wu, J; Zhang, G1
Geng, YD; Kong, LY; Shi, YM; Yang, L; Zhang, C1
Ali, Z; Aumsuwan, P; Avula, B; Dasmahapatra, AK; Helferich, WG; Katzenellenbogen, BS; Khan, IA; Khan, SI; Shariat-Madar, Z; Walker, LA1
Guo, Z; Ito, Y; Li, J; Sun, W; Zhang, X1
Gu, W; Lin, P; Lu, JM; Wang, YF; Yan, HL; Yu, J1
Tong, Y; Wang, H; Wang, L; Wei, M; Yu, L1
Du, LW; Feng, JG; Jiang, H; Li, JH; Ma, SL; Song, SC; Zhao, PJ; Zhou, GH; Zhu, XH1
Goto, T; Hoshino, S; Kawada, T; Takahashi, N; Taketani, K; Tsuge, N; Uemura, T1
Cai, H; Meng, X; Yang, C1
Herling, VR; Hussain, SM; Kowalczyk, M; Pecio, Ł; Pérez, AJ; Stochmal, A1
Chen, HF; Chung, YL; Hsu, KC; Pan, CH; Sheu, MJ; Wang, CC; Wu, CH1
Guo, Z; Ito, Y; Sun, W; Xian, L; Xue, X; Zhang, X1
Chen, P; Jin, HY; Ma, SC; Sun, L1
Ji, L; Liang, T; Liang, Y; Liu, R; Shi, L; Xu, L; Yang, F; Yao, N1
Liu, YC; Shakya, S; Wu, JW; Zhu, H1
Gao, W; Liu, J; Liu, Z; Ma, L; Man, S1
Almasry, M; Faggio, C; Jemaà, M; Lang, F; Mischitelli, M1
Moura, ML; Pereira de Oliveira, A; Rolim, HM1
Guan, H; Hao, J; Li, M; Wang, C; Wang, P; Zhang, X1
Chen, W; Gao, W; Li, X; Liu, Z; Man, S; Pan, G; Teng, Y; Wu, M; Yang, K; Yu, P; Zheng, Q1
Tohda, C1
Du, L; Jiang, H; Li, J; Song, S; Xu, J; Zhu, X1
Guo, C; Meng, Z; Shen, J; Yang, X1
Cho, Y; Choi, SZ; Kang, KB; Ryu, J; Son, M; Sung, SH1
Gil, J; Guillén-Bejarano, R; Jaramillo-Carmona, S; Jiménez-Araujo, A; López, S; Moreno, R; Rodriguez-Arcos, R1
Hwang, DY; Kim, BR; Kim, D; Kim, DS; Kim, M; Kim, WB; Koo, KY; Lee, CY; Lee, H; Lee, S; Son, HJ1
Gu, W; Lu, J; Wang, Y; Yan, H; Yang, X; Yu, J1
Hara, F; Naoe, A; Suzuki, T; Uga, N; Watanabe, S; Yasui, T1
Chang, IL; Chen, CL; Chen, HY; Cheng, CH; Hsieh, CP; Shen, TS; Tseng, SC; Wu, CC1
Chen, JC; Chen, MK; Chien, SY; Chuang, YC; Hsi, YT; Hsieh, MJ; Lin, CC; Lin, CW; Lo, YS; Yang, SF1
Diaz, GJ; Lozano, MC; Martinez, NM1
Agnihotri, VK; Chand, G; Kumar, A; Maurya, AK1
Cao, R; Cheng, GH; Hou, YL; Liu, D; Liu, JY; Qiu, HX; Tu, R; Wang, L; Zhang, JL1
Wang, YZ; Wu, Z; Xu, FR; Zhang, J; Zhang, JY1
Deng, ZK; Wu, J; Zhao, YM1
Boudjeniba, M; Krauze-Baranowska, M; Król-Kogus, B; Lamine, KM; Migas, P1
Dawgul, MA; Grzywacz, D; Kamysz, W; Liberek, B; Myszka, H1
Cheng, P; Fujiwara, Y; Ikeda, T; Komohara, Y; Ohnishi, K; Saito, Y; Shiota, T; Takeya, M1
Fang, X; He, F; Li, H; Li, W; Wang, N1
Chen, CM; Chen, PN; Cheng, CW; Hsieh, YH; Lee, CH; Lin, CL; Ying, TH1
Belli, V; Chambery, A; Ciardiello, F; D'Abrosca, B; Esposito, A; Fiorentino, A; Graziani, V; Panella, M; Potenza, N; Russo, A; Russo, R; Scognamiglio, M; Troiani, T1
Cui, J; Gao, W; Ma, L; Man, S; Yang, L; Zhang, L1
Liu, H; Ma, B; Pang, X; Wei, Y; Xiang, H; Yu, L; Zhang, T; Zhang, Y1
Chen, Y; Chi, Y; Dong, Y; He, Q; Ren, Y; Wu, H1
Honda, A; Ishikawa, Y; Miyahara, M; Miyako, K; Oikawa, M; Otsuka, K; Sakai, R; Shiozaki, H; Takamizawa, S; Takasaki, Y; Tukada, H1
Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S1
Chung, ELT; Jesse, FFA; Loh, TC; Nobilly, F; Predith, M; Samsudin, AA1
Cai, MT; Liu, DH; Xu, YL; Zhang, ZL; Zuo, YM1
Cui, J; Cui, N; Gao, W; Guo, Q; Ma, L; Man, S; Yang, L1
Almeida, JD; Barbosa, MC; Ishii-Iwamoto, EL; Kagami, FL; Kern-Cardoso, KA; Mantovanelli, GC; Mito, MS; Silva, AA1
Amorim, RNL; Biscoto, GL; Diamantino, GML; Keller, KM; Melo, MM; Pedroza, HP; Soto-Blanco, B1
Dong, Y; Guo, C; Liu, Y; Xie, G; Zhu, H1
Chen, M; Kong, AN; Li, P; Wen, X; Xin, Q; Yang, J; Ye, K; Zhang, B1
Guo, S; Li, YQ; Liu, WN; Luo, XJ; Peng, J; Peng, JJ; Tang, MX; Yang, J; Zhang, XJ; Zhang, YY1
An, L; Ma, J; Piao, X; Wang, H; Wu, X; Yuan, Y; Zhang, J; Zhou, L1
Ma, YL; Thakur, K; Wei, ZJ; Zhang, F; Zhang, JG; Zhang, YS; Zhang, YY1
Choi, IY; Park, NI; Yeoung, YR; Yi, TG1
Shu, K; Zhang, Y1
Liu, X; Ma, Z; Ren, S; Wang, L; Xu, F; Yang, L1
Chen, J; Gai, Y; Li, Y; Xu, Z1
Cheng, P; Feng, FF; Sun, C; Wang, H; Wang, W1
Bai, L; Liu, H; Peng, S; Sun, F; Wang, L; Yan, H1
Gao, W; Wang, G; Weng, G; Wu, Q; Zheng, B; Zhu, W1
Xiao, MF1
Diamantino, GML; Ferreira, MIC; Martins, CE; Pierezan, F; Rocha, WSD; Soto-Blanco, B; Veiga, MO; Veiga, VMO1
Aharoni, A; Beritza, K; Garagounis, C; Georgopoulou, ME; Goossens, A; Haralampidis, K; Papadopoulou, KK; Sonawane, P1
Cui, J; Gao, W; Liu, C; Liu, F; Lv, P; Ma, L; Man, S; Peng, L1
Dong, X; Liu, Y; Ni, J; Qu, C; Sun, M; Wang, W; Yin, X; You, L1
Ahn, D; Chung, SJ; Kang, HJ; Kwon, SJ; Yang, HM1
Akhshi, N; Aneva, IY; Darakhshan, S; Echeverría, J; Farzaei, MH; Ghanbari, A; Liao, P; Mollica, A; Nedaei, SE; Qi, Y; Xiao, J1
Buschinelli de Goes, RHT; da Costa, MCM; de Moraes, GJ; de Souza Arco, TFF; de Souza Leal, E; Dias, AM; Dos Santos Difante, G; Gurgel, ALC; Ítavo, CCBF; Ítavo, LCV; Kozerski, ND; Niwa, MVG; Nonato, LM1
Abenavoli, MR; Araniti, F; Baldoqui, DC; Constantin, RP; da Costa Menezes, PVM; de Oliveira Junior, RS; de Souza, LA; Ishii-Iwamoto, EL; Mantovanelli, GC; Mito, MS; Oliveira do Carmo, AA; Silva, AA; Silva, RG; Stulp, GF; Wagner, AL1
Li, H; Liu, J; Liu, W; Liu, Y; Mao, A; Pan, G; Wei, C1
Cao, R; Han, S; Hu, Z; Jin, M; Li, Z; Pan, L; Qin, B; Wang, C; Xiang, Y; Zheng, L1
Anand, U; Bandopadhyay, S; Behl, T; Dey, A; Gadekar, VS; Gupta, PK; Jha, NK; Kumar, M; Shekhawat, MS1
Corzo-Jiménez, IJ; García-Morales, S; León-Morales, JM; Pardo-Núñez, J; Rodríguez-Mejía, DI; Silva-Córdova, NF; Soto-Cordero, AM1
Asai, N; Inoue, M; Kondo, Y; Murayama, M; Naoe, A; Niimi, A; Okada, S; Suzuki, M; Suzuki, T; Takeuchi, T; Tsuchiya, T; Watanabe, S; Yasui, T1
Dat, NT; Dung, LV; Duyen, NT; Ha, DT; Hien, TT; Khoi, NM; Lee, KY; Long, PQ; Phong, NV; Vinh, LB1
Gu, Y; Hou, L; Li, J; Li, S; Zhang, F1
Chen, B; Chen, P; Dong, X; Wu, S; Xu, P; Zhou, M1
Araújo, NJS; Coutinho, HDM; da Silva, ARP; de Freitas, TS; de Sousa, EO; de Vasconcelos, JEL; do Socorro Costa, M; Filho, JMB; Maia, FPA; Pereira Junior, FN; Pinheiro, JCA; Tavares, JF1
Gao, L; Pan, QD; Yan, XX; Yang, LX; Zhou, D1
Dou, J; Guo, Y; Guo, Z; Ito, Y; Xue, P; Xue, Z; Zhang, H; Zhang, X; Zhang, Y1
Hua, X; Kou, C; Li, Y; Liu, J; Lu, J; Song, W; Xue, Z; Yin, X; Zhang, H1
Hanashima, S; Miyazato, DG; Mukogawa, A; Murata, M; Ondevilla, JC; Umegawa, Y1

Reviews

9 review(s) available for diosgenin and beta-escin

ArticleYear
Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.
    Nutrition and cancer, 2009, Volume: 61, Issue:1

    Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Cell Division; Diosgenin; Humans; Neoplasms; Saponins

2009
Cardioprotector Activity of an Esteroidal Saponin: A Scientific and Technological Prospection.
    Recent patents on biotechnology, 2017, Volume: 11, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cardiotonic Agents; Diosgenin; Disease Models, Animal; Dyslipidemias; Humans; Hypertension; Mice; Patents as Topic; Rats; Saponins

2017
New Age Therapy for Alzheimer's Disease by Neuronal Network Reconstruction.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:10

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Atrophy; Diosgenin; Humans; Medicine, Traditional; Neurons; Saponins; Withanolides

2016
Can treatment of Brachiaria decumbens (signal grass) improve its utilisation in the diet in small ruminants?-a review.
    Tropical animal health and production, 2018, Volume: 50, Issue:8

    Topics: Animals; Brachiaria; Diet; Diosgenin; Photosensitivity Disorders; Poaceae; Rumen; Ruminants; Saponins; Sheep; Sheep Diseases; Silage

2018
Recent Advances in the Pharmacological Activities of Dioscin.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Diosgenin; Humans; Saponins

2019
Tribulus terrestris and female reproductive system health: A comprehensive review.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 84

    Topics: Diosgenin; Female; Genitalia, Female; Humans; Libido; Male; Plant Extracts; Saponins; Tribulus

2021
Dioscin: A review on pharmacological properties and therapeutic values.
    BioFactors (Oxford, England), 2022, Volume: 48, Issue:1

    Topics: Diosgenin; Humans; Neoplasms; Plant Extracts; Saponins

2022
[Research progress of steroidal saponins in Paris polyphylla var. yunnanensis and their microbial transformation].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:18

    Topics: Diosgenin; Liliaceae; Melanthiaceae; Rhizome; Saponins

2022
Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics.
    Steroids, 2023, Volume: 192

    Topics: Conservation of Natural Resources; Dioscorea; Diosgenin; Fermentation; Humans; Saponins

2023

Trials

1 trial(s) available for diosgenin and beta-escin

ArticleYear
Performance of sheep grazing in pastures of Brachiaria decumbens, Brachiaria brizantha, Panicum maximum, and Andropogon gayanus with different protodioscin concentrations.
    Tropical animal health and production, 2014, Volume: 46, Issue:5

    Topics: Andropogon; Animals; Brachiaria; Brazil; Diosgenin; Male; Panicum; Plant Poisoning; Saponins; Sheep; Sheep Diseases

2014

Other Studies

227 other study(ies) available for diosgenin and beta-escin

ArticleYear
Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum.
    Pest management science, 2012, Volume: 68, Issue:2

    Topics: Animals; Aphids; Digitonin; Diosgenin; Escin; Insect Control; Insect Repellents; Insecticides; Intestinal Mucosa; Plant Bark; Quillaja; Saponins; Toxicity Tests; Vicia faba

2012
Balanitoside, a furostanol glycoside, and 6-methyldiosgenin from Balanites aegyptiaca.
    Phytochemistry, 1992, Volume: 31, Issue:10

    Topics: Carbohydrate Sequence; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plants, Medicinal; Saponins; Steroids

1992
Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek.
    Lipids, 1991, Volume: 26, Issue:3

    Topics: Alloxan; Animals; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Diosgenin; Dogs; Feces; Gas Chromatography-Mass Spectrometry; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins; Spirostans; Trigonella

1991
Modulation of experimental autoimmune uveitis with formosanin-C in guinea pigs.
    Journal of ocular pharmacology, 1990,Winter, Volume: 6, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Antigens; Arrestin; Autoantibodies; Autoimmune Diseases; Diosgenin; Eye Proteins; Guinea Pigs; Lymph Nodes; Lymphocyte Activation; Male; Saponins; Spleen; Uveitis

1990
Formosanin-C, an immunomodulator with antitumor activity.
    International journal of immunopharmacology, 1990, Volume: 12, Issue:7

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Diosgenin; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon Inducers; Killer Cells, Natural; Liver Neoplasms, Experimental; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Plants, Medicinal; Saponins

1990
The isolation and identification of steroidal sapogenins in Kleingrass.
    Veterinary and human toxicology, 1990, Volume: 32, Issue:4

    Topics: Chromatography, Thin Layer; Diosgenin; Edible Grain; Hemolysis; Panicum; Sapogenins; Saponins; Spectrophotometry, Infrared

1990
Effects of synthetic glycosides on cholesterol absorption.
    Annals of the New York Academy of Sciences, 1985, Volume: 454

    Topics: Animals; Cholesterol, Dietary; Diosgenin; Glycosides; Hypercholesterolemia; Intestinal Absorption; Male; Rats; Rats, Inbred Strains; Saponins; Spirostans

1985
The determination of diosgenin and yamogenin in fenugreek seed by combined column chromatography and infrared spectrometry.
    The Journal of pharmacy and pharmacology, 1971, Volume: 23

    Topics: Chromatography; Chromatography, Thin Layer; Diosgenin; Infrared Rays; Saponins; Seeds; Spectrophotometry; Spirostans

1971
The infra-red spectrometric estimation of diosgenin and yamogenin individually and as their mixtures.
    Planta medica, 1972, Volume: 22, Issue:1

    Topics: Chromatography, Thin Layer; Diosgenin; Plants, Medicinal; Saponins; Spectrophotometry, Infrared; Steroids

1972
The effect of ripening and aqueous incubation on the yield of diosgenin and yamogenin from the fruits of Balanites pedicellaris.
    Planta medica, 1971, Volume: 20, Issue:4

    Topics: Diosgenin; Saponins; Seeds; Spirostans

1971
Synthetic studies in steroidal sapogenins and alkaloids. V. Synthesis of kryptogenin, diosgenin and yamogenin.
    Tetrahedron, 1968, Volume: 24, Issue:2

    Topics: Alkaloids; Chemical Phenomena; Chemistry; Diosgenin; Saponins; Steroids

1968
Effects of steroidal glycosides on blood glucose in normal and diabetic mice.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:1

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Saponins; Spirostans

1995
The in vitro synthesis of diosgenin mono- and diglucoside by enzyme preparations from Solanum melongena leaves.
    Acta biochimica Polonica, 1993, Volume: 40, Issue:1

    Topics: Diosgenin; Glucosides; Glucosyltransferases; Oligosaccharides; Plant Proteins; Plants; Saponins; Spirostans

1993
Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
    Planta medica, 1996, Volume: 62, Issue:6

    Topics: Antineoplastic Agents; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drugs, Chinese Herbal; Glycosides; Molecular Sequence Data; Saponins; Spirostans; Tumor Cells, Cultured

1996
Regulatory effects of saponins in the pathogenesis of root rots in cereal crops.
    Advances in experimental medicine and biology, 1996, Volume: 405

    Topics: Diosgenin; Edible Grain; Fusarium; Plant Diseases; Plant Roots; Saponins

1996
Aculeoside B, a new bisdesmosidic spirostanol saponin from the underground parts of Ruscus aculeatus.
    Journal of natural products, 1998, Volume: 61, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Liliaceae; Molecular Sequence Data; Molecular Structure; Saponins

1998
Structure-activity relationships of saponins and cardiac glycosides. III. Beta-L-xylopyranosyl-(1-->6)-alpha- and -beta-D-glucopyranosides.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:11

    Topics: Adenosine Triphosphatases; Antifungal Agents; Antiviral Agents; Cardiac Glycosides; Digitoxigenin; Diosgenin; Glycyrrhetinic Acid; Hemolysis; Saponins; Structure-Activity Relationship

1998
Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
    Carbohydrate research, 1999, Apr-30, Volume: 317, Issue:1-4

    Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Glycosylation; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Optical Rotation; Saponins; Spectrometry, Mass, Fast Atom Bombardment

1999
Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:2

    Topics: Apoptosis; Cell Differentiation; Cell Division; Diosgenin; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida; Molecular Structure; Saponins

2001
An improved synthesis of the saponin, polyphyllin D.
    Carbohydrate research, 2001, Mar-09, Volume: 331, Issue:1

    Topics: Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Indicators and Reagents; Models, Molecular; Molecular Sequence Data; Molecular Structure; Saponins; Trisaccharides

2001
Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:11

    Topics: Cell Division; Diosgenin; Growth Inhibitors; HL-60 Cells; Humans; Liliaceae; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured

2001
Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.
    Planta medica, 2002, Volume: 68, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Dioscorea; Diosgenin; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; K562 Cells; Neoplasms; Plant Extracts; Plant Stems; Saponins; Tumor Cells, Cultured

2002
Determination of aculeatisides based on immunoassay using a polyclonal antibody against aculeatiside A.
    The Analyst, 2002, Volume: 127, Issue:10

    Topics: Antibodies; Diosgenin; Enzyme-Linked Immunosorbent Assay; Ovalbumin; Saponins; Sensitivity and Specificity; Solanum

2002
A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.
    Carbohydrate research, 2002, Nov-19, Volume: 337, Issue:21-23

    Topics: Antineoplastic Agents; Diosgenin; Magnetic Resonance Spectroscopy; Saponins; Tropanes

2002
Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.
    International journal of molecular medicine, 2003, Volume: 11, Issue:1

    Topics: Apoptosis; Carbohydrate Conformation; Carbohydrate Sequence; Cell Death; Cell Survival; Diosgenin; DNA, Neoplasm; Drugs, Chinese Herbal; HL-60 Cells; Humans; Kinetics; Lymphocytes; Molecular Sequence Data; Oligosaccharides; Saponins; Stomach Neoplasms; Trigonella; Tumor Cells, Cultured

2003
Synthesis of monomethylated dioscin derivatives and their antitumor activities.
    Carbohydrate research, 2003, Jan-20, Volume: 338, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Diosgenin; Humans; Methylation; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured

2003
Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives.
    Carbohydrate research, 2003, Jan-20, Volume: 338, Issue:2

    Topics: 2-Chloroadenosine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Deoxyadenosines; Diosgenin; Glucosamine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Saponins; Structure-Activity Relationship

2003
Biological activities of synthetic saponins and cardiac glycosides.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:1

    Topics: Adenosine Triphosphatases; Antifungal Agents; Antiviral Agents; Diosgenin; Erythrocytes; Glycosides; Glycyrrhetinic Acid; Hemolysis; Humans; Microbial Sensitivity Tests; Phytotherapy; Saponins; Simplexvirus; Structure-Activity Relationship; Trichophyton

2003
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.
    Carbohydrate research, 2003, Apr-04, Volume: 338, Issue:8

    Topics: Acetylation; Carbohydrate Conformation; Diosgenin; Guanidine; Saponins; Spirostans

2003
Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
    The Journal of organic chemistry, 2003, May-02, Volume: 68, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Combinatorial Chemistry Techniques; Diosgenin; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Saponins

2003
[Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of Dioscorea panthaica].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2002, Volume: 27, Issue:7

    Topics: Animals; Anticholesteremic Agents; Cholesterol; Dioscorea; Diosgenin; Female; Hypercholesterolemia; Male; Mice; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar; Saponins

2002
[Intestinal bacteria metabolism of TSDP and characterization of metabolites in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2002, Volume: 27, Issue:9

    Topics: Animals; Biotransformation; Dioscorea; Diosgenin; Gram-Negative Anaerobic Bacteria; Intestines; Male; Molecular Structure; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Spectrometry, Mass, Electrospray Ionization

2002
Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.
    Journal of alternative and complementary medicine (New York, N.Y.), 2003, Volume: 9, Issue:2

    Topics: Analysis of Variance; Androgens; Animals; Aphrodisiacs; Body Weight; Copulation; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ejaculation; Female; Male; Models, Animal; Organ Size; Penis; Random Allocation; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Saponins; Sexual Behavior, Animal

2003
A new steroidal saponin from Dioscorea zingiberensis Wright.
    Natural product research, 2003, Volume: 17, Issue:4

    Topics: Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Structure; Rhizome; Saponins; Sterols

2003
The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.
    Cancer investigation, 2003, Volume: 21, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Survival; Central Nervous System Neoplasms; Colonic Neoplasms; Diosgenin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia; Lung Neoplasms; Male; Saponins; Tumor Cells, Cultured

2003
[Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].
    Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Diosgenin; Flow Cytometry; Humans; K562 Cells; Microscopy, Electron, Scanning; Saponins

2003
Furostanol saponins from Tribulus terrestris.
    Fitoterapia, 2003, Volume: 74, Issue:6

    Topics: Chromatography, High Pressure Liquid; Diosgenin; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Phytotherapy; Plant Components, Aerial; Plant Extracts; Saponins; Tribulus

2003
Isolation of diosgenin by microbiological hydrolysis of saponin.
    Archives of biochemistry and biophysics, 1955, Volume: 57, Issue:1

    Topics: Diosgenin; Hydrolysis; Plants; Saponins

1955
Saponins of Japanese Dioscoreaceae. V. On the structure of dioscin.
    Pharmaceutical bulletin, 1956, Volume: 4, Issue:1

    Topics: Dioscoreaceae; Diosgenin; Saponins

1956
Studies on determination of sapogenins in plants belonging to Dioscorea growing in Japan. II. Determination of diosgenin, tokorogenin, and a new genin contained in the roots.
    Chemical & pharmaceutical bulletin, 1958, Volume: 6, Issue:4

    Topics: Dioscorea; Diosgenin; Japan; Plant Roots; Plants; Sapogenins; Saponins

1958
Biosynthesis of diosgenin in Dioscorea tubers.
    Archives of biochemistry and biophysics, 1961, Volume: 92

    Topics: Dioscorea; Diosgenin; Plant Tubers; Plants; Saponins; Steroids

1961
Dioscorea belizensis Lundell as a source of diosgenin.
    The Journal of pharmacy and pharmacology, 1963, Volume: 15

    Topics: Dioscorea; Diosgenin; Saponins

1963
[Obtaining diosgenin from the barbasco].
    Revista del Instituto de Salubridad y Enfermedades Tropicales, 1962, Volume: 22

    Topics: Diosgenin; Humans; Magnoliopsida; Paullinia; Plants, Medicinal; Saponins

1962
Structures of dioscin, gracillin, and kikuba-saponin. 2. (Saponins of Japanese Dioscoreaceae. XI.
    Chemical & pharmaceutical bulletin, 1962, Volume: 10

    Topics: Dioscoreaceae; Diosgenin; Plants; Saponins; Spirostans; Steroids

1962
[THE INTRODUCTION OF C6-ALPHA-METHYL GROUP INTO DIOSGENIN].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1962, Volume: 9

    Topics: Chemistry, Pharmaceutical; Diosgenin; Research; Saponins

1962
[ON PSEUDOMERIZATION OF DIOSGENIN IN ACETIC ANHYDRIDE IN THE PRESENCE OF ACETIC ACID].
    Meditsinskaia promyshlennost' SSSR, 1963, Volume: 17

    Topics: Acetates; Acetic Acid; Acetic Anhydrides; Chemistry, Pharmaceutical; Diosgenin; Health Services; Pharmacy; Saponins

1963
[COLORIMETRIC METHOD OF DETERMINING DIOSGENIN IN DIOSCOREA].
    Meditsinskaia promyshlennost' SSSR, 1963, Volume: 17

    Topics: Chemistry, Pharmaceutical; Colorimetry; Dioscorea; Diosgenin; Pharmacy; Plants; Plants, Medicinal; Saponins

1963
Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.
    Journal of agricultural and food chemistry, 2003, Oct-08, Volume: 51, Issue:21

    Topics: Asparagus Plant; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diosgenin; Plant Extracts; Rutin; Saponins; Spectrometry, Mass, Electrospray Ionization

2003
Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saindersiae and Galtonia candicans.
    Organic & biomolecular chemistry, 2003, Dec-21, Volume: 1, Issue:24

    Topics: Carbohydrate Conformation; Diosgenin; Glucosides; Glycosylation; Liliaceae; Models, Chemical; Molecular Structure; Saponins; Stereoisomerism

2003
Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway.
    Journal of Asian natural products research, 2004, Volume: 6, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Cell Line, Tumor; Colonic Neoplasms; Cytochromes c; Dioscorea; Diosgenin; Down-Regulation; Flow Cytometry; Humans; Membrane Potentials; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Saponins

2004
In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
    Planta medica, 2004, Volume: 70, Issue:3

    Topics: Animals; Bone Density; Dioscorea; Diosgenin; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Osteoporosis; Ovariectomy; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Saponins

2004
Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.
    Carbohydrate research, 2004, Jul-12, Volume: 339, Issue:10

    Topics: Antineoplastic Agents; Chromatography, Thin Layer; Diosgenin; Magnetic Resonance Spectroscopy; Models, Chemical; Saponins; Silicon; Solvents

2004
Microbial metabolism of pseudoprotodioscin.
    Planta medica, 2004, Volume: 70, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Aspergillus fumigatus; Cell Line, Tumor; Dioscorea; Diosgenin; Drugs, Chinese Herbal; HeLa Cells; Humans; Inhibitory Concentration 50; Mice; Phytotherapy; Rhizome; Saponins

2004
Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.
    The Journal of organic chemistry, 2004, Aug-06, Volume: 69, Issue:16

    Topics: Antineoplastic Agents, Phytogenic; Diosgenin; Drug Screening Assays, Antitumor; Glycosylation; Humans; Inhibitory Concentration 50; Medicine, Chinese Traditional; Molecular Structure; Oligosaccharides; Saponins; Solanum; Stereoisomerism; Tumor Cells, Cultured

2004
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004, Volume: 13, Issue:8

    Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Diosgenin; Disease Models, Animal; History, Early Modern 1451-1600; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Reference Values; Saponins; Sensitivity and Specificity; Trigonella; Tumor Cells, Cultured

2004
Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.
    Cancer letters, 2005, Jan-20, Volume: 217, Issue:2

    Topics: Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochromes c; Diosgenin; Drug Resistance, Neoplasm; Flavoproteins; Flow Cytometry; Humans; Membrane Proteins; Mitochondria; Reactive Oxygen Species; Saponins

2005
Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.
    Bioorganic & medicinal chemistry, 2005, Feb-15, Volume: 13, Issue:4

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Diosgenin; Humans; Models, Molecular; Osteosarcoma; Saponins; Structure-Activity Relationship

2005
Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.
    Organic letters, 2005, Feb-17, Volume: 7, Issue:4

    Topics: Carbohydrate Conformation; Cell Survival; Diosgenin; Fluorides; Glycosylation; HeLa Cells; Humans; Models, Molecular; Saponins; Steroids; Trisaccharides

2005
[Steroidal constituents from Dioscorea parviflora].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:2

    Topics: Dioscorea; Diosgenin; Molecular Conformation; Molecular Structure; Plants, Medicinal; Rhizome; Saponins; Steroids

2005
Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.
    Cancer letters, 2005, Jun-28, Volume: 224, Issue:2

    Topics: Apoptosis; bcl-2-Associated X Protein; Calcium; Cell Cycle; Cell Proliferation; Diosgenin; DNA Damage; Homeostasis; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Saponins; Tumor Cells, Cultured; Up-Regulation

2005
[Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:8

    Topics: Administration, Oral; Animals; Bacteria; Biotransformation; Diosgenin; Intestines; Male; Ophiopogon; Rats; Rats, Wistar; Saponins

2005
Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.
    Cancer biology & therapy, 2005, Volume: 4, Issue:11

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Saponins; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2005
Steroidal saponins from roots of Asparagus officinalis.
    Steroids, 2006, Volume: 71, Issue:2

    Topics: Asparagus Plant; Diosgenin; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Roots; Saponins; Stereoisomerism; Steroids

2006
[Study on chemical constituents in total saponin from Trigonella foenum-graecum].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:18

    Topics: Diosgenin; Plants, Medicinal; Saponins; Seeds; Trigonella

2005
Reactions of 26-iodopseudodiosgenin and 26-iodopseudodiosgenone with various nucleophiles and pharmacological activities of the products.
    Chemical & pharmaceutical bulletin, 2006, Volume: 54, Issue:1

    Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; Bacteria; Carbohydrate Conformation; Carbohydrate Sequence; Diosgenin; Drug Screening Assays, Antitumor; Fungi; Humans; Indicators and Reagents; Microbial Sensitivity Tests; Molecular Sequence Data; Saponins

2006
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
    Cancer letters, 2006, Sep-08, Volume: 241, Issue:1

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; CDC2-CDC28 Kinases; Cell Division; Cell Line, Tumor; Cyclin B; Cyclin B1; Diosgenin; G2 Phase; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins

2006
Proteomic approach to study the cytotoxicity of dioscin (saponin).
    Proteomics, 2006, Volume: 6, Issue:8

    Topics: Apoptosis; Diosgenin; Drug Screening Assays, Antitumor; Electrophoresis, Gel, Two-Dimensional; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Models, Chemical; Polygonatum; Proteomics; Saponins; Silver Staining; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.
    The Journal of steroid biochemistry and molecular biology, 2006, Volume: 100, Issue:1-3

    Topics: Adenocarcinoma; Androstenedione; Aspergillus niger; Biotransformation; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diosgenin; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Lung Neoplasms; Molecular Structure; Saponins; Steroids; Uterine Cervical Neoplasms

2006
Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
    Organic letters, 2006, Jun-22, Volume: 8, Issue:13

    Topics: Cholestanes; Diosgenin; Hydrocarbons, Iodinated; Molecular Structure; Saponins; Spirostans; Sulfur Compounds

2006
Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.
    Steroids, 2006, Volume: 71, Issue:9

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Male; Models, Molecular; Neoplasms; Rats; Rats, Sprague-Dawley; Saponins

2006
Anti-allergic substances from the rhizomes of Dioscorea membranacea.
    Bioorganic & medicinal chemistry, 2006, Dec-15, Volume: 14, Issue:24

    Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Line; Dioscorea; Diosgenin; Heterocyclic Compounds, 4 or More Rings; Interleukin-4; Phenanthrenes; Plant Extracts; Quinones; Rats; Rhizome; Saponins; Structure-Activity Relationship

2006
[Study on steroidal saponins of Dioscorea septemloba thunb].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006, Volume: 29, Issue:11

    Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Tubers; Plants, Medicinal; Saponins; Steroids

2006
Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Apr-01, Volume: 848, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2007
Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
    Chemical & pharmaceutical bulletin, 2007, Volume: 55, Issue:2

    Topics: Animals; Arecaceae; Blood Glucose; Diosgenin; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Methanol; Molecular Structure; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Saponins; Time Factors

2007
Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells.
    Cancer letters, 2007, Oct-08, Volume: 255, Issue:2

    Topics: Apoptosis; beta Catenin; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Diosgenin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Oncogene Protein p21(ras); Saponins

2007
Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.
    Carbohydrate research, 2007, Nov-05, Volume: 342, Issue:15

    Topics: Animals; Carbohydrate Conformation; Cholesterol; Diosgenin; Glucose; Glycolipids; Glycyrrhetinic Acid; Humans; Hydrogen-Ion Concentration; Models, Chemical; PC12 Cells; Pyrans; Rats; Rhamnose; Saponins; Tropanes

2007
Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
    Analytica chimica acta, 2007, Sep-05, Volume: 599, Issue:1

    Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Methanol; Plant Extracts; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2007
Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.
    Carbohydrate research, 2007, Dec-28, Volume: 342, Issue:18

    Topics: Cell Death; Cell Line, Tumor; Diosgenin; Erythrocytes; Hemolysis; Humans; Saponins

2007
Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.
    Applied microbiology and biotechnology, 2007, Volume: 77, Issue:4

    Topics: Biotransformation; Diosgenin; Genes, Bacterial; Saponins; Soil Microbiology; Spiro Compounds; Steroids; Streptomyces; Triterpenes

2007
Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
    Journal of proteome research, 2007, Volume: 6, Issue:12

    Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Diosgenin; HL-60 Cells; Humans; Microsomes; Mitochondria; Molecular Sequence Data; Proteomics; Reactive Oxygen Species; Saponins

2007
Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Drug Evaluation, Preclinical; Molecular Structure; Rats; Reproducibility of Results; Saponins; Tandem Mass Spectrometry

2008
Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.
    Cancer letters, 2008, Mar-18, Volume: 261, Issue:2

    Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Caspases; Diosgenin; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Mitochondria; Saponins; Tumor Cells, Cultured

2008
Balanitin-6 and -7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo.
    International journal of oncology, 2008, Volume: 32, Issue:1

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Balanites; Cell Cycle; Cell Line, Tumor; Diosgenin; Female; Humans; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Reactive Oxygen Species; Saponins

2008
Synthesis and cytotoxic activity of diosgenyl saponin analogues.
    Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

    Topics: Cell Cycle; Cell Death; Cell Line, Tumor; Diosgenin; G1 Phase; G2 Phase; Humans; Inhibitory Concentration 50; Saponins

2008
[Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2008, Volume: 39, Issue:3

    Topics: Diosgenin; Magnoliopsida; Molecular Structure; Plant Extracts; Rhizome; Saponins; Steroids

2008
Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.
    Proteomics, 2008, Volume: 8, Issue:15

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diosgenin; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Lung Neoplasms; Mitochondria; Molecular Chaperones; Proteomics; Saponins; Signal Transduction; Transcription Factor CHOP; Tumor Suppressor Protein p53

2008
Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.
    Journal of separation science, 2008, Volume: 31, Issue:13

    Topics: Carbohydrate Sequence; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dioscorea; Diosgenin; Light; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Plant Roots; Saponins; Scattering, Radiation; Solvents; Spectrometry, Mass, Electrospray Ionization; Spirostans

2008
New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:1

    Topics: Arylsulfonates; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Polyamines; Quinolines; Reproducibility of Results; Saponins; Sulfonium Compounds; Valproic Acid

2009
[Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:11

    Topics: Animals; Antineoplastic Agents; Blood Proteins; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Female; Humans; Male; Protein Binding; Rats; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry; Ultrafiltration

2008
Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla.
    Fitoterapia, 2009, Volume: 80, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Diosgenin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ecdysteroids; Ecdysterone; Humans; Immunosuppressive Agents; K562 Cells; Leukemia; Magnoliopsida; Membrane Transport Modulators; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Plant Extracts; Rhizome; Saponins; Spirostans; Steroids

2009
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.
    Cancer science, 2009, Volume: 100, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase 2; Caspase 3; Caspase 9; Cell Proliferation; Cell Survival; Cytochromes c; Diosgenin; DNA Fragmentation; Enzyme Activation; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Mitochondrial Proteins; Saponins

2009
Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.
    Journal of molecular modeling, 2010, Volume: 16, Issue:1

    Topics: Alkanes; Cholesterol; Diosgenin; Hemolysis; Lipid Bilayers; Membrane Microdomains; Molecular Dynamics Simulation; Molecular Structure; Saponins; Water

2010
Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.
    Applied microbiology and biotechnology, 2010, Volume: 85, Issue:4

    Topics: Biotransformation; Buffers; Dioscorea; Diosgenin; Fermentation; Ions; Saponins; Steroids; Surface-Active Agents; Temperature; Time Factors; Trichoderma

2010
Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation.
    Applied microbiology and biotechnology, 2010, Volume: 85, Issue:5

    Topics: Biotransformation; Chromatography, High Pressure Liquid; Culture Media; Dioscorea; Diosgenin; Fermentation; Glucose; Molecular Structure; Plant Tubers; Rhamnose; Saponins; Starch; Trichoderma

2010
Structural analogues of diosgenyl saponins: synthesis and anticancer activity.
    Bioorganic & medicinal chemistry, 2009, Nov-15, Volume: 17, Issue:22

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diosgenin; Disaccharides; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Monosaccharides; Saponins; Uterine Cervical Neoplasms

2009
Some biomedical applications of Balanites aegyptiaca grown naturally in radioactive area, Southeastern Desert, Egypt.
    Journal of hazardous materials, 2010, Jun-15, Volume: 178, Issue:1-3

    Topics: Animals; Balanites; Blood Glucose; Carbohydrate Metabolism; Cholesterol, HDL; Cholesterol, LDL; Diet; Diosgenin; Egypt; Hypoglycemic Agents; Hypolipidemic Agents; Plant Oils; Plants, Medicinal; Radioactivity; Rats; Saponins; Triglycerides; Uranium

2010
[Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:1

    Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Diltiazem; Diosgenin; Enzyme Activation; Female; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Potassium-Exchanging ATPase

2010
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
    International journal of oncology, 2010, Volume: 36, Issue:5

    Topics: Apoptosis; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Diosgenin; Gene Expression Regulation, Neoplastic; Humans; Leukotriene B4; Nitrobenzenes; Saponins; Steroids; Sulfonamides; Time Factors

2010
Pharmacokinetics of methyl protodioscin in rats.
    Die Pharmazie, 2010, Volume: 65, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Diosgenin; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Mass Spectrometry; Rats; Saponins; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution

2010
Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.
    Planta medica, 2010, Volume: 76, Issue:15

    Topics: Animals; Blood Coagulation; Cholesterol, HDL; Cholesterol, LDL; Dioscorea; Diosgenin; Hypolipidemic Agents; Male; Rats; Rats, Sprague-Dawley; Saponins; Triglycerides

2010
Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:11

    Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Diosgenin; Disease Models, Animal; Glucose; Inflammation; Insulin Resistance; Male; Mice; Mice, Obese; Obesity; Phytotherapy; Plant Extracts; RNA, Messenger; Saponins; Trigonella

2010
Anthelmintic activity of steroidal saponins from Paris polyphylla.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Dec-01, Volume: 17, Issue:14

    Topics: Animals; Anthelmintics; Diosgenin; Goldfish; Liliaceae; Plant Extracts; Rhizome; Saponins; Trematoda

2010
Structural requirement of spirostanol glycosides for rat uterine contractility and mode of their synergism.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:4

    Topics: Animals; Dinoprost; Diosgenin; Drug Synergism; Drugs, Chinese Herbal; Estrogens; Female; Liliaceae; Myometrium; Phytosterols; Pregnancy; Rats; Rats, Wistar; Rhizome; Saponins; Structure-Activity Relationship

2010
[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2010, Volume: 30, Issue:4

    Topics: Animals; Cell Hypoxia; Cells, Cultured; Diosgenin; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxygen; Rats; Rats, Sprague-Dawley; Saponins

2010
Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma.
    Cancer biology & therapy, 2011, Mar-15, Volume: 11, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cisplatin; Diosgenin; Disease Models, Animal; Female; Lung Neoplasms; Male; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Saponins; Wound Healing

2011
Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo.
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Cell Cycle; Cell Differentiation; Cell Line; Cell Movement; Cell Proliferation; Diosgenin; DNA Replication; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Embryo, Nonmammalian; Endothelial Cells; Humans; Liliaceae; Neovascularization, Physiologic; Plants, Medicinal; Saponins; Time Factors; Zebrafish

2011
[Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011, Volume: 42, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Mice; Random Allocation; Saponins

2011
Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.
    Journal of economic entomology, 2011, Volume: 104, Issue:5

    Topics: Animals; Biofuels; Diosgenin; Food Preferences; Illinois; Larva; Moths; Panicum; Plant Leaves; Poaceae; Population Density; Saponins; Zea mays

2011
Paris saponin I induces G₂/M cell cycle arrest and apoptosis in human gastric carcinoma SGC7901 cells.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2011, Volume: 31, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Cell Proliferation; Diosgenin; G2 Phase; Humans; Liliaceae; Plant Extracts; Saponins; Stomach Neoplasms

2011
Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H.
    Fitoterapia, 2012, Volume: 83, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Liliaceae; Magnoliopsida; Neoplasms; Phytotherapy; Rhizome; Saponins

2012
Polyphyllin D induces apoptosis in human erythrocytes through Ca²⁺ rise and membrane permeabilization.
    Archives of toxicology, 2012, Volume: 86, Issue:5

    Topics: Apoptosis; Calcium; Caspase 3; Cell Membrane Permeability; Cell Size; Cells, Cultured; Cytosol; Diosgenin; Erythrocytes; Humans; Mitochondrial Membranes; Saponins

2012
Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
    Fitoterapia, 2012, Volume: 83, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Diosgenin; Glycosides; Humans; Mice; Molecular Structure; Neoplasms; Phytotherapy; Plant Extracts; Saponins; Solanaceous Alkaloids; Solanum; Species Specificity; Spirostans; Steroids

2012
Two new steroidal saponins from the biotransformation product of the rhizomes of Dioscorea nipponica.
    Journal of Asian natural products research, 2012, Volume: 14, Issue:7

    Topics: Aspergillus oryzae; Biotransformation; Dioscorea; Diosgenin; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rhizome; Saponins; Stereoisomerism

2012
Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:5

    Topics: Asparagus Plant; Climate; Diosgenin; Plant Stems; Rutin; Saponins; Soil; Temperature

2012
A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).
    World journal of microbiology & biotechnology, 2012, Volume: 28, Issue:3

    Topics: Aspergillus; beta-Glucosidase; Circular Dichroism; Dioscorea; Diosgenin; Enzyme Stability; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Molecular Weight; Protein Structure, Secondary; Saponins; Spirostans; Temperature

2012
Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Sep-15, Volume: 905

    Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2012
Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells.
    Bioscience trends, 2012, Volume: 6, Issue:4

    Topics: Animals; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Diosgenin; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Flow Cytometry; Humans; Mice; Ovarian Neoplasms; Phosphorylation; Rhizome; Saponins; Xenograft Model Antitumor Assays

2012
Structural and Sensory Characterization of Bitter Tasting Steroidal Saponins from Asparagus Spears (Asparagus officinalis L.).
    Journal of agricultural and food chemistry, 2012, Dec-05, Volume: 60, Issue:48

    Topics: Adult; Asparagus Plant; Chromatography, Liquid; Diosgenin; Female; Humans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Nontherapeutic Human Experimentation; Saponins; Tandem Mass Spectrometry; Taste

2012
Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2012, Volume: 31, Issue:2

    Topics: Animals; Antioxidants; Diosgenin; Disease Models, Animal; Down-Regulation; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Saponins; Treatment Outcome; Trigonella

2012
[Observation on anticancer function of PS II isolated from Rhizoma Paridis].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2012, Volume: 43, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Diosgenin; Female; Humans; Liliaceae; Ovarian Neoplasms; Rhizome; Saponins

2012
Novel organic gelators based on pentose derivatized diosgenyl saponins.
    Organic & biomolecular chemistry, 2013, Feb-07, Volume: 11, Issue:5

    Topics: Crystallography, X-Ray; Diosgenin; Gels; Models, Molecular; Pentoses; Saponins; Solvents; Spectroscopy, Fourier Transform Infrared

2013
Differently N-protected 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranosyl chlorides and their application in the synthesis of diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside.
    Carbohydrate research, 2013, Feb-15, Volume: 367

    Topics: Carbohydrate Sequence; Diosgenin; Molecular Sequence Data; Saponins; X-Ray Diffraction

2013
Protodioscin-glycosidase-1 hydrolyzing 26-O-β-D-glucoside and 3-O-(1 → 4)-α-L-rhamnoside of steroidal saponins from Aspergillus oryzae.
    Applied microbiology and biotechnology, 2013, Volume: 97, Issue:23

    Topics: Aspergillus oryzae; Biotransformation; Cloning, Molecular; Diosgenin; Enzyme Stability; Fungal Proteins; Glycoside Hydrolases; Glycosides; Hydrolysis; Molecular Sequence Data; Saponins; Substrate Specificity

2013
Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius.
    Parasitology, 2013, Volume: 140, Issue:8

    Topics: Animals; Anthelmintics; Aquaculture; Biological Assay; Carps; Diosgenin; Fish Diseases; Helminthiasis, Animal; Magnoliopsida; Medicine, Chinese Traditional; Methanol; Parasitic Sensitivity Tests; Plant Extracts; Plants, Medicinal; Platyhelminths; Rhizome; Saponins

2013
Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
    Natural product communications, 2013, Volume: 8, Issue:3

    Topics: Dioscorea; Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Saponins; Spirostans

2013
Investigation on the mechanisms for biotransformation of saponins to diosgenin.
    World journal of microbiology & biotechnology, 2014, Volume: 30, Issue:1

    Topics: Biotransformation; Dioscorea; Diosgenin; Hydrolases; Kinetics; Metabolic Networks and Pathways; Saponins; Spirostans; Trichoderma

2014
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 59

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Diosgenin; DNA Damage; Glioblastoma; Male; Membrane Potential, Mitochondrial; Mitochondria; Neoplasm Proteins; Neoplasm Transplantation; Permeability; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Survival Analysis; Tumor Burden

2013
Novel method utilizing microbial treatment for cleaner production of diosgenin from Dioscorea zingiberensis C.H. Wright (DZW).
    Bioresource technology, 2013, Volume: 146

    Topics: Bacillus; Cell Wall; Dioscorea; Diosgenin; Environmental Pollutants; Enzymes; Hydrolysis; Industry; Lignin; Polygalacturonase; Pressure; Saponins; Solvents; Steam; Temperature; Wastewater; Water; Water Pollutants, Chemical

2013
Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats.
    Steroids, 2013, Dec-11, Volume: 78, Issue:12-13

    Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Drug Stability; Ginsenosides; Magnoliopsida; Male; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spirostans; Tandem Mass Spectrometry

2013
Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD.
    Biomedical chromatography : BMC, 2014, Volume: 28, Issue:2

    Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Dioscorea; Diosgenin; Limit of Detection; Linear Models; Plant Extracts; Reproducibility of Results; Saponins

2014
[Screening and condition optimization of a strain for efficiently biotransformation of saponins in Dioscorea zingiberensis into diosgenin].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2013, Volume: 29, Issue:6

    Topics: Biotransformation; Culture Media; Dioscorea; Diosgenin; Gibberella; Saponins

2013
The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells.
    Archives of pharmacal research, 2014, Volume: 37, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Survival; Diosgenin; DNA Fragmentation; Electrophoretic Mobility Shift Assay; Estrogen Receptor alpha; Humans; MCF-7 Cells; Molecular Structure; Saponins

2014
Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Diosgenin; Humans; K562 Cells; Leukemia, Myeloid; Liliaceae; Phytotherapy; Plant Extracts; Rhizome; Saponins

2014
Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: China; Chromatography, High Pressure Liquid; Diosgenin; Geography; Magnoliopsida; Models, Biological; Molecular Structure; Multivariate Analysis; Saponins; Species Specificity; Spectroscopy, Near-Infrared

2014
Poisoning by Brachiaria brizantha in flocks of naïve and experienced sheep.
    Toxicon : official journal of the International Society on Toxinology, 2014, Volume: 82

    Topics: Animals; Aspartate Aminotransferases; Brachiaria; Brazil; Diosgenin; gamma-Glutamyltransferase; Liver; Liver Function Tests; Plant Leaves; Plant Poisoning; Saponins; Sheep; Sheep Diseases; Sheep, Domestic

2014
Two new steroidal saponins from the rhizomes of Dioscorea zingiberensis.
    Chinese journal of natural medicines, 2014, Volume: 12, Issue:2

    Topics: Dioscorea; Diosgenin; Molecular Structure; Plant Extracts; Rhizome; Saponins; Spirostans; Steroids

2014
Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Movement; Diosgenin; Female; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Ovarian Neoplasms; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2014
Paris saponin I induces apoptosis via increasing the Bax/Bcl-2 ratio and caspase-3 expression in gefitinib-resistant non-small cell lung cancer in vitro and in vivo.
    Molecular medicine reports, 2014, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Diosgenin; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lung Neoplasms; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Saponins; Xenograft Model Antitumor Assays

2014
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Antineoplastic Agents; bcl-X Protein; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Computational Biology; Diosgenin; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Interleukin-2; Killer Cells, Natural; Medicine, Chinese Traditional; Molecular Docking Simulation; Protein Conformation; Saponins; Triterpenes; Tumor Necrosis Factor-alpha

2014
The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling.
    Chemico-biological interactions, 2014, Sep-05, Volume: 220

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Diosgenin; DNA Damage; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Saponins

2014
Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway.
    Journal of medicinal food, 2014, Volume: 17, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Magnoliopsida; MAP Kinase Signaling System; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Saponins

2014
The Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:2

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Proliferation; Cisplatin; Diosgenin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Signal Transduction; Tumor Cells, Cultured

2015
Inhibition of cell proliferation by mild hyperthermia at 43˚C with Paris Saponin I in the lung adenocarcinoma cell line PC-9.
    Molecular medicine reports, 2015, Volume: 11, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Diosgenin; Hot Temperature; Humans; Hyperthermia, Induced; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins

2015
Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells.
    Molecular medicine reports, 2015, Volume: 11, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Colorectal Neoplasms; Diosgenin; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Neoplasm Metastasis; Saponins

2015
Quantitative detection of eryptosis in human erythrocytes using tunable resistive pulse sensing and annexin-V-beads.
    The Analyst, 2015, Feb-21, Volume: 140, Issue:4

    Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Cell Size; Diosgenin; Erythrocytes; Hemolysis; Humans; Phosphatidylserines; Saponins; Toxicity Tests

2015
Study on the pharmacokinetics profiles of polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Caco-2 Cells; Cell Line, Tumor; Chromatography, Liquid; Cyclosporine; Diosgenin; Humans; Male; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Verapamil

2015
UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study.
    Journal of ethnopharmacology, 2015, May-13, Volume: 165

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Drugs, Chinese Herbal; Feces; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Saponins

2015
Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels.
    Atherosclerosis, 2015, Volume: 239, Issue:2

    Topics: ATP Binding Cassette Transporter 1; Cholesterol; Diosgenin; Dose-Response Relationship, Drug; Down-Regulation; Foam Cells; Hep G2 Cells; Humans; Lipid Metabolism; MicroRNAs; Proprotein Convertase 9; Proprotein Convertases; RNA, Messenger; Saponins; Serine Endopeptidases; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Time Factors; Transcription, Genetic; Triglycerides; Up-Regulation

2015
Paris saponin II inhibits human ovarian cancer cell-induced angiogenesis by modulating NF-κB signaling.
    Oncology reports, 2015, Volume: 33, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Line, Tumor; Diosgenin; Electrophoretic Mobility Shift Assay; Female; Heterografts; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; NF-kappa B; Ovarian Neoplasms; Saponins; Signal Transduction

2015
Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, May-15, Volume: 22, Issue:5

    Topics: Asparagus Plant; Cell Line, Tumor; Diosgenin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Mucin 5AC; Plant Roots; Saponins; Tetradecanoylphorbol Acetate

2015
Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:10

    Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin B1; Diosgenin; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Saponins; Tumor Suppressor Protein p53; Up-Regulation

2015
Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, Dec-01, Volume: 22, Issue:13

    Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Chloroquine; Diosgenin; Drug Synergism; Humans; Liver Neoplasms; Molecular Structure; Saponins; Signal Transduction

2015
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.
    Archives of biochemistry and biophysics, 2016, Feb-01, Volume: 591

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Humans; MCF-7 Cells; Neoplasm Invasiveness; Phytosterols; Plant Extracts; Plant Roots; Saponins; Treatment Outcome

2016
A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study.
    Steroids, 2016, Volume: 106

    Topics: Administration, Oral; Animals; Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Diosgenin; Limit of Detection; Male; Rats; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2016
Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats.
    Journal of ethnopharmacology, 2016, Feb-17, Volume: 179

    Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diosgenin; Dose-Response Relationship, Drug; Gene Expression; Glucose Transporter Type 4; Glucose-6-Phosphatase; Hypoglycemic Agents; Insulin; Lipids; Liver; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (ATP); Polygonatum; PPAR gamma; Rats; Saponins; Signal Transduction; Streptozocin

2016
Low pressure steam expansion pretreatment as a competitive approach to improve diosgenin yield and the production of fermentable sugar from Dioscorea zingiberensis C.H. Wright.
    Bioresource technology, 2016, Volume: 206

    Topics: Biofuels; Bioreactors; Biotransformation; Curcuma; Dioscorea; Diosgenin; Ethanol; Fermentation; Lignin; Microwaves; Plant Tubers; Pressure; Saponins; Steam; Ultrasonic Waves

2016
Paris Saponins enhance radiosensitivity in a gefitinib-resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest.
    Molecular medicine reports, 2016, Volume: 13, Issue:3

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Diosgenin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gefitinib; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Saponins

2016
An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice.
    Journal of nutritional science and vitaminology, 2015, Volume: 61, Issue:6

    Topics: Animals; Chloroform; Chromatography, High Pressure Liquid; Diosgenin; Male; Methanol; Mice, Obese; Plant Extracts; Saponins; Solid Phase Extraction; Tandem Mass Spectrometry; Trigonella

2015
Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells.
    International immunopharmacology, 2016, Volume: 36

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Differentiation; Diosgenin; Genes, abl; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liliaceae; Macrophages; Medicine, Chinese Traditional; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcr; Saponins

2016
Ultrahigh-Performance Liquid Chromatography-High-Resolution Quadrupole Time-of-Flight Mass Spectrometry Based Metabolomics Reveals Key Differences between Brachiaria decumbens and B. brizantha, Two Similar Pastures with Different Toxicities.
    Journal of agricultural and food chemistry, 2016, Jun-08, Volume: 64, Issue:22

    Topics: Animal Feed; Animals; Brachiaria; Brazil; Cattle; Chromatography, High Pressure Liquid; Diosgenin; Mass Spectrometry; Metabolomics; Saponins; Seasons; Sterols

2016
Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo.
    Journal of natural products, 2016, 06-24, Volume: 79, Issue:6

    Topics: ADAM Proteins; Algorithms; Animals; Aorta, Thoracic; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hyperplasia; Membrane Proteins; Models, Theoretical; Molecular Structure; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Phosphatidylinositol 3-Kinases; Plant Roots; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction

2016
Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis.
    Steroids, 2016, Volume: 113

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Diosgenin; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Male; Neuroprotection; Neuroprotective Agents; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins

2016
Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection.
    Journal of separation science, 2016, Volume: 39, Issue:18

    Topics: Chromatography, High Pressure Liquid; Diosgenin; Drugs, Chinese Herbal; Liliaceae; Quality Control; Saponins

2016
Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83

    Topics: Animals; Apoptosis; Bile Acids and Salts; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytochrome P-450 Enzyme System; Dioscorea; Diosgenin; Female; Homeostasis; Humans; Liver; Male; Mitochondria; Oxidative Stress; Rats, Wistar; Rhizome; Saponins; Signal Transduction; Up-Regulation

2016
Metabolic profile and pharmacokinetics of polyphyllin I, an anticancer candidate, in rats by UPLC-QTOF-MS/MS and LC-TQ-MS/MS.
    Biomedical chromatography : BMC, 2017, Volume: 31, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Diosgenin; Male; Metabolome; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry

2017
A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells.
    Bioorganic & medicinal chemistry letters, 2016, 10-15, Volume: 26, Issue:20

    Topics: Apoptosis; Cell Cycle; Diosgenin; Drug Screening Assays, Antitumor; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Saponins

2016
Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 39, Issue:4

    Topics: Aniline Compounds; Calcium; Cations, Divalent; Cell Size; Ceramides; Diosgenin; Dose-Response Relationship, Drug; Eryptosis; Erythrocytes; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Hemolysis; Humans; Oxidative Stress; Reactive Oxygen Species; Saponins; Xanthenes

2016
Synthesis of furostanol glycosides: discovery of a potent α-glucosidase inhibitor.
    Organic & biomolecular chemistry, 2016, Oct-04, Volume: 14, Issue:39

    Topics: Diosgenin; Drug Evaluation, Preclinical; Glycoside Hydrolase Inhibitors; Glycosides; Inhibitory Concentration 50; Molecular Structure; Saponins; Sterols; Structure-Activity Relationship

2016
Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Blotting, Western; Camptothecin; Cell Line, Tumor; Cell Survival; Diosgenin; Drug Synergism; Humans; Lung Neoplasms; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction

2017
Paris Saponin I Sensitizes Gastric Cancer Cell Lines to Cisplatin via Cell Cycle Arrest and Apoptosis.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Oct-18, Volume: 22

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Diosgenin; Drug Synergism; Humans; Proto-Oncogene Proteins c-bcl-2; Saponins; Stomach Neoplasms

2016
Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Nov-15, Volume: 23, Issue:12

    Topics: Animals; Diet; Dietary Carbohydrates; Dioscorea; Diosgenin; Extracellular Signal-Regulated MAP Kinases; Fructose; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Kidney; Kidney Diseases; Male; MAP Kinase Signaling System; Metabolic Syndrome; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Saponins; Tumor Necrosis Factor-alpha; Uric Acid

2016
Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and
    Phytochemical analysis : PCA, 2017, Volume: 28, Issue:3

    Topics: Chromatography, High Pressure Liquid; Dioscorea; Diosgenin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Preparations; Quality Control; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization

2017
Saponin Profile of Wild Asparagus Species.
    Journal of food science, 2017, Volume: 82, Issue:3

    Topics: Asparagus Plant; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Saponins; Species Specificity; Vegetables

2017
Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on
    Journal of microbiology and biotechnology, 2017, Apr-28, Volume: 27, Issue:4

    Topics: Analysis of Variance; Anti-Inflammatory Agents; Asparagus Plant; Chromatography, High Pressure Liquid; Diosgenin; Fermentation; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Plant Extracts; Saponins; Weissella

2017
Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Mar-15, Volume: 26

    Topics: Animals; China; Diabetes Mellitus; Diosgenin; Gastrointestinal Microbiome; Hypoglycemic Agents; Male; Plant Extracts; Polygonatum; Polysaccharides; Rats; Rats, Sprague-Dawley; Saponins

2017
Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells.
    Pediatric surgery international, 2017, Volume: 33, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Diosgenin; Drugs, Chinese Herbal; Humans; Liliaceae; Necrosis; Neuroblastoma; Phytotherapy; Saponins

2017
Methyl Protodioscin Induces Apoptosis in Human Osteosarcoma Cells by Caspase-Dependent and MAPK Signaling Pathways.
    Journal of agricultural and food chemistry, 2017, Apr-05, Volume: 65, Issue:13

    Topics: Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Dioscorea; Diosgenin; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Osteosarcoma; Phosphorylation; Plant Extracts; Saponins

2017
Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways.
    Scientific reports, 2017, 03-22, Volume: 7

    Topics: Apoptosis; Autophagy; Cathepsins; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Survival; Diosgenin; Humans; MAP Kinase Signaling System; Mouth Neoplasms; Saponins

2017
Content of the Saponin Protodioscin in Brachiaria spp. from the Eastern Plains of Colombia.
    Toxins, 2017, 07-13, Volume: 9, Issue:7

    Topics: Brachiaria; Colombia; Diosgenin; Environmental Monitoring; Saponins; Seasons

2017
Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS.
    Natural product research, 2018, Volume: 32, Issue:7

    Topics: Caffeic Acids; Costus; Diosgenin; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Plant Leaves; Plants, Medicinal; Rhizome; Saponins; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization; Steroids; Sterols; Tandem Mass Spectrometry

2018
Protodioscin ameliorates oxidative stress, inflammation and histology outcome in Complete Freund's adjuvant induced arthritis rats.
    Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Experimental; Catalase; Cyclooxygenase 2; Dinoprostone; Diosgenin; Dose-Response Relationship, Drug; Edema; Freund's Adjuvant; Gene Expression Regulation; Glutathione; Hindlimb; Interleukin-1beta; Interleukin-6; Male; Nitric Oxide; Oxidative Stress; Pancreatic Elastase; Peroxidase; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2017
[Rapid prediction of the content of polyphyllin in various species of Paris by infrared spectrometry].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017, Volume: 42, Issue:17

    Topics: Diosgenin; Least-Squares Analysis; Melanthiaceae; Phytochemicals; Saponins; Spectrophotometry, Infrared; Spectroscopy, Near-Infrared; Steroids

2017
Neuroprotective action and mechanistic evaluation of protodioscin against rat model of Parkinson's disease.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Cell Line, Tumor; Cognition; Dihydroxyphenylalanine; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Humans; Male; Maze Learning; Neuroprotective Agents; NF-E2-Related Factor 2; Parkinsonian Disorders; Rats, Wistar; Saponins

2018
HPTLC determination of diosgenin in fenugreek seeds.
    Acta pharmaceutica (Zagreb, Croatia), 2018, Mar-01, Volume: 68, Issue:1

    Topics: Acetates; Chromatography, High Pressure Liquid; Diosgenin; Plant Extracts; Saponins; Seeds; Trigonella

2018
Activity of Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its Hydrochloride, and N,N-dialkyl Derivatives Against Non-albicans Candida Isolates.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2018, Volume: 14, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Candida; Clotrimazole; Diosgenin; Erythrocytes; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Natamycin; Nystatin; Saponins

2018
Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
    Journal of clinical and experimental hematopathology : JCEH, 2018, Volume: 58, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Diosgenin; Extracellular Matrix Proteins; Flavanones; Humans; Hyaluronan Receptors; Interleukin-12; Interleukin-1beta; Lymph Nodes; Macrophage Activation; Macrophages; Mice; Saponins; Sialic Acid Binding Ig-like Lectin 1

2018
Purification of the total steroidal saponins from fenugreek seeds ( Trigonella foenum- graecum L.) using aqueous two-phase system and determination of diosgenin content using micellar electrokinetic chromatography method.
    Natural product research, 2019, Volume: 33, Issue:3

    Topics: Chromatography, Micellar Electrokinetic Capillary; Diosgenin; Plant Extracts; Saponins; Seeds; Solvents; Trigonella

2019
Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:1

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Diosgenin; Down-Regulation; Drugs, Chinese Herbal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Female; Heat-Shock Proteins; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; RNA Interference; Saponins; Transcription Factor CHOP; Up-Regulation; Uterine Cervical Neoplasms

2018
Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells.
    Scientific reports, 2018, 03-28, Volume: 8, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Proliferation; Chemical Fractionation; Colorectal Neoplasms; Diosgenin; Fabaceae; Glycosides; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Saponins; Triterpenes

2018
Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells.
    Cell proliferation, 2018, Volume: 51, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Diosgenin; Drug Synergism; Fas Ligand Protein; G2 Phase Cell Cycle Checkpoints; Humans; Insulin-Like Growth Factor Binding Protein 1; Lung Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor; Saponins; Signal Transduction

2018
Isolation of endophytic fungi from Dioscorea zingiberensis C. H. Wright and application for diosgenin production by solid-state fermentation.
    Applied microbiology and biotechnology, 2018, Volume: 102, Issue:13

    Topics: Dioscorea; Diosgenin; Fermentation; Fusarium; Hydrolysis; Industrial Microbiology; Saponins

2018
Eco-friendly microbial production of diosgenin from saponins in Dioscorea zingiberensis tubers in the presence of Aspergillus awamori.
    Steroids, 2018, Volume: 136

    Topics: Aspergillus; Biotechnology; Dioscorea; Diosgenin; Fermentation; Green Chemistry Technology; Hydrolysis; Plant Tubers; Saponins; Temperature

2018
Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N-Terminal Amino Acid of Aculeine B.
    Organic letters, 2018, 06-01, Volume: 20, Issue:11

    Topics: Amino Acid Sequence; Amino Acids; Animals; Diosgenin; Indoles; Mice; Molecular Structure; Polyamines; Saponins

2018
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
    European journal of pharmacology, 2018, Aug-15, Volume: 833

    Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspase 3; Corpus Striatum; Diosgenin; Disease Models, Animal; Down-Regulation; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Mice; Pilocarpine; Proto-Oncogene Proteins c-bcl-2; Saponins; Up-Regulation

2018
[Chemical Constituents from Roots and Rhizome of Trillium tschonoskii( Ⅳ)].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:4

    Topics: Diosgenin; Glycosides; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Roots; Rhizome; Saponins; Steroids; Trillium

2016
The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase-mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis.
    Cell proliferation, 2019, Volume: 52, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Diosgenin; Drug Synergism; Humans; Lung Neoplasms; Saponins; Signal Transduction

2019
Responses of the weed Bidens pilosa L. to exogenous application of the steroidal saponin protodioscin and plant growth regulators 24-epibrassinolide, indol-3-acetic acid and abscisic acid.
    Plant biology (Stuttgart, Germany), 2019, Volume: 21, Issue:2

    Topics: Abscisic Acid; Antioxidants; Bidens; Brassinosteroids; Diosgenin; Dose-Response Relationship, Drug; Flowers; Germination; Indoleacetic Acids; Malondialdehyde; Plant Growth Regulators; Plant Proteins; Plant Roots; Saponins; Seedlings; Steroids, Heterocyclic

2019
Liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (QTOF/MS) assay for quantification of protodioscin in Brachiaria grasses.
    Toxicon : official journal of the International Society on Toxinology, 2018, Dec-01, Volume: 155

    Topics: Brachiaria; Chromatography, Liquid; Diosgenin; Mass Spectrometry; Saponins

2018
Ameliorative effects of protodioscin on experimental diabetic nephropathy.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Dec-01, Volume: 51

    Topics: Albuminuria; Animals; Blood Glucose; Blood Urea Nitrogen; Carboxymethylcellulose Sodium; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Diosgenin; Fatty Acids, Nonesterified; Kidney; Male; Metformin; Phospholipids; Proteinuria; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha

2018
Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway.
    Pharmacological research, 2019, Volume: 139

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Diosgenin; Female; HCT116 Cells; HT29 Cells; Humans; Mice, Nude; Mitochondrial Dynamics; NF-kappa B; Saponins

2019
Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway.
    European journal of pharmacology, 2019, Apr-15, Volume: 849

    Topics: Animals; Apoptosis; Biological Products; Brain; Caspase 3; Cell Hypoxia; Cell Line; Cytoprotection; Diosgenin; Gene Knockdown Techniques; Mitochondrial Proteins; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Superoxide Dismutase; Ubiquitin-Protein Ligases

2019
NMR-based metabolomics approach to investigate the distribution characteristics of metabolites in Dioscorea opposita Thunb. cv. Tiegun.
    Food chemistry, 2019, Nov-15, Volume: 298

    Topics: Cluster Analysis; Dioscorea; Diosgenin; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Plant Exudates; Plants, Medicinal; Principal Component Analysis; Saponins

2019
Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 132

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Diosgenin; G2 Phase Cell Cycle Checkpoints; HEK293 Cells; HeLa Cells; Humans; Polygonatum; Reactive Oxygen Species; Saponins

2019
Transcriptome analysis of Asparagus officinalis reveals genes involved in the biosynthesis of rutin and protodioscin.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Asparagus Plant; Diosgenin; Genes, Plant; Rutin; Saponins; Transcriptome

2019
Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway.
    Cell stress & chaperones, 2019, Volume: 24, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Diosgenin; Heat-Shock Proteins; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Reperfusion Injury; Saponins

2019
Pseudoprotodioscin inhibits SREBPs and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
    Fitoterapia, 2019, Volume: 139

    Topics: ATP Binding Cassette Transporter 1; Cholesterol; Dioscorea; Diosgenin; Hep G2 Cells; Humans; MicroRNAs; Plant Extracts; Proprotein Convertase 9; Receptors, LDL; Rhizome; Saponins; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; THP-1 Cells; Triglycerides

2019
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition.
    Chinese journal of natural medicines, 2019, Volume: 17, Issue:10

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cisplatin; Diosgenin; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation

2019
Fabrication of a cycloalkyl-monolith for on-line solid-phase extraction and determination of four polyphyllins in plasma.
    Analytical biochemistry, 2020, 02-15, Volume: 591

    Topics: Animals; Cycloparaffins; Diosgenin; Mice; Polymers; Saponins; Solid Phase Extraction; Steroids

2020
SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1.
    Acta pharmaceutica (Zagreb, Croatia), 2020, Jun-01, Volume: 70, Issue:2

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Diosgenin; Down-Regulation; G1 Phase; Humans; Male; PC-3 Cells; Resting Phase, Cell Cycle; Saponins; SOXF Transcription Factors

2020
[Effect of polyphyllin D on proliferation and apoptosis of human pancreatic cancer cells].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2020, Volume: 45, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saponins

2020
Photosensitization by Brachiaria ruziziensis in a sheep herd.
    Toxicon : official journal of the International Society on Toxinology, 2020, Oct-15, Volume: 185

    Topics: Animals; Brachiaria; Diosgenin; Liver; Photosensitivity Disorders; Plant Poisoning; Saponins; Sheep; Sheep Diseases; Skin

2020
A hairy-root transformation protocol for Trigonella foenum-graecum L. as a tool for metabolic engineering and specialised metabolite pathway elucidation.
    Plant physiology and biochemistry : PPB, 2020, Volume: 154

    Topics: Agrobacterium; Diosgenin; Humans; Metabolic Engineering; Metabolic Networks and Pathways; Plant Roots; Saponins; Transformation, Genetic; Trigonella

2020
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin.
    Toxicology and applied pharmacology, 2020, 11-01, Volume: 406

    Topics: Antineoplastic Agents; Autophagy; Cell Death; Cell Line, Tumor; Cisplatin; Diosgenin; Endoplasmic Reticulum Stress; Humans; MAP Kinase Signaling System; Saponins

2020
Inhibitory effects of Paris saponin I, II, Ⅵ and Ⅶ on HUVEC cells through regulation of VEGFR2, PI3K/AKT/mTOR, Src/eNOS, PLCγ/ERK/MERK, and JAK2-STAT3 pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Angiogenesis Inhibitors; Apoptosis; Cell Proliferation; Cells, Cultured; Diosgenin; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinase 2; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor Receptor-2

2020
Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2).
    Molecules (Basel, Switzerland), 2021, Feb-05, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Cell Proliferation; Diosgenin; Enzyme Inhibitors; Humans; Jurkat Cells; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Saponins

2021
Natural intoxication caused by protodioscin in lambs kept in Brachiaria pastures.
    Tropical animal health and production, 2021, May-21, Volume: 53, Issue:3

    Topics: Animal Feed; Animals; Brachiaria; Diet; Digestion; Diosgenin; Rumen; Saponins; Sheep; Sheep, Domestic

2021
Morphogenic responses and biochemical alterations induced by the cover crop Urochloa ruziziensis and its component protodioscin in weed species.
    Plant physiology and biochemistry : PPB, 2021, Volume: 166

    Topics: Diosgenin; Plant Weeds; Poaceae; Saponins

2021
Polyphyllin D induces apoptosis and protective autophagy in breast cancer cells through JNK1-Bcl-2 pathway.
    Journal of ethnopharmacology, 2022, Jan-10, Volume: 282

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diosgenin; Female; Humans; MAP Kinase Signaling System; Melanthiaceae; Mitogen-Activated Protein Kinase 8; Proto-Oncogene Proteins c-bcl-2; Saponins

2022
Identification and a phased pH control strategy of diosgenin bio-synthesized by an endogenous Bacillus licheniformis Syt1 derived from Dioscorea zingiberensis C. H. Wright.
    Applied microbiology and biotechnology, 2021, Volume: 105, Issue:24

    Topics: Bacillus licheniformis; Dioscorea; Diosgenin; Hydrogen-Ion Concentration; Saponins

2021
Comparative study of steroidal sapogenins content in leaves of five Agave species.
    Journal of the science of food and agriculture, 2022, Volume: 102, Issue:13

    Topics: Agave; Diosgenin; Plant Leaves; Sapogenins; Saponins

2022
Antitumor effect of polyphyllin D on liver metastases of neuroblastoma.
    Pediatric surgery international, 2022, Volume: 38, Issue:8

    Topics: Animals; Apoptosis; Cell Line, Tumor; Diosgenin; Liver Neoplasms; Mice; Neuroblastoma; Saponins

2022
Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest.
    Carbohydrate research, 2022, Volume: 519

    Topics: Breast Neoplasms; Cell Cycle Checkpoints; Diosgenin; Female; Humans; Liliaceae; MCF-7 Cells; Molecular Docking Simulation; Plant Components, Aerial; Plant Extracts; Saponins

2022
Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensis.
    Plant physiology and biochemistry : PPB, 2022, Sep-01, Volume: 186

    Topics: Antioxidants; Cyclopentanes; Dioscorea; Diosgenin; Oxylipins; Phytosterols; Saponins; Steroids

2022
Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway.
    Hematology (Amsterdam, Netherlands), 2022, Volume: 27, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Diosgenin; Humans; Multiple Myeloma; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases

2022
Evaluation of the antibacterial and inhibitory activity of NorA and MepA efflux pumps from Staphylococcus aureus by diosgenin.
    Life sciences, 2022, Nov-01, Volume: 308

    Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Diosgenin; Escherichia coli; Ethidium; Fluoroquinolones; Gentamicins; Humans; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Norfloxacin; Saponins; Staphylococcal Infections; Staphylococcus aureus

2022
Deciphering the network of cholesterol biosynthesis in Paris polyphylla laid a base for efficient diosgenin production in plant chassis.
    Metabolic engineering, 2023, Volume: 76

    Topics: Cholesterol; Diosgenin; Liliaceae; Plants; Saponins

2023
Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids.
    Biochimica et biophysica acta. Biomembranes, 2023, Volume: 1865, Issue:5

    Topics: Animals; Diosgenin; Lipid Bilayers; Membrane Lipids; Saponins; Sugars; Ursidae

2023