dinoprost and hesperetin

dinoprost has been researched along with hesperetin* in 1 studies

Other Studies

1 other study(ies) available for dinoprost and hesperetin

ArticleYear
Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.
    Nutrition (Burbank, Los Angeles County, Calif.), 2006, Volume: 22, Issue:9

    The present study investigated the effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells with regard to whether hesperetin acts as an antioxidant or pro-oxidant. Some flavonoids enhance antioxidant systems while increasing oxidative stress in the body.. After their differentiation into endothelial-like cells for 10 d, mES cells were treated with 1 to 100 muM of hesperetin for 24 h.. Hesperetin efficiently inhibited the formation of vessel-like tubular structures consisting of platelet-endothelial cell adhesion molecule-1-immunoreactive cells and significantly (P < 0.05) increased the generation of reactive oxygen species in a concentration-dependent manner. Although glutathione (in its reduced and oxidized forms) in mES cells was not affected by hesperetin, the 8-iso-prostaglandin F2(alpha) content was decreased. In addition, cytotoxicity-induced hesperetin was not found; lactate dehydrogenase release and cell viability were determined as an index of cell damage.. Taken together, the present study shows that hesperetin inhibits vessel formation by pro-oxidant means and suggests its potential as an antiangiogenic agent.

    Topics: Animals; Antioxidants; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Embryonic Stem Cells; Endothelial Cells; Free Radical Scavengers; Glutathione; Hesperidin; Immunohistochemistry; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species

2006