dinoprost and xanthone

The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated as well as cytotoxic activity. Fukugetin, the major component of the bark, showed no activity.

Topics: Animals; Dinoprost; Garcinia; Gentian Violet; HeLa Cells; Humans; Ketoconazole; Mice; Plant Bark; Plant Extracts; Pyrans; Swine; Trypanocidal Agents; Trypanosoma cruzi; Xanthones