dinoprost and sesamodil

dinoprost has been researched along with sesamodil* in 1 studies

Other Studies

1 other study(ies) available for dinoprost and sesamodil

Article	Year
Semotiadil, a new calcium antagonist, is a very potent inhibitor of LDL-oxidation. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:3 The influence of semotiadil, a novel benzothiazine calcium antagonist on in-vitro copper-, 2,2àzo-bis-(2,4 dimethylvaleronitrile)[AMVN]-, and 2,2àzo-bis-(2-amidinopropane) [AAPH]-induced low-density lipoprotein (LDL) oxidation was assessed. The following parameters were measured: lag-time of oxidation, maximal rate of oxidation, dienes formed through continuous monitoring of developing conjugated dienes, thiobarbituric acid reactive substances, isoprostane(8-iso-PGF2alpha)-generation and relative electrophoretic mobility. The effect was compared with nifedipine, amlodipine and diltiazem. Besides the influence on isoprostane (8-iso-PGF2alpha)-generation where nifedipine was equipotent with semotiadil at 10(-3) M, semotiadil demonstrated a strong and significant effect in attenuating the indicated indices of LDL-oxidation, in particular, dose-dependently (10(-3) M to 10(-7) M). These results indicate that semotiadil may have the strongest antioxidant activity on LDL among the calcium antagonists examined. Topics: Adult; Amidines; Azo Compounds; Calcium Channel Blockers; Copper; Dinoprost; F2-Isoprostanes; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitriles; Oxidants; Oxidation-Reduction; Thiazoles; Thiobarbituric Acid Reactive Substances	1999

Article

Year

Semotiadil, a new calcium antagonist, is a very potent inhibitor of LDL-oxidation.

Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:3

The influence of semotiadil, a novel benzothiazine calcium antagonist on in-vitro copper-, 2,2àzo-bis-(2,4 dimethylvaleronitrile)[AMVN]-, and 2,2àzo-bis-(2-amidinopropane) [AAPH]-induced low-density lipoprotein (LDL) oxidation was assessed. The following parameters were measured: lag-time of oxidation, maximal rate of oxidation, dienes formed through continuous monitoring of developing conjugated dienes, thiobarbituric acid reactive substances, isoprostane(8-iso-PGF2alpha)-generation and relative electrophoretic mobility. The effect was compared with nifedipine, amlodipine and diltiazem. Besides the influence on isoprostane (8-iso-PGF2alpha)-generation where nifedipine was equipotent with semotiadil at 10(-3) M, semotiadil demonstrated a strong and significant effect in attenuating the indicated indices of LDL-oxidation, in particular, dose-dependently (10(-3) M to 10(-7) M). These results indicate that semotiadil may have the strongest antioxidant activity on LDL among the calcium antagonists examined.

Topics: Adult; Amidines; Azo Compounds; Calcium Channel Blockers; Copper; Dinoprost; F2-Isoprostanes; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitriles; Oxidants; Oxidation-Reduction; Thiazoles; Thiobarbituric Acid Reactive Substances

1999