dinoprost has been researched along with fructose-2-6-diphosphate* in 2 studies
2 other study(ies) available for dinoprost and fructose-2-6-diphosphate
| Article | Year |
|---|---|
Prostaglandins E2 and F2 alpha increase fructose 2,6-bisphosphate levels in isolated hepatocytes.
In hepatocytes isolated from fed rats, prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) increased, in a time- and dose-dependent manner, fructose 2,6-bisphosphate [Fru(2,6)P2] levels and stimulated the glycolytic flux. The rise in Fru(2,6)P2 was related to an increase in glucose 6-phosphate levels which resulted from the stimulation of glycogenolysis. In cells obtained from 24 h-starved rats, no effects of either PGE2 or PGF2 alpha could be observed. In addition, when the stimulation of glycogenolysis was abolished by incubation of fed-rat hepatocytes in a Ca2(+)-depleted medium, Fru(2,6)P2 levels did not increase. Furthermore, no effects of PGs on 6-phosphofructo-2-kinase activity could be observed. These results indicate that PGE2 and PGF2 alpha show similar actions to Ca2(+)-dependent hormones on hepatic glucose metabolism. Topics: Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Dinoprost; Dinoprostone; Fructosediphosphates; Kinetics; Lactates; Liver; Liver Glycogen; Male; Oxytocin; Phosphorylases; Rats; Rats, Inbred Strains | 1991 |
Control of fructose 2,6-bisphosphate levels in rat macrophages by glucose and phorbol ester.
The presence of fructose 2,6-bisphosphate (Fru 2,6-P2) in elicited peritoneal macrophages of rat was examined. These cells possess an active phosphofructokinase-2 which is diminished by citrate and only slightly inhibited by glycerol 3-phosphate. Phosphofructokinase-1 submaximal activity was increased 26-fold by the addition of 1 microM Fru 2,6-P2. Incubation of cells without glucose decreased the amount of Fru 2,6-P2 to zero, but further addition of 5 mM glucose increased the levels of the sugar ester 20-fold. In addition, the presence of phorbol ester potentiated the synthesis of Fru 2,6-P2. By contrast phenylisopropyladenosine or prostaglandin F2 alpha inhibited the production of Fru 2,6-P2. Topics: Animals; Citrates; Citric Acid; Cyclic AMP; Dinoprost; Fructosediphosphates; Glucose; Glycogen; Hexosediphosphates; Hydrogen-Ion Concentration; Kinetics; Lactates; Lactic Acid; Macrophages; Male; Phenylisopropyladenosine; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1989 |